RSC主编推荐：纳米领域精彩文章快览（免费阅读原文）

英国皇家化学会（RSC）是一个超过175年历史的面向全球化学家的非营利会员制机构，旗下拥有44种期刊，其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点，X-MOL团队与英国皇家化学会合作，推出英国皇家化学会期刊主编推荐的精彩文章快览，本期文章属“纳米领域”，英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评，欢迎在文末写评论发表您的高见！

Chemical Science (IF: 9.556)

1. An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC01070J

Inorganic nano-prodrugs generating localized toxic products in a tumour are reported for the first time. Scientists from China report tellurium nanowires as an inorganic prodrug, which generates toxic TeO₆^6- triggered by hydrogen peroxide for highly selective cancer chemotherapy. The tellurium nanowires selectively kill cancer cells and exert an immune response, while not affecting normal cells, before being completely removed from the body.

本文首次报道了在肿瘤中产生局域毒性产物的无机纳米前药。福州大学的研究人员发现碲纳米线可作为一种无机前药，遇过氧化氢会产生有细胞毒性的TeO₆^6-，可用于高选择性癌症化疗。碲纳米线在从体内完全移除前，能够选择性地杀死癌细胞并引发免疫应答，同时不影响正常细胞。

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2. Solvent-assisted coordination driven assembly of a supramolecular architecture featuring two types of connectivity from discrete nanocages

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC01892A

A team from China and the USA have used a discrete nanocage as the monomer to construct a novel 3D supramolecular architecture using a bottom-up self-assembly approach. The 3D structure comprises two types of nanocage building unit with different connectivities. A novel nanocage dimer intermediate is formed during the solvent-assisted coordination-driven assembly and the structure led to an enhancement in stability and gas adsorption properties.

中国和美国的合作研究团队使用离散纳米笼作为单体，使用自下而上的自组装方法构建了新型三维超分子结构。这种三维结构包括两种具有不同连接性的纳米笼结构单元。在溶剂辅助配位驱动组装过程中，形成了新型的纳米笼二体中间体，该结构增强了稳定性和气体吸附性能。

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Nanoscale Horizons (IF: 9.095)

1. Fully transparent, flexible and waterproof synapses with pattern recognition in organic environments

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/C9NH00341J

By careful design of the material system, we realize waterproof function and pattern recognition application on an array of wearable, biocompatible and fully transparent artificial synapses for the first time. The novel synaptic device could resist short-period damage by water and organic reagents and could be applied in organic environments.

本文作者通过精巧地设计材料系统，在可穿戴及生物相容性的全透明人工突触阵列上首次实现了防水功能和模式识别应用。这种新型突触装置可以抵抗来自水和有机试剂的短时间损伤，并可用于有机环境。

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2. Disease-specific protein corona sensor arrays may have disease detection capacity

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/C9NH00097F

In 2014, the Mahmoudi group introduced the concept of “personalized” and “disease-specific” protein corona. In this new work they make use of this concept and make a sensor array that can detect and identify several different diseases at a very early stage. The protein corona sensor array platform provides a library of corona compositions containing disease signatures. By analysing the corona compositions of different nanoparticles, using supervised classifiers, the authors create a unique protein corona pattern which was the “fingerprint” of each type of cancer.

Mahmoudi 教授研究小组于2014年提出了“个性化”和“疾病特异性”蛋白冠的概念。在这项新工作中，他们基于这种概念，制作了可以检测并鉴别几种处于极早期阶段的不同疾病的传感器阵列。这种蛋白冠传感器阵列平台提供了具有疾病特征的冠层组成库。通过使用监督分类法分析不同纳米粒子上的冠层组成，作者创造了一种独特的蛋白冠图案可以作为每种癌症的“指纹”信息。

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3. Bacterial flagella as an osteogenic differentiation nano-promoter

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/C9NH00124G

Here for the first time, the discover that protein nanofibers used as a molecular machine to enable bacteria to swim, called flagella, could promote the differentiation of stem cells into osteoblasts. Flagella are helically assembled from genetically modifiable protein subunits. When the flagella are genetically modified to bear cell-signaling molecules or chemically modified with bone minerals, the flagella become more capable of promoting the differentiation. Since bacteria naturally grow flagella on their surface, which can be purified, the discovery of flagella being a differentiation nano-promoter provides a cost-effective new nanomaterial that can either fill the bone defects as a scaffold or modify the implant surface as a film to enhance bone regeneration to repair bone defects. This work also suggests that the flagella can be used to control the stem cell differentiation due to their unique morphology and surface chemistry.

本文作者首次发现，作为分子机器使细菌可以游动的蛋白质纳米纤维（被称为鞭毛），能够促进干细胞分化为成骨细胞。这些鞭毛由遗传修饰的蛋白质亚基螺旋组装而成。当鞭毛经遗传修饰以携带细胞信号分子或用骨矿物质进行化学修饰时，鞭毛变得更能促进分化。由于鞭毛通常天然生长在细菌表面，可以进行纯化，所以这项鞭毛作为促进分化的纳米材料的发现提供了一种具有成本效益的新型纳米材料，既可以作为支架填充骨缺陷，还可以作为膜修饰植入物表面增强骨再生、修复骨缺陷。这项工作还表明，由于其独特的形貌和表面化学，鞭毛还可用于控制干细胞分化。

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