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Cortical plasticity in patients with Parkinson's disease a window for therapeutic non-invasive neuromodulation.
Archives Italiennes De Biologie ( IF 1 ) Pub Date : 2015-5-20 , DOI: 10.12871/00039829201444
Angelo Quartarone 1 , Vincenzo Rizzo , Carmen Terranova , Daniele Bruschetta , Demetrio Milardi , Paolo Girlanda , Maria Felice Ghilardi
Affiliation  

Several evidences in animal models have consistently an alteration of cortico-striatal plasticity, which is related to the degeneration of the substantia nigra. An alteration of plasticity have also been reported in humans by recording evoked field potentials in the substantia nigra pars reticulata of PD patients undergoing subthalamic nucleus (STN) stimulation where high-frequency (HF) in the OFF state did not induce a lasting change in field potential amplitude in the substantia nigra. In addition protocols of non-invasive brain stimulation, such as paired associative stimulation (PAS) and theta-burst stimulation (TBS), can be used to investigate cortical plasticity of the human primary motor cortex. Despite data reported in literature are apparently controversial with some studies showing a reduced or increased or even normal LTP and LTD like plasticity, recent evidences suggest the hypothesis that these different pat- terns of cortical plasticity likely depend on the stage of the disease and on the concomitant administration of L-DOPA. The current review will provide an up-to-date of these issues on cortical plasticity in PD discussing the clinical implications in rehabilitation. In addition in the last section we will review the state of art of non invasive neuro- modulation as adjuvant treatment in the advanced stage of the disease.

中文翻译:

帕金森氏病患者的皮质可塑性是治疗性非侵入性神经调节的窗口。

动物模型中的一些证据一致地改变了皮质-纹状体的可塑性,这与黑质的变性有关。通过记录在丘脑下核(STN)刺激下PD患者黑质网状结构中诱发的场电位,在关闭状态下的高频(HF)不会引起场的持久变化,人类中可塑性的变化也得到了报道。黑质中的电位振幅。另外,非侵入性脑刺激的方案,例如配对联想刺激(PAS)和θ-爆裂刺激(TBS),可用于研究人类主要运动皮层的皮质可塑性。尽管文献中报道的数据显然存在争议,但一些研究表明LTP和LTD的可塑性降低或升高,甚至是正常水平,但最新证据表明,这些不同的皮质可塑性模式可能取决于疾病的阶段和疾病的假说。 L-DOPA的同时给药。当前的审查将提供有关PD皮质可塑性的这些问题的最新信息,讨论康复中的临床意义。此外,在最后一节中,我们将回顾非侵入性神经调节作为疾病晚期辅助治疗的最新技术水平。当前的审查将提供有关PD皮质可塑性的这些问题的最新信息,讨论康复中的临床意义。此外,在最后一节中,我们将回顾非侵入性神经调节作为疾病晚期辅助治疗的最新技术水平。当前的审查将提供有关PD皮质可塑性的这些问题的最新信息,讨论康复中的临床意义。此外,在最后一节中,我们将回顾非侵入性神经调节作为疾病晚期辅助治疗的最新技术水平。
更新日期:2020-08-21
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