当前位置: X-MOL 学术J. Neuropsychol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Study of behavioural and neural bases of visuo-spatial working memory with an fMRI paradigm based on an n-back task.
Journal of Neuropsychology ( IF 2.2 ) Pub Date : 2015-06-17 , DOI: 10.1111/jnp.12076
Artemisa R Dores 1, 2 , Fernando Barbosa 3 , Irene P Carvalho 4 , Isabel Almeida 5 , Sandra Guerreiro 5 , Benedita M da Rocha 6 , Liliana de Sousa 1 , Alexandre Castro-Caldas 7
Affiliation  

The goal of this study was to propose a new functional magnetic resonance imaging (fMRI) paradigm using a language‐free adaptation of a 2‐back working memory task to avoid cultural and educational bias. We additionally provide an index of the validity of the proposed paradigm and test whether the experimental task discriminates the behavioural performances of healthy participants from those of individuals with working memory deficits. Ten healthy participants and nine patients presenting working memory (WM) deficits due to acquired brain injury (ABI) performed the developed task. To inspect whether the paradigm activates brain areas typically involved in visual working memory (VWM), brain activation of the healthy participants was assessed with fMRIs. To examine the task's capacity to discriminate behavioural data, performances of the healthy participants in the task were compared with those of ABI patients. Data were analysed with GLM‐based random effects procedures and t‐tests. We found an increase of the BOLD signal in the specialized areas of VWM. Concerning behavioural performances, healthy participants showed the predicted pattern of more hits, less omissions and a tendency for fewer false alarms, more self‐corrected responses, and faster reaction times, when compared with subjects presenting WM impairments. The results suggest that this task activates brain areas involved in VWM and discriminates behavioural performances of clinical and non‐clinical groups. It can thus be used as a research methodology for behavioural and neuroimaging studies of VWM in block‐design paradigms.

中文翻译:

基于n-back任务的功能磁共振成像范式研究视觉空间工作记忆的行为和神经基础。

这项研究的目的是提出一种新的功能性磁共振成像(fMRI)范例,该范例使用无语言适应的2背工作记忆任务来避免文化和教育上的偏见。我们还提供了所提出范式有效性的指标,并测试了实验任务是否能够将健康参与者的行为表现与有工作记忆缺陷的个体的行为表现区分开。十名健康参与者和九名因获得性脑损伤(ABI)而出现工作记忆(WM)缺陷的患者完成了开发的任务。为了检查该范式是否激活了通常涉及视觉工作记忆(VWM)的大脑区域,通过功能磁共振成像对健康参与者的大脑激活进行了评估。要检查任务区分行为数据的能力,将健康参与者的任务表现与ABI患者的表现进行比较。使用基于GLM的随机效应程序分析数据,并t检验。我们发现在VWM的专业领域中,BOLD信号有所增加。关于行为表现,与表现出WM障碍的受试者相比,健康的参与者表现出了更多的命中,更少的遗漏和更少的错误警报,更多的自我纠正的反应以及更快的反应时间的预测模式。结果表明,该任务激活了涉及VWM的大脑区域,并区分了临床和非临床人群的行为表现。因此,它可以用作在块设计范式中对VWM进行行为和神经影像研究的研究方法。
更新日期:2015-06-17
down
wechat
bug