谢会琳博士和程世博同学在《ACS Nano》上发表题为"Harnessing Synergistic Interplay of Twisted and Planar Structures for the Development of NIR-II Phototheranostic Agents"的研究论文！

原文链接：https://pubs.acs.org/doi/full/10.1021/acsnano.5c04254

摘要：Developing phototheranostic agents capable of simultaneous cancer diagnosis and therapy, particularly those emitting in the second near-infrared region (NIR-II, 1000–1700 nm), offers considerable prospects. However, achieving efficient fluorescence imaging (FLI) and heat generation for photothermal therapy (PTT) by NIR-II organic dyes remains a challenge primarily due to inadequate photon absorption and competitive energy dissipation pathways. Herein, we employed a molecular design strategy termed “planar core + twisted periphery” to develop a NIR-II phototheranostic agent, 4TPE-TB. This molecule features a coplanar central core to enhance intramolecular conjugation and four highly twisted peripheral rotors to suppress detrimental intermolecular stacking. 4TPE-TB exhibits high molar absorptivity (4.0 × 104 M–1 cm–1), excitation at long wavelengths (980 nm), and desirable fluorescence and photothermal performance, superior to its analogs synthesized using previous molecular strategies. By formulating 4TPE-TB into nanoparticles, we successfully achieved high-precision NIR-II FLI and efficient PTT in cancer models. And we find out the dual role of the nanoparticles in direct tumor ablation and immune system activation, reinforcing their potential as a powerful therapeutic platform for cancer treatment. This work highlights a successful design rationale of NIR-II phototheranostic agents, offering the potential to enhance the precision and efficacy of cancer diagnostics and treatments.

引用：ACS Nano 2025, 19, 43, 37511–37524