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彭凯 博士     进组时间: 2023/3/1    离组时间: 2023/12/31

毕业去向:扬州大学博士后,己获博后基金


研究经历


tet(X) 和 tmexCD-toprJ 阳性菌在猪肉生产链(养猪场、屠宰场和肉制品)中的流行情况及基因组特征。


利用大规模细菌基因组和宏基因组数据分析,追踪替加环素耐药基因簇 tmexCD-toprJ 的祖先来源。


结合2014年至2017年四川省mcr阳性沙门氏菌和NCBI病原体数据库中mcr阳性沙门氏菌的记录,探究mcr-1阳性肠道沙门氏菌的全球流行病学特征。


齐探科技纳米孔测序在全细菌基因组构建中的生物信息学解决方案。


对产蛋鸡粪便中的微生物群落、抗生素耐药谱和耐药基因的宿主信息进行全面系统的研究。


用于纳米孔宏基因组测序数据分析的生物信息学流程。


用于在线灵活生物信息学分析的Web服务器开发


出版物

1. Peng K, Liu YX, Sun X, Wang Q, Du P, Zhang Y, Wang M, Wang Z, Li R. Long-read metagenomic sequencing reveals that high-copy small plasmids shape the highly prevalent antibiotic resistance genes in animal fecal microbiome. Sci Total Environ. 2023 Oct 1;893:164585. doi: 10.1016/j.scitotenv.2023.164585. 

2. Peng K, Wang Q, Yin Y, Li Y, Liu Y, Wang M, Qin S, Wang Z, Li R. Plasmids Shape the Current Prevalence of tmexCD1-toprJ1 among Klebsiella pneumoniae in Food Production Chains. mSystems. 2021 Oct 26;6(5):e0070221. doi: 10.1128/mSystems.00702-21. 

3. Peng K, Li R, He T, Liu Y, Wang Z. Characterization of a porcine Proteus cibarius strain co-harbouring tet(X6) and cfr. J Antimicrob Chemother. 2020 Jun 1;75(6):1652-1654. 

4. Peng K, Yin Y, Li Y, Qin S, Liu Y, Yang X, Wang Z, Li R. QitanTech nanopore long-read sequencing enables rapid resolution of complete genomes of multi-drug resistant pathogens. Front Microbiol. 2022 Mar 23;13:778659. 

5. Peng K, Wang Q, Li Y, Wang M, Kurekci C, Li R, Wang Z. Molecular mechanisms and genomic basis of tigecycline-resistant Enterobacterales from swine slaughterhouses. Microbiol Res. 2022 Nov;264:127151. 

6. Peng K, Liu YX, Sun X, Wang Q, Wang Z, Li R. Large-scale bacterial genomic and metagenomic analysis reveals Pseudomonas aeruginosa as potential ancestral source of tigecycline resistance gene cluster tmexCD-toprJ. Int J Antimicrob Agents. (Under review)

7. Peng K, Liu Y, Wang Q, Yang P, Wang Z, Li R. Integrative conjugative elements mediate the high prevalence of tmexCD3-toprJ1b in Proteus spp. of animal source. mSystems. (Reversion)

8. Peng K, Deng J, Zou N, Sun X, Huang W, Li R, Yang X. Emergence of the fourth mobile sulfonamide resistance gene sul4 in clinical Salmonella enterica. Front Microbiol. (Reversion)

9. Li R#, Peng K#, Li Y, Liu Y, Wang Z. Exploring tet(X)-bearing tigecycline-resistant bacteriaof swine farming environments. Sci Total Environ. 2020 Sep 1;733:139306. doi:10.1016/j.scitotenv.2020.139306. Epub 2020 May 11. 

10. Li R#, Peng K#, Huang W, Sun X, Huang Y, Lei G, Lv H, Wang Z, Yang X. The genomicepidemiology of mcr-positive Salmonella enterica in clinical patients from 2014 to 2017 in Sichuan, China and global epidemiological features. J Infect. 2022 Sep5:S0163-4453(22)00525-4. 

11. Li R#, Peng K#, Xiao X, Liu Y, Peng D, Wang Z. Emergence of a multidrug resistance efflux pump with carbapenem resistance gene blaVIM-2 in a Pseudomonas putida megaplasmid of migratory bird origin. J Antimicrob Chemother. 2021 May 12;76(6):1455-1458