Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.

中文翻译：

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成功进行抗癌化疗的1型干扰素的自分泌信号转导。

如果基于蒽环类的化学疗法通过诱导肿瘤中的免疫原性细胞死亡（ICD）成功恢复免疫监视，则将特别有效。最近，我们发现ICD与诱导以自分泌方式作用于癌细胞的1型干扰素（IFNs-I）耦合，从而增加了其免疫原性。