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Autophagy cooperates with PDGFRA to support oncogenic growth signaling Autophagy (IF 13.3) Pub Date : 2024-04-18 Joanne E. Simpson, Noor Gammoh
Macroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been...
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Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms Autophagy (IF 13.3) Pub Date : 2024-04-14 Gaëlle Quiniou, Leslie Andromaque, Rémi Duclaux-Loras, Océane Dinet, Ornella Cervantes, Mallorie Verdet, Camille Meunier, Gilles Boschetti, Christophe Viret, Stéphane Nancey, Mathias Faure, Aurore Rozières
Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associate...
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Toxic gain-of-function mechanisms in C9orf72 ALS-FTD neurons drive autophagy and lysosome dysfunction Autophagy (IF 13.3) Pub Date : 2024-04-14 Jimmy Beckers, Philip Van Damme
Hexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative dise...
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Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies Autophagy (IF 13.3) Pub Date : 2024-04-10 Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo
SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets en...
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Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response Autophagy (IF 13.3) Pub Date : 2024-04-10 Yajuan Jiao, Pengwei Zhao, Ling-Dong Xu, Jia-Qi Yu, Hou-Li Cai, Chong Zhang, Chao Tong, Yong-Le Yang, Pinglong Xu, Qiming Sun, Ning Chen, Bin Wang, Yao-Wei Huang
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PED...
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Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP Autophagy (IF 13.3) Pub Date : 2024-04-10 Yuki Hayashi, Hidenori Ichijo
Proteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lyso...
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MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX Autophagy (IF 13.3) Pub Date : 2024-04-10 Mohamed A. Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N. Bayne, Jean-François Trempe, Edward A. Fon
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it ...
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Alcohol-induced Golgiphagy is triggered by the downregulation of Golgi GTPase RAB3D Autophagy (IF 13.3) Pub Date : 2024-04-09 Amanda J. Macke, Taylor E. Divita, Artem N. Pachikov, Sundararajan Mahalingam, Ramesh Bellamkonda, Karuna Rasineni, Carol A. Casey, Armen Petrosyan
The development of alcohol-associated liver disease (ALD) is associated with disorganized Golgi apparatus and accelerated phagophore formation. While Golgi membranes may contribute to phagophores, ...
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The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif Autophagy (IF 13.3) Pub Date : 2024-04-02 Yueming Yuan, An Fang, Zhihui Wang, Huanchun Chen, Zhen F. Fu, Ming Zhou, Ling Zhao
Lyssaviruses are well-known worldwide and often cause fatal encephalitis. Previous studies have shown that autophagy is beneficial for the replication of rabies virus (RABV), the representative lys...
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ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression Autophagy (IF 13.3) Pub Date : 2024-04-02 Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Gabriella D’Orazi, Mara Cirone
The inhibition of the unfolded protein response (UPR), which usually protects cancer cells from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress. However, in ...
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LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes Autophagy (IF 13.3) Pub Date : 2024-04-02 Baptiste Pradel, Guilhem Cantaloube, Marie Villares, Maïka S. Deffieu, Véronique Robert-Hebmann, Vincent Lucansky, Mathias Faure, Nathalie Chazal, Raphaël Gaudin, Lucile Espert
HIV-1 entry into CD4+ T lymphocytes relies on the viral and cellular membranes’ fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B conjugation to lipids, process named...
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TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging Autophagy (IF 13.3) Pub Date : 2024-03-28 David Sebastián, Marc Beltrà, Andrea Irazoki, David Sala, Pilar Aparicio, Cecilia Aris, Esmaeil Alibakhshi, Maria Rubio-Valera, Manuel Palacín, Juan Castellanos, Luis Lores, Antonio Zorzano
Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophag...
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Design and validation of a reporter mouse to study the dynamic regulation of TFEB and TFE3 activity through in vivo imaging techniques Autophagy (IF 13.3) Pub Date : 2024-03-24 Electra Brunialti, Nicoletta Rizzi, Rita Pinto-Costa, Alessandro Villa, Alessia Panzeri, Clara Meda, Monica Rebecchi, Donato A. Di Monte, Paolo Ciana
TFEB and TFE3 belong to the MiT/TFE family of transcription factors that bind identical DNA responsive elements in the regulatory regions of target genes. They are involved in regulating lysosomal ...
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MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases Autophagy (IF 13.3) Pub Date : 2024-03-24 Jiansong Qi, Qingqing Li, Tianli Xin, Qixia Lu, Jinyi Lin, Yang Zhang, Haiting Luo, Feifei Zhang, Yanhong Xing, Wuyang Wang, Derong Cui, Mengmeng Wang
MCOLN1/TRPML1 is a nonselective cationic channel specifically localized to the late endosome and lysosome. With its property of mediating the release of several divalent cations such as Ca2+, Zn2+ ...
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Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain Autophagy (IF 13.3) Pub Date : 2024-03-24 Su Fu, Haojie Sun, Jiaxin Wang, Shuaixin Gao, Liu Zhu, Kun Cui, Shimeng Liu, Xuetao Qi, Rui Guan, Xiaocen Fan, Qingying Liu, Wen Chen, Li Su, Shuang Cui, Feifei Liao, Fengyu Liu, Catherine C L Wong, Ming Yi, You Wan
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanism...
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The activation mechanism of Atg15, a vacuolar phospholipase required for the disintegration of organelle membranes Autophagy (IF 13.3) Pub Date : 2024-03-21 Yasunori Watanabe, Kuninori Suzuki
The disintegration of cytoplasm-to-vacuole targeting (Cvt) bodies and autophagic bodies in vacuoles is essential to the Cvt pathway and macroautophagy in yeast. Atg15 is a vacuolar lipase required ...
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Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication Autophagy (IF 13.3) Pub Date : 2024-03-22 Huisheng Liu, Qiao Xue, Fan Yang, Weijun Cao, Pengfei Liu, Xiangtao Liu, Zixiang Zhu, Haixue Zheng
Many viruses, including foot-and-mouth disease virus (FMDV), can promote the degradation of host proteins through macroautophagy/autophagy, thereby promoting viral replication. However, the regulat...
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PLD1 promotes Spindle Assembly and migration through regulating autophagy in mouse oocyte meiosis Autophagy (IF 13.3) Pub Date : 2024-03-21 Jiaqi Zhang, Ying Tian, Xiangning Xu, Bicheng Wang, Ziqi Huang, Ke Song, Shuo Lou, Jingyi Kang, Ningning Zhang, Jingyu Li, Jing Weng, Yuanjing Liang, Wei Ma
PLD1 has been implicated in cytoskeletal reorganization and vesicle trafficking in somatic cells; however, its function remains unclear in oocyte meiosis. Herein, we found PLD1 stably expresses in ...
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CSNK2/CK2 regulates selective autophagy of the endoplasmic reticulum Autophagy (IF 13.3) Pub Date : 2024-03-21 Alexandra Stolz
Tuning and assimilation of endoplasmic reticulum (ER) content in each cell of the human body is an essential part of organismal homeostasis and adaptation to stress. As such, the lysosomal turnover...
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Emerging Dimensions of Autophagy in Melanoma Autophagy (IF 13.3) Pub Date : 2024-03-18 Christian Pangilinan, Daniel J Klionsky, Chengyu Liang
Macroautophagy/autophagy has previously been regarded as simply a way for cells to deal with nutrient emergency. But explosive work in the last 15 years has given increasingly new knowledge to our ...
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Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin) Autophagy (IF 13.3) Pub Date : 2024-03-18 Luqing Cui, Ruicheng Yang, Dong Huo, Liang Li, Xinyi Qu, Jundan Wang, Xinyi Wang, Hulin Liu, Huanchun Chen, Xiangru Wang
Streptococcus pneumoniae (S. pneumoniae) represents a major human bacterial pathogen leading to high morbidity and mortality in children and the elderly. Recent research emphasizes the role of extr...
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CASM mediates LRRK2 recruitment and activation under lysosomal stress Autophagy (IF 13.3) Pub Date : 2024-03-18 Tomoki Kuwahara, Takeshi Iwatsubo
Conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments has attracted attention as the non-autophagic function of the Atg8-family protein conjugation system, and the V-ATPase-A...
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Quantitative analysis of the spatial distance between autophagy-related membrane structures and the endoplasmic reticulum in Saccharomyces cerevisiae Autophagy (IF 13.3) Pub Date : 2024-03-13 Yang Shi, Kuninori Suzuki
Macroautophagy/autophagy is the process by which cells degrade their cytoplasmic proteins or organelles in vacuoles to maintain cellular homeostasis under severe environmental conditions. In the ye...
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Coronavirus hijacks STX18-ATG14 axis-regulated lipophagy to evade an anti-viral effect Autophagy (IF 13.3) Pub Date : 2024-03-13 Zhen Yuan, Binbin Ding
ATG14 is a core subunit of the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) for macroautophagy/autophagy initiation and also binds to the STX17 to promote autophagosome-lysosome ...
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ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells Autophagy (IF 13.3) Pub Date : 2024-03-13 Sheng Li, Bo-Wen Zhang, Qian-Qian Lou, Yue Liu, Zi-Juan Wei, Jing Huang, Kun-Hou Yao, Qian-Ru Xu, Juan Fan, Yan Xi, Lu Yang, Su Chen
Embryonic stem cells (ESCs), with abilities of infinite proliferation (self-renewal) and to differentiate into distinct cell types (pluripotency), show attenuated inflammatory response against cyto...
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Identification of the YIPF3-YIPF4 heterodimer as a novel Golgiphagy receptor Autophagy (IF 13.3) Pub Date : 2024-03-08 Yuxiang Huang, Daniel J. Klionsky
Golgiphagy is a selective form of macroautophagy, characterized by the targeted degradation of Golgi compartments through specific receptors. In two recent studies, the YIPF3-YIPF4 heterodimer has ...
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Pink1 balances reticulophagy and mitophagy by regulating distinct E3 ubiquitin ligases Autophagy (IF 13.3) Pub Date : 2024-03-08 Zhangyuan Yin, Daniel J. Klionsky
The selective clearance of unwanted, damaged or dangerous components by macroautophagy/autophagy is critical for maintaining cellular homeostasis in organisms from yeast to humans. In recent years,...
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Autophagy—the crossword puzzle Autophagy (IF 13.3) Pub Date : 2024-03-05 Daniel J. Klionsky
It’s April, so it is time to lighten up (think April Fools’ Day). In this issue of the journal, I have two different sets of puzzles for you. Of course, these are not just for your amusement; there...
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WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy Autophagy (IF 13.3) Pub Date : 2024-03-07 Athanasios Kournoutis, Trond Lamark, Terje Johansen, Yakubu Princely Abudu
Macroautophagy/autophagy is a conserved lysosomal degradation process composed of both selective and nonselective degradation pathways. The latter occurs upon nutrient depletion. Selective autophag...
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An unexpected journey for BNIP3 Autophagy (IF 13.3) Pub Date : 2024-03-06 José M Delgado, Christopher J Shoemaker
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for...
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CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival Autophagy (IF 13.3) Pub Date : 2024-03-06 Prakash P. Praharaj, Srimanta Patra, Amruta Singh, Debasna P. Panigrahi, Hwa Y. Lee, Mohammad F. Kabir, Muhammad K. Hossain, Samir K. Patra, Birija S. Patro, Shankargouda Patil, Daniel J. Klionsky, Han J. Chae, Sujit K. Bhutia
Mitophagy involves the selective elimination of defective mitochondria during chemotherapeutic stress to maintain mitochondrial homeostasis and sustain cancer growth. Here, we showed that CLU (clus...
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Autophagy—the crossword puzzle answers Autophagy (IF 13.3) Pub Date : 2024-03-05 Daniel J. Klionsky
This is the answers page so you should not be looking at this page unless you have exhausted the possibility of filling in additional words. Are you certain you are done? Maybe you want to put the ...
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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis Autophagy (IF 13.3) Pub Date : 2024-03-05 Xin Chen, Andrey S. Tsvetkov, Han-Ming Shen, Ciro Isidoro, Nicholas T. Ktistakis, Andreas Linkermann, Werner J.H. Koopman, Hans-Uwe Simon, Lorenzo Galluzzi, Shouqing Luo, Daqian Xu, Wei Gu, Olivier Peulen, Qian Cai, David C. Rubinsztein, Jen-Tsan Chi, Donna D. Zhang, Changfeng Li, Shinya Toyokuni, Jinbao Liu, Jong-Lyel Roh, Enyong Dai, Gabor Juhasz, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling-Qiang
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is...
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Autophagy sustains mitochondrial respiration and determines resistance to BRAFV600E inhibition in thyroid carcinoma cells Autophagy (IF 13.3) Pub Date : 2024-03-04 Sergio Díaz-Gago, Javier Vicente-Gutiérrez, Jose Manuel Ruiz-Rodríguez, Josep Calafell, Alicia Álvarez-Álvarez, Marina Lasa, Antonio Chiloeches, Pablo Baquero
BRAFV600E is the most prevalent mutation in thyroid cancer and correlates with poor prognosis and therapy resistance. Although selective inhibitors of BRAFV600E have been developed, more advanced t...
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Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner Autophagy (IF 13.3) Pub Date : 2024-03-03 Yaran Wu, Yang Chen, Xiaojing Yan, Xufang Dai, Yaling Liao, Jing Yuan, Liting Wang, Dong Liu, Dun Niu, Liangbo Sun, Lingxi Chen, Yang Zhang, Li Xiang, An Chen, Shuhui Li, Wei Xiang, Zhenhong Ni, Ming Chen, Fengtian He, Mingzhen Yang, Jiqin Lian
Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be a prospective anti-tumor target. However,...
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FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy Autophagy (IF 13.3) Pub Date : 2024-02-29 Prajakta Kulkarni, Giang Thanh Nguyen-Dien, Keri-Lyn Kozul, Julia K. Pagan
Mitophagy is a critical mitochondrial quality control process that selectively removes dysfunctional or excess mitochondria through the autophagy-lysosome system. The process is tightly controlled ...
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Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity Autophagy (IF 13.3) Pub Date : 2024-02-27 Ling-Hsuan Sun, Caitlin Lange, Malene Hansen, Caroline Kumsta
A decline in macroautophagic/autophagic activity with age contributes to the accumulation of damaged molecules and is associated with the impairment of neuronal functions and the onset of age-relat...
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General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast Autophagy (IF 13.3) Pub Date : 2024-02-29 Na Kang, Jinling Tan, Sisi Yan, Leiying Lin, Qiang Gao
Lipophagy in the yeast Saccharomyces cerevisiae is a microautophagic process in which lipid droplets (LDs) are directly engulfed into the vacuole, despite the fact that multiple core ATG (autophagy...
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PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion Autophagy (IF 13.3) Pub Date : 2024-02-27 Hajnalka Laczkó-Dobos, Arindam Bhattacharjee, Asha Kiran Maddali, András Kincses, Hussein Abuammar, Krisztina Sebők-Nagy, Tibor Páli, András Dér, Tamás Hegedűs, Gábor Csordás, Gábor Juhász
The autophagosomal SNARE STX17 (syntaxin 17) promotes lysosomal fusion and degradation, but its autophagosomal recruitment is incompletely understood. Notably, PtdIns4P is generated on autophagosom...
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The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy Autophagy (IF 13.3) Pub Date : 2024-02-27 Sarah J. Backe, Jennifer A. Heritz, Mehdi Mollapour
Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroa...
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Aging STINGs: mitophagy at the crossroads of neuroinflammation Autophagy (IF 13.3) Pub Date : 2024-02-27 Juan Ignacio Jiménez-Loygorri, Patricia Boya
Loss of proteostasis and dysregulated mitochondrial function are part of the traditional hallmarks of aging, and in their last revision impaired macroautophagy and chronic inflammation are also inc...
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Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex Autophagy (IF 13.3) Pub Date : 2024-02-26 Ji Hyeon Cho, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Su Jong Han, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produc...
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TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux Autophagy (IF 13.3) Pub Date : 2024-02-23 Dongdong Zhao, Lihua Qiang, Zehui Lei, Pupu Ge, Zhe Lu, Yiru Wang, Xinwen Zhang, Yuyun Qiang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu, Jing Wang
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), remain a global threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is a promising ...
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Selective degradation of ribosomes during oncogene-induced senescence: molecular insights and biological perspectives Autophagy (IF 13.3) Pub Date : 2024-02-21 Aida Rodríguez López, Lisa B. Frankel
Ribosomes are conserved macromolecular machines that are responsible for protein synthesis in all cells. While our knowledge of ribosome biogenesis and function has increased significantly in recen...
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ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4+ Th1 responses Autophagy (IF 13.3) Pub Date : 2024-02-18 Yuanli Gao, Suilin Chen, Shiming Jiao, Yongling Fan, Xiuxiu Li, Nie Tan, Jiaqin Fang, Luming Xu, Yi Huang, Jing Zhao, Shuai Guo, Taiping Liu, Wenyue Xu
Parasite-specific CD4+ Th1 cell responses are the predominant immune effector for controlling malaria infection; however, the underlying regulatory mechanisms remain largely unknown. This study dem...
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Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule Autophagy (IF 13.3) Pub Date : 2024-02-16 Aurore Claude-Taupin, Fabiola Terzi, Patrice Codogno, Nicolas Dupont
Shear stress induced by urinary flow stimulates macroautophagy (hereafter referred to as autophagy) in kidney proximal tubule epithelial cells. Autophagy and selective degradation of lipid droplets...
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The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis Autophagy (IF 13.3) Pub Date : 2024-02-15 Shun Li, Hao Zhang, Weichen Li, Jingbo Zhai, Xiaobo Li, Chunfu Zheng
Although alterations in the autophagy-lysosome pathway have been observed in the SARS-CoV-2 infection and invasion process since the outbreak of the coronavirus disease in 2019, the in-depth mechan...
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Did mitophagy follow the origin of mitochondria? Autophagy (IF 13.3) Pub Date : 2024-02-15 Mauro Degli Esposti
Mitophagy is the process of selective autophagy that removes superfluous and dysfunctional mitochondria. Mitophagy was first characterized in mammalian cells and is now recognized to follow several...
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Synthetic autophagy receptor Autophagy (IF 13.3) Pub Date : 2024-02-14 Ziwen Jiang, Yu-Hsuan Kuo, Michelle R. Arkin
Macroautophagy/autophagy receptors target their substrates to phagophores for subsequent sequestration within autophagosomes. During phagophore membrane expansion in mammalian cells, autophagy rece...
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Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis Autophagy (IF 13.3) Pub Date : 2024-02-13 Yiwei Sun, Xi Wang
The lysosomal degradation of the endoplasmic reticulum (ER), known as “reticulophagy”, is important for protein quality control and organelle turnover. Here we present a noncanonical reticulophagy ...
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Defective autophagy and autophagy activators in Myasthenia Gravis: a rare entity and unusual scenario Autophagy (IF 13.3) Pub Date : 2024-02-12 Ghassan M. Sulaiman, Hayder M. Al-Kuraishy, Majid S. Jabir, Hamdoon A. Mohammed, Ali I. Al-Gareeb, Salim Albukhaty, Daniel J. Klionsky, Mosleh M. Abomughaid
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs. These autoantibodies...
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RABC1, an Arabidopsis RAB18 regulates binding and subsequent detachment of autophagosomes from the ER in autophagy Autophagy (IF 13.3) Pub Date : 2024-02-07 Yang Shao, Jiaqi Sun, Hugo Zheng
Macroautophagy/autophagy is a strategy cells use to cope with detrimental conditions, e.g. nutrient deficiency. Phagophores, the precursors to autophagosomes, are initiated and expanded on the endo...
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Enhancement of LC3-associated efferocytosis for the alleviation of intestinal inflammation Autophagy (IF 13.3) Pub Date : 2024-02-04 Ming-Yue Wu, Er-Jin Wang, Richard D. Ye, Jia-Hong Lu
LC3-associated phagocytosis (LAP) is an instrumental machinery for the clearance of extracellular particles including apoptotic cells for the alleviation of inflammation. While pharmacological appr...
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FREE1 regulates phagophore closure in plants Autophagy (IF 13.3) Pub Date : 2024-02-02 Ying Zhu, Yonglun Zeng, Liwen Jiang
Adenosine monophosphate-activated protein kinase (AMPK), the central energy sensor in more complex eukaryotes, can activate macroautophagy/autophagy upon cellular energy deficiency. However, the re...
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The cocoon into a butterfly: why the HVA22 family proteins turned out to be the reticulophagy receptors in plants? Autophagy (IF 13.3) Pub Date : 2024-01-31 Ning Xu, Yingbo Liang, Jun Liu
Selective degradation of the endoplasmic reticulum (ER) by macroautophagy/autophagy (reticulophagy) is essential for maintaining ER morphology and homeostasis under environmental stresses. Several ...
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Degradative autophagy regulates the homeostasis of miRnas to control cancer development Autophagy (IF 13.3) Pub Date : 2024-01-31 Shan-Ying Wu, Chien-An Chu, Sheng-Hui Lan, Hsiao-Sheng Liu
Macroautophagy/autophagy acts as an anti-tumor mechanism in early cancer stages but promotes growth in established tumors. Similarly, miRNAs function as tumor suppressors or oncogenes, depending on...
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The C9orf72-SMCR8 complex suppresses primary ciliogenesis as a RAB8A GAP Autophagy (IF 13.3) Pub Date : 2024-01-31 Dan Tang, Hui Bao, Shiqian Qi
Approximately half of the familial cases of amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD) are attributed to the abnormal GGGGCC repeat expansion within the first intron of...
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ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells Autophagy (IF 13.3) Pub Date : 2024-01-30 Minsoo Koh, Hyesol Lim, Hao Jin, Minjoo Kim, Yeji Hong, Young Keun Hwang, Yunjung Woo, Eun-Sook Kim, Sun Young Kim, Kyung Mee Kim, Hyun Kyung Lim, Joohee Jung, Sujin Kang, Boyoun Park, Han-Byoel Lee, Wonshik Han, Myung-Shik Lee, Aree Moon
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression and chemoth...
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Ups and downs of lysosomal pH: conflicting roles of LAMP proteins? Autophagy (IF 13.3) Pub Date : 2024-01-25 Jonathan Handy, Gustavo C. Macintosh, Andreas Jenny
The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalia...