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Thermo-optical analysis and selection of the properties of absorbing nanoparticles for laser applications in cancer nanotechnology.
Cancer Nanotechnology ( IF 5.7 ) Pub Date : 2010-09-07 , DOI: 10.1007/s12645-010-0005-1
Victor K Pustovalov 1 , L G Astafyeva 2 , E Galanzha 3 , V P Zharov 3
Affiliation  

Applications of nanoparticles (NPs) as photothermal (PT) and photoacoustic (PA) labels and agents for diagnosis and therapy of cancer and other diseases in laser medicine are fast growing areas of research. Many potential benefits include possibility for imaging with higher resolution and treatment of deeper tissues containing NPs, killing of individual abnormal cells, etc. Nevertheless, despite successful results, there is a lack of focused analysis of requirements to NPs for optimization of PT/PA applications, especially with pulsed lasers. Here, we present a platform for analysis of NP properties (e.g., optical, thermal, acoustic, structural, and geometric), allowing to select their parameters in the presence of different ambient tissues. The several types of NPs are described, which provide significant increased conversion of laser pulse energy in PT/PA phenomena. These NPs make it possible to use them with maximal efficiency for detection and killing single malignant cells labeled with minimal amount of NPs and in laser nanomedicine.

中文翻译:

癌症纳米技术中激光应用的吸收性纳米粒子的热光分析和性质选择。

纳米粒子(NPs)作为光热(PT)和光声(PA)标签以及在激光医学中诊断和治疗癌症及其他疾病的试剂的应用是快速发展的研究领域。许多潜在的好处包括可以进行更高分辨率的成像以及治疗包含NP的较深组织,杀死单个异常细胞等。尽管取得了成功的结果,但仍缺乏针对NP的需求集中分析以优化PT / PA应用的需求,尤其是脉冲激光。在这里,我们提供了一个用于分析NP属性(例如,光学,热,声学,结构和几何形状)的平台,允许在存在不同周围组织的情况下选择其参数。描述了几种类型的NP,这大大提高了PT / PA现象中激光脉冲能量的转换。这些NP使在激光纳米医学中以最高效率将其用于检测和杀死标记有最少NP数量的单个恶性细胞成为可能。
更新日期:2010-09-07
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