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Multi-elemental composition of botanical preparations and probabilistic evaluation of toxic metals and metalloids intake upon dietary exposure Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 Maria Olga Varrà, Lenka Husáková, Giovanni Tommaso Lanza, Martina Piroutková, Jan Patočka, Sergio Ghidini, Emanuela Zanardi
The aim of this study was to evaluate the inorganic elemental composition (49 elements) of 29 botanical preparations obtained from fruits, leaves, peels, seeds, roots, fungi, and spirulina by using inductively coupled-mass spectrometry and a mercury analyzer. Simultaneously, the risk associated with the chronic dietary exposure to 12 toxic metals and metalloids among the European population was evaluated
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Update to RIFM fragrance ingredient safety assessment, 4-ethyloctanoic acid, CAS registry number 16493-80-4 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, 2-methylhexanoic acid, CAS registry number 4536-23-6 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, 2-methylheptanoic acid, CAS registry number 1188-02-9 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, butyl 2-methylvalerate, CAS Registry Number 6297-41-2 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, N,N-diethyloctamide, CAS registry number 996-97-4 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-15 Dunja Kokai, Jelena Markovic Filipovic, Marija Opacic, Ivana Ivelja, Vojislav Banjac, Bojana Stanic, Nebojsa Andric
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Public views of animal testing and alternatives in chemical risk assessment Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-13 Angela Bearth, Lisa Wiesner, Michael Siegrist
Next-Generation Risk Assessment (NGRA) aims to implement New Approach Methodologies (NAMs) into risk assessment and to rely on new testing in animals only as a last resort. However, various technical and regulatory hurdles impede their regulatory implementation. Assumptions about the public's expectations could act as barriers to the acceptance of NAMs. This study aimed at investigating public views
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Testicular dysfunction and “its recovery effect” after cadmium exposure Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-12 Qi Zhang, YanLing Yang, Juan Liu, YuJiao Wu, Yi Liu, Jing Zhang
In recent years, with the acceleration of industrialization, the decline of male fertility caused by heavy metal pollution has attracted much attention. However, whether the inhibition of testicular function after cadmium exposure is reversible remains to be studied. In this study, we constructed rat models of cadmium exposure and dis-exposure, and collected relative samples to observe the changes
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New insight into mycotoxins and bacterial toxins: Toxicity assessment, molecular mechanism and food safety (preface to the special issue of food and chemical toxicology on the outcomes of Myco & bacterial toxin) Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-11 Tong Nie, Qinghua Wu, Miao Long, Wenda Wu, Kamil Kuca
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Risk assessment of feed components of botanical origin – Approaches taken in the European Union Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-10 Birgit Dusemund, Gabriele Aquilina, Maria de Lourdes Bastos, Francesca Marcon, Fabiola Pizzo, Ruud Woutersen, Paola Manini
In view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of
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Deoxynivalenol leads to endoplasmic reticulum stress-mediated apoptosis via the IRE1/JNK/CHOP pathways in porcine embryos Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-10 Ye-Won Kim, Seul-Gi Yang, Byoung-Boo Seo, Deog-Bon Koo, Hyo-Jin Park
The cytotoxic mycotoxin deoxynivalenol (DON) reportedly has adverse effects on oocyte maturation and embryonic development in pigs. Recently, the interplay between cell apoptosis and endoplasmic reticulum (ER) stress has garnered increasing attention in embryogenesis. However, the involvement of the inositol-requiring enzyme 1 (IRE1)/c-jun N-terminal kinase (JNK)/C/EBP homologous protein (CHOP) pathways
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RIFM fragrance ingredient safety assessment, benzonitrile, 3,4-dimethyl-, CAS Registry Number 22884-95-3 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-10 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, phenethyl salicylate, CAS Registry Number 87-22-9 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-10 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-10 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, 3,6-nonadien-1-ol, CAS Registry Number 76649-25-7 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Simultaneous detection of mycotoxins and pesticides in human urine samples: A 24-h diet intervention study comparing conventional and organic diets in Spain Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 Jose A. Gallardo-Ramos, Jesús Marín-Sáez, Vicente Sanchis, Laura Gámiz-Gracia, Ana M. García-Campaña, Maykel Hernández-Mesa, German Cano-Sancho
Pesticides and mycotoxins, prominent chemical hazards in the food chain, are commonly found in plant-based foods, contributing to their pervasive presence in the human body, as evidenced by biomonitoring programs. Despite this, there is limited knowledge about their co-occurrence patterns. While intervention studies have demonstrated that organic diets can significantly reduce pesticide levels, their
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Volatile N-nitrosamines in processed meat products: An approach for monitoring dietary exposure, assessing human risk, and evaluating variable correlations by principal component analysis and heat map Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 Samaneh Nabizadeh, Keyvan Aeini, Fatemeh Barzegar, Majid Arabameri, Hedayat Hosseini, Marzieh Kamankesh, Abdorreza Mohammadi
Several epidemiological studies have reported a positive association between the consumption of processed meats containing N-nitrosamines (NAs) and the incidence of hepatocellular and colon cancer. The health risk assessment in this investigation was based on the concentration of six volatile N-nitrosamines (VNAs) (N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosomethylethylamine, N-nitrosopiperidine
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Corrigendum to “Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway” [Food and Chemical Toxicology 184 (2024) 114386] Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 Hagar M. Shendy, Sarah S. Mohamed, Enas A. Abd El-Haleim, Omneya Galal, Walaa Wadie, Amr Helal, Mohamed T. Khayyal
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RIFM fragrance ingredient safety assessment, ethyl 2-methylpentanoate, CAS Registry Number 39255-32-8 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, ethyl 3,5,5-trimethylhexanoate, CAS Registry Number 67707-75-9 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS registry number 78-37-5 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Determination of the effect of sunset yellow on the morphological parameters of male mice during the development period Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-08 Erhan Şensoy, Eda Güneş
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Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-06 Seul Gi Kim, Jeong Hoon Jeon, Seung Hee Shin, Daniel Chavez Varias, Sung-Hwan Moon, Buom-Yong Ryu
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Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-06 Xuemin Zhang, Zhi Li, Mingqing Qian, Bingya Zhang, Hongxia Zhang, Li Wang, Hui Liu
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Investigating the individual and mixture cytotoxicity of co-occurring aflatoxin B1, enniatin B, and sterigmatocystin on gastric, intestinal, hepatic, and renal cellular models Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-05 Soraia V.M. de Sá, Miguel A. Faria, José O. Fernandes, Sara C. Cunha
This study investigates the individual and combined effects of the mycotoxins, Aflatoxin B1 (AFB1), Enniatin B (ENNB) and Sterigmatocystin (STG), on the cellular viability of gastric (NCI–N87), intestinal (Caco-2), hepatic (Hep-G2) and renal (Hek-293) cells, shedding light on synergistic or antagonistic effects using a constant ratio combination design proposed by Chou-Talalay. These toxins are prevalent
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Potential impact of underlying diseases influencing ADME in nonclinical safety assessment Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Sumin Cho, Harin Jo, Yeon Jeong Hwang, Changuk Kim, Yong Hyeon Jo, Jun-Won Yun
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Update to RIFM fragrance ingredient safety assessment, 4-methyloctanoic acid, CAS Registry Number 54947-74-9 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Advancing the allergenicity assessment of new proteins using a text mining resource Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Jorge Novoa, Antonio Fernandez-Dumont, E.N. Clare Mills, F. Javier Moreno, Florencio Pazos
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Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF-κB/NLRP3/GSDMD signaling pathways Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Abduallah Nasser Mansoure, Mahmoud Elshal, Manar G. Helal
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The relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Hayrunnisa Yeşil Sarsmaz, Seren Gülşen Gürgen, Ali Cansu, Süha Türkmen, Abdülkadir Gündüz
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Arsenic aggravates the progression of diabetic nephropathy through miRNA-mRNA-autophagy axis Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Xiaodan Zhang, Sira Jackson, Jianhao Liu, Jinyu Li, Zhihan Yang, Dianjun Sun, Wei Zhang
Environmental factors play an important role in the progression of diabetic nephropathy (DN), and previous study has shown that arsenic exposure can promote kidney damage in DN rats, however there is no relevant mechanism study so far. In this study, an arsenic-exposed (10 mg/L and 25 mg/L) DN mouse model was established through drinking water for 14 weeks. The results showed that 25 mg/L arsenic exposure
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Per- and polyfluoroalkyls used as cosmetic ingredients - Qualitative study of 765 cosmetic products Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-04 Couteau Céline, Brunet Catherine, Clarke Romane, Coiffard Laurence
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Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-04-01 Sixin Chen, Jiajie Ni, Li Luo, Jinxian Lin, Hongjie Peng, Feihai Shen, Zhiying Huang
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Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-31 Yajie Chu, Qiao Li, Yijing He, Heran Li, Qijia Wang, Shurui Li, Jianuo Wang, Weihan Wang, Shiqiang Ju
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Gut-gonad crosstalk in mice exposed to a “chemical cocktail” combining metabolomics and microbial profile by amplicon sequencing Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-30 C. Parra-Martínez, M. Selma-Royo, B. Callejón-Leblic, M.C. Collado, N. Abril, T. García-Barrera
Testes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of “chemical cocktails” (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented
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Update to RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-29 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-29 Edward J. Calabrese, Peter Pressman, A. Wallace Hayes, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Vittorio Calabrese
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Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-29 Doyoung Kwon, Hyeji Seo, Sou Hyun Kim, Ki Wung Chung, Jaewon Lee, Young-Suk Jung
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In vivo tebuconazole administration impairs heart electrical function and facilitates the occurrence of dobutamine-induced arrhythmias: involvement of reactive oxygen species Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-29 Jorge Lucas Teixeira-Fonseca, Diego Santos Souza, Michael Ramon de Lima Conceição, Leisiane Pereira Marques, Aimée Obolari Durço, Polyana Leal da Silva, Julliane V. Joviano-Santos, Artur Santos-Miranda, Danilo Roman-Campos
Tebuconazole (TEB), a widely used pesticide in agriculture to combat fungal infections, is commonly detected in global food, potable water, groundwater, and human urine samples. Despite its known toxicity, its impact on heart function remains unclear. In a 28-day study on male Wistar rats (approximately 100 g), administering 10 mg/kg/day TEB or a vehicle (control) revealed no effect on body weight
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Attenuated neuronal differentiation caused by acrylamide is not related to oxidative stress in differentiated human neuroblastoma SH-SY5Y cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-28 Ylva Johansson, Mathilda Andreassen, Muriel Hartsch, Stella Wagner, Anna Forsby
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Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-28 Abhishek Pathak, Satya Pal Singh, Apoorv Tiwari
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Update to RIFM fragrance ingredient safety assessment, 2-methylvaleric acid, CAS Registry Number 97-61-0 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-27 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Corrigendum to “Necroptosis and NLPR3 inflammasome activation mediated by ROS/JNK pathway participate in AlCl3-induced kidney damage” [Food Chem. Toxicol. 178 (2023) 113915] Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-27 Jiayu Du, Xuliang Zhang, Jian Zhang, Siming Huo, Bo Li, Qi Wang, Miao Song, Bing Shao, Yanfei Li
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The food additive xylitol enhances the butyrate formation by the child gut microbiota developed in a dynamic colonic simulator Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-25 Alicia Bellanco, Špela Celcar, M. Carmen Martínez-Cuesta, Teresa Requena
The gut microbiota should be included in the scientific processes of risk assessment of food additives. Xylitol is a sweetener that shows low digestibility and intestinal absorption, implying that a high proportion of consumed xylitol could reach the colonic microbiota. The present study has evaluated the dose-dependent effects of xylitol intake on the composition and the metabolic activity of the
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Kidney toxicity and transcriptome analyses of male ICR mice acutely exposed to the mushroom toxin α-amanitin Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-24 Zhijun Wu, Haijiao Li, Wenjin Zhao, Min Zheng, Juan Cheng, Zhengjie Cao, Chengye Sun
Amatoxins are responsible for most fatal mushroom poisoning cases, as it causes both hepatotoxicity and nephrotoxicity. However, studies on amatoxin nephrotoxicity are limited. Here, we investigated nephrotoxicity over 4 days and nephrotoxicity/hepatotoxicity over 14 days in mice. The organ weight ratio, serological indices, and tissue histology results indicated that a nephrotoxicity mouse model was
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Update to RIFM fragrance ingredient safety assessment, 3-methylpentanoic acid, CAS registry number 105-43-1 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-24 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, 4-methylnonanoic acid, CAS Registry Number 45019-28-1 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-22 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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DEHP induces apoptosis and autophagy of the thyroid via Rap1 signaling pathway: In vivo and in vitro study Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-22 Xu Li, Honghao Qian, Hui Ye, Haotang Zhao, Jianwei Cui, Xiaoqi Fang, Zhili Ge, Jingjing Shi, Wen Qi, Lin Ye
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Sub-acute administration of metal-organic Framework-5 induces behavioral impairments and augments the levels of oxidative stress and inflammation in the brain of rats Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-22 Fatemeh Naghdi Babaei, Moein Shirzad, Maryam Ghasemi-Kasman, Sara Ghadir, Nima Hasaniani, Shahram Ghasemi, Danial Amiri Manjili
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A framework for the systematic evaluation of a novel cigarette filter technology Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-20 Ian Crooks, David Thorne, Mark West, Krishna Prasad, Adam Gray, Casandra West, Peter Wan, Richard Savory, Ignacio Suarez, Carolina Garcia-Canton
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Update to RIFM fragrance ingredient safety assessment, 2-ethylbutyric acid, CAS Registry Number 88-09-5 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-19 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Maternal exposure to ZIF-8 derails placental function by inducing trophoblast pyroptosis through neutrophils activation in mice Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-18 Yu Jiang, Yanqing Geng, Rufei Gao, Zhuxiu Chen, Jun Chen, Xinyi Mu, Yan Zhang, Xin Yin, Xuemei Chen, Fangfang Li, Junlin He
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RIFM fragrance ingredient safety assessment, cis- and trans-p-1(7),8-menthadien-2-yl acetate, CAS registry number 71660-03-2 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-16 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Survey of arsenic content in edible seaweeds and their health risk assessment Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-16 Yanli Yu, Alba Morales-Rodriguez, Guangming Zhou, Dolores Barrón, Àngels Sahuquillo, José Fermín López-Sánchez
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Simulated pharmacokinetics of inhaled caffeine and melatonin from existing products indicate the lack of dosimetric considerations Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Aditya R. Kolli, Arkadiusz K. Kuczaj, Florian Calvino-Martin, Julia Hoeng
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RIFM fragrance ingredient safety assessment, diethyldimethylcyclohex-2-en-1-one, CAS Registry Number 68845-36-3 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Assessing the health risks of heavy metals and seasonal minerals fluctuations in Camellia sinensis cultivars during their growth seasons Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Fawad Zaman, Wajid Ali Khattak, Muhammad Ihtisham, Muhammad Ilyas, Ahmad Ali, Abbas Ali, Haroon Khan, Khalid Ali Khan, Dejiang Ni, Hua Zhao, Fu-Sheng Chen
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Characterizing the risk related to the exposure to methylmercury over a lifetime: A global approach using population internal exposure Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Thomas Gastellu, Anna Mondou, Marie Bellouard, Jean-Claude Alvarez, Bruno Le Bizec, Gilles Rivière
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Strategy proposal using QSAR models to approach mutagenicity assessment of non intentionally added substances in recycled plastic resins Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Ishan Djelassi, Pauline Lancia, Isabelle Thuillier, José Ginestar, Elena Fioravanzo, Aurélie Baleydier
Transition to the use of recycled plastics raises an issue concerning safety assessment of Non Intentionally Added Substances (NIAS). To assess the mutagenic potential of the recycled polyethylene impurities and to evaluate the need to perform assays on recycled resins, this study lies in identifying existing NIAS associated with recycled Low/High Density Polyethylene and assessing the mutagenicity