祝贺王璐实验室和袁林实验室！通过结合振动结构和抑制TICT效应，可将传统探针进化为具有高亮度、高光稳定性以及大Stokes Shift的新型探针，可用于活细胞超分辨荧光成像。https://assets.researchsquare.com/files/rs-885436/v1/b47895c2-2d2f-4424-8bfa-68ace6cad016.pdf?c=1632410647

Congratulation to Wang Lab and Yuan Lab! They report a synergistic strategy to simultaneously improve such properties of regular fluorophores. Introduction of quinoxaline motif with fine-tuned electron density to conventional rhodamines generates new dyes with vibronic structure and inhibited twisted-intramolecular-charge-transfer (TICT) formation synchronously, thus increasing the brightness and photostability as well as Stokes shift. Such new probes show excellent performance in superresolution imaging.

https://assets.researchsquare.com/files/rs-885436/v1/b47895c2-2d2f-4424-8bfa-68ace6cad016.pdf?c=1632410647