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  • Transplantation of human-induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects
    BDJ Open Pub Date : 2016-01-29
    Kamichika Hayashi, Hiromi Ochiai-Shino, Takeaki Shiga, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma
    更新日期:2019-01-26
  • 更新日期:2019-01-26
  • 更新日期:2019-01-26
  • Genotoxic effects of X-rays in buccal mucosal cells in children subjected to dental radiographs
    BDJ Open Pub Date : 2016-03-25
    Naveena Preethi, Nagarathna Chikkanarasaiah, Shakuntala S Bethur
    更新日期:2019-01-26
  • 更新日期:2019-01-26
  • 更新日期:2019-01-26
  • Hearing loss and its association with occupational noise exposure among Saudi dentists: a cross-sectional study
    BDJ Open Pub Date : 2016-11-04
    Bander M Alabdulwahhab, Raneem I Alduraiby, May A Ahmed, Lamya I Albatli, Maram S Alhumain, Nada A Softah, Shaza Saleh
    更新日期:2019-01-26
  • Interarch comparison of intraoral pH and temperature: a pilot study
    BDJ Open Pub Date : 2016-11-25
    Jung Eun Choi, Karl M Lyons, Mitten CB McLean, Neil J Waddell
    更新日期:2019-01-26
  • Contamination of dental unit waterlines: assessment of three continuous water disinfection systems
    BDJ Open Pub Date : 2016-12-16
    Damien Offner, Florence Fioretti, Anne-Marie Musset
    更新日期:2019-01-26
  • Assessing dental professionals’ understanding of tobacco prevention and control: a qualitative study in Västerbotten County, Sweden
    BDJ Open Pub Date : 2016-12-23
    Raman Preet, Nausheen Khan, Yulia Blomstedt, Maria Nilsson, Jennifer Stewart Williams
    更新日期:2019-01-26
  • 更新日期:2019-01-26
  • Bacterial morphotype grading for periodontal disease assessment
    BDJ Open Pub Date : 2017-01-20
    Kim Smeda-Pienaar, Eveline Kaambo, Charlene W J Africa
    更新日期:2019-01-26
  • Tooth wear: a cross-sectional investigation of the prevalence and risk factors in Beijing, China
    BDJ Open Pub Date : 2017-01-27
    Kan Sun, Wenhui Wang, Xiaozhe Wang, Xiangru Shi, Yan Si, Shuguo Zheng
    更新日期:2019-01-26
  • Interprofessional enhanced skills training in periodontology: a qualitative study of one London pilot
    BDJ Open Pub Date : 2017-02-10
    Eloise Radcliffe, Swapnil G Ghotane, Victoria Harrison, Jennifer E Gallagher
    更新日期:2019-01-26
  • Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
    BDJ Open Pub Date : 2017-02-10
    Bogusława Orzechowska-Wylęgała, Adam Wylęgała, Michał Buliński, Iwona Niedzielska, Andrzej Madej
    更新日期:2019-01-26
  • Oral health and oral health-related habits of Finnish prisoners
    BDJ Open Pub Date : 2017-03-03
    Raija Vainionpää, Arto Peltokangas, Jukka Leinonen, Paula Pesonen, Marja-Liisa Laitala, Vuokko Anttonen

    Objectives/Aims: This cross-sectional study aimed to examine oral health and oral health-related habits among prisoners at the Pelso Prison in Finland. Materials and Methods: Participants in this cross-sectional study comprises 100 inmates. A calibrated dentist recorded the decayed, filled and missed teeth as well as periodontal status (bleeding-on-probing, pocket probing and Community Periodontal Index) among the participants (n=100). Fifty inmates were also interviewed for marital status, education and oral health-related habits. The Ethical Committee of the Northern Ostrobothnia Hospital District and the Criminal Sanctions Agency approved the study protocol. Results: The participants were on average 35 years old and had 5 (s.d. 5.1) decayed teeth in need of restorative treatment, whereas DMFT was 17 (s.d. 8.9). Half of the study population had periodontal disease in need of professional treatment. Almost all reported brushing their teeth daily. Two-third ate sweets, one-third drank fizzy drinks and majority smoked every day. Almost two-third had used illicit drugs at some point of their lives. Almost all drunk alcohol once a week or more often. No statistically significant associations were discovered between dental treatment need and explanatory factors. Discussion Prisoners appear to be a homogenous group with poor oral health and harmful health behaviours.

    更新日期:2019-01-26
  • What do expectant mothers need to know about oral health? A cohort study from a London maternity unit
    BDJ Open Pub Date : 2017-03-24
    Patricia Nunes Correia, Aishah Alkhatrash, Catherine Ethel Williams, Annette Briley, Jenny Carter, Lucilla Poston, Marie-Therese Hosey
    更新日期:2019-01-26
  • Associations between sleep bruxism and (peri-) implant complications: a prospective cohort study
    BDJ Open Pub Date : 2017-04-14
    Magdalini Thymi, Corine M Visscher, Eiko Yoshida-Kohno, Wim Crielaard, Daniel Wismeijer, Frank Lobbezoo

    Objectives/Aims: To describe the protocol of a prospective cohort study designed to answer the question: ‘Is sleep bruxism a risk factor for (peri-)implant complications?’. Materials and Methods: Our study is a single-centre, double-blind, prospective cohort study with a follow-up time of 2 years. Ninety-eight participants fulfilling inclusion criteria (planned treatment with implant-supported fixed suprastructure(s) and age 18 years or older) will be included. Sleep bruxism will be monitored at several time points as masticatory muscle activity during sleep by means of a portable single-channel electromyographic device. Our main outcomes are biological complications (i.e., related to peri-implant bleeding, probing depth, marginal bone height, quality of submucosal biofilm and loss of osseointegration) and technical complications (i.e., suprastructure, abutment, implant body or other). Results: The study is currently ongoing, and data are being gathered. Discussion: The results of this prospective cohort study will provide important information for clinicians treating bruxing patients with dental implants. Furthermore, it will contribute to the body of evidence related to the behaviour of dental implants and their complications under conditions of high mechanical loadings that result from sleep bruxism activity. Conclusion: The protocol of a prospective cohort study designed to investigate possible associations between sleep bruxism and (peri-) implant complications was presented.

    更新日期:2019-01-26
  • Dental politics and subsidy systems for adults in Sweden from 1974 until 2016
    BDJ Open Pub Date : 2017-05-05
    Bengt Franzon, Björn Axtelius, Sigvard Åkerman, Björn Klinge

    Aims: The dental health sector, as part of the Swedish welfare system, originated in 1974. Since then, the dental insurance has undergone three major changes. The aim of this archive study was to study where in the legislative process the dental politics concerning national dental insurance and subsidies were formed. Materials and Methods: The material, such as Commission of inquiry proposals and Government Bills from four major dental reforms, was collected from the library at the Sveriges Riksdag (Swedish Parliament) and was analysed and structured using a modified version of the Health Field Model. Results: The views on the fundamental ideas, such as the connection between general and dental health, preventive dentistry, rehabilitation of the mouth and promotion of dental health, were the same over the years. The views on dentistry as a market, when it comes to freedom of prices, have undergone a major change since 1974, but the view on the welfare state remains the same. Conclusions: The Swedish dental subsidy systems and how dentistry has been treated politically are the results of a chain of events ranging from care for the population's dental health, political doctrines, ‘zeitgeist‚, dental policy, to state finances.

    更新日期:2019-01-26
  • Eyesight: a study of the staff of a dental school
    BDJ Open Pub Date : 2017-05-19
    Nicholas P Chandler, Andrew R Gray, Colleen M Murray

    Objectives/Aims: The aim was to investigate the vision of all 90 dentally qualified staff at a dental school. Materials and Methods: Ethical approval was obtained and a questionnaire-based survey conducted. Data were screened and analysed using Stata 13.1. The χ2 and Fisher’s Exact tests were used to test for significance with an alpha level of 0.05. Results: The participation rate was 95.6%. Most of the teachers (92%) considered their eyesight was satisfactory to practice dentistry. Of the 97% who had been tested at some stage, 15% had their eye examination due to sight deterioration with 22% needing correction. Almost two-thirds were myopic and a third were hyperopic. Forty-nine per cent wore spectacles only, with about a quarter of this group alternating between spectacles and contact lenses. Of those with corrected vision, 80% followed their optometrist’s recall advice. Four participants reported that they were colour blind. While 4% had had laser-eye surgery, a further 27% were interested in this. Magnification was used by 72% with no significant differences between genders, age of staff member, place of qualification or registration status. Most of the staff (81%) thought that screening of dental student’s eyesight should be mandatory, and regular eye examinations as a condition of dental practice was supported by 67%. Discussion: The number of teachers reporting recent vision tests was encouraging; nevertheless, a worrying 8% surveyed were unsure if their eyesight was satisfactory for work. The commonest vision problem was myopia, with almost half of the teachers wearing spectacles. It is clear that visual standards for dentistry would be helpful. Magnification use was high, with many non-users indicating their intention to buy loupes. Conclusions: Within the limits of this study the teachers were conscientious regarding their eye care, irrespective of their training and age. There was strong support for the mandatory testing of vision for all dentists and especially dental students.

    更新日期:2019-01-26
  • Assessment of noise intensity in a dental teaching clinic
    BDJ Open Pub Date : 2017-06-09
    Kelly Ferreira da Cunha, Rubem Beraldo dos Santos, Celso Afonso Klien Júnior
    更新日期:2019-01-26
  • Dental students’ concerns regarding OSPE and OSCE: a qualitative feedback for process improvement
    BDJ Open Pub Date : 2017-06-09
    Ambreen Shahzad, M Humza Bin Saeed, Sadia Paiker
    更新日期:2019-01-26
  • Clinical study to monitor dentinal hypersensitivity with episodic use of a desensitising dentifrice
    BDJ Open Pub Date : 2017-06-23
    Stephen Mason, Rose Kingston, Lucy Shneyer, Máiréad Harding
    更新日期:2019-01-26
  • A study on light transmittance through red protective shields modified with different window films
    BDJ Open Pub Date : 2017-06-30
    Vanida Nimmanon, Praewpat Pachimsawat, Siribang-on Pibooniyom Khovidhunkit, Bhornsawan Thanathornwong, Thirayost Nimmanon
    更新日期:2019-01-26
  • Diurnal variation of intraoral pH and temperature
    BDJ Open Pub Date : 2017-06-30
    Jung Eun Choi, Karl M Lyons, Jules A Kieser, Neil J Waddell
    更新日期:2019-01-26
  • 更新日期:2019-01-26
  • 更新日期:2019-01-26
  • Actinic cheilitis: proposition and reproducibility of a clinical criterion
    BDJ Open Pub Date : 2017-08-04
    Nádia Antunes Poitevin, Mariana Sudati Rodrigues, Karen Loureiro Weigert, Carmen Lúcia Rodrigues Macedo, Rubem Beraldo dos Santos
    更新日期:2019-01-26
  • Peri-implant health, clinical outcome and patient-centred outcomes of implant-supported overdentures in the mandible and the maxilla
    BDJ Open Pub Date : 2017-09-08
    David Offord, Grant Mathieson, Nicola Kingsford, Carine Matthys, Maarten Glibert, Hugo De Bruyn
    更新日期:2019-01-26
  • What reward does a child prefer for behaving well at the dentist?
    BDJ Open Pub Date : 2017-09-08
    James Coxon, Marie Therese Hosey, Jonathon Timothy Newton

    Background: Paediatric dentists often report using positive reinforcement to encourage their young patients to show co-operative behaviour. For effective reinforcement to take place the reward should be salient to the individual. To date, there is little research into what reward a young patient will choose when attending the dentist. Aim: To identify what reward children between the age of 4–8 years will choose when attending the dentist, and to determine the extent of agreement between children and caregivers in reward choice. Method: Observational study. Fifty-two children from different age groups (4–5 years, 6–7 years and 8 years) attending a primary-care dental clinic were asked to choose between a range of different rewards. The caregiver attending with them was also asked to anticipate the child’s preferred choice. Results: There was no clear favourite reward for children from both genders and different age group. However, no child chose the ‘sticker’ reward that is traditionally given out at the dentist. Overall carers agreed with the child’s choice of toy on 18 occasions (34.6%), but there were significant differences across the age groups with carers of older children showing less agreement Conclusion: To ensure that rewards are salient, children should be given a choice of rewards when attending the dental clinic. Parents ability to predict their child’s preferred rewards decreases as the child ages. Clinical relevance: A child’s motivation to co-operate during dental treatment can be increased by offering a range of rewards. Asking children to choose their reward from a limited range will increase the saliency of the reward for the child.

    更新日期:2019-01-26
  • Microstream capnography during conscious sedation with midazolam for oral surgery: a randomised controlled trial
    BDJ Open Pub Date : 2017-10-13
    Paul Brady, Gabriella Iohom, Ken D O’Halloran, Christine McCreary, Michael Cronin
    更新日期:2019-01-26
  • Craniofacial manifestations in osteogenesis imperfecta type III in South Africa
    BDJ Open Pub Date : 2017-10-20
    Manogari Chetty, Tina Sharon Roberts, Lawrence Stephen, Peter Beighton
    更新日期:2019-01-26
  • Dentists’ opinions on knowledge, attitudes and barriers in providing oral health care to older people living independently in the Netherlands and Flanders (Belgium)
    BDJ Open Pub Date : 2017-12-22
    P C Bots-VantSpijker, J J M Bruers, C P Bots, L M J De Visschere, J M G A Schols

    Objectives: The aim of this study was to investigate how dentists in the Netherlands and Flanders assessed their knowledge on oral health care to older people, what their attitude was and what barriers they experienced in rendering care to older people. Methods: The survey data was collected from a random sample of Dutch and Flemish dentists. Five hundred ninety-five dentists (37%) of the Dutch sample and 494 dentists of the Flemish sample (41%) completed the online questionnaire. Dentists were asked to respond to 15 Likert type items, representing opinions on provision of oral health care to older people and to give information about the number of older patients treated and about some profession-specific and personal characteristics. Results: The average number of patients treated per week was nearly twice as high in the Netherlands as in Flanders. Nevertheless, differences of opinions between dentists in the Netherlands and Flanders were relatively limited. Conclusions: This survey shows that in particular the actual number of older patients treated appears to be related with differences of opinions between Dutch and Flemish dentists about oral health care provided to (vulnerable) older people who live at home.

    更新日期:2019-01-26
  • A randomised study in young subjects of the effects of eating extra fruit or nuts on periodontal inflammation
    BDJ Open Pub Date : 2018-01-05
    Sara Fridell, Edvin Ström, Christian Agebratt, Per Leanderson, Hans Guldbrand, Fredrik H Nystrom

    Objectives/Aims: Fruit is often advocated as a healthy source of nutrients and vitamins. However, the high contents of sugars in many fruits could potentially counteract positive effects on the teeth. Materials and methods: We recruited 30 healthy non-obese participants who were randomised to either supplement their diet with extra fruits or nuts, each at +7 kcal/kg body weight/day, for 2 months. Results: Fructose intake increased from 9.1±6.0 to 25.6±9.6 g/day, P<0.0001, in the fruit group and was reduced from 12.4±5.7 to 6.5±5.3 g/day, P=0.007, in the nut group. Serum-vitamin C increased in both groups (fruit: P=0.017; nuts: P=0.009). α-Tocopherol/cholesterol ratio increased in the fruit group (P=0.0033) while β-carotene/cholesterol decreased in the nut group (P<0.0001). The amount of subjects with probing pocket depths ⩾4 mm in the fruit group was reduced (P=0.045) according to blinded examinations, and the difference in the changes in probing pockets ⩾4 mm was also statistically significant between the food groups (P=0.010). Conclusion: A large increase of fruit intake, compared with nuts, had a favourable effect on periodontal status in some respects, despite the high sugar contents. To search for potential protective micronutrients in fruit that protect the teeth could be an aim for further research.

    更新日期:2019-01-26
  • Factors related to reducing free sugar intake among white ethnic adults in the UK: a qualitative study
    BDJ Open Pub Date : 2018-02-09
    Said Harith Al Rawahi, Koula Asimakopoulou, Jonathon Timothy Newton

    Objective/Aims: To determine the barriers and enablers to behavioural change to reduce free sugar intake related to dental caries in a sample of UK adults who identify their ethnicity as White. Materials and methods: Qualitative study comprising semi-structured interviews of 27 participants. Interviews were recorded, transcribed and analysed using thematic analysis methods. The Capability-Opportunity-Motivation-Behaviour model (COM-B) and the Theoretical Domains Framework (TDF) were used to guide the derivation of themes. Results: Data saturation occurred at 27 interviews. The COM-B Model and TDF domains captured various factors that may influence the consumption of free sugar. TDF elements which are reflected in the study are: Knowledge; Psychological skills; Memory, attention, and decision processes; Behavioural regulation; Physical skills; Social influence; Environmental context and resources; Social and professional role and identity; Beliefs about capabilities; Beliefs about consequence; Intentions and goals reinforcement; and Emotions. COM-B Model elements which are reflected in the study are: psychological capabilities, physical capabilities, social opportunities, physical opportunities, reflective motivation, and automatic motivation. Discussion and conclusion: The COM-B model and TDF framework provided a comprehensive account of the barriers and facilitators of reducing sugar intake among white ethnic groups.

    更新日期:2019-01-26
  • Assessment of information resources for people with hypodontia
    BDJ Open Pub Date : 2018-03-09
    Sophy Barber, Sue Pavitt, David Meads, Balvinder Khambay, Hilary Bekker
    更新日期:2019-01-26
  • The Halitosis Consequences Inventory: psychometric properties and relationship with social anxiety disorder
    BDJ Open Pub Date : 2018-04-06
    Mauricio Duarte da Conceicao, Fernanda Salgueiredo Giudice, Lucas de Francisco Carvalho
    更新日期:2019-01-26
  • Remediation of adult black dental stains by phototherapy
    BDJ Open Pub Date : 2018-04-11
    M. A. Albelda-Bernardo, M. del Mar Jovani-Sancho, V. Veses, C. C. Sheth
    更新日期:2019-01-26
  • 更新日期:2019-01-26
  • Oral health-related quality of life in patients with upper gastrointestinal and hepatic disorders in Pakistan: validation of the Oral Health Impact Profile-14 in the Urdu language
    BDJ Open Pub Date : 2018-04-27
    Ibrahim Warsi, Anjum Younus, Abdur Rasheed, Javeria Ahmed, Hafsa Mahida, Rimsha Hashmi, Ambrina Qureshi

    Introduction The Oral Health Impact Profile (OHIP-14) has been used extensively to measure the impact of oral disease on oral health-related quality of life (HRQoL) but has not been validated in the Urdu language or tested in gastroenterology. Aims To validate the OHIP-14 for use in Pakistan and its ability to assess oral health in patients with upper gastrointestinal (GI) and hepatic disorders. Design Multicentre, cross-sectional. Setting Four major tertiary care hospitals. Methods The OHIP-14 was tested for reliability and validity in 700 patients referred for oesophago-gastro-duodenoscopic (OGD) investigation of the symptoms of upper GI or hepatic disease. Socio-demographic details and oral examination findings (for oral lesions and DMFT) were recorded. Results The mean (±standard deviation) total OHIP-14 score (range 0–56) was estimated to be 23.38 ± 10.47, indicating a significant impact of upper gastrointestinal and hepatic disorders on oral health. The reliability coefficient of the OHIP-14 was above 0.7 threshold, and the tool had good internal consistency (α = 0.83). When associated with worsening DMFT (decayed, missed, and filled teeth) index value, the highest correlations (p < 0.01) were detected with functional limitation (rs = 0.234), physical disability (rs = 0.230), and psychological discomfort (rs = 0.221). Conclusion The OHIP-14 is a precise and valid instrument for assessing oral-HRQoL in a gastroenterological setting amongst Pakistani population.

    更新日期:2019-01-26
  • A randomised controlled trial to evaluate the plaque removal efficacy of sodium bicarbonate dentifrices in a single brushing clinical model
    BDJ Open Pub Date : 2018-06-04
    Mary-Lynn Bosma, Kimberly R Milleman, Ivy Akwagyiram, Darren Targett, Jeffery L Milleman

    Objective To evaluate plaque removal efficacy of dentifrices containing sodium bicarbonate (NaHCO3) compared with a non-NaHCO3 dentifrice after a single-timed brushing. Materials and methods A randomised, controlled, examiner-blinded, four-period, crossover study in 56 adults with a mean whole-mouth plaque index of ≥2.00 (six site modification of Turesky modification of Quigley-Hein Plaque Index [TPI]). Subjects brushed once for one timed minute with a 67% NaHCO3 dentifrice with herbs; a 67% NaHCO3 dentifrice without herbs; a 62% NaHCO3 dentifrice with herbs; or a non-NaHCO3 dentifrice without herbs. All contained 923 p.p.m. fluoride as sodium fluoride. Pre- and post-brushing plaque assessments were performed. Results Mean TPI score decreased from pre- to post-brushing with all treatments. There were statistically significantly greater reductions in plaque for NaHCO3 dentifrices compared to non-NaHCO3 (p < 0.0001 for all) with no significant differences between NaHCO3-containing dentifrices. A post hoc analysis of plaque removal from different oral areas showed statistically significant differences in favour of the NaHCO3 dentifrices over the non-NaHCO3 dentifrice for almost all surfaces. No adverse events were reported. Discussion and conclusion Plaque removal was significantly greater with NaHCO3-containing dentifrices compared with a non-NaHCO3 dentifrice after a single, timed brushing. There was no effect of herbal tinctures. This study was registered at ClincalTrials.org: NCT03285984.

    更新日期:2018-11-29
  • Comparison of antibacterial activity of alexidine alone or as a final irrigant with sodium hypochlorite and chlorhexidine
    BDJ Open Pub Date : 2018-06-01
    Thaís M da Silva, Flávio RF Alves, Márcia TS Lutterbach, Maurício M Paiva, Dennis de Carvalho Ferreira

    To compare the antibacterial activity of alexidine (ALX) alone or as a final irrigant in combination with sodium hypochlorite (NaOCl), with the most common canal irrigants, NaOCl and chlorhexidine (CHX).

    更新日期:2018-11-29
  • Reply to: Relevance of investigating light transmittance through red protective shields in dentistry
    BDJ Open Pub Date : 2018-05-04
    Vanida Nimmanon, Praewpat Pachimsawat, Siribang-on Pibooniyom Khovidhunkit, Bhornsawan Thanathornwong, Thirayost Nimmanon

    Reply to: Relevance of investigating light transmittance through red protective shields in dentistry Reply to: Relevance of investigating light transmittance through red protective shields in dentistry, Published online: 04 May 2018; doi:10.1038/bdjopen.2018.5 Reply to: Relevance of investigating light transmittance through red protective shields in dentistry

    更新日期:2018-11-29
  • Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients
    BDJ Open Pub Date : 2018-11-23
    E. K. Hefni, S. Bencharit, S. J. Kim, K. M. Byrd, T. Moreli, F. H. Nociti, S. Offenbacher, S. P. Barros

    Objectives The long-term success of dental implants is established by literature. Although clinically well defined, the complex genetic pathways underlying osseointegration have not yet been fully elucidated. Furthermore, patients with osteopenia/osteoporosis are considered to present as higher risk for implant failure. Porous tantalum trabecular metal (PTTM), an open-cell porous biomaterial, is suggested to present enhanced biocompatibility and osteoconductivity. The goal of this study was to evaluate the expression patterns of a panel of genes closely associated with osteogenesis and wound healing in osteopenic patients receiving either traditional titanium (Ti) or PTTM cylinders to assess the pathway of genes activation in the early phases of osseointegration. Material and methods Implant cylinders made of Ti and PTTM were placed in osteopenic volunteers. At 2- and 4 weeks of healing, one Ti and one PTTM cylinder were removed from each subject for RT-PCR analysis using osteogenesis PCR array. Results Compared to Ti, PTTM-associated bone displayed upregulation of bone matrix proteins, BMP/TGF tisuperfamily, soluble ligand and integrin receptors, growth factors, and collagen genes at one or both time points. Histologically, PTTM implants displayed more robust osteogenesis deposition and maturity when compared to Ti implants from the same patient. Conclusions Our results indicate that PTTM properties could induce an earlier activation of genes associated with osteogenesis in osteopenic patients suggesting that PTTM implants may attenuate the relative risk of placing dental implants in this population.

    更新日期:2018-11-24
  • A pilot study of the clinical evidence for the methodology for prevention of oral mucositis during cancer chemotherapy by measuring salivary excretion of 5-fluorouracil
    BDJ Open Pub Date : 2018-11-23
    Akiko Kumagai, Shin Iijima, Takayuki Nomiya, Izuru Furuya, Yu Ohashi, Koichi Tsunoda, Kei Onodera, Naoko Tsunoda, Yuko Komatsu, Taifu Hirano

    Objective to re-examine measures to prevent oral mucositis caused by drugs in head and neck cancer patients during cancer treatment by measuring salivary excretion of 5-fluorouracil. Saliva, blood, and urine were simultaneously collected from oral cancer patients and breast cancer patient at the point in time of before, during, and after the administration of 5-FU, then the 5-FU levels of the samples were quantitatively analysed using LC-MS/MS. In all patients, the 5-FU levels in saliva and serum peaked at 30 min to 3 h after the start of 5-FU treatment, and high levels were maintained throughout the administration of the drug. With regard to urinary 5-FU levels, they remained high from 3 to 120 h after the start of 5-FU treatment. After the completion of 5-FU treatment, even though it not appeared in the patients’ serum and urine promptly, 5-FU was detected in saliva at 12 h after the completion of 5-FU treatment in one oral cancer patient and at 48 h after the completion of 5-FU treatment in the breast cancer patient. It was suggested that the level of hydration after the completion of chemotherapy may be involved in the differences in 5-FU excretion.

    更新日期:2018-11-24
  • Influence of mouth breathing on outcome of scaling and root planing in chronic periodontitis
    BDJ Open Pub Date : 2018-11-09
    Manpreet Kaur, Rajinder Kumar Sharma, Shikha Tewari, Satish Chander Narula

    Introduction Dryness is known to be associated with inflammatory diseases such as dry eye disease and atopic dermatitis. There is significant water loss from the oral cavity during mouth breathing. This study is conducted to estimate the influence of mouth breathing on the outcome of scaling and root planing (SRP) in chronic periodontitis (CP). Materials and methods CP patients comprising of 33 mouth breathers (MBs) and 33 nose breathers (NBs) were recruited. Thirty patients in each group completed the study. At baseline, plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were measured. SRP was done in both groups. At the 4th, 8th, and 12th week, PI, GI, and BOP were recorded. PD and CAL were also assessed at the 12th week. Results At the 12th week, there was significantly less improvement in GI at palatal sites of maxillary anterior and maxillary posterior teeth in MB group. Sixty-nine percent of BOP positive sites with PD >4 mm were converted into BOP negative sites with PD ≤4 mm in maxillary posterior palatal sites in NB. This success was 38% in MB. Conclusion Control of periodontal inflammation by SRP in CP patients is affected at palatal sites of mouth breathers.

    更新日期:2018-11-09
  • Experience with bruxism in the everyday oral implantology practice in the Netherlands: a qualitative study
    BDJ Open Pub Date : 2018-11-09
    Magdalini Thymi, Annemiek Rollman, Corine M. Visscher, Daniel Wismeijer, Frank Lobbezoo

    Objective To explore how bruxism is dealt with by accredited oral implantologists within daily clinical practice. Materials and methods Nine semi-structured interviews of oral implantologists practicing in non-academic clinical practices in the Netherlands were performed, and thematic analysis was conducted using a framework-based approach. Results Oral implant treatments in bruxing patients were a generally well-accepted practice. Complications were often expected, with most being of minor impact. Contradictive attitudes emerged on the topic of bruxism being an etiologic factor for peri-implant bone loss and loss of osseointegration. Views on the ideal treatment plan varied, though the importance of the superstructure’s occlusion and articulation features was repeatedly pointed at. Similarly, views on protective splints varied, regarding their necessity and material choice. Bruxism was diagnosed mainly by clinical examination, alongside with patient anamnesis and clinician’s intuition. There was little attention for awake bruxism. Discussion Bruxism was generally not considered a contraindication for implantological treatments by accredited oral implantologists. Views on the interaction between bruxism and bone loss/loss of osseointegration varied, as did views on the ideal treatment plan. Conclusions There is a need for better understanding of the extent to which, and under which circumstances, sleep and/or awake bruxism can be seen as causal factors for the occurrence of oral implant complications.

    更新日期:2018-11-09
  • The antibacterial efficacy of a foam mouthwash and its ability to remove biofilms
    BDJ Open Pub Date : 2018-09-27
    Siân B. Jones, Nicola X. West, Pavel P. Nesmiyanov, Sergey E. Krylov, Vera V. Klechkovskaya, Natalya A. Arkharova, Svetlana A. Zakirova

    Objectives/Aims To evaluate the antimicrobial activity of a newly developed foam mouthwash containing a modified lactoperoxidase system in vitro. Materials and methods Biofilms of five bacterial species were developed on hydrophobic and hydrophilic surfaces whilst salivary-based biofilm was grown on tooth enamel. Each surface was exposed to the foam mouthwash or saline in vitro. Optical density and scanning electron microscopy (SEM) was used to determine retention of the biofilm following 5 or 30 s exposure time. Results The foam mouthwash was active against biofilms formed by S. aureus, K. rhizophila, M. thailandicus, E. coli, and C. violaceum and eliminated significant amount of biofilm from each surface; immature 4 h biofilm was less resistant than 24 h biofilm. A 30 s rinse showed best performance, with removal of up to 66% of biofilm from the hydrophilic surface. SEM imaging confirmed oral biofilm removal from the enamel surface after a 5 s rinse with the foam mouthwash. Discussion Foam mouthwash demonstrated a significant impact on growing biofilm when compared against saline solution. Growing biofilms were more susceptible to the action of the foam mouthwash, which justifies after-meal use of the mouthwash when traditional dentifrices may not be accessible. Conclusions Foam mouthwash can be a convenient on-the-go format of oral care products that can be used after meals or when needed to reduce the risk of biofilm-associated oral conditions.

    更新日期:2018-09-28
  • Relevance of investigating light transmittance through red protective shields in dentistry
    BDJ Open Pub Date : 2018-05-04
    Ellen Bruzell, Bjørn Johnsen, Terje Christensen

    Relevance of investigating light transmittance through red protective shields in dentistry Relevance of investigating light transmittance through red protective shields in dentistry, Published online: 04 May 2018; doi:10.1038/bdjopen.2018.4 Relevance of investigating light transmittance through red protective shields in dentistry

    更新日期:2018-05-05
  • The Halitosis Consequences Inventory: psychometric properties and relationship with social anxiety disorder
    BDJ Open Pub Date : 2018-04-30
    Mauricio Duarte da Conceicao, Fernanda Salgueiredo Giudice, Lucas de Francisco Carvalho

    The Halitosis Consequences Inventory: psychometric properties and relationship with social anxiety disorder The Halitosis Consequences Inventory: psychometric properties and relationship with social anxiety disorder, Published online: 30 April 2018; doi:10.1038/bdjopen.2018.6 The Halitosis Consequences Inventory: psychometric properties and relationship with social anxiety disorder

    更新日期:2018-05-02
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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