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The characteristics of the body mass frequency index in dysmobility syndrome: A pilot study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-17 Wen Sun, Peige Wang, Yongfang Zhao
With the advancement of global aging, there has been an increase in patients with dysmobility syndrome (DS), often accompanied by osteoporosis, sarcopenia, and sarcopenic obesity. The objective of this study was to evaluate the application value of the body mass frequency index (BMFI) in older patients with DS by comprehensively analyzing the differences in BMFI between community-dwelling older subjects
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Cardiorespiratory fitness mediates the relationship between depressive symptomatology and cognition in older but not younger adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-15 Catarina Barros, Adriana Sampaio, Diego Pinal
Aging is commonly associated with emotional, physical, and cognitive changes, with the latter, particularly affecting executive functioning. Further, such changes may interact. For instance, depressive symptomatology is a known risk factor for developing cognitive deficits, especially at older ages. In contrast, an active lifestyle, reflected in high cardiorespiratory fitness (CRF) levels, has proven
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Age-related changes in muscle coordination patterns of stepping responses to recover from loss of balance Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-15 Wouter H.A. Staring, Sarah Zandvliet, Digna de Kam, Teodoro Solis-Escalante, Alexander C.H. Geurts, Vivian Weerdesteyn
Reactive stepping capacity to recover from a loss of balance declines with aging, which increases the risk of falling. To gain insight into the underlying mechanisms, we investigated whether muscle coordination patterns of reactive stepping differed between healthy young and older individuals. We performed a cross-sectional study between 15 healthy young and 14 healthy older adults. They recovered
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Home-based resistance training performed at either fast or slow speeds improves power output in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Kosuke Hirata, Mari Ito, Yuta Nomura, Chiho Kawashima, Tsukasa Yoshida, Yosuke Yamada, Neale A. Tillin, Geoffrey A. Power, Ryota Akagi
We investigated the effect of an unsupervised, body mass- home-based resistance training program in older adults performed at either a fast or slow contractile speed on changes to muscle-power, -volume, -architecture, and fatigue resistance of the knee extensors. Thirty-two male older adults (age 65–88 years) were separated into 1) fast-speed exercise (Fast-group), 2) slow-speed exercise (Slow-group)
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The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 M.J. Price, P.M. Smith, L.M. Bottoms, M.W. Hill
Large scale population norms for peak oxygen uptake (VO) during cycle ergometry (CE) have been published for men and women across a wide range of ages. Although upper body functional capacity has an important role in activities of daily living far less is known regarding the effect of age and sex on upper body functional capacity (i.e. arm crank ergometry; ACE). The aim of this review was to determine
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Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Makenna A. Patterson, Avery Hinks, Binta S. Njai, Benjamin E. Dalton, Emma F. Hubbard, Geoffrey A. Power
Aging is associated with impaired strength and power during isometric and shortening contractions, however, during lengthening (i.e., eccentric) contractions, strength is maintained. During daily movements, muscles undergo stretch-shortening cycles (SSCs). It is unclear whether the age-related maintenance of eccentric strength offsets age-related impairments in power generation during SSCs owing to
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Higher blood biochemistry-based biological age developed by advanced deep learning techniques is associated with frailty in geriatric rehabilitation inpatients: RESORT Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Lihuan Guan, Camilla S.L. Tuttle, Fedor Galkin, Alex Zhavoronkov, Andrea B. Maier
Accelerated biological ageing is a major underlying mechanism of frailty development. This study aimed to investigate if the biological age measured by a blood biochemistry-based ageing clock is associated with frailty in geriatric rehabilitation inpatients. Within the REStORing health of acutely unwell adulTs (RESORT) cohort, patients' biological age was measured by an ageing clock based on completed
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The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Su-ting Jiang, Shu-ying Lian, Yao-huan Sun, Mei-bo Pan, Bin Wang, Hui Wang, Jun Hua, Yi-chen Wang, Qiu-ling Wang, Yin-feng Dong
The beneficial effect of social interaction in mitigating the incidence of post-stroke depression (PSD) and ameliorating depressive symptoms has been consistently demonstrated through preclinical and clinical studies. However, the underlying relationship with oxytocin requires further investigation. In light of this, the present study aimed to explore the protective effect of pair housing on the development
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QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Jinfang Dou, Xin'ai Zhang, Chaoqun Hu, Yuqian Gao, Yue Zhao, Murong Hei, Zhimiao Wang, Nan Guo, Haiyan Zhu
The onset of Alzheimer's disease is related to neuron damage caused by massive deposition of Aβ in the brain. Recent studies suggest that excessive Aβ in the brain mainly comes from peripheral blood, and BBB is the key to regulate Aβ in and out of the brain. In this study, we explored the pathogenesis of AD from the perspective of Aβ transport through the BBB and the effect of QKL injection in AD mice
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Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Haoran Peng, Longyu Wu, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue Li
Lymphocyte antigen 96 () plays an important role in innate immunity and has been reported to be associated with various neurological diseases. However, its role in Parkinson's disease (PD) remains unclear. Transcriptome data from a total of 49 patients with PD and 34 healthy controls were downloaded from the Gene Expression Omnibus (GEO) database to analyse the expression pattern of and its relationship
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PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-11 Yimin Fu, Lei Tao, Xiaojun Wang, Binyou Wang, Weilin Qin, Lei Song
Mitochondrial dysregulation in skeletal myocytes is considered a major factor in aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) on Sestrin2-mediated mechanistic target of rapamycin complex 1 (mTORC1) in aged skeletal muscles. C2C12 myoblasts were stimulated by 50 μM 7β-hydroxycholesterol (7β-OHC) to observe
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Age and sex mediated effects of estrogen and Β3-adrenergic receptor on cardiovascular pathophysiology Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-08 Graziamaria Corbi, Marika Comegna, Caterina Vinciguerra, Alessio Capasso, Luigi Onorato, Alfonso Maria Salucci, Antonio Rapacciuolo, Alessandro Cannavo
Sex differences are consistently identified in determining the prevalence, manifestation, and response to therapies in several systemic disorders, including those affecting the cardiovascular (CV), skeletal muscle, and nervous system. Interestingly, such differences are often more noticeable as we age. For example, premenopausal women experience a lower risk of CV disease than men of the same age.
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Association between Triglyceride-glucose index and sarcopenia in China: A nationally representative cohort study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-08 Yong Chen, Chongwu Liu, Mingdong Hu
The relationship between sarcopenia and insulin resistance (IR) has seldom been reported. Triglyceride-glucose (TyG) index, a new IR indicator, has gained traction as a prognostic tool for many diseases. We aimed to investigate whether the level of TyG index was related to the incidence of sarcopenia. A total of 1819 participants above 60 without sarcopenia at baseline were included from the China
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Relationship between quadriceps femoris echotexture biomarkers and muscle strength and physical function in older adults with heart failure with preserved ejection fraction Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-06 Iván José Fuentes-Abolafio, Michele Ricci, María Rosa Bernal-López, Ricardo Gómez-Huelgas, Antonio Ignacio Cuesta-Vargas, Luis Miguel Pérez-Belmonte
Muscle wasting is pronounced in patients with heart failure with preserved ejection fraction (HFpEF). The quadriceps femoris echotexture biomarkers assessed by ultrasound (US) have not been studied in these patients. To describe echotexture biomarkers assessed by the US and to assess their relationship with sex, age, body mass index (BMI), self-reported outcomes, muscle strength and physical function
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Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-05 Yibao Wei, Junfeng Kang, Zhenyuan Ma, Taiyang Liao, Peng Wu, Peimin Wang, Zhengquan Huang
Osteoporotic osteoarthritis (OP-OA) is a severe pathological form of OA, urgently requiring precise management strategies and more efficient interventions. Emodin (Emo), an effective ingredient found in the traditional Chinese medicine rhubarb, has been dEmonstrated to promote osteogenesis and inhibit extracellular matrix degradation. In this study, we aimed to investigate the interventional effects
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Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-02 Svetlana Ukraintseva, Arseniy P. Yashkin, Igor Akushevich, Konstantin Arbeev, Hongzhe Duan, Galina Gorbunova, Eric Stallard, Anatoliy Yashin
Diverse pathogens (viral, bacterial, fungal) have been associated with Alzheimer's disease (AD) and related traits in various studies. This suggests that compromised immunity, rather than specific microbes, may play a role in AD by increasing an individual's vulnerability to various infections, which could contribute to neurodegeneration. If true, then vaccines that have heterologous effects on immunity
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The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-01 Robert G. Memelink, Rose Njemini, Minse J.J. de Bos Kuil, Suzan Wopereis, Johan de Vogel-van den Bosch, Josje D. Schoufour, Michael Tieland, Peter J.M. Weijs, Ivan Bautmans
Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption
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Microbiome interactions with different risk factors in development of myocardial infarction Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-27 Manisha Bijla, Sunil Kumar Saini, Ajai Kumar Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
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Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-23 Yong-Fang Fu, Yi-Xun Guo, Shi-Hui Xia, Ting-Ting Zhou, Yun-Chao Zhao, Zhen-Hua Jia, Yan Zhang
Active vitamin D analog eldecalcitol is clinically applied in treatment of postmenopausal osteoporosis. This study aims to determine the role of eldecalcitol in the protection of osteocytes from senescence and the associated ferroptosis. The MLO-Y4 osteocytes were exposed to D-gal inducing senescence. The ovariectomized (OVX) mice treated with D-gal using as an aging inducer were intraperitoneally
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Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-23 Zhiyuan Wang, Bin Han, Jianjiao Qi, Xuelei Cao, Huali Gu, Jinping Sun
Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer's Disease (AD). Chuanzhitongluo capsule (CZTL) is a Traditional Chinese Medicine (TCM) preparation known for its effective protection against cerebral ischemia. However, its potential to ameliorate VCI remains unclear. This study aimed to investigate the cognitive improvement
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Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-22 Yuge Xia, Zhirui Xu, Yicong Zhang, Dongli Jiang, Yunyi Zhu, Xiaolun Liang, Rui Sun
Inflammatory responses are associated with the development of vascular dementia (VaD). Circulating cytokines modulate the inflammatory response and are important for the immune system. To further elucidate the role of the immune system in VaD, we used Mendelian randomization (MR) to comprehensively and bi-directionally assess the role of circulating cytokines in VaD.
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Corrigendum to “Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults” [Exp. Gerontol. 181 (2023) 112278] Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Yujiro Asano, Taishi Tsuji, Tomohiro Okura
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Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43 Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Jing Xia, Yang Tan, Congli Mao, Wenting Shen, Ying Zhao
To explore the mechanism by which Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury (TBI). The oxygen -glucose deprivation/recovery (OGD/R) cell model was constructed to simulate the pathological state of astrocytes in a TBI environment. The viability of astrocytes was measured by CCK-8, and the cytoskeleton changes were observed by Phalloidin- TRITC staining
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Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Steven P. Winesett, Sudeshna A. Chatterjee, Brianne Borgia, Brigette A. Cox, Kelly A. Hawkins, Jon W. Miles, Clayton W. Swanson, Julia T. Choi, Rachael D. Seidler, Emily J. Fox, David J. Clark
Walking performance and cognitive function demonstrate strong associations in older adults, with both declining with advancing age. Walking requires the use of cognitive resources, particularly in complex environments like stepping over obstacles. A commonly implemented approach for measuring the cognitive control of walking is a dual-task walking assessment, in which walking is combined with a second
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Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Samira Nemati, Zohreh Zavvari-Oskuye, Soleyman Bafadam, Behnaz Mokhtari, Reza Badalzadeh, Abedin Vakili
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Pulmonary function and trajectories of cognitive decline in aging population Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-18 Albert J. Ksinan, Andrea Dalecká, Tatyana Court, Hynek Pikhart, Martin Bobák
The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pulmonary function and the trajectories of cognitive decline using prospective population-based SHARE data from 14 countries
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Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-16 Zhongwu Su, Yi Liu, Weijian Zhang, Wenhui Liang, Yuyan Chen, Jinyuan Cao, Yu Liu, Yiqing Zheng, Qi Li
Age-related hearing loss (ARHL) is the most common sensory disorder associated with human aging. Chronic inflammation is supposed to be an important contributor to ARHL. Yet, the underlying mechanisms of developing cochlear inflammation are still not well understood. In this study, we found that the inflammation, endoplasmic reticulum (ER) stress and necroptosis signalings are activated in the cochlea
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Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-15 Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming Hu
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The mediating role of lower body muscle strength and IGF-1 level in the relationship between age and cognition. A MIDUS substudy Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-14 Evrim Gökçe, Navin Kaushal, Theo Fontanille, Tudor Vrinceanu, Kathia Saillant, Wouter A J Vints, Thomas Freret, Antoine Gauthier, Louis Bherer, Antoine Langeard
Aging is a natural process associated with a decline in cognition. However, the mediating effect of physical function and circulating myokines on this relationship has yet to be fully clarified. This study investigated how muscle strength and circulating insulin-like growth factor-1 (IGF-1) levels mediate the relationship between age and cognitive functions. A total of 1255 participants aged 25–74 years
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Parental age at death is associated with age at first birth in offspring Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-14 Anna Thalén, Anders Ledberg
People age at different rates and the available evidence suggests that the rate of aging is partly inherited from previous generations. This heterogeneity in aging is evident already in midlife, but to what extent aging is associated with the timing of events earlier in life is not fully known. Here we aim to shed light on this topic by investigating the trade-off between reproduction and aging postulated
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Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-12 Youngju Choi, Keisei Kosaki, Nobuhiko Akazawa, Koichiro Tanahashi, Seiji Maeda
Although sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50–83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity
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CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-11 Xia Lin, Lingqun Mao, Qiuyue Chen, Tianyu Wang, Taotao Tao, Luping Pan
Dysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the role of circHIVP2 in Parkinson's disease (PD) and its molecular mechanism is not well understood. 127 patients with PD and 85 healthy people were enrolled. RT-qPCR was employed to examine the levels of circHIVEP2. ROC curve to explore the diagnostic. Mpp induced the SH-SY5Y to construct
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Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-10 Dan-Qian Chen, Hao-Jun Zhang, Wen Zhang, Kai Feng, Hui Liu, Hai-Ling Zhao, Ping Li
Diabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF)
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p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6 Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Ying Cheng, Man Zhang, Rong Xu, Lingli Fu, Mei Xue, Chaofei Xu, Chao Tang, Ting Fang, Xiaohuan Liu, Bei Sun, Liming Chen
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed
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Kaempferol: Paving the path for advanced treatments in aging-related diseases Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Gaurav Gupta, Moyad Shahwan, Neelima Kukreti, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against
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Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Qingrong Ouyang, Lei Xu, Yunwei Zhang, Luwen Huang, Yang Du, Ming Yu
Chronic Post-Stroke Fatigue (PSF) is a common and persistent complications among ischemic stroke survivors. The serum glycated hemoglobin (HbA1c) level, as it is known has emerged as a critical risk factor for Acute Ischemic Stroke (AIS) and post-stroke cognitive and emotional impairment. However, no studies have been conducted on the link between HbA1c and PSF. Therefore, this study aims to estimate
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Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Xue Bai, Hong Xiang, Yangjing Li, Hongmei Wang
Sarcopenia is a harmful condition common among older adults for which no treatment is available. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor inducible 14 (FN14) are known to play important roles in the pathogenesis of sarcopenia. This study investigated alterations in methylation in and to identify potential targets for the managing sarcopenia
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Path analysis to identify factors influencing osteoporosis: A cross-sectional study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-05 Qiaofeng Chen, Jie Chen, Rongdong Zeng, Jianhui Shi
Osteoporosis is characterized by low bone mass and deterioration of bone tissue, which is influenced by both environmental factors and nutritional metabolism. The relationship between biochemical indicators and bone mineral density (BMD) is intricate and involves complex mechanisms. Path analysis, a statistical method that investigates causal relationships and the strength of associations among multiple
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Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-02 James B. Hengenius, Rebecca Ehrenkranz, Xiaonan Zhu, Nancy W. Glynn, Theodore J. Huppert, Caterina Rosano
Declining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neural substrates are not known. We examined brain resting state connectivity in relation to declining self-reported energy levels (SEL) and occurrence of fatigue over time. We examined resting-state functional MRI in 272 community dwelling older adults participating in the Health Aging and
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The role of mitochondrial quality control mechanisms in chondrocyte senescence Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-27 Tianlei Zhao, Dawei Niu, Yancheng Chen, Peiliang Fu
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte senescence. In hypoxia and hypodextrose environment, chondrocytes heavily rely on glycolysis for energy metabolism. Mitochondria, acting as the regulatory
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Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Nan Wang, Weihao Rong, Yimin Xie, Shuang Chen, Zhipeng Xi, Rongrong Deng
Intervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative diseases (SDD) and stands as a primary contributor to both low back pain (LBP) and disability. The progression of IVDD is linked to structural and functional alterations in tissues, where an imbalance in the inflammatory microenvironment can induce extracellular matrix (ECM) degradation, senescence
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Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Olli-Pekka Mattila, Taina Rantanen, Merja Rantakokko, Laura Karavirta, Neil Cronin, Timo Rantalainen
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Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Fatma Ben Waer, Dan Iulian Alexe, Mariam Lahiani, Rubén Sanchez-Gomez, Fatma Chaari, Cristina Ioana Alexe, Dragos Ioan Tohanean, Haithem Rebai, Teodora Mihaela Iconomescu, Laurențiu Gabriel Talaghir, Sonia Sahli
The current study aimed to compare the effects of Pilates versus Zumba training on postural performance in middle-aged postmenopausal women. Fifty-seven eligible women, aged between 50 and 60 years, were randomized into three groups: Zumba (ZG) group, Pilates (PG) group or control (CG) group. Postural control was assessed using a force platform under 4 sensory manipulation conditions: on firm and foam
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Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Gustavo Z. Schaun, Matthias Gumpenberger, Leonie Konermann, Alexandra Graf, Peter Raidl, Barbara Wessner, Robert Csapo
Age-associated remodeling processes affect the intramuscular connective tissue (IMCT) network, which may significantly impair muscle function. Thus, we aimed to test whether including exercises shown to efficiently target the IMCT to a conventional resistance exercise intervention (CONV) would result in greater functional gains as compared to CONV alone. Fifty-three men and women (66.2 ± 3.3 years)
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Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-17 Chiara Ceolin, Marina De Rui, Cristina Simonato, Margherita Vergadoro, Sara Cazzavillan, Vittorio Acunto, Mario Virgilio Papa, Giulia Salerno Trapella, Bruno Micael Zanforlini, Chiara Curreri, Anna Bertocco, Maria Devita, Alessandra Coin, Giuseppe Sergi
Coronavirus Disease-2019 (COVID-19), driven by the SARS-CoV-2 virus, has disproportionately affected the elderly, with comorbidities like sarcopenia worsening prognosis. Considering the significant impact of RNA vaccines on survival rates in this population, our objective is to investigate the impact of vaccination on the survival of hospitalized elderly patients with COVID-19, considering the presence
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Does excess body weight accelerate immune aging? Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-15 Anna Tylutka, Barbara Morawin, Łukasz Walas, Agnieszka Zembron-Lacny
Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion in T lymphocytes. Therefore, the study was designed to explain whether excess body mass in older individuals affected the disproportion in numbers of T lymphocytes and whether
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Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-09 Kaiwu He, Lulin Nie, Chen Yang, Zizhen Liu, Xinfeng Huang, Shupeng Li, Xifei Yang
Stress response is a fundamental mechanism for cell survival, providing protection under unfavorable conditions. Mitochondrial stress, in particular, can trigger mitophagy, a process that restores cellular health. Exhaustive exercise (EE) is a form of acute mitochondrial stress. The objective of this current study is to investigate the impact of EE on tau pathology in pR5 mice, as well as the potential
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Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Hui Wang, Ye Wang, Wei Huang
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner. To detect the presence of these α-syn aggregates in clinical samples, seed amplification assays (SAAs) have been developed. These SAAs are capable of amplifying the α-syn seeds, allowing for their detection. αSyn-SAAs have been reported
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Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Ding Zhang, Ni Jia, Zhihan Hu, Zhou Keqing, Song Chenxi, Sun Chunying, Canrong Chen, Wei Chen, Yueqiang Hu, Ziyun Ruan
Ischemic stroke and vascular dementia, as common cerebrovascular diseases, with the former causing irreversible neurological damage and the latter causing cognitive and memory impairment, are closely related and have long received widespread attention. Currently, the potential causative genes of these two diseases have yet to be investigated, and effective early diagnostic tools for the diseases have
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Identification of genes and key pathways underlying the pathophysiological association between sarcopenia and chronic obstructive pulmonary disease Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Weixi Wang, Weiying Ren, Lin Zhu, Yu Hu, Cong Ye
Chronic obstructive pulmonary disease (COPD) patients are likely to develop sarcopenia, while the exact mechanism underlying the association between sarcopenia and COPD is still not clear. This cohort study aims to explore the genes, signaling pathways, and transcription factors (TFs) that are related to the molecular pathogenesis of sarcopenia and COPD. According to the strict inclusion criteria,
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Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Breno Caldas Ribeiro, Anselmo de Athayde Costa e Silva, Leonardo Brynne Ramos de Souza, Janine Brasil de Araújo Moraes, Saul Rassy Carneiro, Laura Maria Tomazi Neves
Frailty is associated with an increased susceptibility to functional decline, impairment, hospitalization, and mortality among the older adults. However, the potential reversibility of frailty lies in identifying modifiable factors that could prevent, mitigate, or interrupt its progression. While there is a suggestion that sleep disorders may increase the risk of frailty and impairment, the risk stratification
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Causal relationship between circulating immune cells and the risk of Alzheimer's disease: A Mendelian randomization study Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-01 Hua Xue, Jiajia Chen, Li Zeng, Wenhui Fan
Increasing evidence has shown a link between immune cells and Alzheimer's disease (AD). Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the causal association between 731 immune cell signatures and AD in this study. We extracted genetic variants of 731 immune cell traits and AD from the publicly available GWAS dataset. The immune features included median fluorescence
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P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-01 Xiaodong Zhang, Guangyi Huang, Zhixuan Zhang, Fen Wang, Qian Liu, Yingqiang Du, Xiaoyan Wang, Xin Gu
Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired acute kidney injury. Cellular senescence is associated with CI-AKI. P16 (p16) is a cell cycle regulator and link to aging and senescence. We found that the expression of p16 was elevated in CI-AKI renal tissues, however its role in CI-AKI remains insufficiently understood. In this study, we used p16 knockout
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Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-25 Kah Poh Loh, Ying Wang, Chandrika Sanapala, Nikesha Gilmore, Colleen Netherby-Winslow, Jason H. Mendler, Jane Liesveld, Eric Huselton, AnnaLynn M. Williams, Heidi D. Klepin, Marielle Jensen-Battaglia, Karen Mustian, Paula Vertino, Martha Susiarjo, Michelle C. Janelsins
Tumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation of TNFα in the context of an exercise intervention among older adults with cancer is understudied. In this exploratory analysis, we used data from a single-arm mobile health (mHealth) exercise intervention among older adults with myeloid malignancies to 1) assess changes in TNFα promoter methylation
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Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-24 Shaun Hanley, Yung-Yi Chen, Jon Hazeldine, Janet M. Lord
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-line defence against infection and cancer and is also involved in the removal of senescent cells, so preventing innate immunosenescence and inflammaging
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14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-18 Guilherme da Silva Rodrigues, Natália Yumi Noronha, Isabella Harumi Yonehara Noma, João Gabriel Ribeiro de Lima, Andressa Crystine da Silva Sobrinho, Marcela Augusta de Souza Pinhel, Mariana Luciano de Almeida, Lígia Moriguchi Watanabe, Carla Barbosa Nonino, Carlos Roberto Bueno Júnior
Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk of developing Alzheimer's disease (AD) due to risk factors such as age, family history, genetics and low level of education associated with AD. We aim to analyze the effect of a 14-week combined exercise training (CT) on the methylation of genes associated with AD in non-alzheimer's disease women. CT
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Effects of a multicomponent training followed by a detraining period on metabolic syndrome profile of older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-19 Jorge Subías-Perié, David Navarrete-Villanueva, Ángel Iván Fernández-García, Ana Moradell, Gabriel Lozano-Berges, Eva Gesteiro, Jorge Pérez-Gómez, Ignacio Ara, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José Antonio Casajús
Aims The present study sought to analyze the effects of 6-month multicomponent training (MCT) combined with a 4-month detraining on metabolic syndrome (MetS) profile among older adults with decreased functional capacity. Methods This quasi-experimental study included a total of 104 older adults (80.5 ± 6.0 years) and the sample was divided into a training (TRAIN, n = 55) or control group (CON). Harmonized
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Changes in strength-related outcomes following velocity-monitored resistance training with 10 % and 20 % velocity loss in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-17 Diogo Luís Marques, Henrique Pereira Neiva, Daniel Almeida Marinho, Mário Cardoso Marques
We compared the effects of velocity-monitored resistance training with an intra-set velocity loss (i.e., the decrement in repetition velocity over the set) of 10 % vs. 20 % on strength-related outcomes in older adults. We randomly assigned eighteen older adults to a velocity loss group of 10 % (n = 10; 78 ± 12 years) or 20 % (n = 8; 73 ± 10 years) to perform a 10-week training program. The primary