样式: 排序: IF: - GO 导出 标记为已读
-
Omics analysis unveils changes in the metabolome and lipidome of Caenorhabditis elegans upon polydopamine exposure J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-04-01 Bao Tan Nguyen, Quoc-Viet Le, Jeongjun Ahn, Ky Anh Nguyen, Huy Truong Nguyen, Jong Seong Kang, Nguyen Phuoc Long, Hyung Min Kim
Polydopamine (PDA) is an insoluble biopolymer with a dark brown-black color that forms through the autoxidation of dopamine. Because of its outstanding biocompatibility and durability, PDA holds enormous promise for various applications, both in the biomedical and non-medical domains. To ensure human safety, protect health, and minimize environmental impacts, the assessment of PDA toxicity is important
-
Development of a rapid LC-MS/MS method for simultaneous quantification of ten commonly used antibiotic drugs in human serum J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-30 Stefania Ramirez, Margherita Scapaticci, Francesca Barbella, M. Marcella Panico, Ileana A. Fecca, Barbara Cocchini, Nadia Brizzi, Sonia Cavina, Irene Accorsi, Silvia Rizzato, Eric Ramazzotti, Rita Mancini
-
A universal method for profiling and characterization of oligosaccharides in traditional Chinese medicines J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-29 Yue Liu, Juan Song, Si Liu, Yi Nan, Wei Zheng, Xu Pang, Xiaojuan Chen, Haizhen Liang, Jie Zhang, Baiping Ma
-
Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-28 Nabeel Mujtaba Abbasi, Jared L. Anderson, Jackson D. Pellett, Peter M. Yehl, Mary-Anne del Barrio, Qiqing Zhong
-
Development and validation of a simple and affordable LC-UV method for identification and assay of selected antimicrobial medicines J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-27 Haile Kassahun, Ann Van Schepdael, Gebremariam Ketema, Erwin Adams
-
A fast and efficient method for screening and evaluation of hypoglycemic ingredients of Traditional Chinese Medicine acting on PTP1B by capillary electrophoresis J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-27 Juan Gao, Zhengjin Jiang, Erwin Adams, Ann Van Schepdael
As a pivotal enzyme that regulates dephosphorylation in cell activities and participates in the insulin signaling pathway, protein tyrosine phosphatase 1B (PTP1B) is considered to be an important target for the therapy of diabetes. In this work, a rapid and efficient inhibitor screening method of PTP1B was established based on capillary electrophoresis (CE), and used for screening and evaluating the
-
Less is more: Validating a single method for comprehensive rh-insulin analysis J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-21 Sanjay Mendiratta, Gurminder Bindra, Sukhwinder Singh, Poonam Katoch, Kritika Pandey, Harish Chander, Anupkumar R. Anvikar, Charu Mehra Kamal
-
Identification and characterization of the in-vivo metabolites of the novel soluble epoxide hydrolase inhibitor EC5026 using liquid chromatography quadrupole time of flight mass spectrometry J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-21 Shankha Dey, Rushikesh Biradar, Sayalee Sanjay Mane, Anandhu Kunnath Shaji, Agneesh Pratim Das, Subhash Mohan Agarwal, Swapnil Jayant Dengale
EC5026 is a novel soluble epoxide hydrolase inhibitor being developed clinically to treat neuropathic pain and inflammation. In the current study, we employed the LC-ESI-Q-TOF-MS/MS technique to identify four in-vivo phase-I metabolites of EC5026 in rat model, out of which three were found to be novel. The identified metabolites include aliphatic hydroxylation, di-hydroxylation, terminal desaturation
-
Enhancing breast cancer screening with urinary biomarkers and Random Forest supervised classification: A comprehensive investigation J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-20 Eugenio Alladio, Fulvia Trapani, Lorenzo Castellino, Marta Massano, Daniele Di Corcia, Alberto Salomone, Enrico Berrino, Riccardo Ponzone, Caterina Marchiò, Anna Sapino, Marco Vincenti
-
Addressing common challenges of biotherapeutic protein peptide mapping using recombinant trypsin J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Thomas Menneteau, Sergei Saveliev, Claire I. Butré, Alba Katiria González Rivera, Marjeta Urh, Arnaud Delobel
-
Comparative analysis of Herceptin N-Linked glycosylation by HILIC-FLD and LC-MS/MS methods J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Navin Rauniyar, Joy Khetani, Xuemei Han
Monoclonal antibodies like Herceptin play a pivotal role in modern therapeutics, with their glycosylation patterns significantly influencing their bioactivity. To characterize the N-glycan profile and their relative abundance in Herceptin, we employed two analytical methods: hydrophilic interaction chromatography with fluorescence detection (HILIC-FLD) for released glycans and liquid chromatography
-
HPLC-ESI/MS-MS metabolic profiling of white pitaya fruit and cytotoxic potential against cervical cancer: Comparative studies, synergistic effects, and molecular mechanistic approaches J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Heba A.S. El-Nashar, Mahmood A. Al-Azzawi, Hassan Hadi Al-Kazzaz, Yasemin Khudiar Alghanimi, Shaden Mohamed Kocaebli, Moaz Alhmammi, Ahmed Asad, Tarek Salam, Mohamed El-Shazly, Mohamed A.M. Ali
Natural approach became a high demand for the prevention and treatment of such diseases for their proven safety and efficacy. This study is aimed to perform comparative phytochemical analysis of white pitaya () peel, pulp and seed extracts via determination of total flavonoid content, phenolic content, and antioxidant capacity, coupled with HPLC-ESI/MS-MS analysis. Further, we evaluated the synergistic
-
LC-HRMS and NMR studies for the characterization of degradation impurities of ubrogepant along with the in silico approaches for the prediction of degradation and toxicity J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Sowmya Chaganti, Usha Chauhan, Nehal Bhatt, Hemasree Kommalapati, Vijaya Madhyanapu Golla, Pushpa Pilli, Gananadhamu Samanthula
-
Green innovation in analytical chemistry: A sustainable densitometric HPTLC approach for the distinctive separation and quantification of structurally related abused drugs - tramadol, tapentadol, and venlafaxine - in seized pharmaceutical dosage forms J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Hala M. Heneedak, Mohamed A. Abdelshakour, Khaled M. Darwish, Samia M. Mostafa, Mohamed Saleh Elgawish
-
Application of eco-friendly natural deep eutectic solvents (NADES) in HPLC for separation of complex natural products: Current limitations and future directions J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-19 Kabre Lynne Heck, Lin Si, Da Jin Jung, Angela Isabel Calderón
-
Development of a platform method for rapid detection and characterization of domain-specific post-translational modifications in bispecific antibodies J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-18 Sophia Liu, Jennifer B. Nguyen, Yimeng Zhao, Svetlana Schussler, Sunnie Kim, Haibo Qiu, Ning Li, Michael P. Rosconi, Erica A. Pyles
Charge heterogeneity is inherent to all therapeutic antibodies and arises from post-translational modifications (PTMs) and/or protein degradation events that may occur during manufacturing. Among therapeutic antibodies, the bispecific antibody (bsAb) containing two unique Fab arms directed against two different targets presents an additional layer of complexity to the charge profile. In the context
-
Implications of analytical nanoscience in pharmaceutical and biomedical fields: A critical view J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-17 Claudia López-Sánchez, Fernando de Andrés, Ángel Ríos
-
“Plant Golden” C. sativus: Qualitative and quantitative analysis of major components in stigmas and petals and their biological activity in vitro J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-17 Xue Li, Jiao Song, Jin Tan, Dingkun Zhang, Yongmei Guan, Funeng Geng, Ming Yang, Jin Pei, Hongyan Ma
-
Multiple-matrices metabolomics combined with serum pharmacochemistry for discovering the potential targets and active constituents of Qifu decoction against heart failure J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-16 Xingxing Zhang, Wenting Liao, Xin Ding, Ya Zhang, Cuiping Long, Qian Zhou, Yuwei Wang, Hong Wu, Guangguo Tan
-
A multiplex UPLC-MS/MS method for the quantification of three PD-L1 checkpoint inhibitors, atezolizumab, avelumab, and durvalumab, in human serum J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-16 Pauline L.M. Buitelaar, Karen A.M. de Jong, Leon Aardenburg, Michiel S. van der Heijden, Alwin D.R. Huitema, Jos H. Beijnen, Hilde Rosing
To support pharmacokinetic studies, a multiplex UPLC-MS/MS assay was developed and validated to quantify PD-L1 checkpoint inhibitors atezolizumab, avelumab, and durvalumab in serum. A bottom-up sample pre-treatment procedure was developed to determine atezolizumab, avelumab, and durvalumab in serum. This procedure consisted of (1) precipitation of the monoclonal antibody with ammonium sulfate, (2)
-
A novel strategy for the multi-components division and discovering pharmacodynamic material basis of Chinese herbal compounds: A case study of Xian-Ling-Gu-Bao capsule J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-16 Yuxin Guan, Bing Yang, Jingqi Zeng, Yulin Mo, Xiaochun Wu, Yanjun Yang, Liang Feng, Xiaobin Jia
The therapeutic effects of Chinese herbal compounds are often achieved through the synergistic interactions of multiple ingredients. However, current research predominantly focuses on individual ingredients, neglecting the holistic nature of Chinese herbal compounds. This study proposes a novel strategy to elucidate the pharmacodynamic material basis of Chinese herbal compounds based on their multi-components
-
A LC-MS-based serum pharmacochemistry approach to reveal the compatibility features of mutual promotion/assistance herb pairs in Xijiao Dihuang decoction J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-15 Guisheng Zhou, Yu Zhuang, Yang Dai, Cuihua Chen, Baoping Jiang, Guochun Li, Lian Yin
Xijiao Dihuang decoction (XDT), a famous formula, was usually used to improve the prognosis of patients with blood-heat and blood-stasis syndrome-related diseases. There were some mutual promotion and mutual assistance herb pairs in XDT. However, the exact functions of these herb pairs in the compatibility of XDT were not elucidated due to the lack of appropriate methodologies. Based on the theory
-
Magnetic nanoparticles immobilized thrombin ligand fishing to screen thrombin inhibitors in natural products J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-15 Hui Guo, Lili Guo, Jianwei Yu, Fengju Zhao, Wei Yang, Jiaxin Li, Hanqi Chen, Junqing Qian
-
Explore the active ingredients and potential mechanism of action on Actinidia arguta leaves against T2DM by integration of serum pharmacochemistry and network pharmacology J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Yu-Fei Hou, Yang Liu, Lu Bai, Jun Du, Shao-Jing Liu, Long Jia, Ya-Long Wang, Sen Guo, Chi-Tang Ho, Nai-Sheng Bai
-
A combined toxicokinetic and metabolic approach to investigate deschloro-N-ethylketamine exposure in a multidrug user J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Romain Magny, Bruno Mégarbane, Lucie Chevillard, Emmanuel Roulland, Benoit Bardèche-Trystram, Véronique Dumestre-Toulet, Laurence Labat, Pascal Houzé
-
Atomic force microscopy correlates mechanical and electrical properties of HepG2 cells with curcumin concentration J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Zeling Guo, Yu Meng, Shang Zhou, Jiangting Li, Xinyu Li, Rongrong Feng, Yulan Zou, Wenchao Liao, Weiting Wu, Mingjing Xu, Xiangfu Zeng, Weidong Zhao, Haijian Zhong
Hepatocellular carcinoma (HCC) is a highly prevalent cancer with a significant impact on human health. Curcumin, a natural compound, induces cytoskeletal changes in liver cancer cells and modifies the distribution of lipids, proteins, and polysaccharides on plasma membranes, affecting their mechanical and electrical properties. In this study, we used nanomechanical indentation techniques and Kelvin
-
Metabolites rapid-annotation in mice by comprehensive method of virtual polygons and Kendric mass loss filtering: A case study of Dendrobium nobile Lindl J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Xingdong Wu, Qingjie Fan, Chunxue Gao, Jiajia Wu, Di Wu, Enming Hu, Daopeng Tan, Yongxia Zhao, Xiaoshan Li, Zhou Yang, Lin Qin, Yuqi He
-
Network pharmacology and untargeted metabolomic-based investigation of anti-osteoporotic effects of viscozyme-assisted polysaccharide from Portulaca oleracea L. J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Xitao Yue, Yunhua Fu, Zhuoran Li, Yuanjun Zou, Yulin Dai
-
Screening and characterization of potential anti-gout components from Polygonum cuspidatum by integration off-line two-dimensional liquid chromatography-mass spectrometry with affinity ultrafiltration and on-line HPLC-ABTS J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-13 Huanying Guo, Simeng Hu, Hongyu Ran, Hongjing Dong, Xiao Wang, Hengqiang Zhao
-
Plasma metabolomics identifies S-adenosylmethionine as a biomarker and potential therapeutic target for vascular aging in older adult males J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-12 Zhenghui Gu, Yujia Wang, Zhiyi Fang, Tianhu Wang, Shan Gao, Qian Yang, Yingjie Zhang, Yabin Wang, Linghuan Wang, Li Fan, Feng Cao
Brachial-ankle pulse wave velocity (baPWV) is a noninvasive index of vascular aging. However, the metabolic profile underlying vascular aging has not yet been fully elucidated. The current study aimed to identify circulating markers of vascular aging as assessed by baPWV and to elucidate its mechanism from a metabolomic perspective in older adults. A total of 60 and 61 Chinese male participants aged
-
Quantum dots-based multiplexed immunosensors for accurate diagnosis of attention deficit hyperactivity disorder in childhood J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-11 Xinyue Shao, Zhao Dong, Shuai Zhang, Yunyun Qiao, Hongwei Zhang, Hua Guo
Attention-deficit/hyperactivity disorder (ADHD) lacks objective diagnostic markers. In clinical settings, reliance on subjective judgments can often lead to missed or misdiagnoses. Some biomarkers have been reported to be associated with ADHD, but using one biomarker alone is not enough. To address this, we developed a fluorescent immunoassay platform based on quantum dots (QDs) to detect assay capable
-
Quantification of endogenous Angiotensin 1-10, 1-9, 1-8, 1-7, and 1-5 in human plasma using micro-UHPLC-MS/MS: Outlining the importance of the pre-analytics for reliable results J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-09 Jonathan Maurer, Anke de Groot, Léon Martin, Eric Grouzmann, Grégoire Wuerzner, Philippe J. Eugster
-
NPS–EQA PART II: Four years’ experience in external quality assessment program in Italy for classical and new psychoactive substances analysis in hair J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-08 Maria Concetta Rotolo, Silvia Graziano, Maria Rosaria Varì, Adele Minutillo, Alessandro Di Giorgi, Valeria Aquilina, Simona Pichini, Emilia Marchei
In 2019, the Italian National Institute of Health established an external quality assessment (EQA) program to evaluate the performance of laboratories of collaborative centres participating in the National Early Warning System in hair testing for classical and new psychoactive substances (NPS). The results obtained in the four rounds (2019–2023) and the evolution in hair testing performance for classic
-
Network pharmacology analysis and experimental validation of Xiao-Qing-Long-Tang’s therapeutic effects against neutrophilic asthma J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-08 Zhifeng Chen, Yaoliang Zhou, Yuanfei Tan, Sheng-dong He, Xiaoying Ji, Bing Xiao, Hongda Chen
Xiao-Qing-Long-Tang (XQLT), a classical Chinese herbal medicine formula, has been extensively used for allergic asthma treatment. However, there is limited research on its anti-inflammatory effects and mechanisms specifically in neutrophilic asthma (NA). This study aims to investigate the potential therapeutic effects of XQLT against NA using a combination of network pharmacology and experimental validation
-
Simultaneous monitoring of seven antiepileptic drugs by dried blood spot and dried plasma spot sampling: method validation and clinical application of a LC–MS/MS-based technique J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-07 Haiwei Cao, Yi Jiang, Qiang Sun, Ruichen Liu, Yanyan Li, Jing Huang
Alternative blood sampling strategy can enhance the application of therapeutic drug monitoring (TDM), then improve precision therapy and medication compliance. In developing nations, alternative sampling strategy that allows self-sampling and room temperature transport is especially important. This study validates the use of dried blood spot (DBS) and dried plasma spot (DPS) sampling along with liquid
-
Drug deconjugation-assisted peptide mapping by LC–MS/MS to identify conjugation sites and quantify site occupancy for antibody-drug conjugates J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-07 Tongdan Wang, Zi-Ao Huang, Moyin Zhou, Ruxin Wang, Yufei Li, Longyun Guo, Xiaolin Cao, Jincui Huang
-
Solid state NMR study of the bioenhancer piperine, supported by GIPAW DFT calculations J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-07 Paweł Siudem, Łukasz Szeleszczuk, Katarzyna Paradowska
-
High-throughput method for Peptide mapping and Amino acid sequencing for Calcitonin Salmon in Calcitonin Salmon injection using Ultra High Performance Liquid Chromatography – High Resolution Mass Spectrometry (UHPLC-HRMS) with the application of Bioinformatic tools J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-07 Akhilesh Kumar Kuril, K. Saravanan
Tandem mass spectrometry (MS/MS) can provide direct and accurate sequence characterization of synthetic peptide drugs, and peptide drug products including side chain modifications in the Peptide drugs. This article explains a step-by-step guide to developing a high-throughput method using high resolution mass spectrometry for characterization of Calcitonin Salmon injection containing high proportion
-
Multiplexed quantification of venlafaxine and metabolites in human plasma by liquid chromatography-tandem mass spectrometry J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-07 Aashish Pandey, Amelia Price, Nadia Ayala-Lopez, Kyana Y. Garza, Mark A. Marzinke, Claire E. Knezevic
Venlafaxine (VEN) and its O-demethylated metabolite, -desmethylvenlafaxine (ODV), are commonly prescribed serotonin-norepinephrine reuptake inhibitors, approved for the treatment of depression and anxiety. Both are metabolized to inactive metabolites via cytochrome P450 enzymes. While previous studies have focused on quantifying VEN and ODV, bioanalytical methods for the simultaneous measurement of
-
Impurity assessment, development and validation of an RP-HPLC method for the determination of eleven potential impurities of eltrombopag precursor J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-06 Timur Demirhan, Elif Guksu, Yücel Yazar, Elif Keskin, Esen Bellur Atici, Sibel A. Özkan
-
Ultrasensitive and label-free electrochemical immunosensor for the detection of the ovarian cancer biomarker CA125 based on CuCo-ONSs@AuNPs nanocomposites J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-05 Wendi Mu, Chunyan Wu, Fangfang Wu, Hongmin Gao, Xinshui Ren, Jing Feng, Meng Miao, Hehua Zhang, Dong Chang, Hongzhi Pan
Cancer antigen 125 (CA125) is pivotal as a tumor marker in early ovarian cancer prevention and diagnosis. In this work, we introduced an ultrasensitive label-free electrochemical immunosensor tailored for CA125 detection, leveraging nanogold-functionalized copper-cobalt oxide nanosheets (CuCo-ONSs@AuNPs) as nanocomposites. For the inaugural application, copper-cobalt oxide nanosheets delivered the
-
A multicomponent LC-MS/MS method for drugs of abuse testing using volumetric DBS and a clinical evaluation by comparison with urine J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-03 Joar Guterstam, Christoffer Tavic, Miguel Barosso, Olof Beck
Drug testing commonly use urine as a specimen and immunoassays for screening. The need for supervised urine collection has led to an interest in alternative specimens and a need for using mass spectrometry methods already for screening. In addition, mass spectrometry methods allow for broad multipanel screening which of great value because of the increased number of substances that needs to be covered
-
Integrated component identification, network pharmacology, and experimental verification revealed mechanism of Dendrobium officinale Kimura et Migo against lung cancer J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-03 Yan Zhao, Shuaitao Zhu, Yuan Li, Xuan Niu, Guanxiong Shang, Xiaoqi Zhou, Jiu Yin, Beihua Bao, Yudan Cao, Fangfang Cheng, Zhipeng Li, Ran Wang, Weifeng Yao
-
A validated LC-MS/MS method for the quantitation of daratumumab in rat serum using rapid tryptic digestion without IgG purification and reduction J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-02 Weiqiang Li, Wensi Huang, Xiong Yu, Chong Chen, Yali Yuan, Donghui Liu, Feiyu Wang, Jinghua Yu, Xingxing Diao
Daratumumab, a humanized monoclonal antibody utilized in treating immunoglobulin light-chain amyloidosis and relapsed/refractory multiple myeloma, was quantified in rat serum through a simple, economical and effective liquid chromatography tandem-mass spectrometry (LC-MS/MS) method. A surrogate peptide, LLIYDASNR, derived from trypsin hydrolysis, was quantitatively analyzed with LLIYDASN [C, N] RAT
-
A metabolomics footprinting approach using GC-MS to study inhibitory effects of the fungal metabolite diplopyrone C against nosocomial pathogen biofilms J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-02 Maria Michela Salvatore, Angela Maione, Marianna Imparato, Francesco Salvatore, Marco Guida, Emilia Galdiero, Anna Andolfi
-
NPS–EQA PART I: Four years’ experience in external quality assessment program in Italy for classical and new psychoactive substances analysis in oral fluid J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-02 Emilia Marchei, Silvia Graziano, Maria Rosaria Varì, Adele Minutillo, Valeria Aquilina, Simona Pichini, Maria Concetta Rotolo
In 2019, Italian National Institute of Health established an external quality assessment program (EQA) to evaluate the performance of oral fluid testing for classical and new psychoactive substances by laboratories participating in the National Early Warning System collaborative centres. This report presents the results of four rounds between 2019 and 2023. Eleven oral fluid specimens, including 3
-
Alterations in serum metabolic profiles of early-stage hepatocellular carcinoma patients after radiofrequency ablation therapy J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-02 Fengmei Zhang, Jing Wu, Lei Zhang, Jian Zhang, Rui Yang
To investigate the alterations in serum metabolic profiles and early-stage hepatocellular carcinoma (HCC) patient characteristics after radiofrequency ablation (RFA) therapy. This evaluation aimed to assess treatment effectiveness and identify potential novel approaches and targets for HCC treatment and prognosis monitoring. Untargeted metabolomics technology was employed to analyze serum metabolic
-
Simultaneous determination of iguratimod and its metabolite in rat plasma using a UPLC-MS/MS method: Application for drug-drug interaction J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-02 Lu Shi, Jinyu Hu, Hualu Wu, Yuxin Shen, Xiaohai Chen, Qinghua Weng, Ren-ai Xu, Congrong Tang
-
Testing for Kratom alkaloids in fingernail clippings – not only mitragynine J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-03-01 Alice Ameline, Laurie Gheddar, Nadia Arbouche, Adeline Blanchot, Jean-Sebastien Raul, Pascal Kintz
Kratom () is a species of large tree that grows in Southeast Asia and is part of the Rubiaceae family. Its fresh leaves are harvested for their medicinal properties and used for their psychoactive effects. Kratom contains many biologically active alkaloids, including mitragynine and 7-OH-mitragynine, which are considered the two most important psychoactive components and constitute approximately 66%
-
Determination of four aminoglycoside antibiotics and spectinomycin in feed at cross-contamination level: Development and in-house validation of a LC–MS/MS method for enforcing EU Regulation J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-27 Luca Ferrari, Carlos Gonçalves, Joerg Stroka, Christoph von Holst, Luciano Pinotti, Ursula Vincent
Combating antimicrobial resistance is a top priority worldwide involving a concerted action by several high-level institutions and organisations in the health sector. To ensure that a meaningful progress is achieved, several campaigns and political initiatives have been launched targeting the health professionals, the industry, the farmers, and the general public. The Regulation (EU) 2019/4 on medicated
-
Development and functionalization of electrospun fiber coated thin film microextraction devices for rapid mass spectrometric determination of biologically important polar molecules J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-27 Merve Öztürk, Bekir Salih, Ahmet E. Eroğlu, Ezel Boyaci
-
Optimization of enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its phase-1 metabolites in human biological fluids J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-27 Giorgia Sprega, Giorgi Kobidze, Alfredo Fabrizio Lo Faro, Simona Pichini, Tivadar Farkas, Anastasio Tini, Antonina Mskhiladze, Francesco Paolo Busardò, Bezhan Chankvetadze
Recently we published in this journal an enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 3,4-methylenedioxymethamphetamine (MDMA) and its major phase-1 metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat, oral
-
Metabolic profile of Phellodendron amurense Rupr. in vivo of rat and its metabolomic study on intervention in rheumatoid arthritis J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-27 Ying Hao, Bingcheng Wang, Yuan Feng, Xiaodong Xin, Yawei Deng, Mingsong Liu, Chunhua Li, Shiqiao Liu, Qingqing Zhang
To analyze the metabolites (blood, urine and feces) in normal rats after intragastric administration of the decoction of Phellodendri Amurensis Cortex (PAC) and to map the metabolic profile of PAC of rat; meanwhile, to evaluate the anti-rheumatoid arthritis (RA) effect of PAC by blood metabolomics technique and to explore its mechanism. Performing on UPLC-Q-TOF-MS technology with a Waters ACQUITY UPLC
-
Pteridine and tryptophan pathways in children with type 1 diabetes: Isoxanthopterin as an indicator of endothelial dysfunction J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-27 Yavuz Özer, Mehmet Şerif Cansever, Hande Turan, Elvan Bayramoğlu, Dilek Bingöl Aydın, Esra İşat, Emre Ceyhun, Tanyel Zubarioğlu, Ayşe Çiğdem Aktuğlu Zeybek, Ertuğrul Kıykım, Olcay Evliyaoğlu
Type 1 diabetes (T1D) and its complications are known to be associated with oxidative stress. Pteridine derivatives and indoleamine 2,3-dioxygenase (IDO) activity can be used as biomarkers in the evaluation of oxidative stress. In this study, our aim is to compare the concentrations of serum and urinary pteridine derivatives, as well as serum IDO activity, in children and adolescents diagnosed with
-
Establishment of a multi-strategy platform for quality control and quality markers screen of Mailuoshutong pill J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-23 Yaojuan Chu, Xiangyu Zhang, Lihua Zuo, Xiaobao Wang, Yingying Shi, Liwei Liu, Lin Zhou, Jian Kang, Bing Li, Wenbo Cheng, Shuzhang Du, Zhi Sun
-
A GC×GC-MS method based on solid-state modulator for non-targeted metabolomics: Comparison with traditional GC-MS method J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-23 Yueyi Zhang, Haihui Ren, Xiao Tang, Qiaorong Liu, Wen Xiao, Zunjian Zhang, Yuan Tian
-
Pharmacokinetic and tissue distribution analysis of bioactive compounds from Fuke Qianjin capsules in rats by a validated UPLC[sbnd]MS/MS method J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-23 Xiujie Guo, Jiaying Yang, Wei Wang, Yun Gong, Peng Zhang, Mengyao Wu, Yuanqing Zheng, Chaoran Wang
-
LC-MS/MS determination of atropine toxicity: Pre-analytical effect of blood collection tube and analytical matrix J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-23 Faten Farouk, Ehab Elkady
Atropine (ATR) intoxication is a recurrent case in emergency departments. The diagnosis is dependent on clinical evaluation and is supported by analytical assessment The assay is limited by the rapid degradation/metabolism of ATR into TRP as well as the preanalytical factors impairing correct detection and diagnosis.
-
Application of electron paramagnetic resonance spectroscopy to examine free radicals formed in indapamide and torasemide storage under UV irradiation and at the higher temperatures which appear under light exposition J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-22 Kinga Orlińska, Paweł Ramos, Katarzyna Komosińska-Vassev, Krystyna Olczyk, Jerzy Stojko, Anna Rzepecka-Stojko, Yoana Kiselova-Kaneva, Diana Ivanova, Paweł Olczyk, Barbara Pilawa
Free radical formation in two diuretics: indapamide and torasemide was examined during UV irradiation and storage at higher temperatures using X-band (9.3 GHz) electron paramagnetic resonance spectroscopy (EPR). The aim of this study was to investigate the possibility of storing indapamide and torasemide under UV irradiation and at higher temperatures, which may occur during exposure to light. The
-
Exploration of the intestinal flora to reveal the important contribution of Radix Astragali to Huangqi Jianzhong Tang in treating chronic atrophic gastritis rats J. Pharmaceut. Biomed. Anal. (IF 3.4) Pub Date : 2024-02-22 Ruonan Zhang, Xuemei Qin, Yuetao Liu
Radix Astragali (Huangqi in Chinese, HQ) is a commonly used Chinese herbal medicine for thousands of years. In this study, A classic prescription Huangqi Jianzhong tang (HQJZ) was selected to evaluate the important effect of HQ on rats with chronic atrophic gastritis (CAG) from the perspective of intestinal flora in cecal contents samples. Traditional pharmacological indicators, including weight change