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The key role of altered tubule cell lipid metabolism in kidney disease development Kidney Int. (IF 19.6) Pub Date : 2024-04-16 Lauren E. Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent
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NELL-1–associated membranous nephropathy linked to skin fairness cream use: insights from an Indian case series Kidney Int. (IF 19.6) Pub Date : 2024-04-12 Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien
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Deciphering missense coding variants with AlphaMissense Kidney Int. (IF 19.6) Pub Date : 2024-04-10 Zhicheng Pan, Chandra L. Theesfeld
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Implementation science: a tool to narrow know-do gap and widen equity in kidney diseases and transplantation Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Ekamol Tantisattamo
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee
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Bridging the knowledge–practice gap in kidney care: insights from a medical student in Thailand Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Abhishet Varama
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee
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Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality Kidney Int. (IF 19.6) Pub Date : 2024-04-04 Germaine Wong, Amélie Bernier-Jean, Brad Rovin, Pierre Ronco, Editors of Kidney International
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CAR T-cell therapy—paving the way for sensitized kidney transplant patients Kidney Int. (IF 19.6) Pub Date : 2024-04-02 Tambi Jarmi, Yan Luo, Rose Mary Attieh, Yaqing Qie, Martha E. Gadd, Tanya Hundal, Shennen Mao, Hemant S. Murthy, Burcin C. Taner, Mohamed A. Kharfan-Dabaja, Hong Qin
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Single-cell lineage tracing approaches to track kidney cell development and maintenance Kidney Int. (IF 19.6) Pub Date : 2024-03-28 Baul Yoon, Hayoung Kim, Su Woong Jung, Jihwan Park
The kidney is a complex organ consisting of various cell types. Previous studies have aimed to elucidate the cellular relationships among these cell types in developing and mature kidneys using Cre-loxP–based lineage tracing. However, this methodology falls short of fully capturing the heterogeneous nature of the kidney, making it less than ideal for comprehensively tracing cellular progression during
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Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-03-28 Shubha S. Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian S.D. Roberts, Validation in IgA Nephropathy study group, R. Coppo MD, J. Feehaly MD, S. Troyanov MD, D.C. Cattran MD, H.T. Cook MD, I. Roberts MD, John Radcliffe, M.L. Russo PhD, V. Tesar MD, D. Maixnerova MD, S. Lundberg MD, L. Gesualdo MD, F. Emma MD, L. Fuiano MD, G. Beltrame MD, C. Rollino MD, A. Amore MD, R. Camilla MD, L.
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A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-03-27 Richard Lafayette, Sean Barbour, Rubeen Israni, Xuelian Wei, Necmi Eren, Jürgen Floege, Vivekanand Jha, Sung Gyun Kim, Bart Maes, Richard K.S. Phoon, Harmeet Singh, Vladimír Tesař, Celia J.F. Lin, Jonathan Barratt
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A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis Kidney Int. (IF 19.6) Pub Date : 2024-03-26 Wolfgang C. Winkelmayer, Anthonie W.A. Lensing, Ravi I. Thadhani, Kenneth W. Mahaffey, Michael Walsh, Ákos F. Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J.M. Ingham, John Eikelboom, RE-THINC investigators
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Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-03-25 Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, Utano Tomaru, Yasuaki Aratani, Mamiko Yamamoto, Akihiro Ishizu, Tatsuya Atsumi
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Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis Kidney Int. (IF 19.6) Pub Date : 2024-03-21 Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong
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Genetic testing in kidney transplantation helped develop a morbidity gene panel for evaluation of kidney transplant recipients Kidney Int. (IF 19.6) Pub Date : 2024-03-21 Becky M. Ma, Naama Elefant, Martina Tedesco, Kelsie Bogyo, Natalie Vena, Sarath K. Murthy, Shiraz A. Bheda, Sandy Yang, Nikita Tomar, Jun Y. Zhang, Syed Ali Husain, Sumit Mohan, Krzysztof Kiryluk, Hila Milo Rasouly, Ali G. Gharavi
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Biomarker use in acute kidney injury: are we there yet? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 T. Alp Ikizler
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Throwing off the keratin chains: a potential therapy for hereditary podocytopathy Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Kálmán Tory
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A toolkit for ISN’s registry initiative, SharE-RR Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Maria Pippias, Rajitha A. Abeysekera, Silvia Arruebo, M. Razeen Davids, Sandrine Damster, Maria C. Gonzales-Bedat, Norio Hanafusa, Junichi Hoshino, Anne Hradsky, Georgina L. Irish, Kitty J. Jager, Sabine Karam, Vivek Kumar, Stephen P. McDonald, Guillermo J. Rosa-Diez, Elliot K. Tannor, James B. Wetmore, Fergus J. Caskey
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Autosomal dominant chronic tubulointerstitial nephropathy: do not forget amyloidosis Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Frank Bridoux, Samih H. Nasr
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Charting new frontiers in IgA nephropathy: a paradigm shift toward precision medicine and early intervention? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Haresh Selvaskandan, Jonathan Barratt
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Oligonephronia: another piece in the CKDu jigsaw? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Wendy E. Hoy, John F. Bertram
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Integrating essence of “time” for blood pressure control in nephrology care Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Yejin Mok, Kunihiro Matsushita
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Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Chirag R. Parikh, Steven G. Coca
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Interleukin-37: a new therapeutic target in autosomal dominant polycystic kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Bo Yang, Steven D. Crowley
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Biomarker blues: balancing hope and hype in acute kidney injury Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Sushrut S. Waikar
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Back to the future: the uncharted role of T cells in chronic and unexplained microvascular inflammation Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Jasper Callemeyn, Maarten Naesens
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Cytoreductive treatment and kidney vascular damage in patients with chronic myeloproliferative neoplasms Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Ivan Krecak, Marko Lucijanic
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Thibaut d’Izarny-Gargas, Alexandre Karras, Jean-Paul Duong-Van-Huyen
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Lysosomal cystine accumulation activates mTOR signaling in cystinosis: are mTOR inhibitors the cure? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Salómon Christer, Matias Simons
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Multimodal characterization of sexual dimorphism in the mammalian kidney Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Haikuo Li, Benjamin D. Humphreys
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Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Adeera Levin, Sofia B. Ahmed, Juan Jesus Carrero, Bethany Foster, Anna Francis, Rasheeda K. Hall, Will G. Herrington, Guy Hill, Lesley A. Inker, Rümeyza Kazancıoğlu, Edmund Lamb, Peter Lin, Magdalena Madero, Natasha McIntyre, Kelly Morrow, Glenda Roberts, Dharshana Sabanayagam, Elke Schaeffner, Michael Shlipak, Rukshana Shroff, Navdeep Tangri, Teerawat Thanachayanont, Ifeoma Ulasi, Germaine Wong, Chih-Wei
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) updates the KDIGO 2012 guideline and has been developed with patient partners, clinicians, and researchers around the world, using robust methodology. This update, based on a substantially broader base of evidence than has previously been available, reflects
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The Case | Proximal muscle weakness, hypertension, and electrolyte abnormalities Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Katharina W. Horn, Suraj S. Shah, Devin Skoll, Danielle Carter, Natasha S. Freeman, Syed A. Husain
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An unusual complication of arteriovenous fistula Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Marc-Antoine Béland, Nicolas A.D. Bergeron, Mathieu Béland, Ludwig Haydock, Paul Isenring
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Sickle cell disease in the kidney transplant Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Lynn D. Cornell, Divya Shankaranarayanan, Pablo Serrano Rodriguez, Sibel Erdogan Damgard
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Discrepancies between transcutaneous and estimated glomerular filtration rates in rats with chronic kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-03-19 Tobias T. Pieters, Paul J. Besseling, Dominique M. Bovée, Maarten B. Rookmaaker, Marianne C. Verhaar, Benito Yard, Ewout J. Hoorn, Jaap A. Joles
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Cutting back on low-value health care practices supports sustainable kidney care Kidney Int. (IF 19.6) Pub Date : 2024-03-19 Scott McAlister, Valerie A. Luyckx, Andrea K. Viecelli
July 2023 marked the hottest month on record, underscoring the urgent need for action on climate change. The imperative to reduce carbon emissions extends to all sectors, including health care, with it being responsible for 5.5% of global emissions. In decarbonizing health care, although much attention has focused on greening health care infrastructure and procurement, less attention has focused on
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Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3-dimensional fast marching algorithm Kidney Int. (IF 19.6) Pub Date : 2024-03-06 Alexander M.C. Böhner, Alexander Effland, Alice M. Jacob, Karin A.M. Böhner, Zeinab Abdullah, Sebastian Brähler, Ulrike I. Attenberger, Martin Rumpf, Christian Kurts
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The 14th International Podocyte Conference 2023: from podocyte biology to glomerular medicine Kidney Int. (IF 19.6) Pub Date : 2024-03-04 Sybille Koehler, Felicitas E. Hengel, Bernhard Dumoulin, Laurel Damashek, Lawrence B. Holzman, Katalin Susztak, Tobias B. Huber, International Podocyte Conference Organizing Committee
The 14th International Podocyte Conference took place in Philadelphia, Pennsylvania, USA from May 23 to 26, 2023. It commenced with an early-career researchers' meeting on May 23, providing young scientists with a platform to present and discuss their research findings. Throughout the main conference, 29 speakers across 9 sessions shared their insights on podocyte biology, glomerular medicine, novel
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Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy Kidney Int. (IF 19.6) Pub Date : 2024-03-04 Benjamin Madden, Raman Deep Singh, Mark Haas, Lilian M.P. Palma, Alok Sharma, Maria J. Vargas, LouAnn Gross, Vivian Negron, Torell Nate, M. Cristine Charlesworth, Jason D. Theis, Samih H. Nasr, Karl A. Nath, Fernando C. Fervenza, Sanjeev Sethi
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Development of PD in lower-income countries: a rational solution for the management of AKI and ESKD Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Brett Cullis, Mignon McCulloch, Fredric O. Finkelstein
It is estimated that >50% of patients with end-stage kidney disease (ESKD) in low-resource countries are unable to access dialysis. When hemodialysis is available, it often has high out-of-pocket expenditure and is seldom delivered to the standard recommended by international guidelines. Hemodialysis is a high-cost intervention with significant negative effects on environmental sustainability, especially
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Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Valentin Maisons, Anna Duval, Laurent Mesnard, Marie Frimat, Fadi Fakhouri, Steven Grangé, Aude Servais, Claire Cartery, Laurent Fauchier, Paul Coppo, Dimitri Titeca-Beauport, Nicolas Fage, Yahsou Delmas, Anne-Hélène Quérard, Guillaume Seret, Mickaël Bobot, Moglie Le Quintrec, Simon Ville, Florent von Tokarski, Sophie Chauvet, Alain Wynckel, Manon Martins, Juliet Schurder, Christelle Barbet, Bénédicte
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Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Evans O. Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y. Tan, Scott Hoffmann, Margaret M. Huang, Krishnaa T. Mahbubani, Fynn N. Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L. Griffin, Magnus Soderberg, Stephanie Ling, Pernille B.L. Hansen, Kourosh Saeb-Parsy, Kevin J. Woollard
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Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Jeonghwan Lee, Jinhaeng Lee, Kyuhong Kim, Jiwon Lee, Youngae Jung, Jin Seong Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee, Geum-Sook Hwang, Seung Hee Yang
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Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis Kidney Int. (IF 19.6) Pub Date : 2024-02-28 Josep M. Cruzado, Anna Manonelles, Sandra Rayego-Mateos, Núria Doladé, Ana Amaya-Garrido, Cristian Varela, Roser Guiteras, Jose Luis Mosquera, Michaela Jung, Sergi Codina, Laura Martínez-Valenzuela, Juliana Draibe, Carlos Couceiro, Francesc Vigués, Álvaro Madrid, M. Carolina Florian, Marta Ruíz-Ortega, Anna Sola
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Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Yue Lu, Linlin Meng, Ruiqing Ren, Xinlu Wang, Wenhai Sui, Fei Xue, Lin Xie, Ang Chen, Yuxia Zhao, Jianmin Yang, Wencheng Zhang, Xiao Yu, Bo Xi, Feng Xu, Meng Zhang, Yun Zhang, Cheng Zhang
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Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Jianchun Chen, Xiaoyong Wang, Qian He, Hai-Chun Yang, Agnes B. Fogo, Raymond C. Harris
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Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Lou C. Duret, Tynhinane Hamidouche, Nicholas J. Steers, Catherine Pons, Nicolas Soubeiran, Delphine Buret, Eric Gilson, Ali G. Gharavi, Vivette D. D’Agati, Marina Shkreli
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A case-based narrative review of pregnancy-associated atypical hemolytic uremic syndrome/complement-mediated thrombotic microangiopathy Kidney Int. (IF 19.6) Pub Date : 2024-02-24 Michael Che, Sarah M. Moran, Richard J. Smith, Kevin Y.M. Ren, Graeme N. Smith, M. Khaled Shamseddin, Carmen Avila-Casado, Jocelyn S. Garland
Atypical hemolytic uremic syndrome is a complement-mediated thrombotic microangiopathy caused by uncontrolled activation of the alternative complement pathway in the setting of autoantibodies to or rare pathogenic genetic variants in complement proteins. Pregnancy may serve as a trigger and unmask atypical hemolytic uremic syndrome/complement-mediated thrombotic microangiopathy (aHUS/CM-TMA), which
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Quantitative assessment of glomerular basement membrane collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis and Alport gene variants Kidney Int. (IF 19.6) Pub Date : 2024-02-22 Pongpratch Puapatanakul, Suramath Isaranuwatchai, Ankanee Chanakul, Jerasit Surintrspanont, Kroonpong Iampenkhae, Talerngsak Kanjanabuch, Kanya Suphapeetiporn, Vivek Charu, Hani Y. Suleiman, Kearkiat Praditpornsilpa, Jeffrey H. Miner
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Disrupting circadian control of autophagy induces podocyte injury and proteinuria Kidney Int. (IF 19.6) Pub Date : 2024-02-21 Lulu Wang, Han Tian, Haiyan Wang, Xiaoming Mao, Jing Luo, Qingyun He, Ping Wen, Hongdi Cao, Li Fang, Yang Zhou, Junwei Yang, Lei Jiang
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The role of desmoglein-2 in kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-02-21 Tong Xu, Lea Herkens, Ting Jia, Barbara M. Klinkhammer, Sebastian Kant, Claudia A. Krusche, Eva M. Buhl, Sikander Hayat, Jürgen Floege, Pavel Strnad, Rafael Kramann, Sonja Djudjaj, Peter Boor
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Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA–Associated Vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Ethan M. Balk, Craig E. Gordon, Gaelen Adam, Marcello A. Tonelli, Michael Cheung, Amy Earley, Brad H. Rovin
In 2021, the Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for the Management of Glomerular Diseases was published. KDIGO is committed to providing the nephrology community with periodic updates, based on new developments for each disease. For patients with anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), avacopan received regulatory approval in late 2021, leading
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Anti-nephrin antibodies in recurrence of focal segmental glomerulosclerosis: closer to discovering the Holy Grail? Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Marina Vivarelli, Manuela Colucci
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Wenjun Ju, Hiddo J.L. Heerspink, Matthias Kretzler, Petter Bjornstad
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KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)–Associated Vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Kidney Disease: Improving Global Outcomes (KDIGO) ANCA Vasculitis Work Group, Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Brad H. Rovin
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Bile cast nephropathy after sinusoidal obstruction syndrome Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Toshiki Terao, Kyosuke Horikawa, Ken-ichi Matsuoka