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RSC主编推荐:有机领域精彩文章快览(免费阅读原文)

英国皇家化学会(RSC)是一个超过175年历史的面向全球化学家的非营利会员制机构,旗下拥有44种期刊,其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点,X-MOL团队与英国皇家化学会合作,推出英国皇家化学会期刊主编推荐的精彩文章快览,本期文章属“有机领域”,英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评,欢迎在文末写评论发表您的高见!


Chemical Science (IF: 9.063)



1. Intramolecular Asymmetric Reductive Amination: Synthesis of Enantioenriched Dibenz[c,e]azepines

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C8SC04482A



Researchers from Southern University of Science and Technology, Shenzhen, have developed a method for the iridium-catalysed intramolecular asymmetric reductive amination of bridged biaryl derivatives with excellent enantioselective control. This methodology represents a rare example of enantioselective chemocatalytic synthesis of chiral dibenz[c,e]azepines.


南方科技大学的研究人员开发了一种铱催化桥联双芳香族衍生物分子内不对称还原胺化的方法,其具有优异的对映选择性。该方法实现了罕见的对映选择性化学催化合成手性二苯并[c,e]氮杂䓬类化合物。


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2. Benzene construction via Pd-catalyzed cyclization of 2,7-alkadiynylic carbonates in the presence of alkynes

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C8SC04681F



Researchers from Zhejiang University have developed a palladium-catalysed highly regio- and chemo-selective cyclisation of 2,7-alkadiynylic carbonates with functionalised alkynes to prepare 1,3-dihydroisobenzofuran and isoindoline derivatives under mild conditions.


浙江大学的研究人员开发了钯催化高区域选择性和高化学选择性2,7-烷二炔碳酸酯与官能化炔烃的环化反应,由此在温和条件下制备1,3-二氢异苯并呋喃和异吲哚啉衍生物。


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Organic Chemistry Frontiers (IF: 5.455)



1. Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(III) catalysis

Org. Chem. Front., 2018, Advance Article

DOI: 10.1039/C8QO01105B



Herein, direct cross-dehydrogenative C–H alkynylations of amides and primary sulfonamides with terminal alkynes is reported. This general process features predictable regioselectivity towards multiple functionalized arenes and the stereoselective generation of tetrasubstituted olefins, which might provide insight into the expedient delivery of related bioactive and material molecules.


本文报道了酰胺及伯磺酰胺与端炔烃之间的直接交叉脱氢C-H键炔基化反应。这种通用方法对多种官能化的芳香烃具有可预测的区域选择性,立体选择性生成四取代烯烃,由此为相关生物活性分子和材料分子的有效构建提供见解。


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2. Direct conjugate additions using aryl and alkyl organic halides in air and water

Org. Chem. Front., 2018, Advance Article

DOI: 10.1039/C8QO01141A



The direct aryl-conjugate addition to electron-deficient alkenes without prior stoichiometric formation of organometallic reagents in water catalyzed by copper represents an important but unresolved challenge. Herein, we describe a simple and convenient one-pot protocol for this type of conjugate addition. Compared with traditional methods that feature pre-formed stoichiometric organometallic reagents and strict anhydrous conditions, this transformation is actually performed in water and successfully applied to α,β-unsaturated esters, acrylonitriles and α,β-unsaturated phosphonates via direct arylation. Furthermore, this process is scalable and accommodates both aryl and alkyl halides. Importantly, the same reaction carried out in an organic solvent proceeded sluggishly to provide much inferior yields.


无需预先形成化学计量的有机金属试剂,实现水中铜催化芳基对缺电子烯烃的直接共轭加成是一项重要但未解决的挑战。本文介绍了简单方便的一锅法实现该类共轭加成反应。与需要预先形成化学计量有机金属试剂和严格无水条件的传统方法相比,该转化可在水中进行,并通过直接芳基化成功应用于α,β-不饱和酯、丙烯腈和α,β-不饱和膦酸酯。此外,该方法可扩大规模且适用于芳基卤化物和烷基卤化物。重要的是,相同反应在有机溶剂中进行缓慢且产率要低得多。


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