Clinical staging model at the nanoscale (CSMN) has been performed on adenocarcinoma of the colon from five patients ranging in age from 57 to 76 years based on determining their malignant size, estimating their doubling time through imaging techniques, and thus by measuring the average of the tumor nanoparticle doubling time their histologic grade has been identified at the nanoscale. Another two pathologic staging models at the nanoscale PSM [H-3] N and PSM [C-14] N for evaluating the histologic grade have been performed on those tumors based on the in vitro measuring of cell proliferating of tumor slices by either of the [H-3] tritiated and [C-14] thymidine incorporation hypothesizing in PSM [H-3] N that the malignant fraction of the detected tumor is the unlabeled fraction of the tumor by the [H-3] tritiated thymidine, while positing in PSM [C-14] N that the percentage increase of the tumor nanoparticle doubling time than that of the normal tissue at the Natural Background Radiation is equivalent to the percentage deficit of [C-14] incorporation in tumor cells. The consistency of results of the three staging models has been analyzed using ANOVA. Identical histologic grades have been identified by the three staging models for tumors of early stages (p < 0.0001). While for those of advanced disease, evaluation of the histologic grade was identical by CSMN and PSM [H-3] N only (p < 0.0001), whereas was invalid by PSM [C-14] N.

中文翻译：

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纳米级癌症的临床和病理分期。

纳米级临床分期模型（CSMN）对5名年龄在57至76岁的患者进行了结肠腺癌的研究，方法是确定其恶性程度，并通过影像学技术估计其加倍时间，从而测量平均水平。肿瘤纳米颗粒的倍增时间已在纳米尺度上被证实其组织学等级。根据体外切片检测肿瘤切片细胞增殖的方法，在这些肿瘤上进行了另外两个病理学分期模型，分别在纳米级PSM [H-3] N和PSM [C-14] N上评估组织学等级。 [H-3] and和[C-14]胸腺嘧啶核苷的掺入假说在PSM [H-3] N中，检测到的肿瘤的恶性部分是[H-3] ti化胸腺嘧啶的未标记部分，而在PSM [C-14] N中，在自然本底辐射下，肿瘤纳米粒子倍增时间比正常组织增加的百分比等于[C-14]掺入肿瘤细胞的百分比。使用ANOVA分析了三个阶段模型的结果的一致性。通过早期肿瘤的三种分期模型已经确定了相同的组织学等级（p <0.0001）。对于晚期疾病，仅CSMN和PSM [H-3] N对组织学等级的评估相同（p <0.0001），而PSM [C-14] N对组织学等级的评估无效。使用ANOVA分析了三个阶段模型的结果的一致性。通过早期肿瘤的三种分期模型已经确定了相同的组织学等级（p <0.0001）。对于晚期疾病，仅CSMN和PSM [H-3] N对组织学等级的评估相同（p <0.0001），而PSM [C-14] N对组织学等级的评估无效。使用ANOVA分析了三个阶段模型的结果的一致性。通过早期肿瘤的三种分期模型已经确定了相同的组织学等级（p <0.0001）。对于晚期疾病，仅CSMN和PSM [H-3] N对组织学等级的评估相同（p <0.0001），而PSM [C-14] N对组织学等级的评估无效。