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Therapeutic applications of mesenchymal/medicinal stem/signaling cells preconditioned with external factors: Are there more efficient approaches to utilize their regenerative potential? Life Sci. (IF 6.1) Pub Date : 2024-04-14 Magdalena Strecanska, Tatiana Sekelova, Maria Csobonyeiova, Lubos Danisovic, Michaela Cehakova
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Molecular and cellular signalling pathways for promoting neural tissue growth - A tissue engineering approach Life Sci. (IF 6.1) Pub Date : 2024-04-13 Kanagavalli Ramasubbu, Ganesh Venkatraman, Ganasambanthan Ramanathan, Sivaraman Dhanasekar, V. Devi Rajeswari
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Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions Life Sci. (IF 6.1) Pub Date : 2024-04-08 Sharanya Paramshetti, Mohit Angolkar, Sirajunisa Talath, Riyaz Ali M. Osmani, Asha Spandana, Adel Al Fatease, Umme Hani, K.V.R.N.S. Ramesh, Ekta Singh
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Gut microbiota as a key regulator of intestinal mucosal immunity Life Sci. (IF 6.1) Pub Date : 2024-04-06 Jing Wang, Mei He, Ming Yang, Xiaopeng Ai
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Molecular targets for management of diabetes: Remodelling of white adipose to brown adipose tissue Life Sci. (IF 6.1) Pub Date : 2024-04-05 Shushmita Chand, Alok Shiomurti Tripathi, Anil P. Dewani, Naheed Waseem A. Sheikh
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Oncology's trial and error: Analysis of the FDA withdrawn accelerated approvals Life Sci. (IF 6.1) Pub Date : 2024-04-04 Anthony J. Preziosi, Ronny Priefer
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Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics Life Sci. (IF 6.1) Pub Date : 2024-04-04 Riya Thapa, Muhammad Afzal, Ahsas Goyal, Gaurav Gupta, Asif Ahmad Bhat, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Moyad Shahwan, Neelima Kukreti, Haider Ali, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Sachin Kumar Singh, Kamal Dua
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Retraction notice to “Angiotensin receptor blockade improves the net balance of cardiac Ca2+ handling-related proteins in sympathetic hyperactivity-induced heart failure” [Life Sci. 88/13-14 (2011) 578–585] Life Sci. (IF 6.1) Pub Date : 2024-04-04 Julio C.B. Ferreira, Jose B.N. Moreira, Juliane C. Campos, Marcelo G. Pereira, Katt C. Mattos, Marcele A. Coelho, Patricia C. Brum
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Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy Life Sci. (IF 6.1) Pub Date : 2024-04-03 Eman Casper, Lamia El Wakeel, Nagwa Sabri, Ramy Khorshid, Sarah F. Fahmy
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Midbrain organoids for Parkinson's disease (PD) - A powerful tool to understand the disease pathogenesis Life Sci. (IF 6.1) Pub Date : 2024-04-03 Harysh Winster Suresh Babu, Sindduja Muthu Kumar, Harsimrat Kaur, Mahalaxmi Iyer, Balachandar Vellingiri
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Unraveling the significance of PPP1R1A gene in pancreatic β-cell function: A study in INS-1 cells and human pancreatic islets Life Sci. (IF 6.1) Pub Date : 2024-04-03 Jalal Taneera, Abdul Khader Mohammed, Anila Khalique, Bashair M. Mussa, Nabil Sulaiman, Yasser Bustanji, Mohamed A. Saleh, Mohamed Madkour, Eman Abu-Gharbieh, Waseem El-Huneidi
The protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A) has been linked with insulin secretion and diabetes mellitus. Yet, its full significance in pancreatic β-cell function remains unclear. This study aims to elucidate the role of the gene in β-cell biology using human pancreatic islets and rat INS-1 (832/13) cells. Disruption of in INS-1 cells was associated with reduced insulin secretion
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Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence Life Sci. (IF 6.1) Pub Date : 2024-04-03 Chanin Sillapachaiyaporn, Chamaiphorn Wongwan, Kuljira Mongkolpobsin, Sunita Nilkhet, Ciro Isidoro, Siriporn Chuchawankul, Tewin Tencomnao
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Pellino1 orchestrates gut-kidney axis to perpetuate septic acute kidney injury through activation of STING pathway and NLRP3 inflammasome Life Sci. (IF 6.1) Pub Date : 2024-04-03 Yu Jia, Ge Zhu, Cheng Qiu, Jun-Mei Lai, Ye Shen, Shu-Wen Jin, Xue Yang, Hai-Ping Zhu, Bang-Chuan Hu, Xiang-Ming Ye, Shi-Jing Mo
Intestinal barrier dysfunction is the initial and propagable factor of sepsis in which acute kidney injury (AKI) has been considered as a common life-threatening complication. Our recent study identifies the regulatory role of Pellino1 in tubular death under inflammatory conditions in vitro. The objective of our current study is to explore the impact of Pellino1 on gut-kidney axis during septic AKI
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Retraction notice to “The protective role of sulforaphane and Homer1a in retinal ischemia-reperfusion injury: Unraveling the neuroprotective interplay” [Life Sci. 329 (2023) 121968] Life Sci. (IF 6.1) Pub Date : 2024-03-28 Mohamed J. Saadh, Roxana Yolanda Castillo-Acobo, Hala Baher, Jayasankar Narayanan, Jessica Paola Palacios Garay, Michelle Naomi Vera Yamaguchi, José Luis Arias-Gonzáles, Juan Carlos Cotrina-Aliaga, Shaik Vaseem Akram, Natrayan Lakshmaiya, Ali H. Amin, Mohamed Mohany, Salim S. Al-Rejaie, Muhammad Ahsan, Abolfazl Bahrami, Reza Akhavan-Sigari
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Retraction notice to “Cathelicidin-BF attenuate kidney injury through inhibiting oxidative stress, inflammation and fibrosis in streptozotocin-induced diabetic rats” [Life Sci. 257 (2020) 117918] Life Sci. (IF 6.1) Pub Date : 2024-03-28 Yuan Liu, Danhua Kou, Naying Chu, Guangjun Ding
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Molecular and functional insight into anti-EGFR nanobody: Theranostic implications for malignancies Life Sci. (IF 6.1) Pub Date : 2024-03-28 Rajan K. Tripathy, Abhay H. Pande
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Inhibition of NF-κB and ERK signaling pathways in osteoclasts and M1 macrophage polarization: Mechanistic insights into the anti-osteoporotic effects of Pseudolaric acid B Life Sci. (IF 6.1) Pub Date : 2024-03-28 Liyan Liu, Cheng Xiang, Tao Li, Ziyue Zhao, Tao Xiao, Zhengxiao Ouyang
Osteoporosis, characterized by bone metabolism disruption leading to gradual bone loss and increased fracture susceptibility, is linked to the excessive activation of osteoclasts. Pseudolaric acid B (PAB), identified as an NF-κB signaling inhibitor crucial for osteoclastogenesis, is explored here for its protective effects in osteoporosis. Noncytotoxic PAB's impact on osteoclast differentiation was
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Human β-defensins and their synthetic analogs: Natural defenders and prospective new drugs of oral health Life Sci. (IF 6.1) Pub Date : 2024-03-26 Mumian Chen, Zihe Hu, Jue Shi, Zhijian Xie
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An improved mouse model of sepsis based on intraperitoneal injections of the enriched culture of cecum slurry Life Sci. (IF 6.1) Pub Date : 2024-03-26 Rajat Atre, Rahul Sharma, Alexander G. Obukhov, Uzma Saqib, Sadiq Umar, Gajanan N. Darwhekar, Mirza S. Baig
Sepsis is a life-threatening clinical syndrome comprising multiorgan dysfunctions caused by a disproportionate body immune response. There are several animal sepsis models which are based on cecum ligation, cecal puncture, and cecum slurry injection. The major limitation of all current sepsis models is the high variability owing to the variable degree of ligation, puncture and inconsistent microbial
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Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward Life Sci. (IF 6.1) Pub Date : 2024-03-25 Weiyi Xia, Miao Zhang, Chang Liu, Sheng Wang, Aimin Xu, Zhengyuan Xia, Lei Pang, Yin Cai
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Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy Life Sci. (IF 6.1) Pub Date : 2024-03-25 Xiaoyan Wu, Yufei Meng, Jinsi Chen, Yongchen Zhang, Huihui Xu
Diabetic nephropathy (DN) is one of the most common complications of diabetes and represents a prototypical form of chronic kidney disease (CKD). Interstitial fibrosis is a key pathological feature of DN. During DN-associated renal fibrosis, resident fibroblasts trans-differentiate into myofibroblasts to remodel the extracellular matrix, the underlying epigenetic mechanism of which is not entirely
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Retraction notice to “Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma” [Life Sci. 247 (2020) 117425] Life Sci. (IF 6.1) Pub Date : 2024-03-23 Yan Chen, Ning Li, Haijing Wang, Ningning Wang, Hui Peng, Jing Wang, Yihong Li, Mingdi Liu, Hui Li, Yu Zhang, Zhaohui Wang
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Retraction notice to “Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer” [Life Sci. 218 (2019) 47–57] Life Sci. (IF 6.1) Pub Date : 2024-03-23 Zhao Ma, Xuebin Bao, Junbao Gu
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Retraction notice to “Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway” [Life Sci. 209 (2018) 498–506] Life Sci. (IF 6.1) Pub Date : 2024-03-23 Ning Wang, Fang Zhou, Jinhui Guo, Huaiyuan Zhu, Shanshui Luo, Jingjing Cao
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Retraction notice to “Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2” [Life Sci. 189 (2017) 96–105] Life Sci. (IF 6.1) Pub Date : 2024-03-23 Honggai Liu, Qingfen Yue, Shehong He
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Thyroid hormone deprival and TSH/TSHR signaling deficiency lead to central hypothyroidism-associated intestinal dysplasia Life Sci. (IF 6.1) Pub Date : 2024-03-21 Li Peng, Sisi Luan, Xin Shen, Huidong Zhan, Yueping Ge, Yixiao Liang, Jing Wang, Yang Xu, Shanshan Wu, Xia Zhong, Haiqing Zhang, Ling Gao, Jiajun Zhao, Zhao He
Central hypothyroidism (CH) is characterized by low T levels and reduced levels or bioactivity of circulating TSH. However, there is a lack of studies on CH-related intestinal maldevelopment. In particular, the roles of TH and TSH/TSHR signaling in CH-related intestinal maldevelopment are poorly understood. Herein, we utilized mice as a congenital hypothyroidism model with TH deprival and absence of
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Regulatory pathways and therapeutic potential of PDE4 in liver pathophysiology Life Sci. (IF 6.1) Pub Date : 2024-03-21 Noureen Zahra, Shazia Rafique, Zoya Naveed, Jannat Nadeem, Muhammad Waqas, Amjad Ali, Masaud Shah, Muhammad Idrees
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Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy Life Sci. (IF 6.1) Pub Date : 2024-03-20 Mohamed M. Kamal, Reham A. Ammar, Dina H. Kassem
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Food preference-based screening method for identification of effectors of substance use disorders using Caenorhabditis elegans Life Sci. (IF 6.1) Pub Date : 2024-03-19 Aaron Taehwan Kim, Sida Li, Yoo Kim, Young-Jai You, Yeonhwa Park
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Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing Life Sci. (IF 6.1) Pub Date : 2024-03-19 Xinlin Yang, Wan'an Xiao, Quang Le, Zhichang Zhang, Weicheng Wang, Sang-Hyun Lee, Abhijit Dighe, Jason R. Kerrigan, Quanjun Cui
Formyl peptide receptor 1 (FPR1), from a G-protein coupled receptor family, was previously well-characterized in immune cells. But the function of FPR1 in osteogenesis and fracture healing was rarely reported. This study, using the FPR1 knockout (KO) mouse, is one of the first studies that try to investigate FPR1 function to osteogenic differentiation of bone marrow-derived stem cells (BMSCs) in vitro
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PTGS2: A potential immune regulator and therapeutic target for chronic spontaneous urticaria Life Sci. (IF 6.1) Pub Date : 2024-03-19 Yihui Chen, Xingxing Jian, Lei Zhu, Pian Yu, Xiaoqing Yi, Qiaozhi Cao, Jiayi Wang, Feng Xiong, Jie Li
Chronic spontaneous urticaria (CSU) is a common and debilitating skin disease that is difficult to control with existing treatments, and the pathogenesis of CSU has not been fully revealed. The aim of this study was to explore the underlying mechanisms of CSU and identify potential treatments. Microarray datasets of CSU were obtained from Gene Expression Omnibus database. Differentially expressed genes
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A direct estrogenic involvement in the expression of human hypocretin Life Sci. (IF 6.1) Pub Date : 2024-03-19 Haimei Li, Xinlu Chen, Jingyi Dong, Ripeng Liu, Jinfeng Duan, Manli Huang, Shaohua Hu, Jing Lu
Hypocretin is synthesized exclusively in the hypothalamus and distributes inputs to several areas of the brain, which may play an important role in depression. Our previous study showed that hypocretin-1 was increased in the lateral hypothalamus in female patients with depression compared to female controls. Estrogen acts through estrogen receptor (ER)α and ERβ. We studied the possibility of a direct
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VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives Life Sci. (IF 6.1) Pub Date : 2024-03-18 Mohammad Malekan, Nikolas K. Haass, Ghasem Rahmatpour Rokni, Nasim Gholizadeh, Mohammad Ali Ebrahimzadeh, Armaghan Kazeminejad
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Trifluoperazine mitigates cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in mice by modulating the AKT/mTOR-driven autophagy and Nrf2/HO-1 signaling cascades Life Sci. (IF 6.1) Pub Date : 2024-03-17 Ahmed K. Saleh, Nageh A. El-Mahdy, Thanaa A. El-Masry, Aya H. El-Kadem
This study aims to investigate the hepatoprotective effect of the antipsychotic drug trifluoperazine (TFP) against cyclophosphamide (CPA)-induced hepatic injury by exploring its effect on autophagy and the Nrf2/HO-1 signaling pathway. The hepatotoxicity of CPA was assessed by biochemical analysis of the serum hepatotoxicity markers (ALT, AST, and direct bilirubin), histopathological examination, and
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Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice Life Sci. (IF 6.1) Pub Date : 2024-03-16 Diego Gomes de Melo, Vivian Cristina da Cruz Rodrigues, Gustavo José de Sá Pereira, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, José Rodrigo Pauli, Adelino Sanchez Ramos da Silva, Célio Junior da Costa Fernandes, Leandro Pereira de Moura
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Future perspectives on the roles of mitochondrial dynamics in the heart in obesity and aging Life Sci. (IF 6.1) Pub Date : 2024-03-14 Chayodom Maneechote, Siriporn C. Chattipakorn, Nipon Chattipakorn
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Polyglutamine disorders: Pathogenesis and potential drug interventions Life Sci. (IF 6.1) Pub Date : 2024-03-14 Shweta Tandon, Prerna Aggarwal, Surajit Sarkar
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The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy Life Sci. (IF 6.1) Pub Date : 2024-03-14 Peng Huang, Feng Wen, YiShan Li, Qiu Li
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Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia Life Sci. (IF 6.1) Pub Date : 2024-03-14 Xuehan Dou, Zhongyuan Chen, Yunzhang Liu, Yun Li, Junli Ye, Ling Lu
Prolyl hydroxylase domain 2 (PHD2), encoded by the gene, serves as a pivotal regulator of the hypoxia-inducible factor (HIF) pathway and acts as a cellular oxygen sensor. Somatic inactivation of in mice results in polycythemia and congestive heart failure. However, due to the embryonic lethality of deficiency, its role in development remains elusive. Here, we investigated the function of two paralogous
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Alpha-glycosyl isoquercitrin alleviates subchronic social defeat stress-induced depression symptoms by modulating the microbiota-gut-brain axis in mice Life Sci. (IF 6.1) Pub Date : 2024-03-13 Hong Liu, Junjie Li, Shogo Takahashi, Atsushi Toyoda, Ryo Inoue, Mihoko Koyanagi, Shim-mo Hayashi, Meiyu Xu, Yuki Yamamoto, Kentaro Nagaoka
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Ursodeoxycholic acid alleviates atopic dermatitis-associated inflammatory responses in HaCaT and RBL-2H3 cells and DNCB/DFE-treated mice Life Sci. (IF 6.1) Pub Date : 2024-03-13 Eom Ji Kim, Hoyeon Park, Eun-Young Kim, Do Kyung Kim, Hyuk-Sang Jung, Youngjoo Sohn
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The role of gut microbiota and probiotics in preventing, treating, and boosting the immune system in colorectal cancer Life Sci. (IF 6.1) Pub Date : 2024-03-13 Forough Masheghati, Mohammad Reza Asgharzadeh, Abbas Jafari, Naser Masoudi, Hadi Maleki-Kakelar
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An alternative hybrid lipid nanosystem combining cytotoxic and magnetic properties as a tool to potentiate antitumor effect of 5-fluorouracil Life Sci. (IF 6.1) Pub Date : 2024-03-11 Afonso Azevedo, Mariana P. Coelho, Jacinta O. Pinho, Paula I.P. Soares, Catarina P. Reis, João P. Borges, M. Manuela Gaspar
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CAR T treatment beyond cancer: Hope for immunomodulatory therapy of non-cancerous diseases Life Sci. (IF 6.1) Pub Date : 2024-03-11 Zhibo Yang, Yingfeng Liu, Hai Zhao
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Cinnamaldehyde/lactulose combination therapy alleviates thioacetamide-induced hepatic encephalopathy via targeting P2X7R-mediated NLRP3 inflammasome signaling Life Sci. (IF 6.1) Pub Date : 2024-03-11 Al Shaima G. Abd El Salam, Nesma A. Abd Elrazik
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Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases Life Sci. (IF 6.1) Pub Date : 2024-03-11 Azam Hosseinzadeh, Nazila Alinaghian, Mohammad Sheibani, Farnoosh Seirafianpour, Ali Jamshidi Naeini, Saeed Mehrzadi
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Plasma membrane calcium ATPase powered by glycolysis is the main mechanism for calcium clearance in the hippocampal pyramidal neuron Life Sci. (IF 6.1) Pub Date : 2024-03-08 Vitor S. Alves, Fernando A. Oliveira
This study sought to elucidate the primary ATP-dependent mechanisms involved in clearing cytosolic Ca in neurons and determine the predominant ATP-generating pathway—glycolysis or tricarboxylic acid cycle/oxidative phosphorylation (TCA/OxPhos)—associated with these mechanisms in hippocampal pyramidal neurons. Our investigation involved evaluating basal Ca levels and analyzing the kinetic characteristics
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Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress – unfolded protein response (UPR) – autophagy, and their regulatory miRNA Life Sci. (IF 6.1) Pub Date : 2024-03-08 Safaa I. Khater, Mahran Mohamed Abd El-Emam, Hussein Abdellatif, Mahmoud Mostafa, Tarek Khamis, Rania Hassan Mohamed Soliman, Heba S. Ahmed, Sahar K. Ali, Heba Mohammed Refat M. Selim, Leena S. Alqahtani, Doaa Habib, Mohamed M.M. Metwally, Anwar M. Alnakhli, Asmaa Saleh, Amira Mohammed Abdelfattah, Hanim M. Abdelnour, Mohamed F. Dowidar
Autophagy is a well-preserved mechanism essential in minimizing endoplasmic reticulum stress (ER)-related cell death. Defects in β-cell autophagy have been linked to type 1 diabetes, particularly deficits in the secretion of insulin, boosting ER stress sensitivity and possibly promoting pancreatic β-cell death. Quercetin (QU) is a potent antioxidant and anti-diabetic flavonoid with low bioavailability
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The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis Life Sci. (IF 6.1) Pub Date : 2024-03-08 Xiaohui Hu, Xinyi Yuan, Guokun Zhang, Haoyun Song, Pengfei Ji, Yanan Guo, Zihua Liu, Yixiao Tian, Rong Shen, Degui Wang
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The evidence-based multifaceted roles of hepatic stellate cells in liver diseases: A concise review Life Sci. (IF 6.1) Pub Date : 2024-03-07 Jong-Won Kim, Yu Ji Kim
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Nox2 inhibition reduces trophoblast ferroptosis in preeclampsia via the STAT3/GPX4 pathway Life Sci. (IF 6.1) Pub Date : 2024-03-07 Xia Xu, Mengwei Zhu, Yizheng Zu, Guiying Wang, Xiuli Li, Jianying Yan
Ferroptosis, a novel mode of cell death characterized by lipid peroxidation and oxidative stress, plays an important role in the pathogenesis of preeclampsia (PE). The aim of this study is to determine the role of Nox2 in the ferroptosis of trophoblast cells, along with the underlying mechanisms. The mRNA and protein levels of Nox2, STAT3, and GPX4 in placental tissues and trophoblast cells were respectively
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Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors Life Sci. (IF 6.1) Pub Date : 2024-03-07 Serbay Ozkan, Basak Isildar, Hakan Sahin, Halil Ibrahim Saygi, Dildar Konukoglu, Meral Koyuturk
The secretome of mesenchymal stem cells (MSCs) could be a potential therapeutic intervention for diabetes and associated complications like nephropathy. This study aims to evaluate the effects of conditioned mediums (CMs) collected from umbilical cord-derived MSCs incubated under 2-dimensional (2D) or 3D culture conditions on kidney functions of rats with type-I diabetes (T1D). Sprague-Dawley rats
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Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers Life Sci. (IF 6.1) Pub Date : 2024-03-06 Noella Abraham, Tejaswini Kolipaka, Giriraj Pandey, Mansi Negi, Dadi A. Srinivasarao, Saurabh Srivastava
Type-1 Diabetes Mellitus (T1DM) manifests due to pancreatic beta cell destruction, causing insulin deficiency and hyperglycaemia. Current therapies are inadequate for brittle diabetics, necessitating pancreatic islet transplants, which however, introduces its own set of challenges such as paucity of donors, rigorous immunosuppression and autoimmune rejection. Organoid technology represents a significant
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Multifaced roles of the long non-coding RNA DRAIC in cancer progression Life Sci. (IF 6.1) Pub Date : 2024-03-06 Kouhei Sakurai, Hiroyasu Ito
Long non-coding RNAs (lncRNA) are functional RNAs, with over 200 nucleotides in length and lacking protein-coding potential. Studies have indicated that lncRNAs are important gene regulators under physiological conditions. Aberrant lncRNA expression is associated with the initiation and progression of various diseases, including cancers. High-throughput transcriptome analyses have revealed thousands
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Corrigendum to “Maresin1 ameliorates acute lung injury induced by sepsis through regulating Th17/Treg balance” [Life Sci. 254 (2020) 117773] Life Sci. (IF 6.1) Pub Date : 2024-03-01 Haifa Xia, Fuquan Wang, Min Wang, Jingxu Wang, Shujun Sun, Ming Chen, Shiqian Huang, Xiangdong Chen, Shanglong Yao
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Hesperetin regulates the intestinal flora and inhibits the TLR4/NF-κB signaling axis to protect the blood-milk barrier and prevent mastitis Life Sci. (IF 6.1) Pub Date : 2024-02-29 Xin Ran, Guiqiu Hu, Weiwei Guo, Kefei Li, Xiaoxuan Wang, Juxiong Liu, Shoupeng Fu
The World Health Organization recommends breastfeeding for 6 months, but mastitis, a common disease during lactation, presents a major obstacle to fulfilling this recommendation. Maternal nutrient intake during lactation has been shown to be related to mastitis. Therefore, this study aimed to explore the effect of hesperetin, a phytonutrient, on mastitis. The oral administration of hesperetin to lipopolysaccharide
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Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes Life Sci. (IF 6.1) Pub Date : 2024-02-29 Sonia Dhiman, Ashi Mannan, Ayushi Taneja, Maneesh Mohan, Thakur Gurjeet Singh
Parkinson's disease (PD) is a progressive neurodegenerative condition that primarily affects motor function and is caused by a gradual decline of dopaminergic neurons in the brain's substantia pars compacta (Snpc) region. Multiple molecular pathways are involved in the pathogenesis, which results in impaired cellular functions and neuronal degeneration. However, the role of sirtuins, a type of NAD-dependent
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Molecular mechanisms of TACE refractoriness: Directions for improvement of the TACE procedure Life Sci. (IF 6.1) Pub Date : 2024-02-29 Jiahao Li, Yingnan Liu, Ruipeng Zheng, Chao Qu, Jiarui Li
Transcatheter arterial chemoembolisation (TACE) is the standard of care for intermediate-stage hepatocellular carcinoma and selected patients with advanced hepatocellular carcinoma. However, TACE does not achieve a satisfactory objective response rate, and the concept of TACE refractoriness has been proposed to identify patients who do not fully benefit from TACE. Moreover, repeated TACE is necessary
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Vascular dysfunction programmed in male rats by topiramate during peripubertal period Life Sci. (IF 6.1) Pub Date : 2024-02-28 Kawane F. Moura, Deborah Gomes da Silva, Camila Borecki Vidigal, Gabriel Smolak Sobieski e Silva, Ingrid Caroline Pinto, Andréa Name Colado Simão, Bruno V.D. Marques, Fábio Goulart de Andrade, Rúbia Casagrande, Daniela C.C. Gerardin, Eliana H. Akamine, Maria do Carmo P. Franco, Graziela S. Ceravolo
The present study evaluated whether topiramate (TPM) treatment during the peripubertal period affects vascular parameters of male rats and whether oxidative stress plays a role in these changes. Rats were treated with TPM (41 mg/kg/day, gavage) or vehicle (CTR group) from the postnatal day (PND) 28 to 50. At PND 51 and 120 the rats were evaluated for: thoracic aorta reactivity to phenylephrine, in
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ATM deficiency differentially affects expression of proteins related to fatty acid oxidation and oxidative stress in a sex-specific manner in response to Western-type diet prior to and following myocardial infarction Life Sci. (IF 6.1) Pub Date : 2024-02-28 Hui Wang-Heaton, Mary C. Wingard, Suman Dalal, Paige L. Shook, Barbara A. Connelly, Patrick Johnson, Phillip L. Nichols, Mahipal Singh, Krishna Singh
Published work has shown that ataxia-telangiectasia mutated kinase (ATM) deficiency is associated with cardioprotective effects in Western-type diet (WD)-fed female mice. This study assessed the expression of proteins related to fatty acid oxidation (FAO) and oxidative stress in WD-fed male and female mouse hearts, and investigated if sex-specific cardioprotective effects in WD-fed female ATM-deficient