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How conspecific and allospecific eggs and larvae drive oviposition preference in Drosophila Chem. Senses (IF 3.5) Pub Date : 2024-04-12 Rolando D Moreira-Soto, Mohammed A Khallaf, Bill S Hansson, Markus Knaden
Where to lay the eggs is a crucial decision for females as it influences the success of their offspring. Female flies prefer to lay eggs on food already occupied and consumed by larvae, which facilitates social feeding, but potentially could also lead to detrimental interactions between species. Whether females can modulate their attraction to cues associated with different species is unknown. Here
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Astringency and its sub-qualities: A review of astringency mechanisms and methods for measuring saliva lubrication Chem. Senses (IF 3.5) Pub Date : 2024-04-09 Shaoyang Wang, Heather E Smyth, Sandra M Olarte Mantilla, Jason R Stokes, Paul A Smith
Astringency is an important mouthfeel attribute that influences the sensory experiences of many food and beverage products. While salivary lubricity loss and increased oral friction were previously believed to be the only astringency mechanisms, recent research has demonstrated that non-tactile oral receptors can trigger astringency by responding to astringents without mechanical stimulation. Various
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The trilogy of human musk receptors: Linking receptor activation, genotype and sensory perception Chem. Senses (IF 3.5) Pub Date : 2024-04-08 Roger Emter, Christel Merillat, Sandro Dossenbach, Andreas Natsch
The scent of musk plays a unique role in the history of perfumery. Musk odorants comprise six diverse chemical classes and perception difference in strength and quality among human panelists have long puzzled the field of olfaction research. Three odorant receptors (OR) had recently been described for musk odorants: OR5AN1, OR1N2 and OR5A2. High functional expression of the difficult-to-express human
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The impact of temperature and a chemesthetic cooling agent on lingual roughness sensitivity Chem. Senses (IF 3.5) Pub Date : 2024-03-25 Sebastiano Ricci, Min Sung Kim, Christopher T Simons
Oral tactile sensitivity underpins food texture perception, but few studies have investigated mechanoreception in oral tissues. During food consumption, oral tissues are exposed to a wide range of temperatures and chemical entities. The objective of the present study was to assess the influence of thermal sensations on lingual roughness sensitivity. Just-noticeable difference thresholds (JNDs) were
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Factors influencing olfactory function in an adult general population sample: the CHRIS study Chem. Senses (IF 3.5) Pub Date : 2024-03-07 Martin Gögele, David Emmert, Christian Fuchsberger, Johannes Frasnelli
The sense of smell allows for the assessment of the chemical composition of volatiles in our environment. Different factors are associated with reduced olfactory function, including age, sex, as well as health and lifestyle conditions. However, most studies that aimed at identifying the variables that drive olfactory function in the population suffered from methodological weaknesses differences in
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What are Olfaction and Gustation, And Do All Animals Have Them? Chem. Senses (IF 3.5) Pub Date : 2024-02-28 Charles D Derby, John Caprio
Different animals have distinctive anatomical and physiological properties to their chemical senses that enhance detection and discrimination of relevant chemical cues. Humans and other vertebrates are recognized as having two main chemical senses, olfaction and gustation, distinguished from each other by their evolutionarily conserved neuroanatomical organization. This distinction between olfaction
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Cyclophosphamide induces the loss of taste bud innervation in mice Chem. Senses (IF 3.5) Pub Date : 2024-02-27 Ryan M Wood, Erin L Vasquez, Krystal A Goyins, Eduardo Gutierrez Kuri, Kevin Connelly, Saima Humayun, Lindsey J Macpherson
Many common chemotherapeutics produce disruptions in the sense of taste which can lead to loss of appetite, nutritional imbalance, and reduced quality of life, especially if taste loss persists after treatment ends. Cyclophosphamide (CYP), an alkylating chemotherapeutic agent, affects taste sensitivity through its cytotoxic effects on mature taste receptor cells (TRCs) and on taste progenitor cell
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Odor dilution sorting as a clinical test of olfactory function: normative values and reliability data Chem. Senses (IF 3.5) Pub Date : 2024-02-24 Jörn Lötsch, Anne Wolter, Antje Hähner, Thomas Hummel
Clinical assessment of an individual's sense of smell has gained prominence, but its resource-intensive nature necessitates the exploration of self-administered methods. In this study, a cohort of 68 patients with olfactory loss and 55 controls were assessed using a recently introduced olfactory test. This test involves sorting two odorants (eugenol, phenylethyl alcohol) in five dilutions according
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Development of the gas chromatography/mass spectrometry-based aroma designer capable of modifying volatile chemical compositions in complex odors Chem. Senses (IF 3.5) Pub Date : 2024-02-22 Kaname Obara, Reiko Uenoyama, Yutaro Obata, Masao Miyazaki
Many volatile organic compounds (VOCs) are used to produce various commercial products with aromas mimicking natural products. The VOCs responsible for aromas have been identified from many natural products. The current major strategy is to analyze chemical compositions and aroma qualities of individual VOCs using gas chromatography/mass spectrometry (GC/MS) and GC-olfactometry. However, such analyses
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Methodologies for smellwalks and scentwalks– a critical review Chem. Senses (IF 3.5) Pub Date : 2024-02-13 Murray Parker, Dirk H R Spennemann, Jennifer Bond
Olfactory elements of the human environment are essential with respect to culture, society and heritage, and robust methodological approaches are necessary to identify and describe aspects of this sensory component. To accurately investigate and advance knowledge of olfactory composition of spaces and places, that is, a smellscape – an olfactory contextualized landscape – innovative methodologies such
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Male dingo urinary scents code for age class and wild dingoes respond to this information Chem. Senses (IF 3.5) Pub Date : 2024-02-06 Benjamin J J Walker, Mike Letnic, Martin P Bucknall, Lyn Watson, Neil R Jordan
Chemical information in canid urine has been implicated in territoriality and influences the spacing of individuals. We identified the key volatile organic compound (VOC) components in dingo (Canis lupus dingo) urine and investigated the potential role of scents in territorial spacing. VOC analysis, using headspace gas chromatography-mass spectrometry (GC-MS), demonstrated that the information in fresh
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Smelling of the mothers’ diet in amniotic fluid by adult noses Chem. Senses (IF 3.5) Pub Date : 2024-01-29 Janine Gellrich, Pauline Breidel, Cahit Birdir, Elisabeth C Lohrer, Valentin A Schriever
In this study, the transfer of odorants, namely vanilla, and garlic, into the amniotic fluid (AF) during the second trimester was investigated by examination of collected AF samples through healthy adults. Eleven AF samples were collected from pregnant women (aged 32,9±4.9 years, 16 to 25 weeks of gestation) undergoing diagnostic amniocentesis after eating garlic oil or vanilla powder in high-fat yogurt
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An Electronic Nose Can Identify Humans by The Smell of Their Ear Chem. Senses (IF 3.5) Pub Date : 2024-01-17 Stephanie Brener, Kobi Snitz, Noam Sobel
Terrestrial mammals identify conspecifics by body odor. Dogs can also identify humans by body odor, and in some instances, humans can identify other humans by body odor as well. Despite potential for a powerful biometric tool, smell has not been systematically used for this purpose. A question arising in the application of smell to biometrics is which bodily odor source should we measure. Breath is
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Legacies of salient environmental experiences – insights from chemosensation Chem. Senses (IF 3.5) Pub Date : 2024-01-14 B G Dias
Evidence for parental environments profoundly influencing the physiology, biology and neurobiology of future generations has been accumulating in the literature. Recent efforts to understand this phenomenon and its underlying mechanisms have sought to use species like rodents and insects to model multi-generational legacies of parental experiences like stress and nutritional exposures. From these studies
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Diagnosed and subjectively perceived long-term effects of COVID-19 infection on olfactory function assessed by supervised machine learning Chem. Senses (IF 3.5) Pub Date : 2024-01-11 Jörn Lötsch, Oskar Brosig, Jana Slobodova, Dario Kringel, Antje Haehner, Thomas Hummel
Loss of olfactory function is a typical acute COVID-19 symptom, at least in early variants of SARS-CoV2. The time that has elapsed since the emergence of COVID-19 now allows assessing the long-term prognosis of its olfactory impact. Participants (n = 722) of whom n = 464 reported having had COVID-19 dating back with a mode of 174 days) were approached in a museum as a relatively unbiased environment
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Ribonucleotides differentially modulate oral glutamate detection thresholds Chem. Senses (IF 3.5) Pub Date : 2024-01-10 Nicholas J Amado, Emily C Hanselman, Caroline P Harmon, Daiyong Deng, Suzanne M Alarcon, Ashley A Sharples, Paul A S Breslin
The savory or umami taste of the amino acid glutamate is synergistically enhanced by the addition of the purines inosine 5’-monophosphate (IMP) and guanosine 5’-monophosphate (GMP) disodium salt. We hypothesized that the addition of purinergic ribonucleotides, along with the pyrimidine ribonucleotides, would decrease the absolute detection threshold of (increase sensitivity to) L-glutamic acid potassium
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TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose Chem. Senses (IF 3.5) Pub Date : 2024-01-05 V Ascencio Gutierrez, L E Martin, A Simental Ramos, K F James, K F Medler, L A Schier, A-M Torregrossa
The peripheral taste system is more complex than previously thought. The novel taste-signaling proteins TRPM4 and PLCβ3 appear to function in normal taste responding as part of Type II taste cell signaling or as part of a broadly responsive taste cell that can respond to some or all classes of tastants. This work begins to disentangle the roles of intracellular components found in Type II taste cells
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Can humans smell tastants? Chem. Senses (IF 3.5) Pub Date : 2024-01-04 Shuo Mu, Markus Stieger, Sanne Boesveldt
Although studies have shown that olfaction may contribute to the perception of tastant, literature is scarce or circumstantial, especially in humans. This study aims to (a) explore whether humans can perceive solutions of basic prototypical tastants through orthonasal and retronasal olfaction, (b) and to examine what volatile odor compounds (VOCs) underlie this ability. Solutions of five basic tastants
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Sucrose, NaCl, and citric acid suppress the metallic sensation of FeSO4 Chem. Senses (IF 3.5) Pub Date : 2023-12-26 Sasi Tansaraviput, Alissa Nolden
Metallic sensation is often described as unpleasant and can reduce acceptance of foods and beverages and compliance with medication. Masking and suppressing aversive sensations can help to improve acceptance of these products, with many successful strategies identified for bitterness. However, there are few studies investigating effective strategies for suppressing metallic sensation. This study aims
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Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis Chem. Senses (IF 3.5) Pub Date : 2023-12-15 Mackenzie E Hannum, Riley J Koch, Vicente A Ramirez, Sarah S Marks, Aurora K Toskala, Riley D Herriman, Cailu Lin, Paule V Joseph, Danielle R Reed
Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before COVID-19 taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID-19 patients, we conducted a systematic review and meta-analysis of 376 papers published in 2020–2021, with 235 meeting all inclusion criteria.
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An olfactory perceptual fingerprint in people with olfactory dysfunction due to COVID-19 Chem. Senses (IF 3.5) Pub Date : 2023-12-13 Eva Drnovsek, Maria Rommel, Antonie Louise Bierling, Alexander Croy, Ilona Croy, Thomas Hummel
The sense of smell is based on sensory detection of the molecule(s), which is then further perceptually interpreted. A possible measure of olfactory perception is an odor independent olfactory perceptual fingerprint (OPF) defined by Snitz et al. We aimed to investigate, whether OPF can distinguish patients with olfactory dysfunction due to COVID-19 from controls and which perceptual descriptors are
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Masking Effects on Iso-valeric Acid Recognition by Sub-threshold Odor Mixture Chem. Senses (IF 3.5) Pub Date : 2023-11-13 Jianbo Huang, Jiehua Lin, Rachel Yueng, Shuyi Wu, Leto Solla, Terry Acree
Masking unpleasant odors with pleasant-smelling odorants has a long history and is utilized in various industries, including perfumery and consumer products. However, the effectiveness of odor masking is idiosyncratic and temporary. In this study, we employed Sniff Olfactometry (SO) to investigate the psychophysics of masking using brief 70ms stimulations with mixtures of the mal-odorant iso-valeric
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Unraveling the Universality of Chemical Fear Communication: Evidence from Behavioral, Genetic, and Chemical Analyses. Chem. Senses (IF 3.5) Pub Date : 2023-11-07 Jasper H B de Groot,Tobias Haertl,Helene M Loos,Christin Bachmann,Athanasia Kontouli,Monique A M Smeets
Abundant evidence indicates that humans can communicate threat-related information to conspecifics through their body odors. However, prior research has been primarily conducted on Western (WEIRD) samples. In this study, we aimed to investigate whether threat-related information can be transmitted by individuals of East Asian descent who carry a single-nucleotide polymorphism (SNP) 538G → A in the
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Olfaction and Declarative Memory in Aging: A Meta-analysis Chem. Senses (IF 3.5) Pub Date : 2023-10-24 Benoît Jobin, Frédérique Roy-Côté, Johannes Frasnelli, Benjamin Boller
Olfactory and declarative memory performances are associated, as both functions are processed by overlapping medial-temporal and prefrontal structures and decline in older adults. While a decline in olfactory identification may be related to a decline in declarative memory, the relationship between olfactory detection threshold and declarative memory remains unclear. In this meta-analysis, we assessed
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Oral thermal processing in the gustatory cortex of awake mice Chem. Senses (IF 3.5) Pub Date : 2023-10-18 Cecilia G Bouaichi, Katherine E Odegaard, Camden Neese, Roberto Vincis
Oral temperature is a sensory cue relevant to food preference and nutrition. To understand how orally-sourced thermal inputs are represented in the gustatory cortex (GC), we recorded neural responses from the GC of male and female mice presented with deionized water at different innocuous temperatures (14 °C, 25 °C, 36 °C) and taste stimuli (room temperature). Our results demonstrate that GC neurons
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Expression of taste sentinels, T1R, T2R, and PLCß2, on the passageway for olfactory signals in zebrafish Chem. Senses (IF 3.5) Pub Date : 2023-10-16 Günes Birdal, Percival P D'Gama, Nathalie Jurisch-Yaksi, Sigrun I Korsching
The senses of taste and smell detect overlapping sets of chemical compounds in fish, e.g. amino acids are detected by both senses. However, so far taste and smell organs appeared morphologically to be very distinct, with a specialized olfactory epithelium for detection of odors and taste buds located in the oral cavity and lip for detection of tastants. Here we report dense clusters of cells expressing
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Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices Chem. Senses (IF 3.5) Pub Date : 2023-10-04 Yao Zhao, Surabhi Bhutani, Thorsten Kahnt
Odors guide food seeking, and food intake modulates olfactory function. This interaction is mediated by appetite-regulating hormones like ghrelin, insulin, and leptin, which alter activity in the rodent olfactory bulb, but their effects on downstream olfactory cortices have not yet been established in humans. The olfactory tract connects the olfactory bulb to the cortex through three main striae, terminating
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Liking of salt is associated with depression, anxiety, and stress Chem. Senses (IF 3.5) Pub Date : 2023-09-18 Celeste Ferraris, Christopher J Scarlett, Tamara Bucher, Emma L Beckett
Early research has shown variations in salt taste qualities in depression, anxiety, and stress. These studies evaluated changes to salt taste intensity and liking (pleasantness) of salt solutions but not of salty foods. Therefore, an Australian population survey (n = 424) was conducted where participants rated recalled intensity and liking of salt index foods and completed the Depression, Anxiety,
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Olfactory training: Effects of multisensory integration, attention towards odors and physical activity Chem. Senses (IF 3.5) Pub Date : 2023-09-16 Zetian Li, Anne Abriat, Thomas Hummel
Olfactory training (OT) has been shown to be of value in the treatment of olfactory dysfunction. The present study aimed to investigate whether the efficacy of OT could be modulated with multisensory integration, attention towards odors, odor complexity, or physical activity assessed with a questionnaire. One hundred healthy participants were recruited and divided into four groups. Except for controls
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Suppression of Sweetness: Evidence for Central Mechanism for Suppression of Sweetness from Sucrose by Citric Acid Chem. Senses (IF 3.5) Pub Date : 2023-09-05 J Y Junge, G H Andersen, U Kidmose
The underlying mechanisms of taste interactions in humans are not well understood, and three mechanisms have been proposed, namely a chemical interaction, a peripheral physiological, and a central mechanism. In the present study, it was investigated which of these mechanisms causes the suppression of sweetness by citric acid. This was investigated using a split-tongue gustometer that can stimulate
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Emotional self-body odours do not influence the access to visual awareness by emotional faces Chem. Senses (IF 3.5) Pub Date : 2023-08-29 Marta Rocha, Joana Grave, Sebastian Korb, Valentina Parma, Gün R Semin, Sandra C Soares
A growing body of research suggests that emotional chemosignals in others’ body odour (BO), particularly those sampled during fearful states, enhance emotional face perception in conscious and preconscious stages. For instance, emotional faces access visual awareness faster when presented with others’ fear BOs. However, the effect of these emotional signals in self-BO, i.e., one’s own BO, is still
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Anti-HIV Drugs Lopinavir/Ritonavir Activate Bitter Taste Receptors Chem. Senses (IF 3.5) Pub Date : 2023-08-22 Shurui Chen, Xinyi Zhou, Yongcheng Lu, Keman Xu, Jiao Wen, Meng Cui
Lopinavir and ritonavir (LPV/r) are the primary anti-HIV drugs recommended by the World Health Organization for treating children aged three and above who are infected with the human immunodeficiency virus (HIV). These drugs are typically available in liquid formulations to aid in dosing for children who cannot swallow tablets. However, the strong bitter taste associated with these medications can
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Can non-volatile tastants be smelled during food oral processing? Chem. Senses (IF 3.5) Pub Date : 2023-08-17 Yue He, Jianshe Chen, Weiyao Shi, Jingang Shi, Tian Ma, Xinmiao Wang
While accumulating evidence implied the involvement of retro-nasal sensation in the consumption of non-volatile taste compounds, it is still unclear whether it was caused by the taste compounds themselves, and if so, how can they migrate from the oral to nasal cavity. At first, we proposed aerosol particles as an alternative oral-nasal mass transfer mechanism. The high-speed camera approved that aerosol
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Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman’s gland Chem. Senses (IF 3.5) Pub Date : 2023-08-16 Xinnan Zhao, Gang Liu, Xin Yu, Xiaohan Yang, Wenting Gao, Zinan Zhao, Jianmei Ma, Tonghui Ma
Smell detection depends on nasal airflow, which can make absorption of odors to the olfactory epithelium by diffusion through the mucus layer. The odors then act on the chemo-sensitive epithelium of olfactory sensory neurons (OSNs). Therefore, any pathological changes in olfactory area, for instance dry nose caused by Sjögren's Syndrome (SS) may interfere with olfactory function. SS is the autoimmune
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A Quick Test to Objectify Smell and Taste Dysfunction at Home: a Proof-of-Concept for the Validation of the Chemosensory Perception Test Chem. Senses (IF 3.5) Pub Date : 2023-08-16 Cindy Levesque-Boissonneault, Nicholas Bussière, Frédérique Roy-Côté, Frank Cloutier, Marie-Ève Caty, Johannes Frasnelli
Recent studies have shown the efficacy of a home test for the self-evaluation of olfactory and gustatory functions in quarantined COVID-19 patients. However, testing was often limited to COVID-19 participants, and the accuracy of home test kits was rarely compared to standardized testing. This study aims at providing proof-of-concept for the validation of the new Chemosensory Perception Test (CPT)
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Umami taste perception and preferences of the domestic cat (Felis catus), an obligate carnivore Chem. Senses (IF 3.5) Pub Date : 2023-08-08 Scott J McGrane, Matthew Gibbs, Carlos Hernangomez de Alvaro, Nicola Dunlop, Marcel Winnig, Boris Klebansky, Daniel Waller
The domestic cat (Felis catus) is an obligate carnivore, and as such has a meat-based diet. Several studies on the taste perception of cats have been reported, indicating that their sense of taste has evolved based on their carnivorous diet. Here we propose that umami (mediated by Tas1r1-Tas1r3) is the main appetitive taste modality for the domestic cat by characterising the umami taste of a range
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Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease Chem. Senses (IF 3.5) Pub Date : 2023-08-03 Mariah R Stavrou, Sean Souchiart So, Angela M Finch, Sara Ballouz, Nicola J Smith
The sweet taste receptor (STR) is a G protein-coupled receptor (GPCR) responsible for mediating cellular responses to sweet stimuli. Early evidence suggests that elements of the STR signalling system are present beyond the tongue in metabolically active tissues, where it may act as an extraoral glucose sensor. This study aimed to delineate expression of the STR in extraoral tissues using publicly available
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Effects of zinc deficiency on the regeneration of olfactory epithelium in mice Chem. Senses (IF 3.5) Pub Date : 2023-08-01 Hiroyuki Ikushima, Jun Suzuki, Tomotaka Hemmi, Ryoukichi Ikeda, Yuta Kobayashi, Nobuo Ohta, Yukio Katori
The olfactory epithelium can regenerate after damage; however, the regeneration process is affected by various factors, such as viral infections, head trauma, and medications. Zinc is an essential trace element that has important roles in organ development, growth, and maturation. Zinc also helps regulate neurotransmission in the brain; nevertheless, its relationship with olfactory epithelium regeneration
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A Mobile APP-based, Customizable Automated Device for Self-Administered Olfactory Testing and an Implementation of Smell Identification Test Chem. Senses (IF 3.5) Pub Date : 2023-06-30 Lan Zhihao, Qing X Yang, Zhi-hong Lyu, Cailing Feng, Liansheng Wang, Baowei Ji, Xuefei Yu, Sherman Xuegang Xin
Olfactory tests are used for evaluation of ability to detect and identify common odors in humans psychophysically. Olfactory tests are currently administered by professionals with a set of given odorants. Manual administration of such tests can be labor and cost intensive and data collected as such are confounded with experimental variables, which adds personnel costs and introduces potential errors
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Selective pressure on a saccharin intake phenotype and its correlates: A replication study Chem. Senses (IF 3.5) Pub Date : 2023-06-30 Nancy K Dess, Clinton D Chapman, Paulina M Jacobi
The Occidental High- and Low-Saccharin rats (respectively, HiS and LoS lines) were selectively bred for decades to examine mechanisms and correlates of a saccharin intake phenotype. Observed line differences ranged from taste and eating to drug self-administration and defensive behavior, paralleling human research on relationships between gustation, personality, and psychopathology. The original lines
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Covid-19 affects taste independent of taste-smell confusions: results from a combined chemosensory home test and online survey from a large global cohort Chem. Senses (IF 3.5) Pub Date : 2023-06-24 Ha Nguyen, Javier Albayay, Richard Höchenberger, Surabhi Bhutani, Sanne Boesveldt, Niko A Busch, Ilja Croijmans, Keiland W Cooper, Jasper H B de Groot, Michael C Farruggia, Alexander W Fjaeldstad, John E Hayes, Thomas Hummel, Paule V Joseph, Tatiana K Laktionova, Thierry Thomas-Danguin, Maria G Veldhuizen, Vera V Voznessenskaya, Valentina Parma, M Yanina Pepino, Kathrin Ohla
People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-administering chemosensory tests with ten household items. Between June 2020 and March 2021, 10,953 individuals participated. Of these, 5,225
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Expansive Linguistic Representations to Predict Interpretable Odor Mixture Discriminability Chem. Senses (IF 3.5) Pub Date : 2023-06-02 Amit Dhurandhar, Hongyang Li, Guillermo A Cecchi, Pablo Meyer
Language is often thought as being poorly adapted to precisely describe or quantify smell and olfactory attributes. In this work, we show that semantic descriptors of odors can be implemented in a model to successfully predict odor mixture discriminability, an olfactory attribute. We achieved this by taking advantage of the structure-to-percept model we previously developed for monomolecular odorants
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An inhibitory mechanism for suppressing high salt intake in Drosophila Chem. Senses (IF 3.5) Pub Date : 2023-05-26 Manali Dey, Anindya Ganguly, Anupama Dahanukar
High concentrations of dietary salt are harmful to health. Like most animals, Drosophila melanogaster are attracted to foods that have low concentrations of salt, but show strong taste avoidance of high salt foods. Salt in known on multiple classes of taste neurons, activating Gr64f sweet-sensing neurons that drive food acceptance and 2 others (Gr66a bitter and Ppk23 high salt) that drive food rejection
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Analysis of the rat chorda tympani nerve response to “super salty” sodium carbonate Chem. Senses (IF 3.5) Pub Date : 2023-05-24 Joseph M Breza, Steven J St. John
In behavioral experiments, rats perceive sodium carbonate (Na2CO3) as super salty. In fact, when the dissociated Na+ ions are accounted for, rats perceive Na2CO3 as 5× saltier than equinormal concentrations of NaCl. The chorda tympani nerve (CT) responds to salts through at least two receptor mechanisms and is a model system for understanding how salt taste is transmitted to the brain. Here, we recorded
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The development of sniffing Chem. Senses (IF 3.5) Pub Date : 2023-05-23 Natalie L Johnson, Daniel W Wesson
Sniffing is a commonly displayed behavior in rodents, yet how this important behavior adjusts throughout development to meet the sensory demands of the animals has remained largely unexplored. In this issue of Chemical Senses, Boulanger-Bertolus and colleagues investigates the ontogeny of odor-evoked sniffing through a longitudinal study of rats engaged in several olfactory paradigms from infancy to
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Comparing Fear and Anxiety Chemosignals: Do they modulate facial muscle activity and facilitate identifying facial expressions? Chem. Senses (IF 3.5) Pub Date : 2023-05-20 Nuno Gomes, Bettina M Pause, Monique A M Smeets, Gün R Semin
Fear and anxiety are the most frequently studied emotional states in chemosignal research. Despite differences between these two emotional states, findings from research using fear and anxiety body odors (BOs) are often treated as part of a similar phenomenon. In this article, we examine possible similarities and differences between participants exposed to fear and anxiety BOs on 2 dependent variables
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Palatability Profile In Spontaneously Hypertensive Rats Chem. Senses (IF 3.5) Pub Date : 2023-04-22 Emilson Donizete Pereira Junior, Laurival A De Luca Junior, José Vanderlei Menani, Carina Aparecida Fabrício Andrade
The spontaneously hypertensive rats (SHRs) have enhanced palatability for NaCl taste as measured by the increased number of hedonic versus aversive responses to intraoral infusion (1 ml/1 min) of 0.3 M NaCl, in a taste reactivity test in euhydrated condition or after 24 h of water deprivation + 2 h of partial rehydration (WD-PR). SHRs also ingested more sucrose than normotensive rats, without differences
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Chemosensation In Anxiety: The Trigeminal System Matters Chem. Senses (IF 3.5) Pub Date : 2023-03-28 Olivier Fortier-Lebel, Émilie Hudon, Benjamin Boller, Johannes Frasnelli
The presence of a perceptual bias due to anxiety is well demonstrated in cognitive and sensory task for the visual and auditory modality. Event-related potentials, by their specific measurement of neural processes, have strongly contributed to this evidence. There is still no consensus as to whether such a bias exists in the chemical senses; chemosensory event-related potentials (CSERP) are an excellent
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Electrogustometry: validation of bipolar electrode stimulation. Chem. Senses (IF 3.5) Pub Date : 2023-01-01 Toshi Matsuda,Pavana Mysore Ganesh,Robert Brown,Vince Grosso,Richard L Doty
Electrogustometry (EGM) is a practical way to test taste. It is typically performed using unipolar electrodes, with the anode on the tongue and the cathode on the hand, forearm, or neck. This results in electric current passing through nontaste tissues and adds a level of impracticality to its clinical application. We compared, using a repeated measures counterbalanced design, anodal thresholds from
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No significant salt or sweet taste preference or sensitivity differences following ad libitum consumption of ultra-processed and unprocessed diets: A randomized controlled pilot study Chem. Senses (IF 3.5) Pub Date : 2023-03-10 Rosario B Jaime-Lara, Alexis T Franks, Khushbu Agarwal, Nafisa Nawal, Amber B Courville, Juen Guo, Shanna Yang, Brianna E Brooks, Abhrarup Roy, Karen Taylor, Valerie L Darcey, James D LeCheminant, Stephanie Chung, Ciarán G Forde, Kevin D Hall, Paule V Joseph
Ultra-processed food consumption has increased world-wide, yet little is known about the potential links with taste preference and sensitivity. This exploratory study aimed to (i) compare sweet and salty taste detection thresholds and preferences following consumption of ultra-processed and unprocessed diets, (ii) investigate whether sweet and salty taste sensitivity and preference were associated
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Vitamin C Deficiency in Osteogenic Disorder Shionogi/Shi Jcl-od/od Rats: Effects on Sour Taste Preferences, Lick Rates, Chorda Tympani Nerve Responses, and Taste Transduction Elements Chem. Senses (IF 3.5) Pub Date : 2023-03-09 Toshiaki Yasuo, Fumihiko Nakamura, Takeshi Suwabe, Noritaka Sako
Animals use sour taste to avoid spoiled food and to choose foods containing vitamins and minerals. To investigate the response to sour taste substances during vitamin C (ascorbic acid; AA) deficiency, we conducted behavioral, neural, anatomical, and molecular biological experiments with Osteogenic Disorder Shionogi/Shi Jcl-od/od rats, which lack the ability to synthesize AA. Rats had higher 3 mM citric
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Respiratory response to an odor throughout development in rats Chem. Senses (IF 3.5) Pub Date : 2023-03-07 Julie Boulanger-Bertolus, Emmanuelle Courtiol, Nathalie Buonviso, Anne-Marie Mouly
Odor-induced sniffing has proven to be a useful behavioral readout for assessing olfactory performance in adult rats. However, little is known about how the respiratory response changes throughout ontogeny. Thus, this study aimed at characterizing respiratory response to an odor in rats using paradigms suitable to infants, juveniles and adults. We first analyzed the respiratory response to a neutral
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Sensitivity of human sweet taste receptor subunits T1R2 and T1R3 to activation by glucose enantiomers Chem. Senses (IF 3.5) Pub Date : 2023-02-18 Nitzan Dubovski, Yaron Ben-Shoshan Galezcki, Einav Malach, Masha Y Niv
We have previously shown that L-glucose, the non-caloric enantiomer of D-glucose, activates the human sweet taste receptor T1R2/T1R3 transiently expressed in HEK293T cells. Here we show that D- and L-glucose can also activate T1R2 and T1R3 expressed without the counterpart monomer. Serine mutation to alanine in residue 147 in the binding site of T1R3 VFT domain, completely abolishes T1R3S147A activation
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Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders Chem. Senses (IF 3.5) Pub Date : 2023-02-17 Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O’Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma
It is estimated that 20%–67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of this study was to provide a proof-of-concept that SCENTinel 1.1, a rapid, inexpensive, population-wide olfactory test, can discriminate between anosmia (total smell
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Enhancement of taste by retronasal odors in patients with Wolfram Syndrome and decreased olfactory function Chem. Senses (IF 3.5) Pub Date : 2023-02-16 Raul Alfaro, Jessica G Nicanor-Carreón, Tasha Doty, Heather Lugar, Tamara Hershey, M Yanina Pepino
Wolfram syndrome is a rare disease characterized by diabetes, neurodegeneration, loss of vision, and audition. We recently found, in a young sample of participants (mean age 15 yrs), that Wolfram syndrome was associated with impairment in smell identification with normal smell sensitivity and whole-mouth taste function. However, these senses were assessed separately, and it is unknown whether smell-taste
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Paradoxical electro-olfactogram responses in TMEM16B knock-out mice Chem. Senses (IF 3.5) Pub Date : 2023-02-06 Giorgia Guarnieri, Simone Pifferi, Michele Dibattista, Johannes Reisert, Anna Menini
The Ca 2+-activated Cl¯ channel TMEM16B carries up to 90% of the transduction current evoked by odorant stimulation in olfactory sensory neurons and control the number of action potential firing and therefore the length of the train of action potentials. A loss of function approach revealed that TMEM16B is required for olfactory-driven behaviors such as tracking unfamiliar odors. Here, we used the
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Neural Suppression in Odor Recognition Memory Chem. Senses (IF 3.5) Pub Date : 2023-01-30 Tom Eek, Fredrik Lundin, Maria Larsson, Paul Hamilton, Charalampos Georgiopoulos
Little is known about the neural basis of lower and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with three functions: passive smelling (PS), odor encoding (OE) and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using fMRI conducted
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Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks Chem. Senses (IF 3.5) Pub Date : 2023-01-10 Narumi Sato-Akuhara, Casey Trimmer, Andreas Keller, Yoshihito Niimura, Mika Shirasu, Joel Mainland, Kazushige Touhara
Humans have significant individual variations in odor perception, derived from their experience or sometimes from differences in the olfactory receptor (OR) gene repertoire. In several cases, the genetic variation of a single OR affects the perception of its cognate odor ligand. Musks are widely used for fragrance and are known to demonstrate specific anosmia. It, however, remains to be elucidated
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Correction to: Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis. Chem. Senses (IF 3.5) Pub Date : 2023-01-01
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Taste perception of oligosaccharides derived from pullulan. Chem. Senses (IF 3.5) Pub Date : 2023-01-01 Shashwat Damani,Michael H Penner,Juyun Lim
Recent studies indicate that humans can taste starch hydrolysis products (i.e. maltooligosaccharides; MOS). However, the structural specificity of oligosaccharides that elicit such perception is not known. This study investigated taste perception of pullulan-derived oligosaccharides (PDOS) that are structurally similar to MOS, but differ in that every third glycosidic linkage in PDOS is α-1,6, rather