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In vitro protein digestibility of RuBisCO-enriched wheat dough: a comparative study with pea and gluten proteins Food Funct. (IF 6.1) Pub Date : 2024-04-22 Maude Ducrocq, Adeline Boire, Claire Bourlieu-Lacanal, Cécile Barron, Agnieszka Nawrocka, Marie-Hélène Morel, Marc Anton, Valerie Micard
Growing demand for sustainable, plant-based protein sources has stimulated interest in new ingredients for food enrichment. This study investigates the nutritional and digestive implications of enriching wheat dough with RuBisCO, in comparison to pea protein-enriched and gluten-enriched doughs. Wheat doughs were enriched with 10% of extrinsic proteins and thermally treated. The protein quality and
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Correction: Therapeutic effects of a walnut-derived peptide on NLRP3 inflammasome activation, synaptic plasticity, and cognitive dysfunction in T2DM mice Food Funct. (IF 6.1) Pub Date : 2024-04-22 Yanru Li, Qiao Dang, Yue Shen, Linxin Guo, Chunlei Liu, Dan Wu, Li Fang, Yue Leng, Weihong Min
Correction for ‘Therapeutic effects of a walnut-derived peptide on NLRP3 inflammasome activation, synaptic plasticity, and cognitive dysfunction in T2DM mice’ by Yanru Li et al., Food Funct., 2024, 15, 2295–2313, https://doi.org/10.1039/D3FO05076A.
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Inulin mitigated antibiotic-induced intestinal microbiota dysbiosis – a comparison of different supplementation stages Food Funct. (IF 6.1) Pub Date : 2024-04-22 Ran An, Xilong Zhou, Penglin He, Chenang Lyu, Dapeng Wang
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The Protective Role of Water Intake in Age-Related Eye Diseases: Insights from a Mendelian Randomization Study Food Funct. (IF 6.1) Pub Date : 2024-04-22 yuze Mi, qinnan zhu, Xinni Zheng, Minghui Wan
Age-related eye diseases (AREDs), including age-related cataracts (ARCs), age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are a leading cause of visual loss globally. This study aimed to explore the effects of dietary water intake on AREDs using Mendelian randomization. In the European population, genome-wide association study (GWAS) summary statistics of water intake
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Understanding the mechanism of high viscosity food delaying gastric emptying Food Funct. (IF 6.1) Pub Date : 2024-04-19 Weilin Liu, Weiping Jin, Peter J. Wilde, Yangyi Jin, Yujie Pan, Jianzhong Han
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Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state Food Funct. (IF 6.1) Pub Date : 2024-04-19 Lianghua Xie, Xin Hao, Jiahong Xie, Jianling Mo, changzheng yuan, Wei Chen
Nonalcoholic fatty liver disease (NAFLD) is a worldwide public health issue, but a widely accepted therapy is still lacking until now. Anthocyanins are natural flavonoid compounds that possess various bioactivities, but their applications are limited due to their low bioavailability and stability. Acylated anthocyanins are reported to show higher stability, whereas their effects on NAFLD are still
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Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation Food Funct. (IF 6.1) Pub Date : 2024-04-16 Pengfei Zhao, Xiran Meng, Mo Sun, Bingqing Qin, Shuaiwen Kong, Lixia Xie, Wei Zhang, Xudong Ding, Chenning Zhang
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Concentration and composition of odd-chain fatty acids in phospholipids and triacylglycerols in Chinese human milk throughout lactation Food Funct. (IF 6.1) Pub Date : 2024-04-18 Xiao-Yan Chen, Meng-Tao Yang, Si-Yu Huang, Ying-Zhen Qiu, Wei Wei, Chen-Yu Jiang, Shuang Song, Hui-Lian Zhu, Qiu-Ye Lan
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Exploring peptidome of by-products generated during Chhurpi production using Lactobacillus delbrueckii WS4 for identification of novel bioactive peptides Food Funct. (IF 6.1) Pub Date : 2024-04-18 Rounak Chourasia, Gayatri Dabrha, Md Minhajul Abedin, Loreni C Phukon, Ashish Kumar Singh, D. Sahoo, Sudhir Singh, Amit Kumar Rai
The considerable value of whey is evident in its significant potential applications and contributions to the functional foods and nutraceutical market. The by-product was obtained during functional chhurpi and novel soy chhurpi cheese production using defined lactic acid bacterial strains of Sikkim Himalaya’s traditional chhurpi. Hydrolysis of substrate proteins by starter proteinases resulted in a
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Omics-based approaches for discovering active ingredients and regulating gut microbiota of Actinidia arguta exosome-like nanoparticles Food Funct. (IF 6.1) Pub Date : 2024-04-18 Chunping Chen, Guangjun Xia, Song Zhang, Yuxin Tian, Yuchen Wang, Duanduan Zhao, Hongyan Xu
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Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea Food Funct. (IF 6.1) Pub Date : 2024-04-17 Siyu Du, Xin Chen, Rumeng Ren, Li Li, Baohui Zhang, Qi Wang, Yan Meng, Zhenpeng Qiu, Guihong Wang, Guohua Zheng, Junjie Hu
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Both live and heat killed Lactiplantibacillus plantarum DPUL-F232 alleviate whey protein-induced food allergy by regulating cellular immunity and repairing intestinal barrier Food Funct. (IF 6.1) Pub Date : 2024-04-17 Lu Feng, Gang Liang Chen, Zihao Guo, Wenpu Yao, Xinling Li, Guangqing Mu, Xuemei Zhu
Postbiotics have been proposed as clinically viable alternatives to probiotics, addressing limitation and safety concerns associated with probiotic use. However, direct comparisons between the functional differences and health benefits of probiotics and postbiotics remain scarce. This study compared directly the desensitization effect of probiotics and postbiotics derived from Lactiplantibacillus plantarum
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Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry Food Funct. (IF 6.1) Pub Date : 2024-04-17 Shumeng Hu, Runan Zhao, Xuesong Chi, Tao Chen, Yangjing Li, Yu Xu, Beiwei Zhu, Jiangning Hu
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Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice Food Funct. (IF 6.1) Pub Date : 2024-04-17 Lili Chen, Li Zhao, Gaowei Zhang, Zhuozhen Li, Liangliang Qu, Liping Luo
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Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension Food Funct. (IF 6.1) Pub Date : 2024-04-17 Yiming Song, Danyang Liu, Jiayan Xie, Jianhua Xie, Yi Chen, Xinyi Chen, Xiaobo Hu, Qiang Yu
In this study, it was found that epigallocatechin-3-gallate (EGCG) could extend the lifespan of Caenorhabditis elegans (C. elegans) induced by 100 μM acrolein (ACR) at all test concentrations (300, 400, 500, 600, and 700 μM). Notably, 500 μM EGCG exhibited the most significant mean lifespan extension, increasing it by approximately 32.5%. Furthermore, 500 μM EGCG effectively reduced elevated levels
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Ginsenoside Rk1 improves endothelial function in diabetes through activating peroxisome proliferator-activated receptors Food Funct. (IF 6.1) Pub Date : 2024-04-17 Lingchao Miao, Yan Zhou, Dechao Tan, Chunxiu Zhou, Cheng-Chao Ruan, Shengpeng Wang, Yitao Wang, Chi Teng Vong, Wai San Cheang
Ginsenoside Rk1, one kind of ginsenosides, is a minor ginsenoside found in Panax Ginseng and used as traditional Chinese medicine for centuries. It exhibits anti-tumor and anti-aggregation effects. However, little research has been done about its effect on endothelial function. This study investigated whether ginsenoside Rk1 improved endothelial dysfunction in diabetes and the underlying mechanisms
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Milk-derived Lactobacillus with high production of short-chain fatty acids relieves antibiotic-induced diarrhea in mice Food Funct. (IF 6.1) Pub Date : 2024-04-16 Baofeng Xu, Zengbo Wang, Yuqi Wang, Kangyong Zhang, Jian Li, Linyi Zhou, Bailiang Li
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Correction: Nutrikinetics and urinary excretion of phenolic compounds after a 16-week supplementation with a flavanone-rich ingredient Food Funct. (IF 6.1) Pub Date : 2024-04-16 Jananee Muralidharan, Cindy Romain, Letizia Bresciani, Pedro Mena, Donato Angelino, Daniele Del Rio, Linda H. Chung, Pedro E. Alcaraz, Julien Cases
Correction for ‘Nutrikinetics and urinary excretion of phenolic compounds after a 16-week supplementation with a flavanone-rich ingredient’ by Jananee Muralidharan et al., Food Funct., 2023, 14, 10506–10519, https://doi.org/10.1039/D3FO02820H.
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Extrusion and chlorogenic acid treatment increase the ordered structure and resistant starch levels in rice starch with amelioration of gut lipid metabolism in obese rats Food Funct. (IF 6.1) Pub Date : 2024-04-16 Xixi Zeng, Ling Chen, Bo Zheng
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Different types of dairy products intake, genetic predisposition, and the risks of nonalcoholic fatty liver disease and cirrhosis: A prospective cohort study Food Funct. (IF 6.1) Pub Date : 2024-04-15 Hanzhang Wu, Shiwen li, Liangkai Chen, Yang Xia, Xiao Tan
Background: The associations of dairy products consumption with nonalcoholic fatty liver disease (NAFLD) and cirrhosis remain controversial. This study aimed to prospectively investigate the associations between different types of dairy products consumption, genetic predisposition, and the risks of NAFLD and cirrhosis. Methods: This cohort study included 190,145 participants from the UK Biobank Study
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Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway Food Funct. (IF 6.1) Pub Date : 2024-04-15 Fenglin Zhang, Yiming Fu, Junfeng Wang, Limin Lang, Shuyi Liang, Shilei Zhang, Lina Wang, Ping Gao, Gang Shu, Canjun Zhu, Ruifan Wu, Qingyan Jiang, Songbo Wang
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Physiologic effects of the maqui berry (Aristotelia chilensis): a focus on metabolic homeostasis Food Funct. (IF 6.1) Pub Date : 2024-04-10 Alexandre Martchenko, Alexandra Papaelias, Steffen-Sebastian Bolz
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The dairy-derived peptide Miltin exerts anti-obesity effects by increasing adipocyte thermogenesis Food Funct. (IF 6.1) Pub Date : 2024-04-12 Hong Zhong, Xiaoxiao Zhang, Yangyang Wu, Lu Li, Zhuo Zhang, Xia Chi, Xianwei Cui, Chenbo Ji
Growing research has highlighted that dairy consumption provides metabolic health status in obese indiciduals by functioning as regulatory molecules. However, the molecular basis in dairy remains largely unknown. Here, we report a dairy-derived peptide that activates the thermogenesis of brown adipocytes and increases white adipocytes browning, which we named Miltin. Previously, Miltin was merely identified
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Colon-available Mango (Poly)phenols Exhibit Mitigating Effects on the Intestinal Barrier Function in Human Intestinal Cell Monolayers Under Inflammatory Conditions Food Funct. (IF 6.1) Pub Date : 2024-04-12 Gema Pereira Caro, Salud Cáceres-Jiménez, Alicia Moreno-Ortega, Sara Dobani, Kirsty Pourshahidi, Chris Gill, Pedro Mena, Daniele Del Rio, José M. Moreno-Rojas, Giuseppe Taurino, Ovidio Bussolati, Tahani Mazyad Almutairi, Alan Crozier, Massimiliano G. Bianchi
This study investigated the impact of in vivo available colon-mango (poly)phenols on stress-induced impairment of intestinal barrier function. Caco-2/HT29-MTX cells were incubated with extracts of ileal fluid collected pre- and 4-8 h post- mango consumption before being subjected to inflammatory stress. (Poly)phenols in ileal fluids were analysed by UHPLC-HR-MS. Epithelial barrier function was monitored
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Effect of L-arabinose and lactulose combined with Lactobacillus plantarum on obesity induced by high-fat-diet in mice Food Funct. (IF 6.1) Pub Date : 2024-04-12 Qiong Wang, Jialu Xiong, Yalun He, Juncheng He, Miaomiao Cai, Zexian Luo, Tongcun Zhang, Xiang Zhou
L-arabinose, lactulose, and Lactobacillus plantarum (L. plantarum) have been reported to have glucolipid-lowering effects. Here, the effects of L-arabinose and lactulose combined with L. plantarum on obesity traits were investigated. According to the experimental results, the combination of L-arabinose, lactulose, and L. plantarum was more effective in reducing body weight, regulating glucolipid metabolism
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Medicinal and edible polysaccharides from ancient plants: extraction, isolation, purification, structure, biological activity and market trends of sea buckthorn polysaccharides Food Funct. (IF 6.1) Pub Date : 2024-04-12 Xinmei Xu, Xianfeng Liu, Shufu Yu, Ting Wang, Rui Li, Yi Zhang, Yue Liu
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Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway Food Funct. (IF 6.1) Pub Date : 2024-04-11 Luying Zhao, Xiangting Zhang, Zhuofeng Chen, Yuning Lai, Jun Xu, Ruoru Zhou, Peipei Ma, Weimin Cai, Yuan Zeng, Xiao Wu, Huiya Ying, Fujun Yu
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Eicosapentaenoic acid activates P62/KEAP/NRF2 pathway in the prevention of diabetes-associated cognitive dysfunction Food Funct. (IF 6.1) Pub Date : 2024-04-11 Ao Tian, Yan Zheng, Hui Li, Zhiyue Zhang, Lei Du, Xiaoli Huang, Lei Sun, Hao Wu
Diabetes-associated cognitive dysfunction (DCD) is a severe complication of diabetes mellitus (DM), threatening life quality of the diabetic population. However, there still lacks effective approaches for its intervention. Eicosapentaenoic acid (EPA) is an omega-3 poly unsaturated fatty acid that was not previously investigated for its effect on DCD. In this study, EPA was found to improve DCD in a
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Taurocholic acid ameliorates hypertension through activation of TGR5 in hypothalamic paraventricular nucleus Food Funct. (IF 6.1) Pub Date : 2024-04-11 Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu
Diets rich in taurine can increase the production of taurine-conjugated bile acids, which are known to exert antihypertensive effects. But despite their benefits to the heart, kidney and arteries, their role in the central nervous system during the antihypertensive process remains unclear. Since hypothalamic paraventricular nucleus (PVN) is a pivot for blood pressure regulation, we aimed to investigate
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Efficient regioselective enzymatic acylation of troxerutin: Difference characterization in vitro cellular uptake and cytotoxicity Food Funct. (IF 6.1) Pub Date : 2024-04-11 Lisha Hao, Mengmeng Zhang, Xiaofeng Li, Xuan Xin, Guanglei Zhao
In this study, we developed a multi-site acylation strategy to improve the lipophilicity and cellular uptake of troxerutin, a natural flavonoid with many health-promoting bioactivities. By clarifying the acylation properties of troxerutin catalyzed by lipases from different sources, a series of troxerutin ester derivatives acylated at different sites was synthesized, including troxerutin dipropyl (TDP)
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Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats Food Funct. (IF 6.1) Pub Date : 2024-04-10 Julio Baudin, Julia Hernandez-Baixauli, Sergio Quesada-Vázquez, Francisca Mulero, Francesc Puiggròs, Lluís Arola, Antoni Caimari
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Comparative analysis of isothiocyanates in eight cruciferous vegetables and evaluation of the hepatoprotective effects of 4-(methylsulfinyl)-3-butenyl isothiocyanate (sulforaphene) from daikon radish (Raphanus sativus L.) sprouts Food Funct. (IF 6.1) Pub Date : 2024-04-10 Yusuke Yamaguchi, Mikio Sugiki, Motomi Shimizu, Kazuki Ogawa, Hitomi Kumagai
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Potential antibacterial and milk fermentation capabilities of Staphylococcus warneri KYS-164 isolated from Tibetan kefir grain Food Funct. (IF 6.1) Pub Date : 2024-04-10 Xing Guo, yining He, Yifan Cheng, Jingyimei Liang, Pandi Xu, WW He, Jiayin Che, Jiexing Men, Yahong Yuan, Tianli Yue
This study utilized high-throughput sequencing and SEM observation to elucidate the microbial composition of TKG-Y, a Tibetan herder's homemade kefir grain. Staphylococcus warneri KYS-164, which could produce bacteriocin-like inhibitory substances (BLIS), was subsequently screened from it. BLIS (1×MIC) produced by KYS-164 could inhibit the growth of Escherichia coli 366-a and Staphylococcus aureus
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Breaking barriers: How modified citrus pectin inhibits galectin-8 Food Funct. (IF 6.1) Pub Date : 2024-04-08 Ming Shuai, Yiqing Li, Fanqi Guan, Guixia Fu, Chengxin Sun, Qianqian Ren, Li Wang, Tao Zhang
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trans-Palmitoleic acid promotes adipose thermogenesis to reduce obesity via hypothalamic FFAR1 signaling Food Funct. (IF 6.1) Pub Date : 2024-04-05 Huidong Zhan, Wanjing Wang, Yueping Ge, Yixiao Liang, Jing Wang, Yang Xu, Shanshan Wu, Li Peng, Zhao He
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Effect of inulin, galacto-oligosaccharides, and polyphenols on the gut microbiota, with a focus on Akkermansia muciniphila Food Funct. (IF 6.1) Pub Date : 2024-04-09 Ruocen Tian, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai
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Vitamin D3 exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D Food Funct. (IF 6.1) Pub Date : 2024-04-05 Aolin Yang, Yanmei Chen, Yizhen Gao, Qingqing Lv, Yao Li, Fengna Li, Ruirui Yu, Ziyu Han, Shimiao Dai, Junying Zhu, Chenggang Yang, Shi Zhan, Litao Sun, Ji-Chang Zhou
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Bioactive components and mechanisms of Pu-erh tea in improving levodopa metabolism in rats through COMT inhibition Food Funct. (IF 6.1) Pub Date : 2024-04-09 Ziqiong Zhou, Yan Li, Fangyuan Wang, Guanghao Zhu, Shenglan Qi, Haonan Wang, Yuhe Ma, Rong Zhu, Yuejuan Zheng, Guangbo Ge, Ping Wang
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Vitamin C regulates skeletal muscle post-injury regeneration by promoting myoblast proliferation through its direct interaction with the Pax7 protein Food Funct. (IF 6.1) Pub Date : 2024-04-08 Xiaoyu Zhang, Bo Tian, Hong Yu, Shuang Li, Shufeng Li, Jingyan Su, Huili Tong
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Probiotics induce intestinal IgA secretion in weanling mice potentially through promoting intestinal APRIL expression and modulating the gut microbiota composition Food Funct. (IF 6.1) Pub Date : 2024-04-08 Maozhen Zhao, Xi Liang, Yang Meng, Haiyan Lu, Kai Lin, Pimin Gong, Tongjie Liu, Huaxi Yi, Jiancun Pan, Yongjiu Zhang, Zhe Zhang, Lanwei Zhang
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Effect of short-term moderate intake of ice wine on hepatic glycolipid metabolism in C57BL/6J mice Food Funct. (IF 6.1) Pub Date : 2024-04-06 Xinyuan Ma, Yang Liu, Fuliang Han, Tiantian Cheng, Kaixian Wang, Yiwen Xu
As the correlation between high fructose intake and metabolism-related diseases (e.g., obesity, fatty liver, and type 2 diabetes) has been increasingly reported, the health benefits of consuming ice wine high in fructose have been called into question. In this study, 6-week-old male C57BL/6J mice were divided into control (pure water), fructose (130 g/L fructose solution), alcohol (11% alcohol solution)
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Pomegranate Supplementation Alleviates Dyslipidemia and the Onset of Non-Alcoholic Fatty Liver Disease in Wistar Rats by Shifting Microbiota and Producing Urolithin-like Microbial Metabolites Food Funct. (IF 6.1) Pub Date : 2024-04-05 Guadalupe Sánchez-Terrón, Remigio Martínez, David Morcuende, Victor Caballero, Mario Estevez
Non-alcoholic fatty liver disease (NAFLD), obesity and related chronic diseases remain one of the major non-communicable diseases with high mortality rates worldwide. While dietary sugars are known to be responsible for insulin resistance and metabolic syndrome (MetS), the underlying pathophysiological effects of sustained fructose consumption requires further elucidation. We hypothesize that, certain
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Potential application of green extracts rich in phenolics for innovative functional foods: natural deep eutectic solvents as media for isolation of biocompounds from berries Food Funct. (IF 6.1) Pub Date : 2024-04-04 Mila Č. Lazović, Marko D. Jović, Marija Petrović, Ivica Z. Dimkić, Uroš M. Gašić, Dušanka M. Milojković Opsenica, Petar M. Ristivojević, Jelena Đ. Trifković
The health-promoting effects of berries have attracted attention due to the possible application of their extracts as functional ingredients in food products. Natural deep eutectic solvents (NADESs) are a new generation of environmentally friendly solvents for the extraction of natural products, and they are green alternatives to organic solvents, and they can improve the solubility, stability, and
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Bifidobacterium pseudocatenulatum NCU-08 ameliorated senescence via modulation of the AMPK/Sirt1 signaling pathway and gut microbiota in mice Food Funct. (IF 6.1) Pub Date : 2024-04-02 Qingwei Zeng, Zhanghua Qi, Xia He, Chuanlin Luo, Jianing Wen, Jing Wei, Fenfang Yue, Xuanqi Zhao, Hong Wei, Tingtao Chen
Aging is a degenerative disease in which organisms and neurological functions decline. Emerging research has underscored the vital role of the gut microbiota in age-related processes. However, the identification of aging-associated core microbiota remains limited. In this investigation, we isolated a strain of B. pseudocatenulatum NCU-08 from the feces of centenarians and assessed its impact on aging
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Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier Food Funct. (IF 6.1) Pub Date : 2024-04-03 Wen-Yin Xie, Zhong-Hao Ji, Wen-Zhi Ren, Pei-Sen Zhao, Fan-Hao Wei, Jinping Hu, Bao Yuan, Wei Gao
Inflammatory bowel disease (IBD) is difficult to cure, and formulating a dietary plan is an effective means to prevent and treat the disease. Wheat peptides contain a variety of bioactive peptides with anti-inflammatory and antioxidant functions. The results of this study show that preventive supplementation with wheat peptide (WP) can significantly alleviate the symptoms of dextran sulfate sodium
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Dietary supplementation with Lacticaseibacillus rhamnosus IDCC3201 alleviates sarcopenia by modulating the gut microbiota and metabolites in dexamethasone-induced models Food Funct. (IF 6.1) Pub Date : 2024-04-03 Minkyoung Kang, Minji Kang, Jiseon Yoo, Juyeon Lee, Sujeong Lee, Bohyun Yun, Minho Song, Jun-Mo Kim, Hyung Wook Kim, Jungwoo Yang, Younghoon Kim, Sangnam Oh
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Effect of the probiotic Weissella cibaria CMS1 on the immune response and the oral microbiome: a randomized, double-blind, placebo-controlled, parallel study Food Funct. (IF 6.1) Pub Date : 2024-04-02 Min Ju Park, Soo-yeon Park, Kyeong Jin Kim, Bumjo Oh, Ji Yeon Kim
The oral cavity connects the external environment and the respiratory and digestive systems, and the oral microbial ecosystem is complex and plays a crucial role in overall health and immune defense against external threats. Recently, the potential use of probiotics for disease prevention and treatment has gained attention. This study aimed to assess the effect of Weissella cibaria CMS1 (W. cibaria
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Effectiveness of Probiotic- and Fish Oil-loaded Water-in-Oil-in-Water (W1/O/W2) Emulsions at Alleviating Ulcerative Colitis Food Funct. (IF 6.1) Pub Date : 2024-04-02 Qingzhuo Gu, Zhaowei Jiang, Kun Li, Yueting Li, Xiaojia Yan, David J. McClements, Cuicui Ma, Fuguo Liu
Ulcerative colitis (UC) is a common chronic inflammatory disease that causes serious harm to human health. Probiotics have the effect of improving UC. This study evaluated the preventative potential of water-in-oil-in-water (W1/O/W2) emulsions containing both probiotics and fish oil on UC and associated anxiety-like behavior using a mice model. UC models were established in mice by administering dextran
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Lacticaseibacillus rhamnosus HF01 fermented yogurt alleviated high-fat diet-induced obesity and hepatic steatosis via the gut microbiota–butyric acid–hepatic lipid metabolism axis Food Funct. (IF 6.1) Pub Date : 2024-04-02 Yue Sun, Xiaolin Liu, Rongchun Wang, Rongmei Liu, Xuepeng Lv, Ying Ma, Qiming Li
The objective of this study was to investigate the anti-obesity effects and underlying mechanism of Lacticaseibacillus rhamnosus HF01 fermented yogurt (HF01-Y). Herein, obesity was induced in mice through a high-fat diet and the changes in the gut microbiota were evaluated using 16S rRNA gene sequencing, combined with the expression levels of the liver AMPK signaling pathway to analyze the potential
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Promising probiotic-fermented soymilk for alleviating acute diarrhea: insights into the microbiome and metabolomics Food Funct. (IF 6.1) Pub Date : 2024-04-02 Philippe Madjirebaye, Zhen Peng, Abdul Mueed, Tao Huang, Fei Peng, Yammadjita Allasra, Mbaiguebada Etienne Benar, Zhengchen Hu, Mingyong Xie, Tao Xiong
Fermented soymilk (FSM4) has attracted much attention due to its nutritional and health characteristics. Exploring FSM4 products to alleviate diarrhea can ensure their effectiveness as a therapeutic food for alleviating gastrointestinal disorders. However, the relationship between gut microbiota and gut metabolite production remains unknown during diarrheal episodes. Therefore, the diarrhea-alleviating
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High-protein high-konjac glucomannan diets changed glucose and lipid metabolism by modulating colonic microflora and bile acid profiles in healthy mouse models Food Funct. (IF 6.1) Pub Date : 2024-04-02 Yetong Xu, Chengyu Zhou, Minyue Zong, Junwei Zhu, Xutong Guo, Zhihong Sun
High protein and fiber diets are becoming increasingly popular for weight loss; however, the benefits or risks of high protein and fiber diets with a normal calorie level for healthy individuals still need to be elucidated. In this study, we explored the role and mechanisms of long-term high protein and/or konjac glucomannan diets on the metabolic health of healthy mouse models. We found that high
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Pickering emulsion emulsified using novel cellulose nanofibers significantly lowers the lipid release rate and cellular absorption Food Funct. (IF 6.1) Pub Date : 2024-04-02 Yin-Liang Kuo, Yu-Jou Chou, Jing-Yu Hu, Yuwen Ting
A Pickering emulsion is an emulsion system stabilized by solid particles and represents a promising candidate for emulsifying lipids. Cellulose nanofibers (CNFs) have excellent ability to control the lipid release rate. This study aims to find the optimal formulation for a nanocellulose-stabilized Pickering emulsion that is the most effective in reducing the lipid release rate. The Pickering emulsion
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Comparative analysis of tropomyosin allergenicity in three different species of molluscs: insights into the role of amino acid composition in IgE epitopes Food Funct. (IF 6.1) Pub Date : 2024-04-02 Xinyu Han, Xinrong He, Xinya Wang, Lianzhong Luo, Yubao Li, Dong Lai, Hong Liu, Jingwen Liu, Shitao Rao, Guangming Liu
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Assessing the impact of insect protein sources on intestinal health and disease: insights from human ex vivo and rat in vivo models Food Funct. (IF 6.1) Pub Date : 2024-04-02 Helena Segú, Florijan Jalševac, Marta Sierra-Cruz, Francesc Feliu, Jamileh Movassat, Esther Rodríguez-Gallego, Ximena Terra, Montserrat Pinent, Anna Ardévol, M. Teresa Blay
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Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice via regulation of intestinal flora and lipopolysaccharide-related signaling pathways Food Funct. (IF 6.1) Pub Date : 2024-04-02 Liping Chen, Yifan Lei, Changxin Lu, Dingyang Liu, Wenyu Ma, Hengqian Lu, Yongzhong Wang
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Iron-saturated bovine lactoferrin: a promising chemopreventive agent for hepatocellular carcinoma Food Funct. (IF 6.1) Pub Date : 2024-04-01 Hury Viridiana Hernández-Galdámez, Samia Fattel-Fazenda, Teresita N. J. Flores-Téllez, Mario Alejandro Aguilar-Chaparro, Jonathan Mendoza-García, Lidia C. Díaz-Fernández, Eunice Romo-Medina, Yesennia Sánchez-Pérez, Jaime Arellanes-Robledo, Mireya De la Garza, Saúl Villa-Treviño, Carolina Piña-Vázquez
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Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension Food Funct. (IF 6.1) Pub Date : 2024-03-25 Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Michael Wolzt, Oliver Neubauer
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Nutritional profiling, fiber content and in vitro bioactivities of wheat-based biscuits formulated with novel ingredients Food Funct. (IF 6.1) Pub Date : 2024-03-27 Marta Mesias, Francisco J. Morales, Cristina Caleja, Tânia C. S. P. Pires, Ricardo C. Calhelha, Lillian Barros, Eliana Pereira
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Reprogramming of arachidonic acid metabolism using α-terpineol to alleviate asthma: insights from metabolomics Food Funct. (IF 6.1) Pub Date : 2024-03-25 Ying Rong, Fanglin Liu, Hui Zhou, Tong Yu, Zhaolong Qin, Qianwen Cao, Luyao Liu, Xiaoge Ma, Lingbo Qu, Peirong Xu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia Xu
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The antioxidant peptides from walnut protein hydrolysates and their protective activity against alcoholic injury Food Funct. (IF 6.1) Pub Date : 2024-03-27 Peihang Chen, Pantian Huang, Yingyan Liang, Qiaoe Wang, Jianyin Miao