Postdoc Position at City of Hope, Duarte, CA, USA
Metabolic Alteration in Cancer and Diabetes
Postdoc Position at City of Hope, Duarte, CA, USA
Dr. Lei Jiang’s laboratory investigates the contribution of metabolic alterations to the developmentof cancer and diabetes. His previous study identified a novel NADPH shuttle system supporting ROS defense in the anchorage independent cancer cells (Jiang L, et al. Nature, 2016). The mass spec based stable isotope (NOT radioactive) tracing has been a great tool in the cancer metabolism field, with the advantage of directly studying metabolism in patients (Hensley CT, et al. Cell, 2016).These studies provided additional knowledge to the well-known “Warburg Effect”. In addition to generate ATP for energy requirement, metabolism also provides building blocks and controls stress defense. Not only glycolysis, TCA cycle, amino acid and nuclide acid metabolism are all very active in both cultured cancer cells and patient tumors.
Dr. Jiang’s lab focuses on the molecular mechanisms regulating central carbon metabolism (citrate) and signaling amino acid (serine) during the development and progress of metabolic diseases. The application of mathematical bioengineering based modeling prediction and experimental mass spec based metabolic tracing will provide a better understanding of the metabolic rewiring in diabetes, cancer and other diseases.
Motivated postdoc is encouraged to join Dr. Jiang’s laboratory at City of Hope, which is a world leader in the research and treatment of cancer, diabetes, and other serious diseases. His laboratory is a new addition to the Diabetes & Metabolism Research Institute, headed by Arthur D.Riggs, Ph.D., a pioneer in the field renowned for his work on synthesizing the first man-made gene
and using synthetic genes to produce human insulin.
Requirements:
3 years or less postdoc experience
Determined and self-motivated scientist
PhD in biochemistry, molecular and cellular biology
Good publication record in metabolism, cancer or diabetes
Excellent in written and verbal communication
Good knowledge in statistics
Excellent in computer skills
Please send your cover letter, CV with three listed references to ljiang@coh.org
Lei Jiang, Ph.D.
Assistant Professor
Department of Molecular and Cellular Endocrinology
Diabetes and Metabolism Research Institute
Beckman Research Institute at City of Hope
1500 E. Duarte Road, Duarte, CA, 91010-3000