Background: Limited studies have investigated the attitudes of Chinese adults toward the role of nurse prescribing, particularly based on population-based cross-sectional research.

Objective: To investigate the associations of socio-demographic and health-related factors with the acceptance of the role of nurse prescribing.

Design: A cross-sectional study.

Setting: In China.

Participants: A total of 30,054 participants were included in this study.

Methods: We employed univariate generalized linear model and multivariable generalized linear model analyses to explore the factors that were associated with the acceptance of the role of nurse prescribing.

Results: Individuals of older age (β: 0.08, 95 % CI: 0.05-0.10) and residing in the Western region of China (β: 1.99, 95 % CI: 1.29-2.70), with average monthly household income per capita in the range of 3001-6000 (β: 2.58, 95 % CI: 1.84-3.32) and ≥ 6001 (β: 3.90, 95 % CI: 3.01-4.80), as well as those reporting higher levels of perceived social support (β: 0.46, 95 % CI: 0.35-0.56), better self-rated health status (β: 0.15, 95 % CI: 0.14-0.17), and increased eHealth literacy (β: 0.61, 95 % CI: 0.53-0.68), tend to demonstrate an inclination toward accepting nurse prescribing.

Conclusions: These findings provide valuable insights for healthcare policymakers and practitioners aiming to promote the integration of nurse prescribing into the Chinese healthcare system. Our results emphasize the need for targeted interventions to address barriers to acceptance and enhance the accessibility and utilization of nurse-prescribing services among diverse demographic characteristics.