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Exploring the physiology and pathology of aging in the intestine ofDrosophila melanogaster
Invertebrate Reproduction & Development ( IF 0.8 ) Pub Date : 2014-12-09 , DOI: 10.1080/07924259.2014.963713
Heinrich Jasper 1
Affiliation  

The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the exterior and interior milieus, is critically impacted by dietary, environmental, and inflammatory conditions that influence health and lifespan. Work in flies is now uncovering the multifaceted molecular mechanisms that control homeostasis in this tissue, and establishing its central role in health and lifespan of metazoans. The Drosophila intestine has thus emerged as a productive, genetically accessible model to study various aspects of the pathophysiology of aging. Studies in flies have characterized the maintenance of regenerative homeostasis, the development of immune senescence, the loss of epithelial barrier function, the decline in metabolic homeostasis, as well as the maintenance of epithelial diversity in this tissue. Due to its fundamental similarity to vertebrate intestines, it can be anticipated that findings obtained in this system will have important implications for our understanding of age-related changes in the human intestine. Here, I review recent studies exploring age-related changes in the fly intestine, and their insight into the regulation of health and lifespan of the animal.

中文翻译:

探索黑腹果蝇肠道衰老的生理学和病理学

胃肠道作为消化器官和内外环境之间的屏障,受到影响健康和寿命的饮食、环境和炎症条件的严重影响。果蝇的工作现在正在揭示控制该组织内稳态的多方面分子机制,并确定其在后生动物健康和寿命中的核心作用。因此,果蝇肠道已成为研究衰老病理生理学各个方面的高效、可遗传的模型。对果蝇的研究表明,再生稳态的维持、免疫衰老的发展、上皮屏障功能的丧失、代谢稳态的下降以及该组织中上皮多样性的维持。由于其与脊椎动物肠道的基本相似性,可以预期在该系统中获得的发现将对我们理解人类肠道中与年龄相关的变化具有重要意义。在这里,我回顾了最近探索苍蝇肠道年龄相关变化的研究,以及他们对动物健康和寿命调节的洞察。
更新日期:2014-12-09
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