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The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration Cell. Immunol. (IF 4.3) Pub Date : 2024-03-19 Justin D. Glenn, Henos Negash, William Henry, Randolph Qian, Ye Liu, Olivier Danos, Joseph T. Bruder, Subha Karumuthil-Melethil
AAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2–3-fold as early
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HLA-class-I expression loss, tumor microenvironment and breast cancer prognosis Cell. Immunol. (IF 4.3) Pub Date : 2024-03-05 Alexandra Giatromanolaki, Georgios D. Michos, Erasmia Xanthopoulou, Michael I. Koukourakis
Loss of HLA-class-I molecule expression by cancer cells is a frequent event in human tumors that may lead to immune evasion from cytotoxic -cells. We examined the expression patterns of HLA-class-I molecules in a series of 175 patients with operable breast cancer (BCa). Extensive loss of BCa cell HLA-class-I expression was noted 76.6 % of patients (27.5 % complete loss). A significant association of
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Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status Cell. Immunol. (IF 4.3) Pub Date : 2024-02-27 Guillaume Lezmi, Clément Poirault, Marta Grauso, Céline Dietrich, Karine Adel-Patient, Maria Leite-de-Moraes
Severe asthma (SA) affects 2% to 5% of asthmatic children. Atopic dermatitis can affect up to 34% of children with SA (cwSA). Atopic dermatitis and asthma share common genetic and immunological features. However, not all children with SA suffer from AD, and it remains unclear whether the overall immune profiles of these children are similar. In this study, seventeen cwSA (9.8 [7.1–13.2] years; seven
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MALT1 inhibition suppresses antigen-specific T cell responses Cell. Immunol. (IF 4.3) Pub Date : 2024-02-24 Iliana K. Kerzeli, Aikaterini Nasi, Erika Fletcher, Aikaterini Chourlia, Anders Kallin, Niklas Finnberg, Karolina Ersmark, Maria Lampinen, Mark Albertella, Fredrik Öberg, Sara M. Mangsbo
The aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory -cells (Tregs). In vitro, MALT1 inhibition suppressed the proteolytic cleavage of the MALT1-substrate HOIL1 and blocked IL-2 secretion in Jurkat cells. It selectively suppressed the proliferation of PBMC-derived Tregs, with no effect on
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Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation Cell. Immunol. (IF 4.3) Pub Date : 2024-02-15 Mahvash Sadeghi, Mojgan Mohammadi, Jalil Tavakol Afshari, Sara Iranparast, Bahareh Ansari, Sajad Dehnavi
Due to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs
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Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation Cell. Immunol. (IF 4.3) Pub Date : 2024-02-03 Sandeep Kumar, Monisha Dhiman
-associated stomach infection is a leading cause of gastric ulcer and related cancer. modulates the functions of infiltrated immune cells to survive the killing by reactive oxygen and nitrogen species (ROS and RNS) produced by these cells. Uncontrolled immune responses further produce excess ROS and RNS which lead to mucosal damage. The persistent oxidative stress is a major cause of gastric cancer
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The research progression of direct NLRP3 inhibitors to treat inflammatory disorders Cell. Immunol. (IF 4.3) Pub Date : 2024-01-24 Xiu Chen, Pingping Zhang, Yu Zhang, Mengzhu Wei, Tian Tian, Dacheng Zhu, Yanling Guan, Wei Wei, Yang Ma
The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the capability to recognize a wide range of pathogen-derived, environmental, and endogenous stress-related factors. Dysregulated activation of the NLRP3 inflammasome has been implicated in the development of various inflammasome-associated disorders, highlighting its significance as a pivotal target for the treatment of inflammatory
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The mechanism by which cannabidiol (CBD) suppresses TNF-α secretion involves inappropriate localization of TNF-α converting enzyme (TACE) Cell. Immunol. (IF 4.3) Pub Date : 2024-01-17 Christa M. Frodella, Liyuan Liu, Wei Tan, Stephen B. Pruett, Barbara L.F. Kaplan
Cannabidiol (CBD) is a phytocannabinoid derived from that exerts anti-inflammatory mechanisms. CBD is being examined for its putative effects on the neuroinflammatory disease, multiple sclerosis (MS). One of the major immune mediators that propagates MS and its mouse model experimental autoimmune encephalomyelitis (EAE) are macrophages. Macrophages can polarize into an inflammatory phenotype (M1) or
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Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy Cell. Immunol. (IF 4.3) Pub Date : 2024-01-13 Cristina D. Gaddie, Kevin G. Senior, Christopher Chan, Brad E. Hoffman, Geoffrey D. Keeler
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Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability Cell. Immunol. (IF 4.3) Pub Date : 2024-01-13 Alessandro Borghesi
In humans, the interindividual variability of clinical outcome following exposure to a microorganism is immense, ranging from silent infection to life-threatening disease. Age-specific immune responses partially account for the high incidence of infection during the first 28 days of life and the related high mortality at population level. However, the occurrence of life-threatening disease in individual
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PIM kinase inhibitor AZD1208 in conjunction with Th1 cytokines potentiate death of breast cancer cells in vitro while also maximizing suppression of tumor growth in vivo when combined with immunotherapy Cell. Immunol. (IF 4.3) Pub Date : 2024-01-08 Ariel Anwar, Carissa Lepore, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter
PIM kinases are over-expressed by a number of solid malignancies including breast cancer, and are thought to regulate proliferation, survival, and resistance to treatment, making them attractive therapeutic targets. Because PIM kinases sit at the nexus of multiple oncodriver pathways, PIM antagonist drugs are being tested alone and in conjunction with other therapies to optimize outcomes. We therefore
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Concomitant assessment of PD-1 and CD56 expression identifies subsets of resting cord blood Vδ2 T cells with disparate cytotoxic potential Cell. Immunol. (IF 4.3) Pub Date : 2023-12-23 Haoting Hsu, Claudio Zanettini, Modupe Coker, Sarah Boudova, David Rach, Godfrey Mvula, Titus H. Divala, Randy G. Mungwira, Francesca Boldrin, Giulia Degiacomi, Laura Cioetto Mazzabò, Riccardo Manganelli, Miriam K. Laufer, Yuji Zhang, Luigi Marchionni, Cristiana Cairo
Vγ9Vδ2 T lymphocytes are programmed for broad antimicrobial responses with rapid production of Th1 cytokines even before birth, and thus thought to play key roles against pathogens in infants. The process regulating Vδ2 cell acquisition of cytotoxic potential shortly after birth remains understudied. We observed that perforin production in cord blood Vδ2 cells correlates with phenotypes defined by
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Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy Cell. Immunol. (IF 4.3) Pub Date : 2023-12-10 Fernanda Agostini Rocha, Caio Raony Farina Silveira, Ancély Ferreira dos Santos, Ana Carolina Buzzo Stefanini, Nelson Hamerschlak, Luciana Cavalheiro Marti
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Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections Cell. Immunol. (IF 4.3) Pub Date : 2023-12-07 Youssouf Sereme, Eya Toumi, Estelle Saifi, Helène Faury, David Skurnik
Newborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also
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Loss of B1 and marginal zone B cells during ovarian cancer Cell. Immunol. (IF 4.3) Pub Date : 2023-11-22 Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Recent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the
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Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies Cell. Immunol. (IF 4.3) Pub Date : 2023-11-11 Nafiseh Maghsoodi, Mohammadrasul Zareinejad, Ali Golestan, Elham Mahmoudi Maymand, Amin Ramezani
The administration of blinatumomab was accompanied by several adverse effects, including activation of regulatory T-cells and cytokine storm. The objective of this study was to produce and evaluate a novel αCD8/CD19 BiTE (αCD8/CD19) with the potency to directly target CD8+ T-cells. In-silico studies were utilized for determining proper folding, receptor binding, and structural stability of αCD8/CD19
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Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice Cell. Immunol. (IF 4.3) Pub Date : 2023-11-10 Naina Monga, Shikha Sharma, Ruchika Bhatia, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Amarjit S. Naura
Given the reported role of gut-microbiota in asthma pathogenesis, the present work was carried to evaluate immunomodulatory action of newly isolated lactic acid producing bacterial strains Bifidobacterium breve Bif11 and Lactiplantibacillus plantarum LAB31 against asthma using ovalbumin (OVA) based mouse model. Our results show that both strains modulate Th2 immune response potentially through production
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Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses” Cell. Immunol. (IF 4.3) Pub Date : 2023-11-10 Susan Murray
Abstract not available
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One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation Cell. Immunol. (IF 4.3) Pub Date : 2023-11-09 Lili Liu, Yateng Li, Yu Song, Zhen Sun, Wenjing Li, Bin Li, Yongjie Wang, Haibo Wang, Bin Wang
Antigenic peptides play a central role in immune surveillance in cancer, infectious disease, autoimmunity, and allergy. The identification and isolation of antigenic peptides for T cell immune response are crucial for successful personalized adoptive immune cell therapy. The mainly methods includes gene sequencing and bioinformatic analysis. The antigenic peptides which identified by analysis and artificially
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A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome Cell. Immunol. (IF 4.3) Pub Date : 2023-11-03 Fangfang Liang, Cheng Peng, Xianze Luo, Linlin Wang, Yanyan Huang, Le Yin, Luming Yue, Jun Yang, Xiaodong Zhao
Wiskott-Aldrich syndrome (WAS) is a disorder characterized by rare X-linked genetic immune deficiency with mutations in the Was gene, which is specifically expressed in hematopoietic cells. The spleen plays a major role in hematopoiesis and red blood cell clearance. However, to date, comprehensive analyses of the spleen in wild-type (WT) and WASp-deficient (WAS-KO) mice, especially at the transcriptome
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Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation Cell. Immunol. (IF 4.3) Pub Date : 2023-11-03 Rui Wang, Tao Zhang, Yuan Lu, Yalong Lin, Shuyuan Kou, Xuefeng Li, Yang Wang, Liangzhi Xie
Type I interferons (IFN), especially human IFN alpha (IFNα), have been utilized for antitumor therapy for decades. Human interferon beta (IFNβ) is rarely used for cancer treatment, despite advantages over IFNα in biological activities such as tumor growth inhibition and dendritic cell (DC) activation. The utilization of pegylated human IFNβ (PEG-IFNβ), as monotherapy or in combination with immune checkpoint
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Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance Cell. Immunol. (IF 4.3) Pub Date : 2023-11-02 Yu Zhang, Xuan Jiang, Qing Wang, Jiayi Wu, Juan Zhou
Pulmonary sarcoidosis is an immune-mediated disorder closely related to Th17/Treg cell imbalance. Dexamethasone has been shown to regulate inflammation and immune responses in sarcoidosis patients. However, the underlying mechanisms of dexamethasone regulating Th17/Treg balance in sarcoidosis remain elusive. Herein, we elucidated the function role of TGF-β/Smad3 signaling in pulmonary sarcoidosis development
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Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation Cell. Immunol. (IF 4.3) Pub Date : 2023-10-30 Brenal K. Singh, Yuichi Yokoyama, Yukinori Tanaka, Dorottya Laczkó, Deepak A. Deshpande, Taku Kambayashi
Allergic airway diseases are caused by inappropriate immune responses directed against inhaled environmental antigens. We previously reported that the inhibition of diacylglycerol (DAG) kinase ζ (DGKζ), an enzyme that terminates DAG-mediated signaling, protects against T cell-mediated allergic airway inflammation by blocking Th2 cell differentiation. In this study, we tested whether DGKζ deficiency
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Differential roles of regulatory T cells in Alzheimer's disease Cell. Immunol. (IF 4.3) Pub Date : 2023-10-29 Abdollah Jafarzadeh, Abdolkarim Sheikhi, Zahra Jafarzadeh, Maryam Nemati
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Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice Cell. Immunol. (IF 4.3) Pub Date : 2023-10-30 Hisashi Nagase, Masaya Takamoto, Nancy Noben-Trauth
Inflammatory bowel diseases are associated with dysregulated inflammatory immune responses in the gastrointestinal tract. We found that deficiencies of both IL-4 receptor alpha chain (IL-4Rα) and IL-10 in BALB/c mice (IL-4Rα × IL-10 KO mice) highly induced spontaneous rectal prolapse and diarrhea. These mice also exhibited severe colitis in their cecum and colon and marked elevation of serum proinflammatory
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Ro52/TRIM21 – From host defense to autoimmunity Cell. Immunol. (IF 4.3) Pub Date : 2023-10-15 Emilia Holwek, Aleksandra Opinc-Rosiak, Joanna Sarnik, Joanna Makowska
Ro52 (TRIM21) belongs to the ubiquitin ligase family. This protein plays a crucial role in many immunological processes, including antibody-dependent intracellular neutralization, synergy with the complement system, antiviral response, death mediation, oxidative stress response, and protein ubiquitination. Abnormal expression of TRIM21 can break immunological tolerance and lead to the production of
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Variability of vaccine responsiveness in early life Cell. Immunol. (IF 4.3) Pub Date : 2023-10-15 Michael E Pichichero
Vaccinations in early life elicit variable antibody and cellular immune responses, sometimes leaving fully vaccinated children unprotected against life-threatening infectious diseases. Specific immune cell populations and immune networks may have a critical period of development and calibration in a window of opportunity occurring during the first 100 days of early life. Among the early life determinants
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Ferroptosis in the post-transplantation inflammatory response Cell. Immunol. (IF 4.3) Pub Date : 2023-10-07 Yun Zhu Bai, Benjamin J. Kopecky, Kory J. Lavine, Daniel Kreisel
Transplantation is a life-saving therapy for patients with end-stage organ disease. Successful outcomes after transplantation require mitigation of the post-transplant inflammatory response, limiting alloreactivity, and prevention of organ rejection. Traditional immunosuppressive regimens aim to dampen the adaptive immune response; however, recent studies have shown the feasibility and efficacy of
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Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses Cell. Immunol. (IF 4.3) Pub Date : 2023-09-30 Jean Bourhis, Xu-Shan Sun, Yungan Tao
Abstract not available
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ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer Cell. Immunol. (IF 4.3) Pub Date : 2023-09-28 Xinyao Zhang, Haiqi Chen, Jiawen Han, Zongren Wang, Yu Guo, Zhongyang Zhou, Rong Luo, Meiqin Dai, Wei Ou, Lingwu Chen, Lan Shao
Immunotherapy for prostate cancer (PCa) faces serious challenges. Therefore, the co-inhibitory receptors that regulate T cell function of PCa must be elucidated. Here we identified that the inhibitory receptor LAG3 was significantly induced in T cells from PCa patients. Gene array analysis revealed that insufficient ataxia telangiectasia mutated (ATM) gene expression in PCa T cells was responsible
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Early-immune development in asthma: A review of the literature Cell. Immunol. (IF 4.3) Pub Date : 2023-09-28 Maria V. Medeleanu, Yu Chen Qian, Theo J. Moraes, Padmaja Subbarao
This review presents a comprehensive examination of the various factors contributing to the immunopathogenesis of asthma from the prenatal to preschool period. We focus on the contributions of genetic and environmental components as well as the role of the nasal and gut microbiome on immune development. Predisposing genetic factors, including inherited genes associated with increased susceptibility
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Interactions of mesenchymal stromal/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis Cell. Immunol. (IF 4.3) Pub Date : 2023-09-22 Sajad Dehnavi, Mahvash Sadeghi, Jalil Tavakol Afshari, Mojgan Mohammadi
Rheumatoid arthritis (RA) is considered to be a degenerative and progressive autoimmune disorder. Although several medicinal regimens are used to treat RA, potential adverse events such as metabolic disorders and increased risk of infection, as well as drug resistance in some patients, make it essential to find an effective and safe therapeutic approach. Mesenchymal stromal/stem cells (MSCs) are a
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Serum IgA augments adhesiveness of cultured lung microvascular endothelial cells and suppresses angiogenesis Cell. Immunol. (IF 4.3) Pub Date : 2023-09-16 Kazufumi Takada, Maho Suzukawa, Sayaka Igarashi, Yuuki Uehara, Shizuka Watanabe, Sahoko Imoto, Masaki Ishii, Yoshiteru Morio, Hirotoshi Matsui, Masahiro Akishita, Ken Ohta
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Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer Cell. Immunol. (IF 4.3) Pub Date : 2023-08-29 Aying Wang, Tangfeng Lv, Yong Song
Chimeric antigen receptor (CAR)-T cells encounter many issues when treating solid tumors, including tumor antigen heterogeneity and immunosuppression. United targeting of two tumor-associated antigens (TAAs) and blocking of PD-1 may solve this problem and enhance the function of CAR-T. Mucin 1 (MUC1) and prostate stem cell antigen (PSCA) are overexpressed in non-small cell lung cancer (NSCLC). Here
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Attenuated airways inflammation and remodeling in IL-37a and IL-37b transgenic mice with an ovalbumin-induced chronic asthma Cell. Immunol. (IF 4.3) Pub Date : 2023-08-29 Lele Cui, Xiaofeng Qin, Tingting Fu, Chenduo Li, Dan Wang, Yue Hu, Yan Li, Yan Chen, Ye Cui, Jingjing Wang, Huihui Yuan, Zhe Lv, Jie Liu, Damo Xu, Rongfei Wei, Sun Ying, Wei Wang
Background Asthma is a common chronic respiratory disease characterized by airways inflammation, hyperresponsiveness and remodeling. IL-37, an anti-inflammatory cytokine, consists of five splice isoforms, that is, a-e. Although it has been previously shown that recombinant human IL-37b is able to inhibit airway inflammation and hyperresponsiveness in animal models of asthma, the effects and difference
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PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival Cell. Immunol. (IF 4.3) Pub Date : 2023-08-22 Shalini Roy, Anand K Gupta, Madhurima Banerjee, Pijush K. Das, Anindita Ukil
The anti-inflammatory role of the programmed death-1 receptor (PD-1) is well appreciated. However, the mechanism of how PD-1 signaling inhibits the pro-inflammatory cytokine responses in macrophages, which is further exploited by Leishmania to foster their intracellular survival, was unknown. We found that among three major MAP kinases regulating immune activation, PD-1 signaling decreased only JNK
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A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia Cell. Immunol. (IF 4.3) Pub Date : 2023-08-20 Dongmei Xie, Zhihui Feng, Wen Yang, Yacan Wang, Renxia Li, Shiqi Zhang, Zeping Zhou
SIRPα is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on monocytes, dendritic cells, and macrophages. Studies recently showed that SIRPα is essential for priming of CD4 + T cells by DCs and for development of Th17 cell-mediated autoimmune diseases. We have now further evaluated the importance of SIRPα
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Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications Cell. Immunol. (IF 4.3) Pub Date : 2023-08-09 Eddie A. James
Abstract not available
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HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5neg/low phenotype of infiltrating cells in solid tumors Cell. Immunol. (IF 4.3) Pub Date : 2023-08-01 Smita Kumari, Srishti Sahu, Bharat Singh, Swarnima Gupta, Amit Kumar Kureel, Ankit Srivastava, Deeksha Rikhari, Sameer Srivastava, Ambak Kumar Rai
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Phloretin suppresses intestinal inflammation and maintained epithelial tight junction integrity by modulating cytokines secretion in in vitro model of gut inflammation Cell. Immunol. (IF 4.3) Pub Date : 2023-07-24 Smita Kapoor, Yogendra S. Padwad
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Haploinsufficiency of A20 caused by a novel pathogenic missense variant of TNFAIP3 and successfully treated with anti-TNF and immunosuppressive therapies Cell. Immunol. (IF 4.3) Pub Date : 2023-07-22 Sun Lina, Han Ya'nan, Yang Ying, Wang Fengfan, Hou Xin, Ren Xiaoxia, Fang Ying
Loss-of-function of protein A20, encoded by TNFAIP3, leads to an early-onset haploinsufficiency of A20 (HA20). This study reports one Chinese child with HA20 and explores the genetic etiology of TNFAIP3 variant. The patient exhibited transient recurrent episodes of fever, intermittent signs of arthritis, gastrointestinal symptoms and multiple colonic ulcers. Laboratory tests revealed elevated inflammatory
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Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition Cell. Immunol. (IF 4.3) Pub Date : 2023-07-22 Qoyama Noel Baito, Halmat M. Jaafar, Talar Ahmad Merza Mohammad
Rheumatoid Arthritis (RA) is a common autoimmune disease recognized by hyperplasia of synoviocytes and chronic joint inflammation. Activation of fibroblast-like synoviocytes (FLSs) is one of the main features of RA which can trigger inflammation leading to articular cartilage and joint destruction. Aberrant activation of NF-κB signaling cascade was found to be responsible for the high proliferation
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The effects of age, origin, and biological sex on rodent mast cell (BMMC and MC/9) and basophil (RBL-2H3) phenotype and function Cell. Immunol. (IF 4.3) Pub Date : 2023-07-14 Ashley Wagner, Syed Benazir Alam, M. Kulka
Mast cells initiate allergic inflammatory immune responses and play a role in disease by releasing various inflammatory and immunomodulatory mediators. Several mast cell-lines and primary cultured cells have been used as mast cell models with inconsistent results among research groups. Bone marrow-derived mast cells (BMMC) cultured from mouse bone marrow progenitor cells are often used as a representative
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Crosstalk between peripheral immunity and central nervous system in Alzheimer’s disease Cell. Immunol. (IF 4.3) Pub Date : 2023-07-08 Hanchen Yang, Qi Qin, Meng Wang, Yunsi Yin, Ruiyang Li, Yi Tang
The significance of peripheral immunity in the pathogenesis and progression of Alzheimer’s diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood–brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central
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Potential role for oral tolerance in gene therapy Cell. Immunol. (IF 4.3) Pub Date : 2023-06-28 John S.S. Butterfield, Xin Li, Sreevani Arisa, Kwang-Chul Kwon, Henry Daniell, Roland W. Herzog
Oral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic
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Interleukin-17 receptor C is essential for the pro-inflammatory pathogenicity of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in experimental autoimmune uveitis Cell. Immunol. (IF 4.3) Pub Date : 2023-06-15 Lina Wu, Lu Wang, Xin Chai
Autoimmune uveitis is an inflammatory disorder of the eye triggered by the responses of autoreactive T cells to ocular autoantigens. This study aims to understand the role of granulocyte–macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in the pathophysiology of mouse experimental autoimmune uveitis (EAU). We established an EAU model by immunizing mice with interphotoreceptor
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Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring Cell. Immunol. (IF 4.3) Pub Date : 2023-06-20 Anjali S. Yennemadi, Gráinne Jameson, Mary Glass, Carolina De Pasquale, Joseph Keane, Massimiliano Bianchi, Gina Leisching
Although clinically effective, the actions of IFNα, either produced endogenously or by therapeutic delivery, remain poorly understood. Emblematic of this research gap is the disparate array of notable side effects that occur in susceptible individuals, such as neuropsychiatric consequences, autoimmune phenomena, and infectious complications. We hypothesised that these complications are driven at least
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Functional responsiveness of in vitro-aged human neutrophils Cell. Immunol. (IF 4.3) Pub Date : 2023-06-09 J. Morin-Genest, A. Saafane, D. Girard
Elimination of apoptotic neutrophils by macrophages is as a major step for the resolution of inflammation. However, the fate and the cellular functionality of neutrophils aged in the absence of macrophages are not well documented. Herein, freshly isolated human neutrophils were aged for several days in vitro and then stimulated with agonists for determining their cell responsiveness. In vitro-aged
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CD300f signalling induces inhibitory human monocytes/macrophages Cell. Immunol. (IF 4.3) Pub Date : 2023-06-02 Sarah I.M. Sutherland, Xinsheng Ju, Pablo A. Silveira, Fiona Kupresanin, Lisa G. Horvath, Georgina J. Clark
The CD300 glycoproteins are a family of related leucocyte surface molecules that regulate the immune response via their paired triggering and inhibitory receptors. Here we studied CD300f, an apoptotic cell receptor, and how it modulates the function of human monocytes and macrophages. We showed that CD300f signalling by crosslinking with anti-CD300f mAb (DCR-2) suppressed monocytes causing upregulation
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Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9 Cell. Immunol. (IF 4.3) Pub Date : 2023-05-16 Yuanyuan Fu, Panpan Zheng, Xiao Zheng, Lujun Chen, Caixia Kong, Wenzhi Liu, Shuping Li, Jingting Jiang
HHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we aimed to determine whether downregulation of HHLA2 inhibited malignant phenotypes of human OC cells and explore its specific mechanism. Our results revealed that downregulation
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Autoimmune susceptible HLA class II motifs facilitate the presentation of modified neoepitopes to potentially autoreactive T cells Cell. Immunol. (IF 4.3) Pub Date : 2023-05-16 Antonis K. Moustakas, Hai Nguyen, Eddie A. James, George K. Papadopoulos
Rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1D), and celiac disease (CD), are strongly associated with susceptible HLA class II haplotypes. The peptide-binding pockets of these molecules are polymorphic, thus each HLA class II protein presents a distinct set of peptides to CD4+ T cells. Peptide diversity is increased through post-translational modifications, generating non-templated
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Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells Cell. Immunol. (IF 4.3) Pub Date : 2023-05-12 Yuanyuan Ding, Baowen Dang, Yonghui Zhang, Shiting Hu, Yuejin Wang, Chenrui Zhao, Tao Zhang, Zijun Gao
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Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation Cell. Immunol. (IF 4.3) Pub Date : 2023-04-26 Simone Dertschnig, Jakob Passweg, Christoph Bucher, Michael Medinger, Alexandar Tzankov
Graft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator
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IFN-β activates cytotoxic function of human natural killer cells toward IL-27 and poly(I:C) stimulated PC3 and DU145 cells Cell. Immunol. (IF 4.3) Pub Date : 2023-04-08 Olena Kourko, Lindsey G. Hawke, Mark L. Ormiston, Katrina Gee
Natural killer (NK) cell phenotype and function are altered in patients with prostate cancer, and increased NK cell activity is associated with a better prognosis in patients with disease. For patients with advanced stage prostate cancer, immunotherapies are a promising approach when standard treatment options have been exhausted. With the rapid emergence of NK cell-based therapies, it is important
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Aberrant pro-inflammatory responses of CD20+ T cells in experimental arthritis Cell. Immunol. (IF 4.3) Pub Date : 2023-04-06 Piaopiao Pan, Miguel A. Pineda, Yilin Wang, Aneesah Khan, Mukanthu H. Nyirenda
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Analysis of the different subpeptidomes presented by the HLA class I molecules of the B7 supertype Cell. Immunol. (IF 4.3) Pub Date : 2023-03-13 Adrián Tirado-Herranz, Pablo Guasp, Alba Pastor-Moreno, María Area-Navarro, Iñaki Alvarez
MHC-I molecules of the HLA-B7 supertype preferentially bind peptides with proline at position 2. HLA-B*51:01 and B*51:08 present two predominant subpeptidomes, one with Pro2 and hydrophobic residues at P1, and another with Ala2 and Asp enriched at position 1. Here, we present a meta-analysis of the peptidomes presented by molecules of the B7 supertype to investigate the presence of subpeptidomes across