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HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses Metabolites (IF 4.1) Pub Date : 2024-04-20 Danica Bajic, Frank Wiens, Eva Wintergerst, Stef Deyaert, Aurélien Baudot, Pieter Van den Abbeele
Recent studies suggest that the dietary intake of human milk oligosaccharides (HMOs) provides health benefits from infancy up to adulthood. Thus far, beneficial changes in the adult gut microbiome have been observed at oral doses of 5–20 g/day of HMOs. Efficacy of lower doses has rarely been tested. We assessed four HMO molecular species—2′Fucosyllactose (2′FL), Lacto-N-neotetraose (LNnT), 3′Sialyllactose
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Salicylic Acid and Water Stress: Effects on Morphophysiology and Essential Oil Profile of Eryngium foetidum Metabolites (IF 4.1) Pub Date : 2024-04-21 Sabrina Kelly dos Santos, Daniel da Silva Gomes, Vanessa de Azevedo Soares, Estephanni Fernanda Oliveira Dantas, Ana Flávia Pellegrini de Oliveira, Moises Henrique Almeida Gusmão, Elyabe Monteiro de Matos, Tancredo Souza, Lyderson Facio Viccini, Richard Michael Grazul, Juliane Maciel Henschel, Diego Silva Batista
The exogenous application of bioregulators, such as salicylic acid (SA), has exhibited promising outcomes in alleviating drought stress. Nevertheless, its impact on culantro (Eryngium foetidum L.) remains unexplored. Thus, the aim of this study was to assess how SA impacts the growth, morphophysiology, and essential oil composition of culantro when subjected to drought. To achieve this, culantro plants
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Widely Targeted Metabolomic Analysis Provides New Insights into the Effect of Rootstocks on Citrus Fruit Quality Metabolites (IF 4.1) Pub Date : 2024-04-21 Min Wang, Yang Chen, Shuang Li, Jianjun Yu, Lei Yang, Lin Hong
The use of different rootstocks has a significant effect on the content of flavor components and overall fruit quality. However, little information is available about the metabolic basis of the nutritional value of citrus plants. In this study, UPLC-MS/MS (ultra-performance liquid chromatography-tandem mass spectrometry) was performed to analyze the metabolites of three late-maturing hybrid mandarin
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A Data-Driven Approach to Sugarcane Breeding Programs with Agronomic Characteristics and Amino Acid Constituent Profiling Metabolites (IF 4.1) Pub Date : 2024-04-21 Chiaki Ishikawa, Yasuhiro Date, Makoto Umeda, Yusuke Tarumoto, Megumi Okubo, Yasujiro Morimitsu, Yasuaki Tamura, Yoichi Nishiba, Hiroshi Ono
Sugarcane (Saccharum spp. hybrids) and its processed products have supported local industries such as those in the Nansei Islands, Japan. To improve the sugarcane quality and productivity, breeders select better clones by evaluating agronomic characteristics, such as commercially recoverable sugar and cane yield. However, other constituents in sugarcane remain largely unutilized in sugarcane breeding
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Transcriptomic and Lipidomic Analysis Reveals Complex Regulation Mechanisms Underlying Rice Roots’ Response to Salt Stress Metabolites (IF 4.1) Pub Date : 2024-04-21 Yingbin Xue, Chenyu Zhou, Naijie Feng, Dianfeng Zheng, Xuefeng Shen, Gangshun Rao, Yongxiang Huang, Wangxiao Cai, Ying Liu, Rui Zhang
Rice (Oryza sativa L.), a crucial food crop that sustains over half the world’s population, is often hindered by salt stress during various growth stages, ultimately causing a decrease in yield. However, the specific mechanism of rice roots’ response to salt stress remains largely unknown. In this study, transcriptomics and lipidomics were used to analyze the changes in the lipid metabolism and gene
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Anaplerotic Therapy Using Triheptanoin in Two Brothers Suffering from Aconitase 2 Deficiency Metabolites (IF 4.1) Pub Date : 2024-04-20 Maximilian Penkl, Johannes A. Mayr, René G. Feichtinger, Ralf Reilmann, Otfried Debus, Manfred Fobker, Anja Penkl, Janine Reunert, Stephan Rust, Thorsten Marquardt
Citric acid cycle deficiencies are extremely rare due to their central role in energy metabolism. The ACO2 gene encodes the mitochondrial isoform of aconitase (aconitase 2), the second enzyme of the citric acid cycle. Approximately 100 patients with aconitase 2 deficiency have been reported with a variety of symptoms, including intellectual disability, hypotonia, optic nerve atrophy, cortical atrophy
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Comparative Lipidomics of Oral Commensal and Opportunistic Bacteria Metabolites (IF 4.1) Pub Date : 2024-04-20 Paul L. Wood, Annie Le, Dominic L. Palazzolo
The oral cavity contains a vast array of microbes that contribute to the balance between oral health and disease. In addition, oral bacteria can gain access to the circulation and contribute to other diseases and chronic conditions. There are a limited number of publications available regarding the comparative lipidomics of oral bacteria and fungi involved in the construction of oral biofilms, hence
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Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction Metabolites (IF 4.1) Pub Date : 2024-04-18 Melania Gaggini, Federica Marchi, Nataliya Pylypiv, Alessandra Parlanti, Simona Storti, Umberto Paradossi, Sergio Berti, Cristina Vassalle
Sphingolipids (SLs) influence several cellular pathways, while vitamin D exerts many extraskeletal effects in addition to its traditional biological functions, including the modulation of calcium homeostasis and bone health. Moreover, Vitamin D and SLs affect the regulation of each others’ metabolism; hence, this study aims to evaluate the relationship between the levels of 25(OH)D and ceramides in
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Development of New Predictive Equations for the Resting Metabolic Rate (RMR) of Women with Lipedema Metabolites (IF 4.1) Pub Date : 2024-04-19 Małgorzata Jeziorek, Jakub Wronowicz, Łucja Janek, Krzysztof Kujawa, Andrzej Szuba
Background: This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. Methods: We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland. RMR was assessed using indirect calorimetry, while body composition and anthropometric measurements were conducted using standardized
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High Starch Induces Hematological Variations, Metabolic Changes, Oxidative Stress, Inflammatory Responses, and Histopathological Lesions in Largemouth Bass (Micropterus salmoides) Metabolites (IF 4.1) Pub Date : 2024-04-19 Yuanyuan Xie, Xianping Shao, Penghui Zhang, Hao Zhang, Jiaxing Yu, Xinfeng Yao, Yifan Fu, Jiao Wei, Chenglong Wu
This study evaluated effects of high starch (20%) on hematological variations, glucose and lipid metabolism, antioxidant ability, inflammatory responses, and histopathological lesions in largemouth bass. Results showed hepatic crude lipid and triacylglycerol (TAG) contents were notably increased in fish fed high starch. High starch could increase counts of neutrophils, lymphocytes, monocytes, eosinophils
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Comprehensive Two-Dimensional Gas Chromatography–Mass Spectrometry as a Tool for the Untargeted Study of Hop and Their Metabolites Metabolites (IF 4.1) Pub Date : 2024-04-19 Glaucimar A. P. Resende, Michelle S. S. Amaral, Bruno G. Botelho, Philip J. Marriott
Since hop secondary metabolites have a direct correlation with the quality of beer and other hop-based beverages, and the volatile fraction of hop has a complex composition, requiring effective separation, here we explore the application of headspace solid-phase microextraction as a sample preparation method, coupled with comprehensive two-dimensional gas chromatography–mass spectrometry (GC×GC–MS)
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Unveiling Metal Tolerance Mechanisms in Leersia hexandra Swartz under Cr/Ni Co-Pollution by Studying Endophytes and Plant Metabolites Metabolites (IF 4.1) Pub Date : 2024-04-18 Mouyixing Chen, Guo Yu, Hui Qiu, Pingping Jiang, Xuemei Zhong, Jie Liu
Heavy metal pollution poses significant environmental challenges, and understanding how plants and endophytic bacteria interact to mitigate these challenges is of utmost importance. In this study, we investigated the roles of endophytic bacteria, particularly Chryseobacterium and Comamonas, in Leersia hexandra Swartz (L. hexandra) in response to chromium and nickel co-pollution. Our results demonstrated
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Computational Applications: Beauvericin from a Mycotoxin into a Humanized Drug Metabolites (IF 4.1) Pub Date : 2024-04-18 Charbel Al Khoury, Sima Tokajian, Nabil Nemer, Georges Nemer, Kelven Rahy, Sergio Thoumi, Lynn Al Samra, Aia Sinno
Drug discovery was initially attributed to coincidence or experimental research. Historically, the traditional approaches were complex, lengthy, and expensive, entailing costly random screening of synthesized compounds or natural products coupled with in vivo validation largely depending on the availability of appropriate animal models. Currently, in silico modeling has become a vital tool for drug
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Comparison of the Effect of Two Different Handling Conditions at Slaughter in Saliva Analytes in Pigs Metabolites (IF 4.1) Pub Date : 2024-04-18 María Botía, Damián Escribano, Alba Ortín-Bustillo, María J. López-Martínez, Pablo Fuentes, Francisco J. Jiménez-Caparrós, Juan L. Hernández-Gómez, Antonio Avellaneda, José J. Cerón, Camila P. Rubio, Asta Tvarijonaviciute, Silvia Martínez-Subiela, Marina López-Arjona, Fernando Tecles
In this report, different handling conditions at slaughterhouse were studied to assess changes in salivary biomarkers. For this purpose, finishing pigs were divided into two groups, one in which handling was improved to minimize stress (Group A, n = 24, transported and stabled at the slaughterhouse at low density without mixing with unfamiliar animals throughout the whole process) and another one in
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Iron Absorption: Molecular and Pathophysiological Aspects Metabolites (IF 4.1) Pub Date : 2024-04-17 Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati
Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can be deleterious. On the other hand, excess iron may lead to cell and tissue damage. Consequently, iron balance is strictly regulated. As iron excretion
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Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer Metabolites (IF 4.1) Pub Date : 2024-04-17 Pierrick Martinez, Ilyes Baghli, Géraud Gourjon, Thomas N. Seyfried
The cancer paradigm is generally based on the somatic mutation model, asserting that cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) proposes that tumorigenesis may result from an alteration of the mitochondria, specifically a chronic oxidative phosphorylation (OxPhos) insufficiency in stem cells, which forms cancer stem cells (CSCs) and leads to malignancy. Reviewed
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Discrimination of Lipogenic or Glucogenic Diet Effects in Early-Lactation Dairy Cows Using Plasma Metabolite Abundances and Ratios in Combination with Machine Learning Metabolites (IF 4.1) Pub Date : 2024-04-17 Xiaodan Wang, Sanjeevan Jahagirdar, Wouter Bakker, Carolien Lute, Bas Kemp, Ariette van Knegsel, Edoardo Saccenti
During early lactation, dairy cows have a negative energy balance since their energy demands exceed their energy intake: in this study, we aimed to investigate the association between diet and plasma metabolomics profiles and how these relate to energy unbalance of course in the early-lactation stage. Holstein-Friesian cows were randomly assigned to a glucogenic (n = 15) or lipogenic (n = 15) diet
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A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals Metabolites (IF 4.1) Pub Date : 2024-04-16 Jeane Maria Oliveira, Jamilli Zenzeluk, Caroline Serrano-Nascimento, Marco Aurelio Romano, Renata Marino Romano
Compounds of natural or synthetic origin present in personal care products, food additives, and packaging may interfere with hormonal regulation and are called endocrine-disrupting chemicals (EDCs). The thyroid gland is an important target of these compounds. The objective of this study was to analyze public data on the human thyroid transcriptome and investigate potential new targets of EDCs in the
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Combined Metabolomics and Biochemical Analyses of Serum and Milk Revealed Parity-Related Metabolic Differences in Sanhe Dairy Cattle Metabolites (IF 4.1) Pub Date : 2024-04-16 Zixin Liu, Aoyu Jiang, Xiaokang Lv, Dingkun Fan, Qingqing Chen, Yicheng Wu, Chuanshe Zhou, Zhiliang Tan
The production performance of dairy cattle is closely related to their metabolic state. This study aims to provide a comprehensive understanding of the production performance and metabolic features of Sanhe dairy cattle across different parities, with a specific focus on evaluating variations in milk traits and metabolites in both milk and serum. Sanhe dairy cattle from parities 1 to 4 (S1, n = 10;
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Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach Metabolites (IF 4.1) Pub Date : 2024-04-15 Jianing Ren, Jing Dai, Yue Chen, Zhenzhen Wang, Ruyi Sha, Jianwei Mao, Yangchen Mao
Rice (Oryza sativa L.) is one of the primary sources of energy and nutrients needed by the body, and rice resistant starch (RRS) has been found to have hypoglycemic effects. However, its biological activity and specific mechanisms still need to be further elucidated. In the present study, 52 RRS differential metabolites were obtained from mouse liver, rat serum, canine feces, and human urine, and 246
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Cryoprotectant-Mediated Cold Stress Mitigation in Litchi Flower Development: Transcriptomic and Metabolomic Perspectives Metabolites (IF 4.1) Pub Date : 2024-04-15 Xue-Wen Zheng, Xin-Yue Cao, Wen-Hao Jiang, Guang-Zhao Xu, Qing-Zhi Liang, Zhuan-Ying Yang
Temperature is vital in plant growth and agricultural fruit production. Litchi chinensis Sonn, commonly known as litchi, is appreciated for its delicious fruit and fragrant blossoms and is susceptible to stress when exposed to low temperatures. This study investigates the effect of two cryoprotectants that counteract cold stress during litchi flowering, identifies the genes that generate the cold resistance
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Characterization and Discrimination of Marigold Oleoresin from Different Origins Based on UPLC-QTOF-MS Combined Molecular Networking and Multivariate Statistical Analysis Metabolites (IF 4.1) Pub Date : 2024-04-15 Xingfu Cai, Juanjuan Wu, Yunhe Lian, Shuaiyao Yang, Qiang Xue, Dewang Li, Di Wu
Marigold oleoresin is an oil-soluble natural colorant mainly extracted from marigold flowers. Xinjiang of China, India, and Zambia of Africa are the three main production areas of marigold flowers. Therefore, this study utilized ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technology, combined with Global Natural Products Social Molecular Networking
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A Comparative Analysis of Polysaccharides and Ethanolic Extracts from Two Egyptian Sweet Potato Cultivars, Abees and A 195: Chemical Characterization and Immunostimulant Activities Metabolites (IF 4.1) Pub Date : 2024-04-14 Rehab M. Elgabry, Mariam Hassan, Ghada A. Fawzy, Khaled M. Meselhy, Osama G. Mohamed, Areej M. Al-Taweel, Mohamed S. Sedeek
Sweet potato (Ipomoea batatas (L.) Lam.) belongs to family Convolvulaceae. The plant is distributed worldwide and consumed, especially for its edible tubers. Many studies have proved that the plant has variable biological activities such as antidiabetic, anti-cancer, antihypertensive, antimicrobial, and immunostimulant activities. The roots of sweet potatoes are rich in valuable phytochemical constituents
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The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways Metabolites (IF 4.1) Pub Date : 2024-04-12 Xiaoyao Liu, Yuxi Wang, Yuan Tian, Jiahui Hu, Zhen Liu, Yuncheng Ma, Wenhui Xu, Weiling Wang, Jian Gao, Ting Wang
Rhubarb (RR), Chinese name Dahuang, is commonly used in the treatment of ischemic stroke (IS). However, its potential mechanism is not fully elucidated. This study intended to verify the effect of RR on IS and investigate the possible mechanism of RR in preventing IS. IS in male rats was induced by embolic middle cerebral artery occlusion (MCAO) surgery, and drug administration was applied half an
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Metabolomic Analysis Reveals the Association of Severe Bronchopulmonary Dysplasia with Gut Microbiota and Oxidative Response in Extremely Preterm Infants Metabolites (IF 4.1) Pub Date : 2024-04-13 Chih-Yung Chiu, Ming-Chou Chiang, Meng-Han Chiang, Reyin Lien, Ren-Huei Fu, Kai-Hsiang Hsu, Shih-Ming Chu
Bronchopulmonary dysplasia (BPD) is a chronic lung disease mainly affecting premature infants needing ventilation or oxygen for respiratory distress. This study aimed to evaluate the molecular linkages for BPD in very and extremely preterm infants using a metabolomics-based approach. A case-control study of enrolling preterm infants born before 32 weeks gestational age (GA) was prospectively performed
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Chronic Administration of Exogenous Lactate Increases Energy Expenditure during Exercise through Activation of Skeletal Muscle Energy Utilization Capacity in Mice Metabolites (IF 4.1) Pub Date : 2024-04-13 Inkwon Jang, Sunghwan Kyun, Deunsol Hwang, Taeho Kim, Kiwon Lim, Hun-Young Park, Sung-Woo Kim, Jisu Kim
We compared the effects of chronic exogenous lactate and exercise training, which influence energy substrate utilization and body composition improvements at rest and during exercise, and investigated the availability of lactate as a metabolic regulator. The mice were divided into four groups: CON (sedentary + saline), LAC (sedentary + lactate), EXE (exercise + saline), and EXLA (exercise + lactate)
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The Effect of Maternal Overweight/Obesity on Serum and Breastmilk Leptin, and Its Associations with Body Composition, Cardiometabolic Health Indices, and Maternal Diet: The BLOOM Study Metabolites (IF 4.1) Pub Date : 2024-04-13 Monika A. Zielinska-Pukos, Łukasz Kopiasz, Jadwiga Hamulka
In overweight and obese patients, elevated serum and breastmilk leptin concentrations are observed, with serum leptin also being likely affected by the diet. We analyzed serum and breastmilk leptin in normal weight (NW) and overweight/obese (OW/OB) mothers, and evaluated its associations with (1) maternal anthropometric parameters; (2) markers of cardiometabolic health; and (3) the maternal diet. The
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Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism Metabolites (IF 4.1) Pub Date : 2024-04-12 Xu Li, Pingdong Cai, Xinyuan Tang, Yingzi Wu, Yue Zhang, Xianglu Rong
Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, pro-thrombotic, and inflammatory health hazards. Due to their complex pathological mechanisms, there is a lack of
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Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective Metabolites (IF 4.1) Pub Date : 2024-04-12 Yansong Fu, Zhipeng Wang, Hong Qin
Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent liver disease worldwide, affecting approximately two-fifths of the global population. The pathogenesis of MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play
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Unveiling the Nexus: Cellular Metabolomics Unravels the Impact of Estrogen on Nicotinamide Metabolism in Mitigating Rheumatoid Arthritis Pathogenesis Metabolites (IF 4.1) Pub Date : 2024-04-11 Swati Malik, Debolina Chakraborty, Prachi Agnihotri, Vijay Kumar, Sagarika Biswas
Rheumatoid arthritis (RA) is a metabolic joint disorder influenced by hormonal regulation, notably estrogen, which plays a cytoprotective role against inflammation. While estrogen’s impact on RA pathogenesis has been studied, the altered metabolite expression under estrogen’s influence remains unexplored. This study investigated the changes in the metabolome of synovial fibroblasts isolated from RA
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Cathepsin S Is More Abundant in Serum of Mycobacterium avium subsp. paratuberculosis-Infected Dairy Cows Metabolites (IF 4.1) Pub Date : 2024-04-11 Heidi C. Duda, Christine von Toerne, Lucia Korbonits, Andrea Didier, Armin M. Scholz, Erwin Märtlbauer, Stefanie M. Hauck, Cornelia A. Deeg
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of bovine paratuberculosis, a chronic granulomatous enteritis leading to economic losses and posing a risk to human health due to its zoonotic potential. The pathogen cannot reliably be detected by standard methods, and immunological procedures during the infection are not well understood. Therefore, the aim of our study was to
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Late Effects of Ionizing Radiation on the Ultrastructure of Hepatocytes and Activity of Lysosomal Enzymes in Mouse Liver Irradiated In Vivo Metabolites (IF 4.1) Pub Date : 2024-04-09 Małgorzata Łysek-Gładysińska, Anna Wieczorek, Anna Walaszczyk, Karol Jelonek, Monika Pietrowska, Piotr Widłak, Roland Kulik, Dorota Gabryś
The study aimed to investigate late radiation-induced changes in the histology, ultrastructure, and activity of lysosomal enzymes in mouse liver exposed to ionizing radiation. The experiment was conducted on C57BL/6J male mice whose distal part of the liver was exposed occasionally to single doses of radiation (6 MV photons) during targeted heart irradiation; estimated doses delivered to analyzed tissue
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Heat-Induced Cross-Tolerance to Salinity Due to Thermopriming in Tomatoes Metabolites (IF 4.1) Pub Date : 2024-04-10 Tobias Körner, Ruven Gierholz, Jana Zinkernagel, Simone Röhlen-Schmittgen
Global plant production is challenged by unpredictable (a)biotic stresses that occur individually, simultaneously or staggered. Due to an increasing demand for environmentally friendly plant production, new sustainable, universal, and preventive measures in crop protection are needed. We postulate thermopriming as a suitable procedure that fulfills these requirements. Therefore, we performed thermopriming
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Influence of Citrus sunki and Poncirus trifoliata Root Extracts on Metabolome of Phytophthora parasitica Metabolites (IF 4.1) Pub Date : 2024-04-05 Héros José Maximo, Francisca Diana da Silva Araújo, Carolina Clepf Pagotto, Leonardo Pires Boava, Ronaldo José Durigan Dalio, Gustavo Henrique Bueno Duarte, Marcos Nogueira Eberlin, Marcos Antonio Machado
Phytophthora parasitica is an oomycete pathogen that infects a broad range of crops of worldwide economic interest; among them are citrus species. In general, some Citrus and the rootstocks of related genera offer considerable resistance against P. parasitica; therefore, understanding the mechanisms involved in the virulence of this pathogen is crucial. In this work, P. parasitica secondary metabolite
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Effects of Summer Heat on Adipose Tissue Activity in Periparturient Simmental Cows Metabolites (IF 4.1) Pub Date : 2024-04-06 Romana Turk, Nikola Rošić, Blanka Beer Ljubić, Silvijo Vince
Hot climate is one of the major factors affecting the dairy industry. Heat stress could be responsible for decreased feed intake and consequently leads to alterations in energy metabolism, particularly during late pregnancy and early lactation. This study aimed to assess the effects of summer heat on adipose tissue activities during the periparturient period in Simmental cows. Two groups of cows were
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Accumulation of Non-Pathological Liver Fat Is Associated with the Loss of Glyoxalase I Activity in Humans Metabolites (IF 4.1) Pub Date : 2024-04-07 Andreas Peter, Erwin Schleicher, Elisabeth Kliemank, Julia Szendroedi, Alfred Königsrainer, Hans-Ulrich Häring, Peter P. Nawroth, Thomas Fleming
The underlying molecular mechanisms for the development of non-alcoholic fatty liver (NAFL) and its progression to advanced liver diseases remain elusive. Glyoxalase 1 (Glo1) loss, leading to elevated methylglyoxal (MG) and dicarbonyl stress, has been implicated in various diseases, including obesity-related conditions. This study aimed to investigate changes in the glyoxalase system in individuals
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A Study of the Synergistic Effects of Essential Oils from Origanum compactum and Origanum elongatum with Commercial Antibiotics against Highly Prioritized Multidrug-Resistant Bacteria for the World Health Organization Metabolites (IF 4.1) Pub Date : 2024-04-07 Aziz Drioiche, Soukayna Baammi, Khalid Zibouh, Omkulthom Al Kamaly, Anwar M. Alnakhli, Firdaous Remok, Soukaina Saidi, Rachid Amaiach, Fadoua El Makhoukhi, Abdelhakim Elomri, Touriya Zair
The irrational use of antibiotics has favored the emergence of resistant bacteria, posing a serious threat to global health. To counteract antibiotic resistance, this research seeks to identify novel antimicrobials derived from essential oils that operate through several mechanisms. It aims to evaluate the quality and composition of essential oils from Origanum compactum and Origanum elongatum; test
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Effect of Bile on Hemodynamics and Blood Micro-Rheological Parameters in Experimental Models of Bilhemia Metabolites (IF 4.1) Pub Date : 2024-04-07 Adam Attila Matrai, Adam Varga, Laszlo Adam Fazekas, Barbara Bedocs-Barath, Noel Johny Nellamkuzhi, Tran Bao Nghi, Norbert Nemeth, Adam Deak
As a rare complication of liver injury and certain interventions, bile can enter the bloodstream depending on the pressure gradient, resulting in bilhemia. Its micro-rheological and hemodynamic effects are still unclear. We aimed to study these parameters in experimental bilhemia models. Under general anesthesia, via laparotomy, bile was obtained by gallbladder puncture from pigs and by choledochal
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Mapping the Metabolic Characteristics and Perturbation of Adult Casper Zebrafish by Ambient Mass Spectrometry Imaging Metabolites (IF 4.1) Pub Date : 2024-04-04 Zhi Zhou, Yue Sun, Ji Yang, Zeper Abliz
Casper, a type of transparent mutant-line zebrafish, was generated to overcome the opaque trunk of an adult zebrafish for tumor modeling to realize real-time visualization of transplanted cells in vivo. However, the molecular information at the metabolic level has not received much attention. Herein, a spatially resolved metabolomics method based on an airflow-assisted desorption electrospray ionization–mass
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Identifying Predictive Biomarkers of Subclinical Mastitis in Dairy Cows through Urinary Metabotyping Metabolites (IF 4.1) Pub Date : 2024-04-04 Grzegorz Zwierzchowski, Klevis Haxhiaj, Roman Wójcik, David S. Wishart, Burim N. Ametaj
Mastitis is a significant infectious disease in dairy cows, resulting in milk yield loss and culling. Early detection of mastitis-prone cows is crucial for implementing effective preventive measures before disease onset. Current diagnosis of subclinical mastitis (SCM) relies on somatic cell count assessment post-calving, lacking predictive capabilities. This study aimed to identify metabolic changes
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Pancreatic Beta Cell Function in Infants Varies by Maternal Weight Metabolites (IF 4.1) Pub Date : 2024-04-06 Lisa R. Staimez, Anubrati Dutta, Yara S. Beyh, Ruby Gupta, Hari Krishna Noule, Vyakaranam Sapna, Kothapally Deepa, Aryeh D. Stein, KM Venkat Narayan, D Prabhakaran, Basany Kalpana, Poornima Prabhakaran
Background: The Asian Indian Beta Cell function (ABCs) in Infants Study examined the associations of maternal weight on infant pancreatic beta cell function across 7 months postpartum. Methods: Pregnant women aged 18–35 years were recruited in Hyderabad, India. Women were classified by first trimester weight as underweight (UW), BMI < 18.5 kg/m2; normal weight (NW), BMI 18.5–22.9 kg/m2; or overweight
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Time-Course Metabolomic Analysis: Production of Betaine Structural Analogs by Fungal Fermentation of Seaweed Metabolites (IF 4.1) Pub Date : 2024-04-03 Nao Inoue, Keisuke Tsuge, Teruyoshi Yanagita, Akira Oikawa, Koji Nagao
Betaine structural analogs are compounds characterized by the presence of positive and negative charges in a single molecule and have been reported to have physiological properties, such as anti-inflammatory activities. In this study, we performed a metabolomic analysis of metabolite composition changes during the fermentation of Neopyropia yezoensis, an edible red alga, with Aspergillus oryzae for
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Evaluation of the Aquatic Toxicity of Several Triazole Fungicides Metabolites (IF 4.1) Pub Date : 2024-04-02 Bianca-Vanesa Boros, Diana-Larisa Roman, Adriana Isvoran
Fungicides play an important role in crop protection, but they have also been shown to adversely affect non-target organisms, including those living in the aquatic environment. The aim of the present study is to combine experimental and computational approaches to evaluate the effects of flutriafol, metconazole, myclobutanil, tebuconazole, tetraconazole and triticonazole on aquatic model organisms
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Evolutive Models, Algorithms and Predictive Parameters for the Progression of Hepatic Steatosis Metabolites (IF 4.1) Pub Date : 2024-04-03 Marinela Sînziana Tudor, Veronica Gheorman, Georgiana-Mihaela Simeanu, Adrian Dobrinescu, Vlad Pădureanu, Venera Cristina Dinescu, Mircea-Cătălin Forțofoiu
The utilization of evolutive models and algorithms for predicting the evolution of hepatic steatosis holds immense potential benefits. These computational approaches enable the analysis of complex datasets, capturing temporal dynamics and providing personalized prognostic insights. By optimizing intervention planning and identifying critical transition points, they promise to revolutionize our approach
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Effect of Low Temperature on Content of Primary Metabolites in Two Wheat Genotypes Differing in Cold Tolerance Metabolites (IF 4.1) Pub Date : 2024-04-03 Alexander Deryabin, Kseniya Zhukova, Natalia Naraikina, Yuliya Venzhik
The study of cold-tolerance mechanisms of wheat as a leading cereal crop is very relevant to science. Primary metabolites play an important role in the formation of increased cold tolerance. The aim of this research is to define changes in the content of primary metabolites (soluble proteins and sugars), growth, and photosynthetic apparatus of freezing-tolerant and cold-sustainable wheat (Triticum
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Challenges in the Metabolomics-Based Biomarker Validation Pipeline Metabolites (IF 4.1) Pub Date : 2024-04-03 Shenghan Li, Nikita Looby, Vinod Chandran, Vathany Kulasingam
As end-products of the intersection between the genome and environmental influences, metabolites represent a promising approach to the discovery of novel biomarkers for diseases. However, many potential biomarker candidates identified by metabolomics studies fail to progress beyond analytical validation for routine implementation in clinics. Awareness of the challenges present can facilitate the development
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Effect of Arbuscular Mycorrhizal Fungi and Rock Phosphate on Growth, Physiology, and Biochemistry of Carob under Water Stress and after Rehydration in Vermicompost-Amended Soil Metabolites (IF 4.1) Pub Date : 2024-04-03 Abderrahim Boutasknit, Mohamed Ait-El-Mokhtar, Boujemaa Fassih, Raja Ben-Laouane, Said Wahbi, Abdelilah Meddich
In the Mediterranean region, reforestation programs record failures following successive drought periods. The use of different plant-growth-promoting amendments and the understanding of drought-induced physiological and biochemical responses of carob will contribute to the reforestation program’s success. In this study, the effects of arbuscular-mycorrhizal-fungi (AMF), vermicompost (VC), and rock
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Grape/Blueberry Anthocyanins and Their Gut-Derived Metabolites Attenuate LPS/Nigericin-Induced Inflammasome Activation by Inhibiting ASC Speck Formation in THP-1 Monocytes Metabolites (IF 4.1) Pub Date : 2024-04-03 Inken Behrendt, Isabella Röder, Frank Will, Gabriela Michel, Elvira Friedrich, Daniela Grote, Zoe Martin, Hanna Pauline Dötzer, Mathias Fasshauer, Martin Speckmann, Sabine Kuntz
Inflammasomes are multi-protein complexes, which are formed in response to tissue injury, infections, and metabolic stress. However, aberrant inflammasome activation has been linked to several inflammatory diseases. Anthocyanins have been reported to attenuate NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation, but the influence of grape/blueberry anthocyanins and especially their
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Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy Metabolites (IF 4.1) Pub Date : 2024-03-29 Bilal El-Mansoury, Kamal Smimih, Abdelaati El Khiat, Ahmed Draoui, Abdelmohcine Aimrane, Redouane Chatoui, Abdesslam Ferssiwi, Abdelali Bitar, Halima Gamrani, Arumugam R. Jayakumar, Omar El Hiba
Hepatic encephalopathy (HE) is a major neuropsychological condition that occursas a result of impaired liver function. It is frequently observed in patients with advanced liver disease or cirrhosis. Memory impairment is among the symptoms of HE; the pathophysiologic mechanism for this enervating condition remains unclear. However, it is possible that neuroinflammation may be involved, as recent studies
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Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption Metabolites (IF 4.1) Pub Date : 2024-03-28 Adeline Vignault, Carole Vaysse, Karène Bertand, Stéphanie Krisa, Arnaud Courtois, Benjamin Moras, Tristan Richard, David Gaudout, Line Pourtau
The therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron’s properties, crocin and crocetin absorption and bioavailability have been the most studied. Nevertheless, the metabolism of these major compounds of saffron has not yet been entirely elucidated. Current data indicate that the phase 2 metabolism of crocetins go through
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COVID-19 and Comorbidities: What Has Been Unveiled by Metabolomics? Metabolites (IF 4.1) Pub Date : 2024-03-30 André Luiz Melo Camelo, Hans Rolando Zamora Obando, Isabela Rocha, Aline Cristina Dias, Alessandra de Sousa Mesquita, Ana Valéria Colnaghi Simionato
The COVID-19 pandemic has brought about diverse impacts on the global population. Individuals with comorbidities were more susceptible to the severe symptoms caused by the virus. Within the crisis scenario, metabolomics represents a potential area of science capable of providing relevant information for understanding the metabolic pathways associated with the intricate interaction between the viral
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Gastric Fluid Metabolomics Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants Results of a Case–Control Study Metabolites (IF 4.1) Pub Date : 2024-03-30 Konstantia Besiri, Olga Begou, Konstantinos Lallas, Angeliki Kontou, Eleni Agakidou, Olga Deda, Helen Gika, Eleni Verykouki, Kosmas Sarafidis
Respiratory distress syndrome (RDS) is a major morbidity of prematurity. In this case–control study, we prospectively evaluated whether untargeted metabolomic analysis (gas chromatography–mass spectrometry) of the gastric fluid could predict the need for surfactant in very preterm neonates. 43 infants with RDS necessitating surfactant (cases) were compared with 30 infants who were not treated with
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Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice Metabolites (IF 4.1) Pub Date : 2024-03-27 Weishou Shen, Meng Zhao, Weichen Xu, Xiaochun Shi, Fangfang Ren, Pengcheng Tu, Nan Gao, Jinjun Shan, Bei Gao
The wide spread of microplastics has fueled growing public health concern globally. Due to their porous structure and large surface area, microplastics can serve as carriers for other environmental pollutants, including heavy metals. Although the toxic effects of microplastics or heavy metals have been reported previously, investigations into the sex-differential health effects of combined exposure
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Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease Metabolites (IF 4.1) Pub Date : 2024-03-28 Helaina E. Huneault, Chih-Yu Chen, Catherine C. Cohen, Xueyun Liu, Zachery R. Jarrell, Zhulin He, Karla E. DeSantos, Jean A. Welsh, Kristal M. Maner-Smith, Eric A. Ortlund, Jeffrey B. Schwimmer, Miriam B. Vos
Little is known about lipid changes that occur in the setting of metabolic-dysfunction-associated steatotic liver disease (MASLD) regression. We previously reported improvements in hepatic steatosis, de novo lipogenesis (DNL), and metabolomic profiles associated with oxidative stress, inflammation, and selected lipid metabolism in 40 adolescent boys (11–16 y) with hepatic steatosis ≥5% (98% meeting
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Exploring Possible Links: Thigh Muscle Mass, Apolipoproteins, and Glucose Metabolism in Peripheral Artery Disease—Insights from a Pilot Sub-Study following Endovascular Treatment Metabolites (IF 4.1) Pub Date : 2024-03-29 Takeshi Ikeda, Hidenori Komiyama, Tomoyo Miyakuni, Masamichi Takano, Kuniya Asai
Peripheral artery disease (PAD) compromises walking and physical activity, which results in further loss of skeletal muscle. The cross-sectional area of the thigh muscle has been shown to be correlated with systemic skeletal muscle volume. In our previous pilot study, we observed an increase in thigh muscle mass following endovascular treatment (EVT) in patients with proximal vascular lesions affecting
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Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis Metabolites (IF 4.1) Pub Date : 2024-03-29 Ji Yeon Noh, Naser Farhataziz, Michael T. Kinter, Xin Yan, Yuxiang Sun
Inflammatory bowel disease (IBD) is multifactorial chronic inflammatory disease in the gastrointestinal tract, affecting patients’ quality of life profoundly. The incidence of IBD has been on the rise globally for the last two decades. Because the molecular mechanisms underlying the disease remain not well understood, therapeutic development is significantly impeded. Metabolism is a crucial cellular
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Metformin and the Liver: Unlocking the Full Therapeutic Potential Metabolites (IF 4.1) Pub Date : 2024-03-25 Federica Perazza, Laura Leoni, Santo Colosimo, Alessandra Musio, Giulia Bocedi, Michela D’Avino, Giulio Agnelli, Alba Nicastri, Chiara Rossetti, Federica Sacilotto, Giulio Marchesini, Maria Letizia Petroni, Federico Ravaioli
Metformin is a highly effective medication for managing type 2 diabetes mellitus. Recent studies have shown that it has significant therapeutic benefits in various organ systems, particularly the liver. Although the effects of metformin on metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis are still being debated, it has positive effects on
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Metabolic Profiling of SH-SY5Y and Neuro2A Cells in Relation to Fetal Calf Serum (FCS) Concentration in Culture Media Metabolites (IF 4.1) Pub Date : 2024-03-26 Lys Kronenberger, Janine Mett, Jessica Hoppstädter, Uli Müller
The neuroblastoma cell lines SH-SY5Y and Neuro2A are commonly utilized models in neurobiological research. DMEM supplemented with different nutrients and 5–10% Fetal Calf Serum (FCS) is typically used for culturing these cell lines. During special treatments, a reduced FCS content is often deployed to reduce cellular proliferation or the content of bioactive compounds. The impact of the reduction of
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Long-Term Adherence to the Mediterranean Diet Reduces 20-Year Diabetes Incidence: The ATTICA Cohort Study (2002–2022) Metabolites (IF 4.1) Pub Date : 2024-03-25 Ioanna Kechagia, Thomas Tsiampalis, Evangelia Damigou, Fotios Barkas, Georgia Anastasiou, Evrydiki Kravvariti, Evangelos Liberopoulos, Petros P. Sfikakis, Christina Chrysohoou, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos
This study aimed to evaluate the association between adherence to the Mediterranean diet and the 20-year incidence of type II diabetes mellitus (T2DM) among adults from the ATTICA study. This study involved a prospective cohort of 3042 men and women recruited at baseline from the Attica region in Greece. Sociodemographic, anthropometric, lifestyle, and clinical characteristics were evaluated at baseline
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Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage Metabolites (IF 4.1) Pub Date : 2024-03-25 Hope D. Welhaven, Avery H. Welfley, Priyanka Brahmachary, Annika R. Bergstrom, Eden Houske, Matthew Glimm, Brian Bothner, Alyssa K. Hahn, Ronald K. June
Osteoarthritis (OA) is a chronic joint disease with heterogenous metabolic pathology. To gain insight into OA-related metabolism, metabolite extracts from healthy (n = 11) and end-stage osteoarthritic cartilage (n = 35) were analyzed using liquid chromatography–mass spectrometry metabolomic profiling. Specific metabolites and metabolic pathways, including lipid and amino acid pathways, were differentially