5,10,15,20-Tetrakis(4-amidinophenyl)porphyrin (Por 1), its Zn complex (Por 2) and amidinophenyl bispophyrin (Por 3) interacting with calf thymus DNA were investigated by scanning electron microscopy (SEM) and the shape and size of the porphyrin–DNA complexes were observed after photo irradiation. The results showed that the shape and size of DNA had significant differences with blank group by virtue of the interaction between the porphyrins and ct-DNA. This suggests the morphological characterization could be used to study the interaction and judge DNA photocleavage activity indirectly through the photo irradiation of porphyrins.

中文翻译：

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photo光卟啉与DNA相互作用的形态表征

通过扫描电子显微镜（SEM）研究了5,10,15,20-四（4--基苯基）卟啉（Por 1），其锌配合物（Por 2）和a基苯基双卟啉（Por 3）与小牛胸腺DNA的相互作用。照射后观察到卟啉-DNA复合物的形状和大小。结果表明，由于卟啉与ct-DNA之间的相互作用，DNA的形状和大小与空白组有显着差异。这表明形态学特征可用于研究相互作用，并通过卟啉的光辐射间接判断DNA的光解活性。