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Distinct patterns of vital sign and inflammatory marker responses in adults with suspected bloodstream infection J. Infect. (IF 28.2) Pub Date : 2024-04-08 Qingze Gu, Jia Wei, Chang Ho Yoon, Kevin Yuan, Nicola Jones, Andrew Brent, Martin Llewelyn, Tim E.A. Peto, Koen B. Pouwels, David W. Eyre, A.Sarah Walker
To identify patterns in inflammatory marker and vital sign responses in adult with suspected bloodstream infection (BSI) and define expected trends in normal recovery. We included patients ≥16 y from Oxford University Hospitals with a blood culture taken between 1-January-2016 and 28-June-2021. We used linear and latent class mixed models to estimate trajectories in C-reactive protein (CRP), white
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Viruses associated with measles-like illnesses in Uganda J. Infect. (IF 28.2) Pub Date : 2024-04-06 Prossy Namuwulya, Shirin Ashraf, Marc Niebel, Alfred Ssekagiri, Phionah Tushabe, Proscovia Kakooza, Lily Tong, Henry Bukenya, Hanna Jerome, Chris Davis, Molly Birungi, Irene Turyahabwe, Arnold Mugaga, James Peter Eliku, Aine Francis, Lucy Nakabazzi, Fred Nsubuga, Edson Katushabe, Annet Kisakye, Immaculate Ampeire, Ann Nanteza, Pontiano Kaleebu, Barnabas Bakamutumaho, Peninah Nsamba, Anne Kazibwe, Ana
In this study, we investigated the causes of measles-like illnesses (MLI) in the Uganda national surveillance program in order to inform diagnostic assay selection and vaccination strategies. We used metagenomic next-generation sequencing (M-NGS) on the Illumina platform to identify viruses associated with MLI (defined as fever and rash in the presence of either cough, coryza or conjunctivitis) in
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Genomic evolution of human respiratory syncytial virus during a decade (2013–2023): bridging the path to monoclonal antibody surveillance J. Infect. (IF 28.2) Pub Date : 2024-04-06 Maria Piñana, Alejandra González-Sánchez, Cristina Andrés, Jorgina Vila, Anna Creus-Costa, Ignasi Prats-Méndez, Maria Arnedo-Muñoz, Narcís Saubi, Juliana Esperalba, Ariadna Rando, Patricia Nadal-Baron, Josep Quer, Juan José González-López, Pere Soler-Palacín, Jaime Martínez-Urtaza, Nieves Larrosa, Tomàs Pumarola, Andrés Antón
This study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023. Respiratory specimens from patients with RTI suspicion at Hospital Universitari Vall d′Hebron were collected from October 2013 to May 2023 for laboratory-confirmation of respiratory viruses. Next-generation sequencing was performed in randomly-selected
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Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study J. Infect. (IF 28.2) Pub Date : 2024-04-05 Saverio Caini, Jean-Sebastien Casalegno, Ana Paula Rodrigues, Vernon Lee, Cheryl Cohen, Q.Sue Huang, Alfredo Bruno Caicedo, Anne Teirlinck, Raquel Guiomar, Li Wei Ang, Jocelyn Moyes, Tim Wood, Doménica de Mora, Mathieu Bangert, VRS Study Group in Lyon, Rolf Kramer, Lisa Staadegaard, Susanne Heemskerk, Jojanneke van Summeren, Adam Meijer, John Paget
We aimed to study whether the percentwise age distribution of RSV cases changes over time during annual epidemics. We used surveillance data (2008–2019) from the Netherlands, Lyon (France), Portugal, Singapore, Ecuador, South Africa, and New Zealand. In each country, every season was divided into “epidemic quarters”, i.e. periods corresponding to each quartile of RSV cases. Multinomial logistic regression
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Transcriptomic crosstalk between viral and host factors drives aberrant homeostasis of T-cell proliferation and cell death in HIV-infected immunological non-responders J. Infect. (IF 28.2) Pub Date : 2024-04-04 Shengquan Tang, Yanqiu Lu, Feng Sun, Yuanyuan Qin, Vijay Harypursat, Renni Deng, Gong Zhang, Yaokai Chen, Tong Wang
Immunological non-responders (INRs) among people living with HIV have inherently higher mortality and morbidity rates. The underlying immunological mechanisms whereby failure of immune reconstitution occurs in INRs require elucidation. HIV-1 DNA and HIV-1 cell-associated RNA (CA-HIV RNA) quantifications were conducted via RT-qPCR. Transcriptome sequencing (RNA-seq), bioinformatics, and biological verifications
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Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages J. Infect. (IF 28.2) Pub Date : 2024-04-02 Aasmund Fostervold, Niclas Raffelsberger, Marit A.K. Hetland, Ragna Bakksjø, Eva Bernhoff, Ørjan Samuelsen, Arnfinn Sundsfjord, Jan E. Afset, Christopher F. Berntsen, Roar Bævre-Jensen, Marit H. Ebbesen, Karianne W. Gammelsrud, Anja D. Guleng, Nina Handal, Aleksandra Jakovljev, Simreen K. Johal, Åshild Marvik, Ane Natvik, Rolf-Arne Sandnes, Ståle Tofteland, Jørgen V. Bjørnholt, Iren H. Löhr, Assoc
Klebsiella pneumoniae species complex (KpSC) bloodstream infections (BSIs) are associated with considerable morbidity and mortality, particularly in elderly and multimorbid patients. Multidrug-resistant (MDR) strains have been associated with poorer outcome. However, the clinical impact of KpSC phylogenetic lineages on BSI outcome is unclear. In an 18-month nationwide Norwegian prospective study of
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Sustained clinical benefit of malaria chemoprevention with sulfadoxine-pyrimethamine (SP) in pregnant women in a region with high SP resistance markers J. Infect. (IF 28.2) Pub Date : 2024-04-02 Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cístero, Henriques Mbeve, Anna Escoda, Gizela Bambo, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Kevin K.A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Eusébio Macete, Alfredo Mayor
The effectiveness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is threatened by increasing SP-resistance in Africa. We assessed the level of SP-resistance markers, and the clinical and parasitological effectiveness of IPTp-SP in southern Mozambique. infection, antimalarial antibodies and SP-resistance mutants were detected by quantitative polymerase
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An early and trustable indicator suggestive of non-tuberculosis mycobacteria isolation in a high tuberculosis burden setting J. Infect. (IF 28.2) Pub Date : 2024-04-02 Qian Liang, Xiaoyi Jiang, Junnan Jia, Liping Zhao, Yunxu Li, Fen Wang, Lingling Dong, Yi Xue, Guanglu Jiang, Hairong Huang
Distinguishing between nontuberculous mycobacterial (NTM) lung infections and pulmonary tuberculosis becomes challenging due to their similar clinical manifestations and radiological images. Consequently, instances of delayed diagnosis or misdiagnosis are highly frequent. A feasible and reliable indicator of the existence of NTM in the early stages of the disease would help to solve this dilemma. In
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Role of SARS-CoV-2 mutations in the evolution of the COVID-19 pandemic J. Infect. (IF 28.2) Pub Date : 2024-04-01 Philippe Colson, Hervé Chaudet, Jérémy Delerce, Pierre Pontarotti, Anthony Levasseur, Jacques Fantini, Bernard La Scola, Christian Devaux, Didier Raoult
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Relapsing epidemic typhus (Brill-Zinsser disease) in China J. Infect. (IF 28.2) Pub Date : 2024-03-30 Miao Lu, Shizhe Chen, Huafeng Li, Wen Wang, Kun Li
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Utility of an in-house real-time PCR in whole blood samples as a minimally invasive method for early and accurate diagnosis of invasive mould infections. J. Infect. (IF 28.2) Pub Date : 2024-03-28 Mragnayani Pandey, Immaculata Xess, Janya Sachdev, Neha Sharad, Sonakshi Gupta, Gagandeep Singh, Renu Kumari Yadav, Bhaskar Rana, Stephen Raj, M.Nizam Ahmad, Neha Nityadarshini, Upendra Baitha, Manish Soneja, Shalimar, Bindu Prakash, Kapil Sikka, Purva Mathur, Viveka P. Jyotsna, Rakesh Kumar, Naveet Wig, Sudesh Gourav, Ashutosh Biswas, Alok Thakar
Invasive mould infections (IMIs) are a leading cause of death in patients with compromised immune systems. Proven invasive mould infection requires detection of a fungus by histopathological analysis of a biopsied specimen, sterile culture, or fungal DNA amplification by PCR in tissue However, the clinical performance of a PCR assay on blood samples taken from patients suspected of invasive mould disease
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Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology J. Infect. (IF 28.2) Pub Date : 2024-03-27 N.G. Martin, S. Defres, L. Willis, R. Beckley, H. Hardwick, A. Coxon, S. Kadambari, L.-M. Yu, X. Liu, U. Galal, K. Conlin, M.J. Griffiths, R. Kneen, S. Nadel, P.T. Heath, D.E. Kelly, T. Solomon, M. Sadarangani, A.J. Pollard, on behalf of the UK-ChiMES and ENCEPH-UK study groups
The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. Children aged <16 years hospitalised with suspected meningitis/encephalitis were included, and prospectively recruited at 31 UK hospitals. Meningitis was defined as identification of bacteria/viruses
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Evaluation of metagenomic and pathogen-targeted next-generation sequencing for diagnosis of meningitis and encephalitis in adults: A multicenter prospective observational cohort study in China J. Infect. (IF 28.2) Pub Date : 2024-03-26 Weibi Chen, Gang Liu, Lili Cui, Fei Tian, Jiatang Zhang, Jiahua Zhao, Ying Lv, Jianxin Du, Xinyu Huan, Yingfeng Wu, Yan Zhang
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Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series J. Infect. (IF 28.2) Pub Date : 2024-03-26 Andrea Meinhardt, Liam Reilly, Marios Kaliakatsos, Khaled Abdel-Aziz, Sondus Alsharidah, Istvan Bodi, Claire Booth, Kritika Chetty, Jennifer Evans, Laura Ferreras-Antolín, Susannah Froude, Clare M. Galtrey, Suba Guruprasad, Robert D. Hadden, Jane Hassell, Heikki Hyöty, Alexandra Y. Kreins, Jutta E. Laiho, David M. Lowe, Michael P. Lunn, Kshitij Mankad, Siske Struik, Elizabeth Whittaker, Austen Worth
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Understanding immune dysregulation in post-acute sequelae of COVID-19 (PASC)—The hunt for effective treatments J. Infect. (IF 28.2) Pub Date : 2024-03-24 Norman B. Gaylis, Otto O. Yang
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Re-emergence of Diphtheria after COVID-19 pandemic in Pakistan: Time to consider booster vaccination strategies J. Infect. (IF 28.2) Pub Date : 2024-03-19 Muhammad Salman, Muhammad S. Rana, Muhammad Usman, Muhammad Tahir, Kashif Muqarrab, Muhammad B. Alam, Massab Umair, Muhammad Anas, Nadeem Ullah, Ayesha Farooq, Zurva Ashraf
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Resurgence and atypical patterns of pertussis in China J. Infect. (IF 28.2) Pub Date : 2024-03-19 Guo Mengyang, Hu Yahong, Meng Qinghong, Shi Wei, Yao Kaihu
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Strong cross immune responses against sarbecoviruses but not merbecoviruses in SARS-CoV-2 BA.5/BF.7-infected individuals with or without inactivated COVID-19 vaccination J. Infect. (IF 28.2) Pub Date : 2024-03-13 Lujia Sun, Qiuhong Man, Hui Zhang, Shuai Xia, Lu Lu, Xinling Wang, Lize Xiong, Shibo Jiang
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COVID-19 mortality amongst the immunosuppresed J. Infect. (IF 28.2) Pub Date : 2024-03-11 Víctor Moreno-Torres, María Martínez-Urbistondo, Jorge Calderón-Parra, Carmen de Mendoza, Vicente Soriano
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Emergence of Astrakhan rickettsial fever in China J. Infect. (IF 28.2) Pub Date : 2024-03-08 Zhong-Qiu Teng, Li Yang, Na Zhao, Xin-Ting Li, Lu-Peng Dai, Xue Zhang, Tong-Tong Shao, Ling Han, Rong-Jiong Zheng, Bo-Hai Wen, Biao Kan, Jian-Guo Xu, Xiao-Bo Lu, Tian Qin
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Within-episode repeat antibiotic prescriptions in patients with respiratory tract infections: A population-based cohort study J. Infect. (IF 28.2) Pub Date : 2024-03-08 Arief Lalmohamed, Roderick P. Venekamp, Albert Bolhuis, Patrick C. Souverein, Janneke H.H.M. van de Wijgert, Martin C. Gulliford, Alastair D. Hay
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Clinical features-based machine learning models to separate sexually transmitted infections from other skin diagnoses J. Infect. (IF 28.2) Pub Date : 2024-03-05 Nyi Nyi Soe, Phyu Mon Latt, Zhen Yu, David Lee, Cham-Mill Kim, Daniel Tran, Jason J. Ong, Zongyuan Ge, Christopher K. Fairley, Lei Zhang
Many sexual health services are overwhelmed and cannot cater for all the individuals who present with sexually transmitted infections (STIs). Digital health software that separates STIs from non-STIs could improve the efficiency of clinical services. We developed and evaluated a machine learning model that predicts whether patients have an STI based on their clinical features. We manually extracted
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Current state of COVID-19 in children: 4 years on J. Infect. (IF 28.2) Pub Date : 2024-03-02 Annabel A. Powell, Alexander C. Dowell, Paul Moss, Shamez N. Ladhani, the sKIDs Investigation Team
Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the rapid spread of SARS-CoV-2 in most parts of the world. In this review we summarise the UK experience of COVID-19 in children four years into the largest
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Mycophenolate mofetil hampers antibody responses to a broad range of vaccinations in kidney transplant recipients: Results from a randomized controlled study J. Infect. (IF 28.2) Pub Date : 2024-03-02 Z. Al Fatly, M.G.H. Betjes, W.A. Dik, R.A.M. Fouchier, M.E.J. Reinders, A.E. de Weerd
To study the effect of mycophenolate mofetil (MMF) on various vaccination responses in kidney transplant recipients. In a randomized controlled trial (EudraCT nr.: 2014-001372-66), low immunologically risk kidney transplant recipients were randomized to TAC/MMF or TAC-monotherapy (TACmono), six months post-transplantation. One year after transplantation, in a pre-specified sub-study, recipients were
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Intra-host genetic diversity of SARS-CoV-2 Omicron variants in children J. Infect. (IF 28.2) Pub Date : 2024-02-29 Pengcheng Liu, Jiehao Cai, He Tian, Jingjing Li, Lijuan Lu, Menghua Xu, Xunhua Zhu, Huaqing Zhong, Ran Jia, Xiaomin Fu, Xiangshi Wang, Yanling Ge, Yanfeng Zhu, Mei Zeng, Jin Xu
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Lymphopenia is associated with broad host response aberrations in community-acquired pneumonia J. Infect. (IF 28.2) Pub Date : 2024-02-29 Susanne E. Doeleman, Tom D.Y. Reijnders, Sebastiaan C.M. Joosten, Alex R. Schuurman, Tjitske S.R. van Engelen, Jan Verhoeff, Valentine Léopold, Xanthe Brands, Bastiaan W. Haak, Jan M. Prins, Maadrika M.N.P. Kanglie, Inge A.H. van den Berk, Daniël R. Faber, Renée A. Douma, Jaap Stoker, Anno Saris, Juan J. Garcia Vallejo, W. Joost Wiersinga, Tom van der Poll
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Ivermectin for COVID-19 in adults in the community (PRINCIPLE): An open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes J. Infect. (IF 28.2) Pub Date : 2024-02-29 Gail Hayward, Ly-Mee Yu, Paul Little, Oghenekome Gbinigie, Milensu Shanyinde, Victoria Harris, Jienchi Dorward, Benjamin R. Saville, Nicholas Berry, Philip H. Evans, Nicholas P.B. Thomas, Mahendra G. Patel, Duncan Richards, Oliver V. Hecke, Michelle A. Detry, Christina Saunders, Mark Fitzgerald, Jared Robinson, Charlotte Latimer-Bell, Julie Allen, Emma Ogburn, Jenna Grabey, Simon de Lusignan, FD Richard
The evidence for whether ivermectin impacts recovery, hospital admissions, and longer-term outcomes in COVID-19 is contested. The WHO recommends its use only in the context of clinical trials. In this multicentre, open-label, multi-arm, adaptive platform randomised controlled trial, we included participants aged ≥18 years in the community, with a positive SARS-CoV-2 test, and symptoms lasting ≤14 days
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AZD1222 effectiveness against severe COVID-19 in individuals with comorbidity or frailty: The RAVEN cohort study J. Infect. (IF 28.2) Pub Date : 2024-02-29 Wilhelmine Meeraus, Mark Joy, Mario Ouwens, Kathryn S. Taylor, Sudhir Venkatesan, John Dennis, Trung N. Tran, Ashkan Dashtban, Xuejuan Fan, Robert Williams, Tamsin Morris, Lucy Carty, Debasish Kar, Uy Hoang, Michael Feher, Anna Forbes, Gavin Jamie, William Hinton, Kornelia Sanecka, Rachel Byford, Sneha N. Anand, F.D. Richard Hobbs, David A. Clifton, Andrew J. Pollard, Sylvia Taylor, Simon de Lusignan
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Identification of a newly emerging second-generation HIV-1 circulating recombinant form (CRF145_0755) among men who have sex with men in China J. Infect. (IF 28.2) Pub Date : 2024-02-21 Min Chen, Yanling Ma, Huichao Chen, Jie Dai, Lijuan Dong, Manhong Jia
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Is paracetamol a missing piece of the severe acute hepatitis of unknown aetiology jigsaw? J. Infect. (IF 28.2) Pub Date : 2024-02-19 Pietro Vajro, Claudia Mandato, Björn Fischler
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Bacteriophage therapy and current delivery strategies for orthopedic infections: A SCOPING review J. Infect. (IF 28.2) Pub Date : 2024-02-17 Jason Young, Sang W. Lee, Mohammad J. Shariyate, Alexandria Cronin, John J. Wixted, Ara Nazarian, Christopher F. Rowley, Edward K. Rodriguez
Interest in phages as adjunctive therapy to treat difficult infections has grown in the last decade. However, phage dosing and delivery for orthopedic infections have not been systematically summarized. Following PRISMA-ScR guidelines, we conducted a SCOPING review through September 1st, 2023, of MEDLINE, Embase, Web of Science Core Collection, and Cochrane Central. In total, 77 studies were included
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People living with HIV who have poor immune status are a key population for SARS-CoV-2 prevention J. Infect. (IF 28.2) Pub Date : 2024-02-16 Jie Zhou, Liuyan Lan, Sufang Ai, Jianyan Lin, Ningmei Liu, Yulan Xie, Ping Cui, Hao Liang, Li Ye, Jiegang Huang, Zhiman Xie
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Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein J. Infect. (IF 28.2) Pub Date : 2024-02-16 Zhuocheng Yao, Lin Zhang, Yuange Duan, Xiaolu Tang, Jian Lu
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged the global economy and human health. The spike (S) protein of coronaviruses plays a pivotal role in viral entry by binding to host cell receptors. Additionally, it acts as the primary target for neutralizing antibodies in those infected and is the central focus for currently
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Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial J. Infect. (IF 28.2) Pub Date : 2024-02-16 Maya Hites, Eva Larranaga Lapique, Clément R. Massonnaud, Drifa Belhadi, Simon Jamard, François Goehringer, François Danion, Jean Reignier, Nathalie de Castro, Denis Garot, Karine Lacombe, Violaine Tolsma, Emmanuel Faure, Denis Malvy, Thérèse Staub, Johan Courjon, France Cazenave-Roblot, Anne Ma Dyrhol Riise, Paul Leturnier, Guillaume Martin-Blondel, Claire Roger, Karolina Akinosoglou, Vincent Le Moing
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Antibiotics to eradicate Streptococcus pyogenes pharyngeal carriage in asymptomatic children and adults: A systematic review J. Infect. (IF 28.2) Pub Date : 2024-02-14 Te-Yu Hung, Linny K. Phuong, Anneke Grobler, Steven Y.C. Tong, Pippin Freeth, Asika Pelenda, Katherine B. Gibney, Andrew C. Steer
is a Gram-positive bacteria which causes a spectrum of diseases ranging from asymptomatic infection to life-threatening sepsis. Studies report up to 2000 times greater risk of invasive disease in close contacts of index cases within 30-days of symptom onset. Despite this, there is variability in the management of asymptomatic carriage of and those at risk of secondary cases of invasive infection. Our
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Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines J. Infect. (IF 28.2) Pub Date : 2024-02-13 Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Joyce S. Plested, Anand Parekh, Drew Gorinson, Rongman Cai, Soham Mahato, Pradhipa Ramanathan, Lidwina Carissa Aurelia, Kevin John Selva, Anthony M. Marchese, Louis Fries, Amy W. Chung, Lisa M. Dunkle
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The clinical outcome of COVID-19 is strongly associated with microbiome dynamics in the upper respiratory tract J. Infect. (IF 28.2) Pub Date : 2024-02-10 Linlin Xie, Gengyan Luo, Zhongzhou Yang, Wei-chen Wu, Jintao Chen, Yuting Ren, Zhikun Zeng, Guangming Ye, Yunbao Pan, Wen-jing Zhao, Yao-qing Chen, Wei Hou, Yanni Sun, Deying Guo, Zifeng Yang, Jun Li, Edward C. Holmes, Yirong Li, Liangjun Chen, Mang Shi
The respiratory tract is the portal of entry for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a variety of respiratory pathogens other than SARS-CoV-2 have been associated with severe cases of COVID-19 disease, the dynamics of the upper respiratory microbiota during disease the course of disease, and how they impact disease manifestation, remain uncertain. We collected
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Cefiderocol either in monotherapy or combination versus best available therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections: A systematic review and meta-analysis J. Infect. (IF 28.2) Pub Date : 2024-02-06 Lorenzo Onorato, Ilaria de Luca, Caterina Monari, Nicola Coppola
The best treatment for carbapenem-resistant (CRAB) infections is still a matter of debate. To describe the outcomes of patients treated with cefiderocol for CRAB infections, and to compare the efficacy of cefiderocol versus best available therapy (BAT). We searched MEDLINE, the Cochrane Library and EMBASE to screen original reports published up to September 2023. Randomized controlled trials (RCTs)
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A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling ‘low risk’ patients with penicillin allergy by non-allergy healthcare professionals (SPACE study): Implications for healthcare systems J. Infect. (IF 28.2) Pub Date : 2024-02-06 Mamidipudi Thirumala Krishna, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Yogini H. Jani, Iestyn Williams, Jonathan A.T. Sandoe, Rachel Pollard, Nicola Jones, Louise Dunsmure, Neil Powell, Chidanand Hullur, Ariyur Balaji, Catherine Moriarty, Beverley Jackson, Amena Warner, Ron Daniels, Robert West, Caroline Thomas, Siraj A. Misbah, Louise Savic
The huge burden of inaccurate penicillin allergy labels (PALs) is an important driver of antimicrobial resistance. This is magnified by insufficient allergy specialists and lack of ‘point-of-care’ tests. We investigated the feasibility of non-allergy healthcare professionals (HCPs) delivering direct oral penicillin challenges (DPCs) for penicillin allergy de-labelling. This prospective observational
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Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections J. Infect. (IF 28.2) Pub Date : 2024-02-05 Sabine E. Olie, Steven L. Staal, Liora ter Horst, Ingeborg E. van Zeggeren, Wing K. Man, Michael W.T. Tanck, Diederik van de Beek, Matthijs C. Brouwer
We aimed to determine diagnostic accuracy of inflammatory markers in plasma and cerebrospinal fluid (CSF) for the diagnosis of central nervous system (CNS) infections and specifically bacterial meningitis. We analyzed 12 cytokines, chemokines, and acute phase reactants in CSF and plasma of 738 patients with suspected neurological infection included in a multicenter prospective cohort. We determined
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Corrigendum to “Tick-borne encephalitis: Acute clinical manifestations and severity in 581 cases from Germany, 2018-2020” [J Infect 86 (2023) 369-375] J. Infect. (IF 28.2) Pub Date : 2024-02-02 Teresa M. Nygren, Antonia Pilic, Merle M. Böhmer, Christiane Wagner-Wiening, Simone-Beatrice Went, Ole Wichmann, Wiebke Hellenbrand
Abstract not available
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Pulmonary dysfunction severity may impact optimal dexamethasone dosing in patients with COVID-19 J. Infect. (IF 28.2) Pub Date : 2024-02-01 Kuo-Chuan Hung, I-Wen Chen, Cheuk-Kwan Sun
Abstract not available
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Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers J. Infect. (IF 28.2) Pub Date : 2024-02-01 Lauri Ivaska, Jethro Herberg, Manish Sadarangani
Diagnostic tools to differentiate between community-acquired bacterial and viral meningitis are essential to target the potentially lifesaving antibiotic treatment to those at greatest risk and concurrently spare patients with viral meningitis from the disadvantages of antibiotics. In addition, excluding bacterial meningitis and thus decreasing antibiotic consumption would be important to help reduce
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IgG glycosylation associates with risk of progression from latent to active tuberculosis J. Infect. (IF 28.2) Pub Date : 2024-02-01 Julie G. Burel, Wenjun Wang, Manfred Wuhrer, Martin Dedicoat, Thomas E. Fletcher, Adam F. Cunningham, Matthew K. O’Shea
Glycosylation motifs shape antibody structure, stability and antigen affinity and play an important role in antibody localization and function. Serum IgG glycosylation profiles are significantly altered in infectious diseases, including tuberculosis (TB), but have not been studied in the context of progression from latent to active TB. We performed a longitudinal study of paired bulk IgG glycosylation
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Disparities in COVID-19 mortality amongst the immunosuppressed: A systematic review and meta-analysis for enhanced disease surveillance J. Infect. (IF 28.2) Pub Date : 2024-01-30 Meredith Leston, Willam Elson, Jose M. Ordóñez-Mena, Debasish Kar, Heather Whitaker, Mark Joy, Nia Roberts, F.D. Richard Hobbs, Simon de Lusignan
Effective disease surveillance, including that for COVID-19, is compromised without a standardised method for categorising the immunosuppressed as a clinical risk group. We conducted a systematic review and meta-analysis to evaluate whether excess COVID-associated mortality compared to the immunocompetent could meaningfully subdivide the immunosuppressed. Our study adhered to UK (Green Book) criteria
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Burden of child mortality from malaria in high endemic areas: Results from the CHAMPS network using minimally invasive tissue sampling J. Infect. (IF 28.2) Pub Date : 2024-01-28 Ikechukwu U. Ogbuanu, Kephas Otieno, Rosauro Varo, Samba O. Sow, Julius Ojulong, Babatunde Duduyemi, Dickens Kowuor, Carrie Jo Cain, Emily A. Rogena, Dickens Onyango, Victor Akelo, Beth A. Tippett Barr, Feiko terKuile, Karen L. Kotloff, Milagritos D. Tapia, Adama Mamby Keita, Jane Juma, Nega Assefa, Nardos Assegid, Yenework Acham, Lola Madrid, J. Anthony G. Scott, Shams El Arifeen, Emily S. Gurley
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DNA mismatch repair in HIV-Associated Lymphoma: Lost in Translation? J. Infect. (IF 28.2) Pub Date : 2024-01-28 Yuanhui Jiang, Suling Chen, Muye Xia, Xuwen Xu, Jie Peng, Shaohang Cai
Abstract not available
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Less is more: Uptake of recommended vaccines in a UK travel clinic J. Infect. (IF 28.2) Pub Date : 2024-01-26 Thomas Harrison, Jacqueline Clark, Thomas C. Darton
Abstract not available
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Longitudinal study of meningococcal carriage in adolescents and young adults in South Australia 2017-2020 J. Infect. (IF 28.2) Pub Date : 2024-01-17 Mark McMillan, Hassen Mohammed, Jana Bednarz, Lex E.X. Leong, Andrew Lawrence, Thomas R. Sullivan, Martin C.J. Maiden, Helen S. Marshall
Background This analysis investigated longitudinal changes in meningococcal carriage in adolescents in South Australia over 4 years. Methods Data from the “B Part of It” study, which included a state-wide cluster randomized controlled trial in secondary-school students (n = 34,489 in 2017 and 2018) and serial cross-sectional studies in school leavers aged 17–25 years (n = 4028 in 2019-2020). Individuals
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Donor respiratory multidrug-resistant bacteria and lung transplantation outcomes J. Infect. (IF 28.2) Pub Date : 2024-01-17 Rayid Abdulqawi, Rana Ahmed Saleh, Reem Mahmoud Alameer, Haifa Aldakhil, Khaled Manae AlKattan, Reem Saad Almaghrabi, Sahar Althawadi, Mahmoud Hashim, Waleed Saleh, Amani Hassan Yamani, Eid Abdullah Al-Mutairy
Rationale Respiratory culture screening is mandatory for all potential lung transplant donors. There is limited evidence on the significance of donor multidrug-resistant (MDR) bacteria on transplant outcomes. Establishing the safety of allografts colonized with MDR bacteria has implications for widening an already limited donor pool. Objectives We aimed to describe the prevalence of respiratory MDR
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SARS-CoV-2 Delta and Omicron community transmission networks as added value to contact tracing J. Infect. (IF 28.2) Pub Date : 2024-01-17 John M. Murray, Daniel D. Murray, Evelyne Schvoerer, Elma H. Akand
Objectives Calculations of SARS-CoV-2 transmission networks at a population level have been limited. Networks that estimate infections between individuals and whether this results in a mutation, can be a way to evaluate fitness of a mutational clone by how much it expands in number as well as determining the likelihood a transmission results in a new variant. Methods Australian Delta and Omicron SARS-CoV-2
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Emergence of a triple reassortment avian influenza virus (A/H5N6) from wild birds J. Infect. (IF 28.2) Pub Date : 2024-01-17 Yan-kun Ke, Xin-yu Han, Si-ru Lin, Han-guang Wu, Ying-xin Li, Rong-qi Liu, Ming Liao, Wei-xin Jia
Abstract not available
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Stillbirths due to placental COVID infection associated with chronic histiocytic intervillositis do not recur in subsequent pregnancies J. Infect. (IF 28.2) Pub Date : 2024-01-11 Emily F. Cornish, Lotte E. van der Meeren, Marie-Louise P. van der Hoorn, Sam Schoenmakers, Alexandre J. Vivanti, Alexandra Benachi, Melissa Whitten, Stephanie Hignett, Thomas McDonnell, David J. Williams
Abstract not available
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Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency J. Infect. (IF 28.2) Pub Date : 2024-01-06 Haoran Zhang, Kangping Zhou, Fei Peng, Zhao Gao,, Guowei Song, Bing Hu, Sophia Chun, Junfeng Xiao, Mengfei Qian, Jin Wu, Kai Pan, Fan Gao, Meng Guo, Cheng Peng, Gang Zou, Jim Zhen Wu, Kun Cai, Yan Li
Abstract not available
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Hepatitis B virus (HBV) screening, linkage and retention-in-care in inclusion health populations: Evaluation of an outreach screening programme in London J. Infect. (IF 28.2) Pub Date : 2023-12-29 Emily Martyn, Sive O’Regan, Philippa Harris, Mark Leonard, Martha Veitch, Binta Sultan, Philippa C. Matthews, Indrajit Ghosh, Alistair Story, Julian Surey
Objectives We evaluate a hepatitis B virus (HBV) screening programme, delivered by a specialist pan-London multidisciplinary outreach team, to understand population characteristics and care cascade among people who experience extreme social exclusion (Inclusion Health (IH) groups). Methods Point-of-care HBV screening was performed in temporary accommodation for people experiencing homelessness (PEH)
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Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry J. Infect. (IF 28.2) Pub Date : 2023-12-22 Damien Caillet Portillo, Xavier Puéchal, Maëva Masson, Marie Kostine, Alexia Michaut, André Ramon, Daniel Wendling, Nathalie Costedoat-Chalumeau, Pascal Richette, Hubert Marotte, Justine Vix-Portet, Jean-Jacques Dubost, Sébastien Ottaviani, Gaël Mouterde, Anne Grasland, Aline Frazier, Vincent Germain, Fabienne Coury, Anne Tournadre, Martin Soubrier, Arnaud Constantin
Objectives Tropheryma whipplei infection can manifest as inflammatory joint symptoms, which can lead to misdiagnosis of inflammatory rheumatic disease and the use of disease-modifying antirheumatic drugs. We investigated the impact of diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease. Methods We initiated a registry including patients with disease-modifying
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Economic burden attributable to healthcare-associated infections at western China hospitals: 6 Year, prospective cohort study J. Infect. (IF 28.2) Pub Date : 2023-12-21 Yu Lv, Xiaobo Huang, Jiayu Wu, Xueqin Xiao, Chunhua Ma, Xiaoyun Jiang, Ping Zhou, Linlin Liu, Yiguo Jiang, Anna Zou, Hui Niu, Juhua Sun, Li Hou, Xiaomeng Wang, Yulin Dai, Shuling Peng, Xiaorong Deng, Hong Xia, Yao Guo, Defen Wang, Qian Xiang
Objectives Healthcare-associated infections (HAIs) represent a major threat to patient safety and are associated with significant economic burden. Calculating the costs attributable to HAIs is challenging given the various sources of bias. Although HAIs as a reasonably preventable medical harm should have been closely linked to medical insurance incentives, there was little linkage between HAIs and
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Beethoven’s deafness more likely linked to viral infection than lead poisoning J. Infect. (IF 28.2) Pub Date : 2023-12-21 Piotr Rzymski, Dorota Zarębska-Michaluk, Robert Flisiak
Abstract not available
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Characterization of a new HIV-1 second-generation circulating recombinant form (CRF170_0107) among men who have sex with men in Yunnan, China J. Infect. (IF 28.2) Pub Date : 2023-12-20 Yi Li, Wei Chang, Jun Liang, Yang Liu, Li Li, Li Liu, Jing-Ying Wang, Rui-Lin Feng, Bin Liao, Yue Feng
Abstract not available