EMBO J | 癌症综述2021：癌症的分子、细胞与组织起源

The EMBO Journal

癌症综述2021

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Cancer evolution: Darwin and beyond

Evolutionary concepts explaining cancer progression, the selective pressures acting on tumours, and their therapeutic implications are discussed in this comprehensive review.

https://doi.org/10.15252/embj.2021108389

Dynamic EMT: a multi-tool for tumor progression

This review contrasts classical and non-classical roles of epithelial-mesenchymal transition in diverse aspects of cancer cell biology.

https://doi.org/10.15252/embj.2021108647

Cell competition in intratumoral and tumor

microenvironment interactions

In this review, Rajan Gogna and colleagues integrate developmental and cancer perspectives on the role of cell competition mechanisms as drivers of malignancies at tissue level.

https://doi.org/10.15252/embj.2020107271

ATP and cancer immunosurveillance

This review summarizes our current view on the dual roles of signaling via adenosine triphosphate and its degradation products in the tumor microenvironment, affecting intracellular metabolism as well as crosstalk between malignant and immune cells.

https://doi.org/10.15252/embj.2021108130

Tumor cell heterogeneity and its transcriptional bases in pancreatic cancer: a tale of two cell types and their many variants

As part of our Cancer reviews series 2021, Natoli and colleagues revisit the roots of pancreatic tumors, and how their heterogeneity depends on lineage-specific regulatory networks.

https://doi.org/10.15252/embj.2020107206

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