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Intensification of a biocatalytic oxidation under fine bubble aeration in a rotating bed reactor Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-15 Zeynep Perçin, Lotta Kursula, Erik Löfgren, Emil Byström, Felix Kexel, Paul Bubenheim, Michael Schlüter, Andreas Liese
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Small-scale perfusion mimic cultures in the ambr250 HT bioreactor system Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-13 Srikanth Rapala, Abiageal Barton, Sarah W. Harcum
Perfusion cell cultures generate higher viable cell densities (VCD) and volumetric productivity compared to fed-batch cultures. However, due to the limited availability of small-scale perfusion models, perfusion systems are seldom used to produce licensed biotherapeutics. This study evaluated two small-scale perfusion mimic protocols to bridge the research-to-production gap. Shake flasks and the ambr250
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Effect of calcium lignosulfonate on surface modification and bioleaching of chalcopyrite Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-12 Mengfei Liu, Jinglei Zhu, Chenyang Zhang, Peng He, Daixiong Chen, Guojian Zhong, Qun Liu, Wenying Hu, Yaozong Chen, Jianyu Zhu
Calcium lignosulfonate is a common anionic surfactant. In this study, calcium lignosulfonate (SL) was employed to modified chalcopyrite surface and promote chalcopyrite bioleaching. The bioleaching experiments revealed that in the absence of SL, the bioleaching rate of chalcopyrite was slower at the initial stage, and it was accelerated after a period of 12 days. Conversely, when SL was introduced
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Integrating glycolysis and enzymatic catalyst to convert waste poly(ethylene terephthalate) into terephthalic acid Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-11 Yufan Pan, Zixin Qi, Shengping You, Yingtong Gao, Yu Zhou, Nan Jiang, Mengfan Wang, Rongxin Su, Wei Qi
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Dual enzyme self-assembly cluster for high efficient asymmetric reduction of ethyl 6-oxo-8-chlorooctanoate Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-07 Mei Liu, Nana Wang, Lixia Deng, Bo Liu, Yanni Wang, Qingyu Zhang, Lan Tang, Qingqing Zhou, Jianhong Pan, Zhimin Ou
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Process integration of foam separation and inverse transition cycling by the thermally responsive properties of ELP-fusion β-glucosidase Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-05 Jingli Xue, Wenrui Huang, Cailiang Zhang, Juan Han, Jiacong Wu, Lei Wang, Yun Wang
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Identification of regulation mechanisms associated with enhanced global protein synthesis ability by Saccharomyces cerevisiae via microfluidic screening and transcriptome analysis Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-04 Yan Yang, Xiaomei Lyu, Wei Zhao
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Efficient L-phosphinothricin production by engineered Escherichia coli co-expressing glutamate dehydrogenase, glucose dehydrogenase and NAD kinase with NADPH regeneration Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-03 Shu-Ping Zou, Wei Ding, Yu-Yue Han, Kun Niu, Ya-Ping Xue, Yu-Guo Zheng
L-Phosphinothricin (L-PPT) is the active compound of a broad-spectrum herbicide. In this study, we biosynthesized L-PPT via the asymmetric reduction of 2-carboxy-4-(hydroxymethylphosphoryl) butyric acid (PPO) using a whole-cell biocatalyst. Glutamate dehydrogenase from (GluDH), Glucose dehydrogenase from (GDH) and NAD kinase from (NADK) were coexpressed in , significantly increasing the catalytic efficiency
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Intensifying outdoor cultivation of oleaginous microalgae in photobioreactors for simultaneous wastewater bioremediation and low-cost production of renewable biodiesel feedstocks Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-02 Faridah Jehalee, Wageeporn Maneechote, Sirasit Srinuanpan, Wasu Pathom-aree, Neeranuch Phusunti, Aidyn Mouradov, Benjamas Cheirsilp
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Olive leaves upgrading applying a novel two-stage organosolv pretreatment: Techno-economic and environmental assessment Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-01 J.M. Romero-García, J.C. Solarte-Toro, Á. Galán-Martín, E. Ruiz, E. Castro, M. Ortiz-Sánchez, C.A. Cardona Alzate
This research study evaluates the techno-economic and environmental performance of an olive leaves based biorefinery to produce antioxidants, bioethanol, and organosolv lignin. The biorefinery comprises processes such as organosolv extraction, organosolv pretreatment and simultaneous saccharification and fermentation, which were simulated in Aspen Plus v9.0. Experimental data were used to simulate
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Effect of geometrical modifications on the mixing and enzymatic conversion of structured lipids in internal-loop airlift bioreactors Biochem. Eng. J. (IF 3.9) Pub Date : 2024-04-01 Daniele Gonçalves de Oliveira, Vítor Teixeira Mazziero, Bruno Willian Picão, Renata Maria de Magalhães Gomes Pontes Ribeiro, Mateus Nordi Esperança, Ariela Veloso de Paula, Marcel Otavio Cerri
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Corrigendum to 'Cellular biocompatibility of cyanophycin substratum prepared with recombinant Escherichia coli’, [Biochem. Eng. J. 105 (2016) 97–106] Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-29 Wen-Chi Tseng, Tsuei-Yun Fang, Sheng-Yang Chen
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A supplementary labor cost model for estimating the fixed capital cost of commercial-scale algae photobioreactors plants Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-28 Asmaa Harfoush, Ean H. Ng, Brian Paul
Scaling up algae photobioreactors (PBR) for commercial production presents challenges in estimating fixed capital investment costs, particularly the labor costs associated with installing low-cost equipment. Using fractions of the equipment cost to estimate the installation labor cost does not necessarily provide a representative estimate for the labor cost as the labor required is no longer proportionate
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Study on one-step purification and immobilization of glycosyltransferase by modified Fe3O4 for the synthesis of rare ginsenoside Rh2 Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-26 Junsong Yue, Yufei Zhang, Jianwen Wang, Zhiyan Li, Hongyang Long, Xiaochen Liu, Zhansheng Wu
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Zero valent iron modified carriers can promote anammox resistance to tetracycline hydrochloride stress Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-24 Tao Liu, Jing Liu, Chaohui Li, Xie Quan
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Improvement of waste frying oil/cottonseed oil-based biodiesel properties by adjusting unsaturation and its effect on engine emission characteristics Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-24 Junzhang Chang, Jingwen Yang, Ben Xing, Xueqin Hu, Changchun Xu, Hongbin Zhang
Waste frying oil is a highly promising feedstock for biodiesel production due to its lower cost compared to refined vegetable oils. In this study, biodiesel was prepared by transesterification of mixed waste frying oil with dimethyl carbonate, utilizing immobilized recombinant lipase in -butanol as the medium. The activation energy () and pre-exponential factor (k) were determined to be 73.8 kJ/mol
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Degradation of brilliant crocein using the halotolerant bacterial consortium DAS Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-23 Ruoju Wang, Qianqian Yang, Yaqi Shi, Xuzhi Zhang, Xianguo Li, Zhixiang Chen, Dahai Zhang
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Research on enhancing sewage sludge lysis and bioreactor initiation through composite thermophilic strains Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-22 Ao Chen, Ying Huang, Baoyan Chi, Jiali Tan, Xinxin Duan, Xiaoqing Ruan
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Effective development of intensified perfusion culture based on shake tube semi-continuous bioreactors and optimal osmolarity constraint Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-21 Weijian Zhang, Qingyuan Ran, Liang Zhao, Yuxiang Wan, Qian Ye, Wen-Song Tan
The development of perfusion strategies supporting ultra-high cell growth and productivity for the intensified perfusion cultures (IPC) is very challenging. In this study, a novel approach was developed to address this issue by utilizing the shake tube semi-continuous bioreactors (ST) combining with a concentrated feed from the traditional fed-batch (TFB) platform. First, the impact of operating conditions
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Efficient synthesis of DHA/EPA-rich phosphatidylcholine using immobilized phospholipase A1 on a novel microflow support Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-19 Qian Zhou, Neng-Bing Long, Rui-Feng Zhang
A new epoxy-based polymerizing/compositing synchronic process was carried out in 3D structure of a melamine sponge. The cured polymer formed a porous and wave-shaped coating on the surface of skeleton in a uniform way. The obtained composite sponge was used as a microflow support for the immobilization of phospholipase A (PLA, from ) by co-adsorption/cross-linking with polyethylenimine (PEI). The loading
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Multidirectional pathway engineering of Mycobacterium neoaurum LY-2 for the enhancement of androstenedione production from phytosterols Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-15 Qiaoqiao Ma, Hui Li, Miaomiao Xue, Wei Liu, Liyang Xu, Jinsong Shi, Zhenghong Xu
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Impact of dissolved oxygen levels on N2O emissions and metabolically active bacterial community in biological nitrogen removal Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-14 Wanli Yan, Jianguo Li, Jieping Liang, Chengsong Ye, Xin Yu
Biological nutrient removal (BNR) is an effective process for removing nitrogen from wastewater using microorganisms under different environmental conditions. However, these processes can result in nitrous oxide (NO) emission. Dissolved oxygen (DO) levels shape bacterial communities and affect NO emissions in BNR. Ammonia-oxidizing bacteria (AOB), the main NO producers in the BNR process, are significantly
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Zinc oxide-gold nanocomposite modification on dielectrode for diagnosing osteosarcoma by dual probes Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-13 Tian Zhoubin, Wang Yanyan, Wu Wenqiang, Hou Chengtai, Wu Shuai
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Dual cytoplasmic-mitochondrial engineering for improved patchoulol production in Komagataella phaffii Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-13 Guangjuan Luo, Ying Lin, Shupeng Ruan, Ruiming Xiao, Xinying Zhang, Shuli Liang
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Biobased propylene glycol production in a sugarcane biorefinery through lactic acid, glycerol, or sorbitol: A techno-economic and environmental evaluation of intermediates and downstream processing methods Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-11 Mensah S. Brobbey, Jeanne Louw, Johann F. Görgens
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The impact of reduced sulfur compounds on aerobic granular sludge formation and biological phosphorus removal Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-09 Karina Seguel Suazo, Thomas Dobbeleers, Jan Dries
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Galactonate bio-preparation from cheese whey waste and its application as a novel bio-retarder Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-07 Rui Zhang, Yao Ye, Ali Nawaz, Ikram ul Haq, Yong Xu, Qiang Li, Xin Zhou, Jiaqing Wang
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Microwave-assisted synthesis of porous graphitized biochar as a super sorbent for tetracycline separation Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-07 Huihao Wang, C. Srinivasakannan, Meijing Liu, Gang Xue, Li Wang, Yaping Wang, Xin Wang, Xinhui Duan
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Enhanced biomass and lipid production from olive processing wastewater using Scenedesmus obliquus in a two-stage cultivation strategy under salt stress Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-07 Andonia Nicodemou, Despoina Konstantinou, Michalis Koutinas
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Metabolic engineering of Bcat1, Adh5 and Hahdb towards controlling metabolic inhibitors and improving performance in CHO cell-cultures Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-05 Bingyu Kuang, Duc Hoang, Qiang Fu, SoYoung Park, George Liang, Seongkyu Yoon
CHO cells are known to secrete growth inhibitory metabolites during growth and production phases, which hampers cellular performance and negatively impacts final productivity and product quality attributes. Previous studies have identified different metabolic by-products derived from CHO metabolism and demonstrated their negative impacts on growth and titer productivity. This work presents a control
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Odorant-binding proteins as recognition elements for smell exploration Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-03 Yi Wang, Chuanting Qin, Xiaoxue Wang, Ting Wang, Jian Dong, Yuan Lu
The sense of smell in animals enables them to detect and discriminate among many volatile odor molecules in complex environments. This task is accomplished by the family of G-proteins (olfactory receptor proteins, odorant-binding proteins, and chemosensory proteins). Here, we mechanistically elucidate how odors bind to odorant-binding proteins (OBPs) by studying the binding properties of 50 odorant
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Nano-differential scanning fluorimetry as a tool for the assessment of refolded antibody fragments: A case study for anti-Pfs25 single-chain antibodies Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-02 Harvinder Kour Khera, Ashwathi Valiyaparambil, Deepak K. Jagannath, Vysakh K. Viswanath, Naveen Kumar, Jay Prakash Shukla, Sabyasachi Pradhan, Anirudha Lakshminarasimhan
Differential Scanning Fluorimetry (DSF) is a valuable and versatile tool in the field of protein and antibody stability studies, providing valuable insights into their thermal stability, and aiding in the optimization of experimental conditions for various applications. Antibody fragments provide armamentarium for researchers and practitioners across various fields, enabling advancements in medicine
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Functional enzyme analysis and metabolic regulation mechanism of the combined microflora LXB in the degradation of lignocellulose Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-02 Yuhao Hao, Mengling Lu, Yu Zhang, Binfeng Lin, Liang Chen, Zhi Huang, Kai Li, Jianbin Li
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A model-based performance analysis of integrated chromatography-ultrafilter separation systems for monoclonal antibody (mAb) manufacturing Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-02 Wil Jones, Dimitrios I. Gerogiorgis
Robust and accurate modelling of bioprocess systems offers the opportunity to visualise strategies for rapid-scale up of production platforms from benchtop to industrial scale, but few studies investigate how mechanistic and hybrid models can be used to design integrated bio-manufacturing. This is especially true for downstream purification technologies used to separate mAbs from culture by-products
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Separation and enrichment of multiple bile acid micelle-disrupting peptides by adsorption/desorption process with heat-treated porous silica gels Biochem. Eng. J. (IF 3.9) Pub Date : 2024-03-02 Momoha Iriyama, Hitomi Hagawa, Shota Shimizu, Hirokazu Akiyama, Kazunori Shimizu, Hiroyuki Honda
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Evolutionary adaptation in the laboratory and the process of retrograde engineering augment autotrophic proliferation in Saccharomyces cerevisiae Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-28 Seyed Mehrdad Mirsalami, Mahsa Mirsalami
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Biomethane recovery performance and microbial community dynamics of a high-biomass submerged AnMBR (HBSAnMBR) treating abattoir wastewater Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-28 Rajneesh Kumar Gautam, Nuwan Vithanage, Nandkishor More, Shobha Muthukumaran, Dimuth Navaratna
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Effect of zero-valent iron addition on ammonia inhibition alleviation and fecal indicators reduction in anaerobic digestion of pig manure Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-28 Hongyuan Sun, Rui Tang, Kuizu Su, Shoujun Yuan, Jingwei Feng, Wei Wang, Zhen-Hu Hu
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Current strategies for the development of high-yield HEK293 cell lines Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-24 Liao Zhang, Jianhui Gao, Xi Zhang, Xiaoyin Wang, Tianyun Wang, Junhe Zhang
At present, approximately 80% of the currently approved recombinant therapeutic proteins are produced by Chinese hamster ovary cells. However, considering that the human embryonic kidney (HEK) 293 cell line comes from human sources and has the advantages of high transfection rate, fast growth rate, good post-translational modifications, and growth rate in serum-free suspension culture, the HEK293 cell
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Electric-field-assisted in situ separation of mandelic acid in an enzymatic milli-reactor improves the control of reaction conversion and enhances the enantiomeric ratio Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-24 Lukáš Sauer, Dominik Kralik, Zdeněk Slouka, Michal Přibyl
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Increasing biosensor-based cell selection pressure improves microbial biosynthesis of 4-hydroxybenzoate Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-23 Yuxin Liu, Xiaonan Wang, Lei Zhuang, Mia Stapleton, Haoran Zhang
Biosensors are powerful tools for improving microbial biosynthesis. For example, biosensors can be used to establish feedback control mechanisms to inhibit the growth of low performing cells in a microbial population. In this study, a previously developed biosensor-assisted cell selection system was further engineered to increase the cell selection pressure for improving the bioproduction of 4-hydroxybenzoate
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Unravelling the role of coumarin on anaerobic digestion of waste activated sludge: Determination of operational dynamics and microbial community structure Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-23 Hongmei Ye, Shuai Tian, Zuwen Liu, Yichun Zhu, Jincai Luo, Qing Mao
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Evaluation of antimicrobial effect of bacteriocin produced by Lactobacillus acidophilus utilizing molasses and corn steep liquor Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-17 Sayyid Zulhelmie Shahrir, Phei Er Kee, Hui Suan Ng, Joo Shun Tan, John Chi-Wei Lan
Bacteriocins are antimicrobial peptides produced by lactic acid bacteria (LAB) which have emerged as safe bio-preservatives in the food industry. However, the conventional commercial medium used to promote bacteriocin production is often costly and impractical for industrial-scale production. This study aimed to explore the utilization of industrial by-products, specifically molasses and corn steep
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Cordyceps fungus-mediated enantioselective synthesis of chiral alcohol and enhanced biocatalytic efficiency in cyclodextrin/surfactant-buffer system Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-17 Qian Gui, Hai-Min Zhang, Feng Qian, Han-Yu Liu, Xiang-Xin Kong, Guo-Ying Lv, Pu Wang
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Characterization, production optimization and ecotoxicity of a lipopeptide biosurfactant by Pseudomonas citronellolis using oily wastewater Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-15 Constantina K. Varnava, Paola Grenni, Livia Mariani, Anna Barra Caracciolo, Haria Hadjipakkou, George Lefkaritis, Eftychia Pinakoulaki, Nikos Chronakis, Nikolaos Kalogerakis, Argyro Tsipa
Considering both fundamental principles and application perspectives, it is imperative to characterize biosurfactants (BSFs) for replacing their synthetic counterparts. In this study, a BSF produced by the 620 C bacterium, using oily wastewater, was identified as a lipopeptide based on ultraviolet spectroscopy, thin layer chromatography, high-pressure liquid chromatography and nuclear magnetic resonance
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Dual coiled-coil protein domain mimic and drug delivery vehicle for SARS-CoV-2 Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-15 Dustin Britton, Chengliang Liu, Sihan Jia, Deven Paul, Jakub Legocki, Yingxin Xiao, Xunqing Jiang, Xiang-Peng Kong, Jin Kim Montclare
SARS-CoV-2 has emerged as a strong target for the development of protein domain mimics (PDMs) as it relies on the helical protein-protein interaction (PPI) between the N-terminal α-helix of ACE2, ACE, with the SARS-CoV-2 receptor binding domain (RBD). We have recently developed an ACE-based multivalent assembled protein (ACE-MAP) that relies on fusion of a binding domain to the cartilage oligomeric
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Synergistic fermenter-electrolytic cell integration and phenomena-based process intensification for competitive bio-succinic acid production Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-15 Alina Anamaria Malanca, Ioannis V. Skiadas, Hariklia N. Gavala, Manuel Pinelo, Seyed Soheil Mansouri
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Different inhibition patterns of ammonia and salt revealed by kinetic analysis of their combined inhibitory effect on methanogenesis of hydrogen: A preliminary study Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-15 Zi-Yan Li, Shintaro Nagao, Daisuke Inoue, Michihiko Ike
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A paradigm shift for biocatalytic microreactors: Decoupling application from reactor design Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-14 Marijan Bajić, Sansanee Khiawjan, Stephen T. Hilton, Gary J. Lye, Marco P.C. Marques, Nicolas Szita
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A precision miRNA-21 detection method based on self-powered biosensors Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-14 Hui Li, Jing Xu, Guanghui Chen, Huiling Wang, Zongshan Zhang
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Influence of initial glucose and lactic acid concentration on hyaluronic acid production by Streptococcus zooepidemicus: Kinetic and modeling Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-13 David Antonio Flores-Méndez, Miriam Granados-Vallejo, Guadalupe María Guatemala-Morales, Rosa Isela Corona-González, Carlos Pelayo-Ortíz, Enrique Arriola-Guevara
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Renewable gases production coupled to synthetic wastewater treatment through a microbial electrolysis cell Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-12 Lorenzo Cristiani, Marco Zeppilli, Giuliano Fazi, Clara Marandola, Marianna Villano
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Immobilization of poly(hexamethylene biguanide) to cellulose acetate- and cellulose-based nanofiber membranes for antibacterial and cytotoxic studies Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-12 Dinh Thi My Huong, Chi-Yun Wang, Pin-Yi Chen, Chien Wei Ooi, Xue Er Crystal Thew, Bing-Lan Liu, Chen-Yaw Chiu, Shen-Long Tsai, Kuei-Hsiang Chen, Yu-Kaung Chang
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Characterization, degradation pathway and microbial community of aerobic granular sludge with ciprofloxacin at environmentally relevant concentrations Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-10 Xia Zhao, Xiran Li, Weina Pei, Xinyi Li, Qian Wei, Weijing Liu
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Methanogenesis performance and microbial characteristics in An-IFFAS process filled with conductive suspended carriers at ambient temperature Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-10 Xiangqian Guan, Tao Liu, Nan Wu, Xie Quan
Direct interspecies electron transfer (DIET) has been proven to be established efficiently on conductive suspended carriers, and thus enhances methane production at thermophilic condition. However, the methanogenesis performance and relevant microbial characteristics in the anaerobic integrated floating-film activated sludge (An-IFFAS) reactor filled with conductive suspended carriers when feeding
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Two-step cultivation of Neochloris oleoabundans in a novel horizontal thin-layer algal reactor: Interplay of pH and dissolved inorganic carbon Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-09 Hongying Zhou, Ju Wang, Zitong Xu, Xinyue Wang, Zisheng Zhang, Christopher Q. Lan
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Engineering artificial fusion naringinase for enhancing naringenin biosynthesis Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-09 Chen-Mu Luo, Wen-Ting Zhang, Song-Yi Xie, Xiao-Yan Zhuang, Ze-Wang Guo, Qiong Xiao, Jun Chen, Fu-Quan Chen, Qiu-Ming Yang, Yi Ru, Hui-Fen Weng, An-Feng Xiao, Yong-Hui Zhang
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Application of ensemble learning to augment fluorescence-based PAT and enable real-time monitoring of protein refolding Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-08 Rashmi Sharma, Naveen G Jesubalan, Anurag S Rathore
Recently, there has been a noticeable increase in the attention given to Process Analytical Technology (PAT) within biopharmaceutical manufacturing. Specifically, there has been a focus on using spectroscopic tools in conjunction with chemometrics analysis. The emergence of computational advancements, such as artificial intelligence and machine learning, has resulted in a shift away from traditional
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Numerical simulation on vortex flow and CO2 bubble aggregation behavior in a raceway pond with diaphragm aerators Biochem. Eng. J. (IF 3.9) Pub Date : 2024-02-07 Xiangbo Zou, Mumin Rao, Ji Ye, Cao Kuang, Cong Huang, Gongda Chen, Shiwei Qin, Yanmei Song, Dongwei Jia, Jun Cheng
To optimize flow field in a raceway pond with diaphragm aerators to promote microalgal CO fixation, numerical simulation on three-phases (CO bubbles-culture medium-microalgae cells) with CFD (Computational Fluid Dynamics) - PBM (population balance model) was conducted to investigate effects of dynamic bubble aggregation/fragmentation on flow field distribution and mixing performance. The inhomogeneity