The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface.

中文翻译：

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用于控制细胞组织的宏观到微观接口

细胞群落的空间组织在决定细胞间通讯和紧急行为方面起着重要作用。然而，很少有工具可以在单个细胞的规模上调节组织组织，特别是在动态操作的情况下。微机械可重构培养通过在微制造板上培养贴壁细胞来实现组织组织的动态控制，微制造板上可以移动以重组细胞的排列。尽管之前已经报道了使用这种方法的生物学研究，但本文侧重于设备的工程设计，包括将手动操作转换为精确的微尺度位置控制的机制、制造的容错设计以及合成到生命的界面。