周倩,2014年本科毕业于辽宁大学生命科学学院,2014年起在复旦大学生命科学院赵世民教授团队攻读博士,2020至今在复旦大学附属肿瘤医院任职唐爽教授研究助理。博士期间的研究方向为代谢物的感知与信号传导,代谢物信号失调的致病机理研究。目前进行的研究方向是代谢在肿瘤中的功能、机制与转化相关研究。
基金项目:
中国自然科学基金青年项目,2025.1.1-2027.12.31,30万元,主持
上海市科委启明星,扬帆培育,2024-12-01至2027-11-30,20万元,主持
上海市卫生健康委员会临床研究专项,2024-10-01至2027-09-30,5万元,主持
抑制胰岛素受体酪氨酰修饰的胰岛素信号增敏新策略 国家自然科学基金重点项目 309万 主要参与人;
乳酸修饰促肿瘤治疗耐药性的分子机理及干预新策略 上海市重点项目 300万 主要参与人.
人才计划与获奖:
2024年 上海市抗癌协会“雏鹰”计划
2024年上海市科委启明星
2022年上海市生物化学与分子生物学学会,“报告新人奖”一等奖
2023年中国生物化学与分子生物学会“青年科学家论坛”二等奖
Publications:
1.Shuang Tang#*, Qian Zhou#, Johann S Bergholz , Tao Jiang , Weihua Wang, Renlei Ji , Wendi Huang , Jiachen Wu , Yutong Li , Xiaochun Wan , Xiadi He , Qianchen Jing , Menghong Sun , Jared L Johnson , Tomer M Yaron-Barir , Da-Qiang Li, Bo Dai, Zefeng Wang, Xiaoling Li , Lewis C Cantley, Thomas M Roberts, Jean J Zhao*. PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis. Cancer Discovery. 2025 Nov 17. doi: 10.1158/2159-8290.CD-25-1126.
2. Qian Zhou#, Wan-Wan Sun#, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin-Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu*, and Shi-Min Zhao*. Phenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake Through Modification of IRβ. Nature Communications, 2022 Jul 25;13(1):4291.
2. Yi Jiang#, Yuejie Xu#, Chang Zheng#, Lei Ye#, Ping Jiang, Sara Malik, Guifang Xu, Qian Zhou* & Mingming Zhang*. Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment. Gut, 2023, 72(7): 1308-1318.
3. Yunzi Mao#; Jiaojiao Zhang#; Qian Zhou#; Xiadi He#; Zhifang Zheng; Yun Wei; Kaiqiang Zhou; Yan Lin; Haowen Yu; Haihui Zhang; Yineng Zhou; Pengcheng Lin; Baixing Wu; Yiyuan Yuan; Jianyuan Zhao; Wei Xu; Shimin Zhao ; Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation, Cell Research, 2024, 34(1): 13-30
4. Yi Liu#, Qian Zhou#, Shaoli Song*, Shuang Tang* (Co-First). Integrating metabolic reprogramming and metabolic imaging to predict breast cancer therapeutic responses. Trends Endocrinol Metab. 2021 Jul 30;S1043-2760(21)00154-5.
5. Qu Yuanyuan#, Zhao Rui#, Zhang Hai-Liang#, Zhou Qian et al (2019). AMPK-GATA3-ECHS1 Pathway Inactivation-Induced Fatty Acid Synthesis Promotes Clear Cell Renal Cell Carcinoma Progression. Cancer Research.
6. Dan Wang#, Rui Zhao#, Yuan-Yuan Qu#, Xin-Yu Mei#, Xuan Zhang, Qian Zhou, et al (2018). Colonic Lysine HomocysteinylationInduced by High-Fat Diet Suppresses DNA Damage Repair. Cell Rep, 25, 398-412.e6.
7. Zhang Mingming, Zhou Qian, et al. Butyrate inhibits interleukin-17 and generates Tregsto ameliorateorectal colitis inrats.[J] .BMC Gastroenterol, 2016, 16: 84.