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Dopaminergic Modulation and Computational ADMET Insights for the Antidepressant-like Effect of N-(3-(Phenylselanyl)prop-2-yn-1-yl)benzamide ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-19 Evelyn Mianes Besckow, Kauane Nayara Bahr Ledebuhr, Camila Simões Pires, Marcia Juciele da Rocha, Natália Emanuele Biolosor Kuntz, Benhur Godoi, Cristiani Folharini Bortolatto, César Augusto Brüning
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The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-19 Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
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Cyclic-NDGA Effectively Inhibits Human γ-Synuclein Fibrillation, Forms Nontoxic Off-Pathway Species, and Disintegrates Preformed Mature Fibrils ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Sneh Lata Singh, Rajiv Bhat
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Formation of Calprotectin Inhibits Amyloid Aggregation of S100A8 and S100A9 Proteins ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Ieva Baronaitė, Darius Šulskis, Aurimas Kopu̅stas, Marijonas Tutkus, Vytautas Smirnovas
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14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Gobert Heesink, Maxime C. M. van den Oetelaar, Slav A. Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M. A. E. Claessens
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Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Lin-yan Huang, Yi-de Zhang, Yi-ning Liu, Zhi-yan Liang, Jie Chen, Bin Wang, Qi-long Yin, Pei-pei Wang, Wan Wang, Su-hua Qi
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Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Lin Qiu, Hao Jiang, Kevin Cho, Yanbo Yu, Lynne A. Jones, Tianyu Huang, Joel S. Perlmutter, Robert J. Gropler, Matthew R. Brier, Gary J. Patti, Tammie L. S. Benzinger, Zhude Tu
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Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Po-Chun Chu, Hsiang-Yu Yu, Robert S. Fisher, Hao-Li Liu
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Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-17 Hanbing Xu, Yubo Wang, Congcong Yu, Chunhong Han, Huifei Cui
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4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-15 Alex R. Lovins, Kevin A. Miller, Anne K. Buck, D. Sophia Ensey, Rose K. Homoelle, Megan C. Murtha, Nathan A. Ward, Liam A. Shanahan, Gopichand Gutti, Pratik Shriwas, Craig A. McElroy, Christopher S. Callam, Christopher M. Hadad
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Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-13 Benjamin M. Williams, Nathan D. Steed, Joel T. Woolley, Aubrey A. Moedl, Christina A. Nelson, Gavin C. Jones, Matthew D. Burris, Hugo R. Arias, Oc-Hee Kim, Eun Young Jang, Arik J. Hone, J. Michael McIntosh, Jordan T. Yorgason, Scott C. Steffensen
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Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-13 Ziwei Ma, Yuming Yu, Ming Gao, Peng Chen, Huixia Hong, Dingle Yu, Zhenjiang Liang, Yu Bai, Qinlian Ye, Yachao Wang, Guodong Huang, Hui Tan
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BDNF- and VEGF-Responsive Stimulus to an NGF Mimic Cyclic Peptide with Copper Ionophore Capability and Ctr1/CCS-Driven Signaling ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-11 Barbara Tomasello, Francesco Bellia, Irina Naletova, Antonio Magrì, Giovanni Tabbì, Francesco Attanasio, Marianna Flora Tomasello, Warren R. L. Cairns, Mariagrazia Fortino, Adriana Pietropaolo, Valentina Greco, Diego La Mendola, Sebastiano Sciuto, Giuseppe Arena, Enrico Rizzarelli
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Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-10 Eric Sparkes, Axelle Timmerman, Jack W. Markham, Rochelle Boyd, Rebecca Gordon, Katelyn A. Walker, Richard C. Kevin, David E. Hibbs, Samuel D. Banister, Elizabeth A. Cairns, Christophe Stove, Adam Ametovski
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Prophylactic Administration of Gut Microbiome Metabolites Abrogated Microglial Activation and Subsequent Neuroinflammation in an Experimental Model of Japanese Encephalitis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-06 Indira Priya Siva Venkatesh, Atreye Majumdar, Anirban Basu
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Similar Binding Modes of cGMP Analogues Limit Selectivity in Modulating Retinal CNG Channels via the Cyclic Nucleotide-Binding Domain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-05 Palina Pliushcheuskaya, Sandeep Kesh, Emma Kaufmann, Sophie Wucherpfennig, Frank Schwede, Georg Künze, Vasilica Nache
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Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-05 Nina Nitzan Soto, Patricia Gaspar, Alberto Bacci
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Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1 ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-04 Hui Li, Qiong Ye, Da Wang, Bowen Shi, Wenjing Xu, Shuning Zhang, Xiaoyang Han, Xiao-Yong Zhang, Garth J. Thompson
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Serotonin Receptors in Myocardial Infarction: Friend or Foe? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-04 F.S. Bahr, M. Ricke-Hoch, E. Ponimaskin, F.E. Müller
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Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-02 Asmaa R. Hashim, Dina W. Bashir, Eman Rashad, Mona K. Galal, Maha M. Rashad, Heba M. A. Khalil, Nasrallah M. Deraz, El-Gharbawy S. M.
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Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-01 Robert A. Ellingford, Mizuki Tojo, M. Albert Basson, Laura C. Andreae
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Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-29 Selim Boukabara, Mehdi Farokhnia, Lorenzo Leggio
Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Delineating the biobehavioral correlates of amylin in relation to alcohol seeking and consumption has the potential of identifying new treatment targets for AUD, yet additional
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Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-28 Kichitaro Nakajima, Tomoki Ota, Hajime Toda, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi
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Substrate Selection Criteria in Regulated Intramembrane Proteolysis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Celine Moser, Nadja Guschtschin-Schmidt, Mara Silber, Julia Flum, Claudia Muhle-Goll
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Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Gourav Singh, Gauri Shankar, Samir Ranjan Panda, Sunil Kumar, Sanskriti Rai, Himanshu Verma, Prabhat Kumar, Prasanta Kumar Nayak, V.G.M. Naidu, Saripella Srikrishna, Saroj Kumar, Gyan Modi
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Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Ge Li, Lan Lan, Tingting He, Zheng Tang, Shuhua Liu, Yunfeng Li, Zhongqiang Huang, Yalun Guan, Xuejiao Li, Yu Zhang, Hsin-Yi Lai
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Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Sadhana Sharma, Sydney Risen, Vincenzo S. Gilberto, Sean Boland, Anushree Chatterjee, Julie A. Moreno, Prashant Nagpal
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Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-24 Therése Klingstedt, Linda Lantz, Hamid Shirani, Junyue Ge, Jörg Hanrieder, Ruben Vidal, Bernardino Ghetti, K. Peter R. Nilsson
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Selective Potentiation of the (α4)3(β2)2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-21 Rebecca Appiani, Franco Viscarra, Philip C. Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
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Rapid FRET Assay for the Early Detection of Alpha-Synuclein Aggregation in Parkinson’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Hang Yu, Rui Feng, Fenglin Chen, Zuodong Wu, Dehai Li, Xue Qiu
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Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Sydney J. Risen, Sean W. Boland, Sadhana Sharma, Grace M. Weisman, Payton M. Shirley, Amanda S. Latham, Arielle J. D. Hay, Vincenzo S. Gilberto, Amelia D. Hines, Stephen Brindley, Jared M. Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno
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Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Maria Teresa Gallo, Beatrice Dolci, Fabio Fumagalli, Paola Brivio, Francesca Calabrese
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Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Theodosia Vallianatou, Carina de Souza Anselmo, Ioanna Tsiara, Nicholas B. Bèchet, Iben Lundgaard, Daniel Globisch
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Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kayed
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Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 James Everett, Jake Brooks, Vindy Tjendana Tjhin, Frederik Lermyte, Ian Hands-Portman, Germán Plascencia-Villa, George Perry, Peter J. Sadler, Peter B. O’Connor, Joanna F. Collingwood, Neil D. Telling
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Histone Lysine Demethylase KDM5 Inhibitor CPI-455 Induces Astrocytogenesis in Neural Stem Cells ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 Thin Thin San, Junhyung Kim, Hyun-Jung Kim
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The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-18 Galina Portnova, Guzal M. Khayrullina, Ivan V. Mikheev, Sofiya M. Byvsheva, Elena V. Proskurnina, Olga Martynova
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Serotonin Signaling through Lipid Membranes ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-18 Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, Christian P. Müller
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Investigating a Novel Neurodegenerative Disease Toxic Mechanism Involving Lipid Binding Specificity of Amyloid Oligomers ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-15 Sarah S. Hirschbeck, Edward T. Lindberg, Joshua H. Jang, MaKenna R. Jacob, Kristi L. Lazar Cantrell, Thanh D. Do
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Structures and Dynamics of β-Rich Oligomers of ATTR (105–115) Assembly ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Liqun Liang, Yuqi Zhang, Yanyan Zhu, Juxia Bai, Yangyang Ni, Junfeng Wan, Haiyan Yue, Qingjie Zhao, Huiyu Li
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Research Report: A Link between Sertraline Treatment and Susceptibility to (Mis)information ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Michal Piksa, Karolina Noworyta, Jan Piasecki, Aleksander Gundersen, Jonas Kunst, Mikolaj Morzy, Rafal Rygula
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Influence of Cigarette Aerosol in Alpha-Synuclein Oligomerization and Cell Viability in SH-SY5Y: Implications for Parkinson’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Yu-Xin Shen, Pe-Shuen Lee, Ming-Chu Teng, Jhih-Hong Huang, Chia C. Wang, Hsiu-Fang Fan
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Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Joanna M. Wasielewska, Kathryn Szostak, Lachlan E. McInnes, Hazel Quek, Juliana C. S. Chaves, Jeffrey R. Liddell, Jari Koistinaho, Lotta E. Oikari, Paul S. Donnelly, Anthony R. White
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Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Lieve van Veggel, Tamara A.M. Mocking, Hubert J. Sijben, Rongfang Liu, Marina Gorostiola González, Majlen A. Dilweg, Jeroen Royakkers, Anna Li, Vijay Kumar, Yin Yao Dong, Alex Bullock, David B. Sauer, Hanne Diliën, Gerard J.P. van Westen, Rudy Schreiber, Laura H. Heitman, Tim Vanmierlo
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Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-12 Qinqin Pei, Qiurong Zhao, Chunhui Lang, Shilong Feng, Juanjuan Meng, Guangjiao Tan, Wei Cui, Cheng Zhang, Xiaohe Luo, Lixin Xu, Jian Chen
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Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-11 Muthu Raj Salaikumaran, Pallavi P. Gopal
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Kynurenines Dynamics in the Periphery and Central Nervous System Steers Behavioral Deficits in Rats under Hypobaric Hypoxia ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-10 Kalyani Verma, Amitabh, Dipti N. Prasad, M. Prasanna Kumar Reddy, Ekta Kohli
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18F-Labeled PET Tracers Specific for Adenosine A2A Receptor: Design, Synthesis, and Biological Evaluation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-08 Tingyu Yang, Wei Zheng, Xuebo Cheng, Hualong Chen, Zeng Jiang, Ziyue Yu, Lu Zhang, Yi Xie, Lianjie Du, Xuan Ge, Jiahuai Zhang, Leilei Yuan, Yajing Liu, Zehui Wu
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Aryl Hydrocarbon Receptor Involvement in the Sodium-Dependent Glutamate/Aspartate Transporter Regulation in Cerebellar Bergmann Glia Cells ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Janisse Silva-Parra, Leticia Ramírez-Martínez, Cecilia Palafox-Gómez, Cristina Sandu, Esther López-Bayghen, Libia Vega, Guillermo Elizondo, Jaqueline Loaeza-Loaeza, Daniel Hernández-Sotelo, Luisa C. Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Arturo Ortega
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Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Xin Lu, Yueqing Li, Qianwen Guan, Huajing Yang, Yijun Liu, Chenxi Du, Lei Wang, Qinghua Wang, Yuqiong Pei, Liang Wu, Haopeng Sun, Yao Chen
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Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Wanxin Cao, Shan Xiong, Wenliang Ji, Huan Wei, Furong Ma, Lanqun Mao
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Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Yuwei Wang, Jirong Shu, Haoyi Yang, kemiao Hong, Xiangji Yang, Weijie Guo, Jie Fang, Fuyi Li, Tao Liu, Zhiming Shan, Taoda Shi, Song Cai, Jian Zhang
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Phytic Acid Maintains Peripheral Neuron Integrity and Enhances Survivability against Platinum-Induced Degeneration via Reducing Reactive Oxygen Species and Enhancing Mitochondrial Membrane Potential ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Arjun Prasad Tiwari, Bayne Albin, Khayzaran Qubbaj, Prashant Adhikari, In Hong Yang
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EB1 Increases the Dynamics of Tau Droplets and Inhibits Tau Aggregation: Implications in Tauopathies ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Anuradha Venkatramani, Anvesh Ashtam, Dulal Panda
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4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-05 Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
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Deciphering the Association of Epstein–Barr Virus and Its Glycoprotein M Peptide with Neuropathologies in Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-04 Annu Rani, Priyanka Patra, Tarun Prakash Verma, Anamika Singh, Ajay Kumar Jain, Neha Jaiswal, Sanjeev Narang, Nitish Mittal, Hamendra Singh Parmar, Hem Chandra Jha
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Reversible Morphological Remodeling of Prefrontal and Hippocampal Serotonergic Fibers by Fluoxetine ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-04 Serena Nazzi, Marta Picchi, Sara Migliarini, Giacomo Maddaloni, Noemi Barsotti, Massimo Pasqualetti
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Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-03 Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T. Kizhakkeduth, Vinesh Vijayan
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Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-29 Laura Staal, Torsten Plösch, Theodora Kunovac Kallak, Inger Sundström Poromaa, Bregje Wertheim, Jocelien D. A. Olivier
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Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-29 Fatema Bhinderwala, Heidi E. Roth, Mary Filipi, Samantha Jack, Robert Powers