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Transient effects of levamisole on Brugia malayi microfilariae.
Invertebrate Neuroscience Pub Date : 2015-07-18 , DOI: 10.1007/s10158-015-0181-0
Eman Mostafa 1 , Bob Storey , Adel Mohammed Farghaly , Hany Abd El-Hai Afify , Afaf Abd El-Raouf Taha , Adrian J Wolstenholme
Affiliation  

Levamisole is an anthelmintic drug that acts by activating nicotinic acetylcholine receptors at the nematode neuromuscular junction and causing paralysis. We measured the in vitro effects of levamisole on the motility of Brugia malayi microfilariae; after 2 h incubation the apparent IC50 was 2.68 mM. Lower drug concentrations, such as 1 mM, caused an immediate total paralysis that lasted for up to 1 h, but was completely reversed by 2 h of incubation. The ‘recovered’ parasites were still completely susceptible to application of a second nicotinic agonist, pyrantel.

中文翻译:

左旋咪唑对马来布鲁氏菌丝虫的瞬时作用。

左旋咪唑是一种驱虫药,其作用是激活线虫神经肌肉接头处的烟碱乙酰胆碱受体并引起麻痹。我们测量了左旋咪唑对马来亚布鲁氏丝虫活力的影响。温育2小时后,表观IC 50为2.68mM。较低的药物浓度(例如1 mM)会导致立即完全麻痹,持续长达1小时,但在孵育2小时后完全逆转。“恢复”的寄生虫仍然完全容易受到第二种烟碱激动剂吡喃酮的影响。
更新日期:2015-07-18
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