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Overweight/obesity, gestational weight gain, postpartum weight retention, and maternal/neonatal complications in the military Obesity (IF 6.9) Pub Date : 2024-04-23 Rebecca A. Krukowski, Erin Solomon, Juan Lang, Emily Stone, Wen You, Rosemary Estevez Burns, Carol Copeland, Zoran Bursac, Marion E. Hare, Teresa M. Waters
ObjectiveThe objective of this study was to examine the prevalence of overweight/obesity and excessive gestational weight gain (GWG) among military beneficiaries and to assess associations of these risk factors with maternal/neonatal complications and substantial postpartum weight retention (PPWR).MethodsWe obtained data for 48,391 TRICARE beneficiaries who gave birth in 2018 or 2019 in the United
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Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults Obesity (IF 6.9) Pub Date : 2024-04-23 Yigit Unlu, Paolo Piaggi, Emma J. Stinson, Tomás Cabeza De Baca, Theresa L. Rodzevik, Mary Walter, Jonathan Krakoff, Douglas C. Chang
ObjectiveWe investigated how changes in 24‐h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.MethodsForty‐four healthy, weight‐stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m2) underwent 24‐h energy expenditure measurements in a respiratory chamber during
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Maternal obesity: sex‐specific in utero changes in fetal brain autophagy and mTOR Obesity (IF 6.9) Pub Date : 2024-04-22 Nana Merabova, Lierni Ugartemendia, Andrea G. Edlow, Claudia Ibarra, Nune Darbinian, Gabriel Tatevosian, Laura Goetzl
ObjectiveMaternal obesity affects 39.7% of reproductive‐age women in the United States. Emerging research has suggested that in utero exposure to maternal obesity is associated with adverse neurodevelopmental outcomes, but knowledge of underlying mechanisms in human samples is lacking.MethodsA matched case–control study was performed in women with singleton fetuses who were undergoing elective pregnancy
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Early outcomes of referrals to the English National Health Service Digital Weight Management Programme Obesity (IF 6.9) Pub Date : 2024-04-22 Katharine Taylor, Tejal Indulkar, Bethany Thompson, Christine Pinkard, Emma Barron, Tom Frost, Priyantha Jayawardane, Neil Davies, Chirag Bakhai, Nita Gandhi Forouhi, Paul Aveyard, Susan Jebb, Jonathan Valabhji
ObjectiveThe study objective was to assess participant weight change for the English National Health Service (NHS) Digital Weight Management Programme, the first such digital intervention to achieve population coverage.MethodsA service evaluation was used to assess intervention effectiveness for adults with obesity and a diagnosis of hypertension and/or diabetes, between April 2021 and March 2022,
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Physiology of the weight‐loss plateau in response to diet restriction, GLP‐1 receptor agonism, and bariatric surgery Obesity (IF 6.9) Pub Date : 2024-04-22 Kevin D. Hall
ObjectiveThe objective of this study was to investigate why different weight‐loss interventions result in varying durations of weight loss prior to approaching plateaus.MethodsA validated mathematical model of energy metabolism and body composition dynamics was used to simulate mean weight‐ and fat‐loss trajectories in response to diet restriction, semaglutide 2.4 mg, tirzepatide 10 mg, and Roux‐en‐Y
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Effect of a low‐carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial Obesity (IF 6.9) Pub Date : 2024-04-17 Julianne Lundanes, Frida Sandnes, Kari Hanne Gjeilo, Patrik Hansson, Sissel Salater, Catia Martins, Siren Nymo
ObjectiveThe primary objective of this study was to evaluate the effect of a low‐carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.MethodsAdult female
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Interindividual differences of dietary fat‐inducible Mest in white adipose tissue of C57BL/6J mice are not heritable Obesity (IF 6.9) Pub Date : 2024-04-15 Rea Victoria P. Anunciado‐Koza, Haifeng Yin, Crystal L. Bilodeau, Diana Cooke, Gene P. Ables, Sergey Ryzhov, Robert A. Koza
ObjectiveDifferences in white adipose tissue (WAT) expression of mesoderm‐specific transcript (Mest) in C57BL6/J mice fed a high‐fat diet (HFD) are concomitant with and predictive for the development of obesity. However, the basis for differences in WAT Mest among mice is unknown. This study investigated whether HFD‐inducible WAT Mest, as well as susceptibility to obesity, is transmissible from parents
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Impact of sustained calorie restriction and weight cycling on body composition in high‐fat diet‐fed male and female C57BL/6J mice Obesity (IF 6.9) Pub Date : 2024-04-11 Daniel L. Smith, Yongbin Yang, Luis M. Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B. Allison, Tim R. Nagy
ObjectiveThe objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet‐induced obesity.MethodsA total of 555 single‐housed mice were fed a high‐fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight loser
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Pre‐pregnancy maternal obesity and infant neurodevelopmental outcomes in Latino infants Obesity (IF 6.9) Pub Date : 2024-04-11 Mahsa Babaei, Christopher J. Machle, Pari Mokhtari, Jonatan Ottino González, Kelsey A. Schmidt, Tanya L. Alderete, Shana Adise, Bradley S. Peterson, Michael I. Goran
ObjectiveThis study explores the impact of maternal pre‐pregnancy BMI on infant neurodevelopment at 24 months in low‐income Latino families. It also investigates whether infant diet mediates this relationship.MethodsLatino mother‐infant pairs (n = 163) were enrolled at 1 month post partum and were followed for 2 years, with assessments at 6‐month intervals. Maternal pre‐pregnancy anthropometrics were
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Correction to “Predictors of racial differences in weight loss: The PROPEL trial” Obesity (IF 6.9) Pub Date : 2024-04-04
Newton, RL, Zhang, D, Johnson, WD, et al. Predictors of racial differences in weight loss: the PROPEL trial. Obesity (Silver Spring). 2024; 32(3): 476–485. doi: 10.1002/oby.23936. In this published article, the spelling of Dachuan Zhang's name was incorrect, and it has now been corrected. We apologize for this error.
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Adipocyte-derived inflammatory molecules induce senescent B cells through metabolic pathways Obesity (IF 6.9) Pub Date : 2024-04-04 Daniela Frasca, Maria Romero, Denisse Garcia, Seth Thaller, Valquiria Bueno
The aim of this study was to demonstrate that an adipocyte tissue-derived conditioned medium (ACM) contains inflammatory molecules that induce senescence in B cells.
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Mutations in the leptin‐melanocortin pathway and weight loss after bariatric surgery: a systematic review and meta‐analysis Obesity (IF 6.9) Pub Date : 2024-04-05 Nianrong Zhang, Hao Wang, Shuman Ran, Zhe Wang, Biao Zhou, Siqi Wang, Zhengqi Li, Baoyin Liu, Yuntao Nie, Yishan Huang, Hua Meng
ObjectiveThe objective of this meta‐analysis was to quantify the overall effects of gene mutations in the leptin‐melanocortin pathway on short‐ and long‐term weight loss after bariatric surgery.MethodsMEDLINE, PubMed, and Embase were searched, and data were analyzed using ReviewManager (RevMan) version 5.4. The datasets were divided into two subgroups based on postoperative time, and the outcome measure
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Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity Obesity (IF 6.9) Pub Date : 2024-04-04 Chi‐Yen Hung, Hsin‐Ju Lee, Zhao‐Ting Tsai, Shu‐Jung Huang, Hsin‐Yi Huang, Hui‐Ju Tsai, Tsung‐Chieh Yao
ObjectiveThis study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.MethodsIn a population‐based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted
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Repeated photodynamic therapy using a chlorin e6‐embedded device to prolong the therapeutic effects on obesity Obesity (IF 6.9) Pub Date : 2024-04-01 Jung‐Hoon Park, Ji Won Kim, Dae Sung Ryu, Hyeonseung Lee, Hee Kyong Na, Jin Hee Noh, Do Hoon Kim, Sanghee Lee, Kun Na, Hwoon‐Yong Jung
ObjectiveThis study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)‐embedded intragastric satiety‐inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig.MethodsThe Ce6‐embedded ISD was fabricated with a dipping method. Twelve pigs were divided into four groups of three and were administered control, single, biweekly
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Identification of minimum thresholds for dietary self‐monitoring to promote weight‐loss maintenance Obesity (IF 6.9) Pub Date : 2024-03-26 Kelsey M. Arroyo, Chelsea A. Carpenter, Rebecca A. Krukowski, Kathryn M. Ross
ObjectiveReduced schedules of dietary self‐monitoring are typically recommended after the end of behavioral weight‐loss programs; however, there exists little empirical evidence to guide these recommendations.MethodsWe explored potential thresholds for dietary self‐monitoring during a 9‐month maintenance period following a 3‐month weight‐loss program in 74 adults with overweight or obesity (mean [SD]
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Neurocognitive factors predicting BMI changes from adolescence to young adulthood Obesity (IF 6.9) Pub Date : 2024-03-26 Sussanne Reyes, Patricio Peirano, Sheila Gahagan, Estela Blanco, Cecilia Algarín
ObjectiveThe objective of this study was to assess whether inhibitory task performance in adolescence could be prospectively related to weight gain in young adulthood. We proposed that this association would differ according to the BMI group in adolescence.MethodsA total of 318 adolescents performed the anti‐saccade task, and 530 completed the Stroop test. Accuracy and reaction time were assessed for
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Associations of change in body fat percentage with baseline body composition and diabetes remission after bariatric surgery Obesity (IF 6.9) Pub Date : 2024-03-22 Shaobo Li, Pin Zhang, Jianzhong Di, Xiaodong Han, Yinfang Tu, Di Yang, Rongrong Xu, Yunfeng Xiao, Jian Zhou, Yuqian Bao, Jun Yin, Haoyong Yu, Weiping Jia, Junfeng Han
ObjectiveThe objective of this study was to determine the role of body fat percentage (BFP) changes in diabetes remission (DR) and the association between baseline body composition and its changes after bariatric surgery.MethodsWe analyzed 203 patients with type 2 diabetes who underwent Roux‐en‐Y gastric bypass. Body composition was measured using a gold‐standard‐derived predictive equation and magnetic
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Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort Obesity (IF 6.9) Pub Date : 2024-03-22 Bruna Rubbo, Zhenjiang Li, Phum Tachachartvanich, Brittney O. Baumert, Hongxu Wang, Shudi Pan, Sarah Rock, Justin R. Ryder, Todd Jenkins, Stephanie Sisley, Xiangping Lin, Scott Bartell, Thomas H. Inge, Stavra Xanthakos, Brooklynn McNeil, Anna R. Robuck, Michele A. La Merrill, Douglas I. Walker, David V. Conti, Rob McConnell, Sandrah P. Eckel, Lida Chatzi
ObjectiveDichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes
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Myocardial mechano‐energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity Obesity (IF 6.9) Pub Date : 2024-03-11 Chiara Maria Assunta Cefalo, Alessia Riccio, Teresa Vanessa Fiorentino, Elena Succurro, Gaia Chiara Mannino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
ObjectiveReduced myocardial mechano‐energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with “metabolically healthy overweight” (MHOW) and “metabolically healthy obesity” (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components
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Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity Obesity (IF 6.9) Pub Date : 2024-03-08 Aalekhya Reddam, Tessa R. Bloomquist, Lindsey T. Covell, Heng Hu, Sharon E. Oberfield, Dympna Gallagher, Rachel L. Miller, Jeff Goldsmith, Andrew G. Rundle, Andrea A. Baccarelli, Julie B. Herbstman, Allison Kupsco
ObjectiveThe objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.MethodsIn a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age
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The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16 Obesity (IF 6.9) Pub Date : 2024-03-06 Takahiro Ichikawa, Hiroshi Okada, Masahide Hamaguchi, Norihiro Nishioka, Yukiko Tateyama, Tomonari Shimamoto, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Taku Iwami, Michiaki Fukui
ObjectiveThe study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.MethodsAll 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events was
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Hepatic and adipose tissue transcriptome analysis highlights a commonly deregulated autophagic pathway in severe MASLD Obesity (IF 6.9) Pub Date : 2024-03-05 Marica Meroni, Emilia De Caro, Federica Chiappori, Miriam Longo, Erika Paolini, Ettore Mosca, Ivan Merelli, Rosa Lombardi, Sara Badiali, Marco Maggioni, Alessandro Orro, Alessandra Mezzelani, Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni
ObjectiveThe incidence of metabolic dysfunction‐associated steatotic liver disease (MASLD) is rapidly ramping up due to the spread of obesity, which is characterized by expanded and dysfunctional visceral adipose tissue (VAT). Previous studies have investigated the hepatic transcriptome across MASLD, whereas few studies have focused on VAT.MethodsWe performed RNA sequencing in 167 hepatic samples from
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Plasma proteomic profile of abdominal obesity in older adults Obesity (IF 6.9) Pub Date : 2024-03-05 Sanish Sathyan, Sofiya Milman, Emmeline Ayers, Tina Gao, Joe Verghese, Nir Barzilai
ObjectiveThis study examines the plasma proteomic profile of abdominal obesity in older adults.MethodsThe association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models. Pathway
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Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity Obesity (IF 6.9) Pub Date : 2024-03-04 Talyia M. Fordham, Nazeen S. Morelli, Yesenia Garcia-Reyes, Meredith A. Ware, Haseeb Rahat, Divya Sundararajan, Kelly N. Z. Fuller, Cameron Severn, Laura Pyle, Craig R. Malloy, Eunsook S. Jin, Elizabeth J. Parks, Robert R. Wolfe, Melanie G. Cree
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study's objective was to determine whether supplementation would decrease HS in PCOS.
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Transforming Big Data into AI‐ready data for nutrition and obesity research Obesity (IF 6.9) Pub Date : 2024-03-01 Diana M. Thomas, Rob Knight, Jack A. Gilbert, Marilyn C. Cornelis, Marie G. Gantz, Kate Burdekin, Kevin Cummiskey, Susan C. J. Sumner, Wimal Pathmasiri, Edward Sazonov, Kelley Pettee Gabriel, Erin E. Dooley, Mark A. Green, Andrew Pfluger, Samantha Kleinberg
ObjectiveBig Data are increasingly used in obesity and nutrition research to gain new insights and derive personalized guidance; however, this data in raw form are often not usable. Substantial preprocessing, which requires machine learning (ML), human judgment, and specialized software, is required to transform Big Data into artificial intelligence (AI)‐ and ML‐ready data. These preprocessing steps
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Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis Obesity (IF 6.9) Pub Date : 2024-02-27 Xin-Hui Pan, Bryan Tan, Yip Han Chin, Ethan Cheng Zhe Lee, Gwyneth Kong, Bryan Chong, Martin Kueh, Chin Meng Khoo, Anurag Mehta, Priyanka Majety, Gowtham R. Grandhi, Georgios K. Dimitriadis, Roger Foo, Nicholas W. S. Chew, Carel W. Le Roux, Mamas A. Mamas, Mark Y. Chan
This network meta-analysis evaluates the efficacy and safety of tirzepatide compared to glucagon-like peptide-1 receptor agonists (GLP-1 RA) and other weight loss drugs in the treatment of overweight and obesity.
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Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults Obesity (IF 6.9) Pub Date : 2024-02-27 Alice S. Ryan, Guoyan Li, Shawna McMillin, Heidi K. Ortmeyer
The authors sought to understand sex differences in muscle metabolism in 73 older men and women.
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Abdominal fat depots are related to lower cognitive functioning and brain volumes in middle‐aged males at high Alzheimer's risk Obesity (IF 6.9) Pub Date : 2024-02-27 Sapir Golan Shekhtman, Ethel Boccara, Ramit Ravona‐Springer, Yael Inbar, Hila Zelicha, Abigail Livny, Barbara B. Bendlin, Orit Lesman‐Segev, Iscka Yore, Anthony Heymann, Mary Sano, Yael Mardor, Joseph Azuri, Michal Schnaider Beeri
ObjectiveHigh BMI, which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. This study examined associations of abdominal fat depots with cognition and brain volumes and whether sex modifies this association.MethodsA total of 204 healthy middle‐aged offspring of Alzheimer's dementia patients (mean age = 59.44, 60%
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Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity Obesity (IF 6.9) Pub Date : 2024-02-27 Aaron L. Slusher, Jessica Nouws, Fuyuze Tokoglu, Alla Vash‐Margita, Marcy D. Matthews, Mark Fitch, Mahalakshmi Shankaran, Marc K. Hellerstein, Sonia Caprio
ObjectiveThe objective of this study was to examine the hypothesis that abdominal and gluteal adipocyte turnover, lipid dynamics, and fibrogenesis are dysregulated among insulin‐resistant (IR) compared with insulin‐sensitive (IS) adolescents with obesity.MethodsSeven IS and seven IR adolescents with obesity participated in a 3‐h oral glucose tolerance test and a multi‐section magnetic resonance imaging
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The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice Obesity (IF 6.9) Pub Date : 2024-02-27 Lin Gao, Sumei Hu, Dengbao Yang, Lu Wang, Jacques Togo, Yingga Wu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Li Li, Yanchao Xu, Moshen Mazidi, Elspeth Couper, Andrew Whittington-Davies, Chaoqun Niu, John R. Speakman
High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed: hedonic overdrive, reverse causality, and passive overconsumption models.
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Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics Obesity (IF 6.9) Pub Date : 2024-02-21 Anna Motger-Albertí, Elena de la Calle, Mònica Giménez, Gerard Blasco, Carles Biarnés, María Arnoriaga-Rodríguez, Josep Puig, Clàudia Coll-Martínez, Oren Contreras-Rodríguez, José Manuel Fernández-Real
This research seeks to shed light on the associations between brain perfusion, cognitive function, and mental health in individuals with and without obesity.
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Does time-restricted eating add benefits to calorie restriction? A systematic review Obesity (IF 6.9) Pub Date : 2024-02-21 Armin Ezzati, Christian McLaren, Carly Bohlman, Javier A. Tamargo, Yi Lin, Stephen D. Anton
A growing body of evidence has supported the health benefits of extended daily fasting, known as time-restricted eating (TRE); however, whether the addition of TRE enhances the known benefits of calorie restriction (CR) remains unclear.
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The associations of “weekend warrior” and regularly active physical activity with abdominal and general adiposity in US adults Obesity (IF 6.9) Pub Date : 2024-02-20 Lubi Lei, Jingkuo Li, Wei Wang, Yanwu Yu, Boxuan Pu, Yue Peng, Lihua Zhang, Zhenyan Zhao
This study examined the association between physical activity patterns and abdominal and general adiposity.
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Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection Obesity (IF 6.9) Pub Date : 2024-02-13 Lydia L. Shook, Victor M. Castro, Emily M. Herzberg, Lindsay T. Fourman, Anjali J. Kaimal, Roy H. Perlis, Andrea G. Edlow
The objective of this study is to determine whether in utero exposure to SARS-CoV-2 is associated with increased risk for a cardiometabolic diagnosis by 18 months of age.
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Comparison of health care costs following sleeve gastrectomy versus Roux-en-Y gastric bypass among patients with type 2 diabetes Obesity (IF 6.9) Pub Date : 2024-02-13 Stephanie Argetsinger, Robert F. LeCates, Fang Zhang, Dennis Ross-Degnan, James F. Wharam, David E. Arterburn, Adolfo Fernandez, Kristina H. Lewis
The objective of this study was to compare the impact of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on overall and diabetes-specific health care costs among patients with type 2 diabetes.
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Maternal macronutrient intake effects on offspring macronutrient targets and metabolism Obesity (IF 6.9) Pub Date : 2024-02-08 Therese Freire, Ximonie Clark, Tamara Pulpitel, Kim Bell-Anderson, Rosilene Ribeiro, David Raubenheimer, Angela J. Crean, Stephen J. Simpson, Samantha M. Solon-Biet
Exposure in utero to maternal diet can program offspring health and susceptibility to disease. Using C57BL6/JArc mice, we investigated how maternal dietary protein to carbohydrate balance influences male and female offspring appetite and metabolic health.
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Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue Obesity (IF 6.9) Pub Date : 2024-02-06 Jacob J. Robino, Alexander P. Plekhanov, Qingzhang Zhu, Michael D. Jensen, Philipp E. Scherer, Charles T. Roberts, Oleg Varlamov
The pathological expansion of white adipose tissue (WAT) in obesity involves adipocyte hypertrophy accompanied by expansion of the collagen-rich pericellular extracellular matrix (ECM) and development of crown-like structures (CLS). Traditionally, WAT morphology is assessed through immunohistochemical analysis of WAT sections. However, manual analysis of large histological sections is time-consuming
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Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system Obesity (IF 6.9) Pub Date : 2024-02-04 Justine Vily-Petit, Maud Soty-Roca, Marine Silva, Manon Micoud, Félicie Evrard, Clara Bron, Margaux Raffin, Daniel Beiroa, Rubén Nogueiras, Damien Roussel, Amandine Gautier-Stein, Fabienne Rajas, Daniela Cota, Gilles Mithieux
Intestinal gluconeogenesis (IGN), via the initiation of a gut-brain nervous circuit, accounts for the metabolic benefits linked to dietary proteins or fermentable fiber in rodents and has been positively correlated with the rapid amelioration of body weight after gastric bypass surgery in humans with obesity. In particular, the activation of IGN moderates the development of hepatic steatosis accompanying
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Reliability of the original and brief versions of the Eating Disorder Examination in binge-eating disorder Obesity (IF 6.9) Pub Date : 2024-02-04 Janet A. Lydecker, Valentina Ivezaj, Ashley A. Wiedemann, Stephanie Kerrigan, Carlos M. Grilo
Psychometric studies evaluating the reliability of eating-disorder assessment among individuals with binge-eating disorder (BED) have been limited. The current study documents the interrater reliability and internal consistency of the Eating Disorder Examination (EDE) interview when administered to adults with Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5)-defined BED
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Pre-pregnancy BMI, rate of gestational weight gain, and preterm birth among US Pacific Islander individuals Obesity (IF 6.9) Pub Date : 2024-02-02 Bohao Wu, Veronika Shabanova, Sarah Taylor, Nicola L. Hawley
The objective of this study was to examine the association between rate of gestational weight gain (GWG) and preterm birth (PTB) classified by pre-pregnancy BMI among Pacific Islander individuals in the United States.
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Influence of the food environment on obesity risk in a large cohort of US veterans by community type Obesity (IF 6.9) Pub Date : 2024-02-01 Pasquale E. Rummo, Rania Kanchi, Samrachana Adhikari, Andrea R. Titus, David C. Lee, Tara McAlexander, Lorna E. Thorpe, Brian Elbel
The aim of this study was to examine relationships between the food environment and obesity by community type.
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Ketones with a twist: Tipping the heart's hat to fat Obesity (IF 6.9) Pub Date : 2024-01-29 Ali Javaheri, Bettina Mittendorfer
CONFLICT OF INTEREST STATEMENT The authors declared no conflict of interest.
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Roles of general and central adiposity in cardiometabolic multimorbidity: revisiting the obesity paradox using a multistate model Obesity (IF 6.9) Pub Date : 2024-01-28 Xue Xia, Shuohua Chen, Xue Tian, Qin Xu, Yijun Zhang, Xiaoli Zhang, Jing Li, Penglian Wang, Shouling Wu, Anxin Wang
The objective of this study was to evaluate the associations of general and central obesity with risk of first cardiometabolic disease (FCMD), cardiometabolic multimorbidity (CMM), and death.
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Branched-chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis Obesity (IF 6.9) Pub Date : 2024-01-25 Jonathan D. Mosley, Mingjian Shi, David Agamasu, Nataraja Sarma Vaitinadin, Venkatesh L. Murthy, Ravi V. Shah, Minoo Bagheri, Jane F. Ferguson
Genetic studies have suggested that the branched-chain amino acids (BCAAs) valine, leucine, and isoleucine have a causal association with type 2 diabetes (T2D). However, inferences are based on a limited number of genetic loci associated with BCAAs.
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Elevated BMI impacts brain-state dynamics within the sensorimotor-to-transmodal hierarchy Obesity (IF 6.9) Pub Date : 2024-01-25 Jinfeng Han, Kaixiang Zhuang, Debo Dong, Yingkai Yang, Yong Liu, Qinghua He, Tingyong Feng, Xu Lei, Jiang Qiu, Hong Chen
Overweight and obesity, as commonly indicated by a higher BMI, are associated with functional alterations in the brain, which may potentially result in cognitive decline and emotional illness. However, the manner in which these detrimental impacts manifest in the brain's dynamic characteristics remains largely unknown.
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A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans Obesity (IF 6.9) Pub Date : 2024-01-23 Thien Vinh Luong, Mette Glavind Bülow Pedersen, Caroline Bruun Abild, Stephen C. Cunnane, Etienne Croteau, Katrine Meyer Lauritsen, Mette Louise Gram Kjærulff, Lars Poulsen Tolbod, Niels Møller, Esben Søndergaard, Lars Christian Gormsen
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Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume Obesity (IF 6.9) Pub Date : 2024-01-22 Andrea Mendez-Gutierrez, Concepcion M. Aguilera, Rubén Cereijo, Francisco J. Osuna-Prieto, Borja Martinez-Tellez, Maria C. Rico, David Sanchez-Infantes, Francesc Villarroya, Jonatan R. Ruiz, Guillermo Sanchez-Delgado
The study objective was to investigate the effect of cold exposure on the plasma levels of five potential human brown adipokines (chemokine ligand 14 [CXCL14], growth differentiation factor 15 [GDF15], fibroblast growth factor 21 [FGF21], interleukin 6 [IL6], and bone morphogenic protein 8b [BMP8b]) and to study whether such cold-induced effects are related to brown adipose tissue (BAT) volume, activity
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Effect of planned pauses versus continuous energy restriction on weight loss and attrition: a systematic review Obesity (IF 6.9) Pub Date : 2024-01-21 Gina M. Wren, Dimitrios A. Koutoukidis, Jadine Scragg, Elena Tsompanaki, Alice Hobson, Susan A. Jebb
The objective of this study was to investigate whether pausing a weight loss program for a defined period of time could enhance weight loss and reduce attrition.
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Longitudinal associations between child discipline methods and physical growth patterns across preschool years Obesity (IF 6.9) Pub Date : 2024-01-17 Rosa S. Wong, Keith T. S. Tung, Frederick K. W. Ho, Nirmala Rao, Ko Ling Chan, Patrick Ip
Research has documented the associations of child maltreatment with a range of physical health problems, but little is known about the physical growth patterns of children who experience maltreatment in early childhood. This study aimed to examine the association between various discipline approaches and physical growth in preschool-aged children.
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The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross-sectional study Obesity (IF 6.9) Pub Date : 2024-01-14 Michaela Šiklová, Veronika Šrámková, Michal Koc, Eva Krauzová, Terezie Čížková, Barbora Ondrůjová, Marek Wilhelm, Zuzana Varaliová, Ondrej Kuda, Jana Neubert, Lukáš Lambert, Moustafa Elkalaf, Jan Gojda, Lenka Rossmeislová
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Net prices of new antiobesity medications Obesity (IF 6.9) Pub Date : 2024-01-16 Inmaculada Hernandez, Sean D. Sullivan
Glucagon-like peptide-1 receptor agonists (GLP1s) are effective antiobesity drugs and the subject of intense debate around insurance coverage due to the large prevalence of obesity and overweight. The estimation of the budget impact associated with GLP1 insurance coverage requires estimates of GLP1 prices that account for manufacturer discounts. The authors applied a peer-reviewed method to estimate
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Impaired plasma glucose clearance is a key determinant of fasting hyperglycemia in people with obesity Obesity (IF 6.9) Pub Date : 2024-01-16 Bettina Mittendorfer, Stephan van Vliet, Gordon I. Smith, Max C. Petersen, Bruce W. Patterson, Samuel Klein
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Effects of time-restricted eating on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease Obesity (IF 6.9) Pub Date : 2024-01-16 Yan Deng, Xiaoming Liu, Yuzhe Sun, Li Zhou, Qiang Li, Ziqiao Lei, Fan Yang, Liangkai Chen, Chen Zhang, Wei Tan, Xin Jin, Zhuang Han, Huiyang Xu, Qing Wang, Qi Nie, Haoran Yi, Wei Bao, Shuang Rong
The study's objective was to explore whether early time-restricted eating (eTRE) and late time-restricted eating (lTRE) have different impacts on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease (NAFLD).
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Correction to “Roux-en-Y gastric bypass, gastric banding, or sleeve gastrectomy for severe obesity: Baseline data from the By-Band-Sleeve randomized controlled trial” Obesity (IF 6.9) Pub Date : 2024-01-11
By-Band-Sleeve Collaborative Group. Roux-en-Y gastric bypass, gastric banding, or sleeve gastrectomy for severe obesity: Baseline data from the By-Band-Sleeve randomized controlled trial. Obesity (Silver Spring). 2023; 31(5): 1290–1299. doi:10.1002/oby.23746 Four authors who made significant contributions to the research project were inadvertently left off the authorship list. The additional authors
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Associations of relative fat mass and BMI with all-cause mortality: Confounding effect of muscle mass Obesity (IF 6.9) Pub Date : 2024-01-10 Navin Suthahar, Victor Zwartkruis, Bastiaan Geelhoed, Coenraad Withaar, Laura M. G. Meems, Stephan J. L. Bakker, Ron T. Gansevoort, Dirk Jan van Veldhuisen, Michiel Rienstra, Rudolf A. de Boer
The study objective was to examine associations of relative fat mass (RFM) and BMI with all-cause mortality in the Dutch general population and to investigate whether additional adjustment for muscle mass strengthened these associations.
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Limitations of BMI z scores for assessing weight change: A clinical tool versus individual risk Obesity (IF 6.9) Pub Date : 2024-01-08 Shana Adise, Kyung E. Rhee, Jennifer Laurent, Elizabeth A. Holzhausen, Panteha Hayati Rezvan, Tanya L. Alderete, Alaina P. Vidmar
Although pediatric growth curves provide clinical utility, using these metrics for within-person change over time can be misleading. As research is focused on understanding cardiometabolic consequences of weight gain, it is important to use precise metrics to analyze these longitudinal research questions. Despite several foundational recommendations to limit the use of reference pediatric growth curves
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Noninvasive tests to identify liver fibrosis in metabolic dysfunction-associated steatotic liver disease are affected by race Obesity (IF 6.9) Pub Date : 2023-12-27 Fernando Bril, Meagan Gray
The objective of this study was to assess the performance of noninvasive tests (NITs) across different racial and ethnic groups in a large multiethnic cohort.