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张曼 博士后     进组时间: 2018.09

四川大学生物医学工程学院专职博士后


主要研究干细胞在生物材料界面的力学响应与力学信号转导。从分子机理出发,揭示细胞与材料的作用机理,指导新材料的设计,利用新材料诱导生物体系的良性反应来开发具有临床实用价值的生物医用材料。在Biomaterials, Journal of Hazardous Materials等杂志发表论文数篇。


研究方向:材料表面改性、细胞力学响应、界面生物材料。


联系邮箱:zhangman7135@hotmail.com


学习经历

09/2017-12.2020    博士,高分子科学与工程学院,四川大学   导师:赵长生教授  

09/2018-03/2020    联合培养博士,德国马普医学所   导师:Prof. Joachim Spatz

09/2014-06/2017    硕士,高分子科学与工程学院,四川大学   导师:赵长生教授  

09/2010-07/2014    学士,材料科学与工程学院,西安建筑科技大学


参与项目:

国家自然科学基金委员会,面上项目,51973129,可调控细胞力学信号转导的动态生物材料界面的研究,2020-01至2023-12,62万元,在研,参与

国家自然科学基金委员会,重点专项,51433007,原位交联聚合/共聚合构筑抗污染的表面类肝素结构聚醚砜膜的研究,2015-01至2019-12,已结题,参与


已发表论文:

1. M.Zhang, Q. Sun, Y. Liu, Z. Chu, L. X. Yu, Y. Hou, H. Kang, Q. Wei*, W. F. Zhao*, J. P. Spatz, C.S. Zhao, E. A. Cavalcanti-Adam, Controllable Ligand Spacing Stimulates Cellular Mechanotransduction and Promotes Stem Cell Osteogenic Differentiation on Soft Hydrogels, Biomaterials, 2021, 268: 120543.

2. M. Zhang, C. X. Li, S. H. Yang, J. Hirte, W. F. Zhao, Q. Wei*, Z. L. Diao*, JP. Spatz; C. S. Zhao*, Ultra-Transparent Slippery Surface, Smart Materials in Medicine, 2021, 2: 38-45.

3. M. Zhang, R. Wang, T. Xiang, W.F. Zhao, C.S. Zhao, Preparation, characterization and application of poly(sodium p-styrenesulfonate)/poly(methyl methacrylate) particles, Journal of Industrial and Engineering Chemistry 34 (2016) 415-421.

4. M. Zhang, R. Wang, Z.Q. Shi, X.L. Huang, W.F. Zhao, C.S. Zhao, Multi-responsive, tough and reversible hydrogels with tunable swelling property, J. Hazard. Mater. 322 (2017) 499-507.

5. C. Wang, Q. Wang, S.S. Li, M. Zhang, W.F. Zhao, S.D. Sun, C.S. Zhao, One-pot synthesis of highly hemocompatible polyurethane/polyethersulfone composite membranes, Polym. Bull. 74(9) (2017) 3797-3818.

6. C. Wang, R. Wang, Y. Xu, M. Zhang, F. Yang, S.D. Sun, C.S. Zhao, A facile way to prepare anti-fouling and blood-compatible polyethersulfone membrane via blending with heparin-mimicking polyurethanes, Materials Science & Engineering C-Materials for Biological Applications 78 (2017) 1035-1045.

7. S.Q. Chen, X. Zhang, H. Huang, M. Zhang, C.X. Nie, T. Lu, W.F. Zhao, C.S. Zhao, Core@ shell poly (acrylic acid) microgels/polyethersulfone beads for dye uptake from wastewater, Journal of Environmental Chemical Engineering 5(2) (2017) 1732-1743.

8. R. Wei, W.Y. Song, F. Yang, J.K. Zhou, M. Zhang, X. Zhang, W.F. Zhao, C.S. Zhao, Bidirectionally pH-Responsive Zwitterionic Polymer Hydrogels with Switchable Selective Adsorption Capacities for Anionic and Cationic Dyes, Ind. Eng. Chem. Res. 57(24) (2018) 8209-8219.

9. Y. Xie, L.T. Chen, X. Zhang, S.Q. Chen, M. Zhang, W.F. Zhao, S.D. Sun, C.S. Zhao, Integrating zwitterionic polymer and Ag nanoparticles on polymeric membrane surface to prepare antifouling and bactericidal surface via Schiff-based layer-by-layer assembly, J. Colloid Interface Sci. 510 (2018) 308-317.

10. F. Yang, X. Fan, M. Zhang, C. Wang, W.F. Zhao, C.S. Zhao, A template-hatched method towards poly(acrylic acid) hydrogel spheres with ultrahigh ion exchange capacity and robust adsorption of environmental toxins, Journal of Industrial and Engineering Chemistry 69 (2019) 422-431.

11. F. Yang, Y. T. Feng, X. Fan, M. Zhang, C. Wang, W.F. Zhao, C.S. Zhao, Biocompatible graphene-based nanoagent with NIR and magnetism dual-responses for effective bacterial killing and removal, Colloids and Surfaces B-Biointerfaces 173 (2019) 266-275.

12. C.X. Li, M. Zhang, X.L. Liu, W.F. Zhao, C.S. Zhao, Immobilization of heparin-mimetic biomacromolecules on Fe3O4 nanoparticles as magnetic anticoagulant via mussel-inspired coating, Materials Science & Engineering C-Materials for Biological Applications 109 (2020).

13. Z.Q. Shi, Y. Zhang, R. Dai, S.Q. Chen, M. Zhang, L.Q. Jin, J.X. Wang, W.F. Zhao, C.S. Zhao, Rationally designed magnetic poly(catechol-hexanediamine) particles for bacteria removal and on-demand biofilm eradication, Colloids and Surfaces B-Biointerfaces 186 (2020).

14. Y. Hou, L.X. Yu, W.Y. Xie, L.C. Camacho, M. Zhang, Z.Q. Chu, Q. Wei, R. Haag, Surface Roughness and Substrate Stiffness Synergize To Drive Cellular Mechanoresponse, Nano Lett. 20(1) (2020) 748-757.

15. Y. Hou, W.Y. Xie, L.X. Yu, L.C. Camacho, C.X. Nie, M. Zhang, R. Haag, Q. Wei, Surface Roughness Gradients Reveal Topography-Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells, Small 16(10) (2020).

16. Q. Wei, A. Holle, J. Li, F. Posa, F. Biagioni, O. Croci, A.S. Benk, J. Young, F. Noureddine, J. Deng, M. Zhang, G.J. Inman, J.P. Spatz, S. Campaner, E.A. Cavalcanti-Adam, BMP-2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ, Adv. Sci.