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Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b Cell Death Discov. (IF 7.0) Pub Date : 2024-04-18 Shuang Zhao, Guiling Mo, Qiang Wang, Jin Xu, Shihui Yu, Zhibin Huang, Wei Liu, Wenqing Zhang
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Improving the power of drug toxicity measurements by quantitative nuclei imaging Cell Death Discov. (IF 7.0) Pub Date : 2024-04-18 Alesya M. Mikheeva, Mikhail A. Bogomolov, Valentina A. Gasca, Mikhail V. Sementsov, Pavel V. Spirin, Vladimir S. Prassolov, Timofey D. Lebedev
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epHero – a tandem-fluorescent probe to track the fate of apoptotic cells during efferocytosis Cell Death Discov. (IF 7.0) Pub Date : 2024-04-17 Sanjna Singh, Julien Bensalem, Leanne K. Hein, Aaron Casey, Ville-Petteri Mäkinen, Timothy J. Sargeant
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PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration Cell Death Discov. (IF 7.0) Pub Date : 2024-04-17 Wenting You, Kèvin Knoops, Tos T. J. M. Berendschot, Birke J. Benedikter, Carroll A. B. Webers, Chris P. M. Reutelingsperger, Theo G. M. F. Gorgels
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AAV-mediated upregulation of VDAC1 rescues the mitochondrial respiration and sirtuins expression in a SOD1 mouse model of inherited ALS Cell Death Discov. (IF 7.0) Pub Date : 2024-04-16 Andrea Magrì, Cristiana Lucia Rita Lipari, Antonella Caccamo, Giuseppe Battiato, Stefano Conti Nibali, Vito De Pinto, Francesca Guarino, Angela Messina
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POLE2 promotes osteosarcoma progression by enhancing the stability of CD44 Cell Death Discov. (IF 7.0) Pub Date : 2024-04-16 Baichuan Wang, Hongzhi Hu, Xiaohui Wang, Zengwu Shao, Deyao Shi, Fashuai Wu, Jianxiang Liu, Zhicai Zhang, Juan Li, Zhidao Xia, Weijian Liu, Qiang Wu
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Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy Cell Death Discov. (IF 7.0) Pub Date : 2024-04-15 Liyun Su, Jingyi Xu, Cheng Lu, Kaimin Gao, Yunyun Hu, Chengfeng Xue, Xiaomei Yan
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Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-04-15 Maria R. Cavallo, Jacob C. Yo, Kayla C. Gallant, Camille J. Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa B. Sanders, Andrew E. Aplin, Edmund A. Pribitkin, Edward J. Hartsough
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Cell death dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR Cell Death Discov. (IF 7.0) Pub Date : 2024-04-11 Xin Zhang, Yuhan Chen, Tinglu Yan, Hengjie Wang, Ruibin Zhang, Yanrong Xu, Yujia Hou, Qi Peng, Fuping Song
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FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-04-11 Na Liu, Anran Wang, Mengen Xue, Xiaoren Zhu, Yang Liu, Minbin Chen
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USP12 facilitates gastric cancer progression via stabilizing YAP Cell Death Discov. (IF 7.0) Pub Date : 2024-04-11 Peng Zhang, Dongyi Liu, Yifeng Zang, Jinqing Wang, Ziping Liu, Jian Zhu, Xin Li, Yinlu Ding
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Increased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERα/NLRP3 pathway and induces adverse pregnancy outcomes in mice Cell Death Discov. (IF 7.0) Pub Date : 2024-04-10 Long Yang, Hao-Ran Xu, Xuan Zhang, Yan Shi, Jia-Xin Shi, Qian-Qian Chen, Xiao-Rong Shen, Ya-Ping He, Jia-Nan Tang, Wen-Wen Gu, Jian Wang
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The crosstalk between exosomes and ferroptosis: a review Cell Death Discov. (IF 7.0) Pub Date : 2024-04-09 Jiao Wu, Zhongyu Li, Yu Wu, Ning Cui
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Methylation in cornea and corneal diseases: a systematic review Cell Death Discov. (IF 7.0) Pub Date : 2024-04-08 Yutong Xia, Kuangqi Chen, Qianjie Yang, Zhitong Chen, Le Jin, Liyue Zhang, Xin Yu, Liyin Wang, Chen Xie, Yuan Zhao, Ye Shen, Jianping Tong
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Mitochondria transcription and cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-04-08 Tang Lei, Yu Rui, Zhou Xiaoshuang, Zhang Jinglan, Zhang Jihong
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Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease Cell Death Discov. (IF 7.0) Pub Date : 2024-04-08 Xiao-yun Niu, Xi-xiu Xie, Hou-zhen Tuo, Cui-ping Lv, Ya-ru Huang, Jie Zhu, Shi-yu Liang, Xiao-yu Du, Cheng-gang Yang, Sheng-jie Hou, Xiao-ying Sun, Ling-jie Li, Fang Cui, Qi-xin Huang, Ying-bo Jia, Yu-jiong Wang, Rui-tian Liu
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Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells Cell Death Discov. (IF 7.0) Pub Date : 2024-04-05 Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, Taichi Oshima, Takuya Hirao, Yuri Miura, John Seubert, Kousei Ito, Shigeki Aoki
Although increased aerobic glycolysis is common in various cancers, pancreatic ductal adenocarcinoma (PDAC) cells can survive a state of glycolysis suppression. We aimed to identify potential therapeutic targets in glycolysis-suppressed PDAC cells. By screening anticancer metabolic compounds, we identified SP-2509, an inhibitor of lysine-specific histone demethylase 1A (LSD1), which dramatically decreased
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Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation Cell Death Discov. (IF 7.0) Pub Date : 2024-04-04 Linxia Li, Yanqi Liu, Na Zhi, Yaoxuan Ji, Jialing Xu, Guoyun Mao, Yazhou Wang, Jin Ma, Yunying Wang
Hypoxic preconditioning (HPC) has been shown to improve organ tolerance to subsequent severe hypoxia or ischemia. However, its impact on intestinal ischemic injury has not been well studied. In this study, we evaluated the effects of HPC on intestinal ischemia in rats. Intestinal rehabilitation, levels of fatty acid oxidation (FAO) by-products, intestinal stem cells (ISCs), levels of hypoxia-inducible
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Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans Cell Death Discov. (IF 7.0) Pub Date : 2024-04-04 Mahmoud Izadi, Tayyiba Akbar Ali, Farah M. Shurrab, Ebrahim Aharpour, Ehsan Pourkarimi
The fidelity of translation is ensured by a family of proteins named aminoacyl-tRNA synthetases (ARSs), making them crucial for development and survival. More recently, mutations in the tryptophanyl-tRNA synthetase 1 (WARS1) have been linked to various human diseases, from intellectual disability to various types of cancer. To understand the function of WARS1, we investigated the effect of WARS-1 depletion
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Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder Cell Death Discov. (IF 7.0) Pub Date : 2024-04-03 Joan Sala-Gaston, Eva M. Pérez-Villegas, José A. Armengol, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Francesc Ventura, Jose Luis Rosa
Sequence variants in the HERC2 gene are associated with a significant reduction in HERC2 protein levels and cause a neurodevelopmental disorder known as the HERC2-related disorder, which shares clinical features with Angelman syndrome, including global developmental delay, intellectual disability, autism, and movement disorders. Remarkably, the HERC2 gene is commonly deleted in individuals with Angelman
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Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth Cell Death Discov. (IF 7.0) Pub Date : 2024-04-02 Natsuki Furukawa, Wendy Yang, Alex R. Chao, Akash Patil, Adam C. Mirando, Niranjan B. Pandey, Aleksander S. Popel
Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in
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Integrating transcriptomics and machine learning for immunotherapy assessment in colorectal cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-04-02 Jun Xiang, Shihao Liu, Zewen Chang, Jin Li, Yunxiao Liu, Hufei Wang, Hao Zhang, Chunlin Wang, Lei Yu, Qingchao Tang, Guiyu Wang
Colorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide. Although immunotherapy has substantially improved CRC outcomes, intolerance remains a major concern among most patients. Considering the pivotal role of the tumor microenvironment (TME) in tumor progression and treatment outcomes, profiling the TME at the transcriptomic level can provide novel insights for developing CRC
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NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC Cell Death Discov. (IF 7.0) Pub Date : 2024-04-01 Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang, Shan Lu, Ping Liu
Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD3 has recently been demonstrated as a crucial oncogenic factor. However, the underlying mechanism of NCAPD3 in prostate cancer (PCa) remains not completely clear. In this study, we confirmed that
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A novel long non-coding RNA SLNCR1 promotes proliferation, migration, and invasion of melanoma via transcriptionally regulating SOX5 Cell Death Discov. (IF 7.0) Pub Date : 2024-04-01 Lele Cong, Qing Zhao, Hongyan Sun, Zilong Zhou, Yue Hu, Chunyi Li, Miao Hao, Xianling Cong
Steroid receptor RNA activator (SRA)-like non-coding RNA (SLNCR1) has been implicated in various tumorigenic processes, but the precise regulatory role in melanoma progression remains uncertain. We performed a comprehensive analysis to investigate the prognostic value of SLNCR1 expression in patients with melanoma by TCGA database and melanoma tissue samples via the Kaplan–Meier method. Subsequently
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Gemcitabine elaidate and ONC201 combination therapy for inhibiting pancreatic cancer in a KRAS mutated syngeneic mouse model Cell Death Discov. (IF 7.0) Pub Date : 2024-03-29 Virender Kumar, Bharti Sethi, Dalton W. Staller, Prakash Shrestha, Ram I. Mahato
Approximately 90% of pancreatic cancer (PC) contain KRAS mutations. Mutated KRAS activates the downstream oncogenic PI3K/AKT and MEK signaling pathways and induces drug resistance. However, targeting both pathways with different drugs can also lead to excessive toxicity. ONC201 is a dual PI3K/AKT and MEK pathway inhibitor with an excellent safety profile that targets death receptor 5 (DR5) to induce
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Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia Cell Death Discov. (IF 7.0) Pub Date : 2024-03-28 Caroline Spertini, Alexandre P. Bénéchet, Flora Birch, Axel Bellotti, Mónica Román-Trufero, Caroline Arber, Holger W. Auner, Robert A. Mitchell, Olivier Spertini, Tatiana Smirnova
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METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging Cell Death Discov. (IF 7.0) Pub Date : 2024-03-27 Yaobin Wang, Yi Chen, Hefang Xiao, Zhongcheng Liu, Xuening Liu, Zhiwei Feng, Xiaoyun Sheng, Bo Peng, Xiaojun Ren, Lihu Xu, Fei Teng, Zhi Yi, YongKang Niu, Dejian Xiang, Yayi Xia, Bin Geng
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Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells Cell Death Discov. (IF 7.0) Pub Date : 2024-03-27 Wuming Liu, Yifan Ren, Tao Wang, Mengzhou Wang, Yujia Xu, Jia Zhang, Jianbin Bi, Zheng Wu, Yuanyuan Zhang, Rongqian Wu
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NAP1L1 regulates BIRC2 ubiquitination modification via E3 ubiquitin ligase UBR4 and hence determines hepatocellular carcinoma progression Cell Death Discov. (IF 7.0) Pub Date : 2024-03-27 Shi-Long Zhang, Shen-Jie Zhang, Lian Li, Ye-Wei Zhang, Zhi Wang, Long Wang, Jie-Yu Lu, Teng-Xiang Chen, Shi Zuo
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Preso enhances mGluR1-mediated excitotoxicity by modulating the phosphorylation of mGluR1-Homer1 complex and facilitating an ER stress after traumatic brain injury Cell Death Discov. (IF 7.0) Pub Date : 2024-03-26 Zhuoyuan Zhang, Xiangyu Gao, Zhicheng Tian, Erwan Yang, Yutao Huang, Dan Liu, Shuhui Dai, Haofuzi Zhang, Mingdong Bao, Xiaofan Jiang, Xin Li, Peng Luo
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RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells Cell Death Discov. (IF 7.0) Pub Date : 2024-03-23 Tao Yang, Cai-gui Xiang, Xiao-han Wang, Qing-qing Li, Shu-yue Lei, Kai-rong Zhang, Jing Ren, Hui-min Lu, Chun-lan Feng, Wei Tang
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miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition Cell Death Discov. (IF 7.0) Pub Date : 2024-03-21 Francesco Davide Naso, Krenare Bruqi, Valeria Manzini, Valerio Chiurchiù, Mara D’Onofrio, Ivan Arisi, Flavie Strappazzon
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COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect? Cell Death Discov. (IF 7.0) Pub Date : 2024-03-19 Fengju Jia, Jing Han
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FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation Cell Death Discov. (IF 7.0) Pub Date : 2024-03-23 Zhigang Shen, Tao Dong, Hongmei Yong, Chuyin Deng, Changxiu Chen, Xintian Chen, Miaolei Chen, Sufang Chu, Junnian Zheng, Zhongwei Li, Jin Bai
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VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson’s disease Cell Death Discov. (IF 7.0) Pub Date : 2024-03-21 Zihui Zheng, Miao Chen, Shengliang Feng, Huanhuan Zhao, Tiange Qu, Xudong Zhao, Qinli Ruan, Lei Li, Jun Guo
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Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment Cell Death Discov. (IF 7.0) Pub Date : 2024-03-20 Yong Liu, Jin-Ling Huo, Kaidi Ren, Shaokang Pan, Hengdao Liu, Yifeng Zheng, Jingfang Chen, Yingjin Qiao, Yang Yang, Qi Feng
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Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling Cell Death Discov. (IF 7.0) Pub Date : 2024-03-19 Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Ingrid R. S. B. Dias, Rafaela G. A. Costa, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Emily M. Johnson, Cristina Pina, Daniel P. Bezerra
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Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection Cell Death Discov. (IF 7.0) Pub Date : 2024-03-18 Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan
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Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Wenjun Huang, Qingyun Zhu, Zhichao Shi, Yao Tu, Qinyuan Li, Wenwen Zheng, Zigao Yuan, Lulu Li, Xuyu Zu, Yue Hao, Bizhu Chu, Yuyang Jiang
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PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Jianchao Zhang, Ying Peng, Wanrong Fu, Ruifei Wang, Jinhua Cao, Shuang Li, Xiaoxu Tian, Zhonggen Li, Chongpei Hua, Yafei Zhai, Yangyang Liu, Mengduan Liu, Jihong Sun, Xiaowei Li, Xiaoyan Zhao, Jianzeng Dong
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The mechanism underlying correlation of particulate matter-induced ferroptosis with inflammasome activation and iron accumulation in macrophages Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Minkyung Park, Sujeong Park, Yumin Choi, Young-Lai Cho, Min Jeong Kim, Young-Jun Park, Su Wol Chung, Heedoo Lee, Seon-Jin Lee
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MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Alessandra Affinito, Cristina Quintavalle, Rosario Vincenzo Chianese, Giuseppina Roscigno, Danilo Fiore, Valeria D’Argenio, Guglielmo Thomas, Alessia Savarese, Francesco Ingenito, Lorenza Cocca, Silvia Nuzzo, Maxim V. Berezovski, Maria Patrizia Stoppelli, Gerolama Condorelli
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Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Qing-Wei Zhang, Xiao-Lu Lin, Zi-Hao Dai, Ran Zhao, Yi-Chao Hou, Qian Liang, Yan Zhang, Zhi-Zheng Ge
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Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Hongli Li, Qinghua Liu, Yaqiong Hu, Chonggao Yin, Yunxiang Zhang, Peng Gao
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Role of protein degradation systems in colorectal cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Zihan Cui, Mingqi Cong, Shengjie Yin, Yuqi Li, Yuguang Ye, Xi Liu, Jing Tang
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Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Yawen Sun, Wenjuan Liu, Mu Su, Tao Zhang, Xia Li, Wenbin Liu, Yuping Cai, Deli Zhao, Ming Yang, Zhengjiang Zhu, Jialin Wang, Jinming Yu
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MCL1 inhibition: a promising approach to augment the efficacy of sorafenib in NSCLC through ferroptosis induction Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Chao-Yuan Huang, Li-Ju Chen, Chi-Shuo Chen, Cheng-Yi Wang, Shiao-Ya Hong
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Ferroptosis: a new hunter of hepatocellular carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-13 Yulang Jiang, Yongxin Yu, Ziyang Pan, Christian Glandorff, Mingyu Sun
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NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Shuman Zhen, Yunlong Jia, Yan Zhao, Jiali Wang, Boyang Zheng, Tianxu Liu, Yuqing Duan, Wei Lv, Jiaqi Wang, Fan Xu, Yueping Liu, Yi Zhang, Lihua Liu
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USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk
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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients Cell Death Discov. (IF 7.0) Pub Date : 2024-03-13 Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju
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Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen, Yanfeng Xu, Haiyang Yu, Sibao Chen, Guo-Qing Chen
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Hypoxia induced exosomal Circ-ZNF609 promotes pre-metastatic niche formation and cancer progression via miR-150-5p/VEGFA and HuR/ZO-1 axes in esophageal squamous cell carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Yu Mao, Jiahao Wang, Yimin Wang, Zhanzhao Fu, Lixin Dong, Jia Liu
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Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Xinxing Wan, Linghao Wang, Md Asaduzzaman Khan, Lin Peng, Keke Zhang, Xiaoying Sun, Xuan Yi, Zhouqi Wang, Ke Chen
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Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Jingtao Liu, Xiaomei Tan, Li Li, Liying Cao, Yan Zhou, He Li, Ting Peng
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mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Zhengming Yang, Wei Yu, Ankai Xu, Bing Liu, Libin Jin, Huimin Tao, Dimin Wang
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Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2 Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
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SLC26A9 promotes colorectal tumorigenesis by modulating Wnt/β-catenin signaling Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Minglin Zhang, Zhiyuan Ma, Zhiqiang Yi, Hu Wang, Jiaxing Zhu, Guorong Wen, Hai Jin, Jiaxing An, Zilin Deng, Biguang Tuo, Taolang Li, Xuemei Liu
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Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Shuman Zhang, Duo Yun, Hao Yang, Markus Eckstein, Gihan Daw Elbait, Yaxing Zhou, Yanxi Lu, Hai Yang, Jinping Zhang, Isabella Dörflein, Nathalie Britzen-Laurent, Susanne Pfeffer, Marc P. Stemmler, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Hang He, Siyuan Zeng, Bin Lan, Benjamin Frey, Chuanpit Hampel, Eva Lentsch, Paradesi Naidu Gollavilli, Christian Büttner, Arif B. Ekici, Andrew Biankin, Regine
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Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He, Jing Xu, Toru Nakazawa, Yong Jie Qin, Hong Yang Zhang