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成果及论文

 

   2023年 

          Recent Advances in the Functionalization of Remote C–H Bonds by Hofmann−Löffler−Freytag-type Reactions

          Xiaoxu Teng, Tingting Yu, Rentian Wang, Wei Peng, Kai Sun,* Shubing Yang, Xin Wang*  

          Adv. Synth. Catal., 2023, 365, 3211.

         


          Chemoselective Electrochemical Seleno-Cyclization of Dienes to Medium-Sized Benzo[b]azocines

          Zhichuan Wang, Xin Wang, Quanxin Li, Shaofei Ni,* Dongyang Zhao, Shubin Yang, Ge Qiu,* Kai Sun*  

          Chin. Chem. Lett., 2023, 109058.

         

         


         Cascade Radical Trifluoromethylthiolation/Cyclization to Access SCF3-Containing Medium-Sized Heterocycles

          Zhen Zhang*, Xiangshan Fang, Ayimnisa Aili, Shilong Wang, Wanjun Lin, Lei Xie, Jinchun Chen, Kai Sun*  

          Org. Lett., 2023, 25, 4598.

         


        Teaching Design in Organic Chemistry Based on “PBL” Model: Taking Benzoin Condensation as an Example

         Cairong Wang, Jing Su, Yaqin Liang, Kai Sun*  

         University Chemistry, 2023, 2212071.


         Visible Light Induced Cascade Sulfonylation/Cyclization to Quinoline-2,4-diones under Metal-Free Conditions

          Yan Zhang, Ge Qiu,* Fei Liu, Dongyang Zhao, Miao Tian, Kai Sun*  

          Molecules2023, 28, 3137.

         


         Synthesis of Medium-Sized Benzo[b]azocines and Benzo[b]azonines by Photoinduced Sulfonyl-Cyclization

         Kai Sun,* Dongyang Zhao, Quanxin Li, Shaofei Ni,* Guangfan Zheng, Qian Zhang*  

         Sci. China Chem., 2023, 66, 2309. 

         

         

        Visible-Light-Promoted Selective Sulfonylation and Selenylation of Dienes to Sulfonyl-/Seleno-Benzazepine Derivatives

         Zhen Zhang*, Pengpeng Tan, Shilong Wang, Huichao Wang, , Liangliang Han, Shubin Yang, Kai Sun*  

         Org. Lett., 2023, 25, 4208.

          

        

          Trifluoromethoxylation/Trifluoromethylthiolation/Trifluoromethylselenolation for the Construction of  

           Heterocycles

         Zhichuan Wang, Zhenjian Li, Kai Sun*  

         Chin. Chem. Lett., 202334, 108045.

          

          

         Synthesis and applications of thiosulfonates and selenosulfonates as free-radical reagents

         Xin Wang*, Jianping Meng, Dongyang Zhao, Shi Tang, Kai Sun*  

         Chin. Chem. Lett., 202334, 107736 (ESI高被引论文,热点论文).

          

          

         In this review, the synthesis and applications of chalcogenative sulfones as radical reagents, classified as (i) metal  

         catalysis; (ii) visible-light catalysis; (iii) synergistic catalysis, as well as other types, are described.


          2022年

         Heterocycle Synthesis via Decarboxylative Cyclization Methods

         Cairong Wang, Ge Qiu, Chen Li, Kai Sun,* Zhichuan Wang, Xin Wang*  

         Adv. Synth. Catal., 2022, 364, 3756–3781.

           

        In this review, the metal-catalyzed, visible-light driven, electrochemically enabled, as well as other types, 

        including heat-, peroxide-, or persulfide-induced decarboxylative cyclization for heterocycle synthesis is described.


         Radical annulation of a designed diene system: access to nitro-benzo[b]azepines

         Kai Sun,* Yan Zhang, Miao Tian, Zhichuan Wang, Dongyang Zhao, Shilong Wang, Shi Tang, Zhen Zhang*  

         Chem. Commun., 2022, 58, 9658-9661.

         


         Traceless proton aided regioselective C(sp2)–C(sp2) construction to synthesize C6-acylated purines and purine 

         nucleosides

         Mingwu Yu,* Zheng Zhou, Chunhui Zou, Zhichuan Wang, Weili Wang, Kai Sun*  

         Org. Chem. Front., 20229, 4460.

           

         A Promoter-free Protocol for the Synthesis of Selenophosphates and Thiophosphates via a Spontaneous Process 

         Bin Yang,* Xin-Yue Zhang, Hui-Qi Yue, Wen-Zuo Li, Zi-Qian Wu, Ji Li, Kai Sun,* Shang-Dong Yang

         Adv. Synth. Catal., 2022364, 3528.

          

         Regioselective C6−H Hydroxyalkylation of Purines and Purine Nucleosides via α‑C−H Functionalization of Alcohols at  

         Room Temperature

         Mingwu Yu,* Zheng Zhou, Yiwen Chen, Zhichuan Wang, Weili Wang, and Kai Sun*

         Org. Lett., 2022, 24, 4886.

          

         

         K2S2O8/I2-Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[b]azepines

         Zhen Zhang*, Shilong Wang, Pengpeng Tan, Xiaowen Gu, Wenjie Sun, Jinchun Chen, Jiazhu Li, Kai Sun*

         Org. Lett., 2022, 24, 12, 2288 (ESI高被引论文).

          

          Radical Selenation of C(sp3)–H Bonds to Asymmetric Selenides and Mechanistic Study

     Xin Wang, Jia Lei, Sa Guo, Yan Zhang, Yong Ye, Shi Tang, Kai Sun*

     Chem. Commun., 2022, 58, 1526 (ESI高被引论文).

       

      TFAA/DMSO-Promoted Fluorination of P(O)H and P(O)OH Compounds: Compatible Access to    

      Fluorophosphonates and Phosphonofluoridates

      Qi-Wei Li, Xin-Yue Zhang, Lu Lu, Zi-Qian Wu, Ji Li, Gui-Zhi Li, Kai Sun*,  Shang-Dong Yang,  Bin Yang* 

      Adv. Synth. Catal., 2022364, 938.

       

      Convenient Access to Ester-Containing Quinolinones Through Sequential Radical Alkoxycarbonylation Cyclization        

      Hydrolysis Process

     Sa Guo, Xin Wang, Dongyang Zhao, Zhiguo Zhang, Guisheng Zhang, Shi Tang, Kai Sun*

     Asian J. Org. Chem., 2022, 11, e20210081.

     

          Construction of Fluoro-containing Heterocycles Mediated by Free Radicals

     Chen Ning, Lei Jia, Wang Zhichuan, Liu Yingjie,* Sun Kai,* Tang Shi

     Chin. J. Org. Chem., 2022doi: 10.6023/cjoc202109033.

2021年

      Silver-catalyzed decarboxylative radical relay difluoroalkylation–carbocyclization: Access to CF2-quinolinones

      Feng Zhao, Sa Guo, Yan Zhang, Ting Sun, Bing Yang,* Yong Ye, Kai Sun*

      Org. Chem. Front., 2021, 8, 6895.

      Study on the Photoelectric Technology in the Synthesis of Selenium-containing Heterocycles

      Xin Wang, Yan Zhang, Kai Sun*, Jianping Meng, Bing Zhang*

      Chin. J. Org. Chem., 2021, 41, 4588.

      Update on the Synthesis of N-Heterocycles via Cyclization of Hydrazones (2017–2021) 

      Yunhe Lv, Jianping Meng, Chen Li, Xin Wang*, Yong Ye, Kai Sun*   

       Adv. Synth. Catal., 2021363, 5235-5265.

          Recent Advances in the Synthetic Use of Migration Reactions of Allyl Alcohols

     Yun Xing, Chen Li, Jianping Meng, Zhen Zhang, Xin Wang*, Zhichuan Wang, Yong Ye, Kai Sun*

       Adv. Synth. Catal., 2021, 363, 3913-3936.

          Metal-Free Organoselenium-Enabled Radical Relay Azidation–Carbocyclization 

     Xin Wang, Sa Guo, Yan Zhang, Zhiguo Zhang,* Guisheng Zhang,* Yong Ye, Kai Sun*

     Adv. Synth. Catal., 2021363, 3290-3296.

      Fluorination and   Fluoroalkylation of Alkenes/Alkynes to Construct Fluoro-Containing   Heterocycle       

    Xin Wang, Jia Lei, Yingjie Liu, Yong Ye, Jiazhu Li, Kai Sun*

    Org. Chem. Front., 20218, 2079-2109 (ESI高被引论文).

         2020年

         Recent Advances in Tandem Selenocyclization and Tellurocyclization with Alkenes and Alkynes

      Kai Sun,* Xin Wang, Chao Li, He Wang, Lei Li*

      Org. Chem. Front., 20207, 3100.

      Synthetic Methods for Compounds Containing Fluoro-Lactam Units  

      Xin Wang,* Jia Lei, Guofeng Li, Jianping Meng, Chen Li, Jiazhu Li* Kai Sun*

      Org. Biomol. Chem., 2020, 18, 9762.

      An Organoselenium-Catalyzed N1- and N2-Selective Aza-Wacker Reaction of Alkenes with Benzotriazoles

      Xin Wang, Qinlin Wang, Yanru Xue, Kai Sun,* Lanlan Wu, Bing Zhang *

      Chem. Commun., 202056, 4436.

      Oxidative Radical   Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin- 6(5H)-ones

      Kai Sun,* Guofeng Li, Yuyang Li, Jie Yu, Qing Zhao, Zhiguo Zhang,* Guisheng Zhang*

      Adv. Synth. Catal., 2020, 362, 1947.

         Electrochemically   Enabled Intramolecular and Intermolecular Annulations of Alkynes

      Kai Sun,* Jia Lei, Yingjie Liu, Bing Liu, Ning Chen

      Adv. Synth. Catal., 2020, 362, 3709. 

          C–H Imidation and Dual C–H Bond Aminobromination of Five-Membered Heterocycles

       Kai Sun*, Yali Li, Ranran Feng, Shiqiang Mu, Xin Wang, Bing Zhang

       J. Org. Chem., 2020851001. (ESI高被引论文)

2019年

      Copper-Catalyzed Radical Selenodifluoromethylation of Alkenes: Access to CF2-Containing γ-Lactams

      Kai Sun,* Songnan Wang, Ranran   Feng, Yixiao Zhang, Xin Wang, Zhiguo Zhang,* Bing Zhang

      Org. Lett., 201921, 2052. ( ESI高被引论文)


      Direct Methyl C(sp3)−H Bonds Azolation of Thioanisoles via Oxidative Radical Coupling

      Kai Sun,* Changhao Li, Zhenhua Liu, Yixiao Zhang, Xin Wang, Bing Zhang

      Org. Biomol. Chem., 2019, 17, 8364.

2018年

      Synthesis of (E)-β-Selenovinyl Sulfones through a Multicomponent Regio- and Stereospecific Selenosulfonation 

      of Alkynes with Insertion of Sulfur Dioxide

      Kai Sun,* Zuodong Shi, Zhenhua Liu, Baixue Luan, Jiali Zhu, Yanru Xue

      Org. Lett., 201820, 6687. (ESI高被引论文)

2017年

     Aptasensors for the Selective Detection of Alpha-synuclein Oligomer by Colorimetry, Surface Plasmon 

     Resonance and Electrochemical Impedance Spectroscopy

     Kai Sun, Ning Xia, Lijuan Zhao, Ke Liu, Wenjing Hou, Lin Liu*

     Senor Actuat B-Chem., 2017245, 87.

     Metal-free Tetra-n-butylammonium Bromide-mediated Aerobic Oxidative Synthesis of β-Ketosulfones from 

     Styrenes

     Xin Wan, Kai Sun* and Guisheng Zhang*

     Sci. China Chem., 2017, 60, 353.

       Direct Access to β-Selenosulfones at Room Temperature through Selenosulfonylation of Alkene

    Kai Sun*, Yunhe Lv, Zuodong Shi, Fangfang Fu, Chong Zhang, Zhiguo Zhang*

    Sci. China Chem., 201760, 730.   

     Metal-free Selenosulfonylation of Alkynes: Rapid Access to β-(Seleno)vinyl Sulfones via a Cationic-species-

     induced Pathway

     Kai Sun, Xin Wang, Fangfang Fu, Chong Zhang, Yao Chen, Lin Liu*

     Green Chem., 2017, 19, 1490.

      Gold Nanoparticles-based Electrochemical Method for the Detection of Protein Kinase with a Peptide-like Inhibitor 

      as the Bioreceptor        

      Kai Sun, Yong Chang, Binbin Zhou, Xiaojin Wang, Lin Liu*       

      Int. J. Nanomed., 2017, 12, 1905.

2016年

    Peroxodisulfate-Mediated Selenoamination of Alkenes yielding Amidoselenide- Ccontaining Sulfamides and       

    Azoles

    Kai Sun,* Xin Wang, Yunhe Lv, Gang Li, Hezhen Jiao, Yangyang Li, Chong Zhang, Lin Liu*

    Chem. Commun., 2016, 52, 8471.

Copper-Catalyzed N‑Arylation of Azoles and Mannich-Type Coupling of Ketones and Azoles under Metal-Free                         Conditions

Kai Sun,* Zhonghong Zhu, Jingjing Sun, Lulu Liu, and Xin Wang*

J. Org. Chem., 2016, 81, 1476-1483.

2015年

        Copper-Catalyzed Arenes Amination with Saccharins

     Kai Sun, Yan Li,* Qian Zhang*

     Sci. China Chem., 201558, 1354.

   

       Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines

    Kai Sun,* Yunhe Lv, Junjie Wang, Jingjing Sun, Lulu Liu, Xin Wang*

    Org. Lett., 2015, 17, 4408.

   

    Copper-Catalyzed Cross-Dehydrogenative C−N Bond Formation of Azines with Azoles: Overcoming the 

    Limitation of  Oxidizing N−O Activation Strategy

    Kai Sun,* Xin Wang, Lulu Liu, Jingjing Sun, Zhiguo Zhang, Guisheng Zhang*

    ACS Catal., 20155, 7194.

    

       Direct N-Methylation Reaction Using DMSO as One-Carbon Bridge: Convenient Access to Heterocycle-Containing b-

          Amino Ketones

        Kai Sun,* Xin Wang, Yongqing Jiang, Yunhe Lv, Liping Zhang, Beibei Xiao, Donghui Li, Zhonghong Zhu, and Lin Liu

        Chem. Asian J., 2015, 10, 536.

 

    Efficient Imidation of C(sp3)–H Bonds adjacent to Oxygen Atoms of Aryl Ethers under Metal-free Conditions

    Kai Sun,* Xin Wang, Gang Li, Zhonghong Zhu, Yongqing Jiang, Beibei Xiao

    Chem. Commun., 201450, 12880.

    Regioselective CH Imidation of Five-Membered Heterocyclic Compounds through a Metal Catalytic or     

    Organocatalytic Approach

    Xin Wang, Kai Sun,* Yunhe Lv, Fengji Ma, Gang Li, Donghui Li, Zhonghong Zhu, Yongqing Jiang, and Feng Zhao* 

    Chem. Asian J., 2014, 9, 3413. 

       Palladium-Catalyzed C–H Aminations of Anilides with N-Fluorosulfonimide

    Kai Sun, Yan Li, Tao Xiong, Jingping Zhang, Qian Zhang*

    J. Am. Chem. Soc., 2011, 133, 1694. (ESI高被引论文)

首次发展了金属催化,酰胺导向的芳烃邻、对位C–H键的高选择性亲核胺化反应,为推动导向的金属催化芳烃“任意”位置C–H键的转化反应模式具有指导作用(J. Am. Chem. Soc. SCI一区,ESI高被引用论文)