Stem cells have attracted much attention due to their distinct features that support infinite self-renewal and differentiation into the cellular derivatives of three lineages. Recent studies have suggested that many stem cells both embryonic and adult stem cells reside in a specialized niche defined by hypoxic condition. In this respect, distinguishing functional differences arising from the oxygen concentration is important in understanding the nature of stem cells and in controlling stem cell fate for therapeutic purposes. ROS act as cellular signaling molecules involved in the propagation of signaling and the translation of environmental cues into cellular responses to maintain cellular homeostasis, which is mediated by the coordination of various cellular processes, and to adapt cellular activity to available bioenergetic sources. Thus, in this review, we describe the physiological role of ROS in stem cell fate and its effect on the metabolic regulation of stem cells.

中文翻译：

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ROS介导的代谢改变对干细胞命运的调节。

干细胞由于其支持无限自我更新和分化为三种谱系的细胞衍生物的独特功能而备受关注。最近的研究表明，许多干细胞，包括胚胎干细胞和成年干细胞，都处于缺氧条件下的特定生态位中。在这方面，区分氧浓度引起的功能差异对于理解干细胞的性质和控制干细胞的命运以达到治疗目的非常重要。ROS充当细胞信号分子，参与信号的传播和环境线索到细胞反应的翻译，以维持细胞稳态（由各种细胞过程的协调介导），并使细胞活性适应可用的生物能来源。因此，