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Fluid Mechanics of Blood Clot Formation
Annual Review of Fluid Mechanics ( IF 27.7 ) Pub Date : 2015-01-03 , DOI: 10.1146/annurev-fluid-010814-014513 Aaron L Fogelson 1 , Keith B Neeves 2
Annual Review of Fluid Mechanics ( IF 27.7 ) Pub Date : 2015-01-03 , DOI: 10.1146/annurev-fluid-010814-014513 Aaron L Fogelson 1 , Keith B Neeves 2
Affiliation
Intravascular blood clots form in an environment in which hydrodynamic forces dominate and in which fluid-mediated transport is the primary means of moving material. The clotting system has evolved to exploit fluid dynamic mechanisms and to overcome fluid dynamic challenges to ensure that clots that preserve vascular integrity can form over the wide range of flow conditions found in the circulation. Fluid-mediated interactions between the many large deformable red blood cells and the few small rigid platelets lead to high platelet concentrations near vessel walls where platelets contribute to clotting. Receptor-ligand pairs with diverse kinetic and mechanical characteristics work synergistically to arrest rapidly flowing cells on an injured vessel. Variations in hydrodynamic stresses switch on and off the function of key clotting polymers. Protein transport to, from, and within a developing clot determines whether and how fast it grows. We review ongoing experimental and modeling research to understand these and related phenomena.
中文翻译:
血凝块形成的流体力学
血管内血凝块在流体动力占主导地位并且流体介导的运输是移动物质的主要方式的环境中形成。凝血系统已经发展到利用流体动力学机制并克服流体动力学挑战,以确保在循环中发现的各种流动条件下可以形成保持血管完整性的凝块。许多大的可变形红细胞和少数小的刚性血小板之间的流体介导的相互作用导致血管壁附近的高血小板浓度,在那里血小板有助于凝血。具有不同动力学和机械特性的受体-配体对协同工作以阻止受损血管上快速流动的细胞。流体动力应力的变化开启和关闭关键凝血聚合物的功能。蛋白质在发育中的凝块之间的运输和运输决定了它是否生长以及生长的速度。我们回顾了正在进行的实验和建模研究,以了解这些和相关现象。
更新日期:2015-01-03
中文翻译:
血凝块形成的流体力学
血管内血凝块在流体动力占主导地位并且流体介导的运输是移动物质的主要方式的环境中形成。凝血系统已经发展到利用流体动力学机制并克服流体动力学挑战,以确保在循环中发现的各种流动条件下可以形成保持血管完整性的凝块。许多大的可变形红细胞和少数小的刚性血小板之间的流体介导的相互作用导致血管壁附近的高血小板浓度,在那里血小板有助于凝血。具有不同动力学和机械特性的受体-配体对协同工作以阻止受损血管上快速流动的细胞。流体动力应力的变化开启和关闭关键凝血聚合物的功能。蛋白质在发育中的凝块之间的运输和运输决定了它是否生长以及生长的速度。我们回顾了正在进行的实验和建模研究,以了解这些和相关现象。