一、个人简介
张文成，男，1986年生，再生医学博士，同济大学高研院研究员，博士研究生导师，上海市浦江人才。2012年博士毕业于军事医学科学院，2014-2020在美国北卡罗来纳大学教堂山分校开展博士后研究、担任研究助理。2021年1月正式加入东方医院，以干细胞移植治疗肝衰竭和帕金森病的基础和转化为研究方向。主持国自然面上项目2项、上海市科委项目2项、以子课题负责人承担国家重点研发计划重点专项课题1项。在Cell Stem Cell、Biomaterials、Bioactive Materials、Advanced Science等国际期刊发表论文36篇， IF累计300。参编（译）中英文论著5部，包括肝病学领域的教科书级别著作《肝脏（第六版）》的原著和译著。申请国家发明专利14项，授权7项，授权实用新型专利1项。研究成果获“春昇杯”医学创新人才大赛一等奖、上海市优秀发明铜奖等。
主要开展基于干细胞移植治疗终末期肝病和帕金森病的基础和应用研究，致力于解决以胆管树干细胞和人羊膜上皮细胞作为代表的种子细胞的体外扩增和体内高效移植中现存的问题，实现干细胞在终末期肝病和帕金森病治疗中的应用。开展硫酸乙酰肝素、透明质酸的等细胞外基质对干细胞增殖和命运调控的作用和机制研究，通过建立干细胞体外规模化扩增体系、体内有效性和量效学研究方案，制定成体干细胞的体外扩增和干细胞向肝脏、胰腺高效移植的补片移植策略，推动胆管树干细胞和人羊膜上皮细胞在肝衰竭和帕金森病治疗中的临床转化应用。
二、研究方向
1. 补片移植治疗终末期肝病
2. 基于糖胺聚糖的胆管树干细胞体外扩增和肝向分化成熟
3. 纤维板层型肝癌模型建立和机制探讨
三、 承担项目
a. 在研项目
1. 国家自然科学基金面上项目，82472691，融合基因DNAJB1-PRKACA通过EMP相关通路诱导胆管树干细胞癌变为纤维板层型肝癌的机制研究，2025.01-2028.12，49万，在研，主持
2. 国家自然科学基金面上项目，82270638，透明质酸调节MMP2-TIMP3平衡实现补片移植胆管树干细胞救治肝衰竭，2023.01-2026.12，52万，在研，主持
b. 结题项目
1. 国家重点研发计划“干细胞及转化研究”重点专项，干细胞治疗产品的规范化与规模化生产及质量评价研究-子课题：2020YFA0112601，人羊膜上皮干细胞和肝前体细胞生产工艺的规范化研究（动物模型相关研究），2020.10-2024.12，50万元，子课题负责人，结题
2. 国家重点研发计划“干细胞及转化研究”重点专项，干细胞治疗产品的规范化与规模化生产及质量评价研究-子课题：2020YFA0112603，基于微载体的肝前体细胞的规模化扩增，2020.10-2024.12，56.87万元，子课题负责人，结题
3. 上海市浦江人才计划，21PJD059，胆管树干细胞补片移植治疗终末期肝病的应用研究，2021.10-2023.09，30万，结题，主持
4. 上海市2022年度“科技创新行动计划”自然科学基金项目，22ZR1451100，3-O硫酸乙酰肝素促进胆管树干细胞肝向分化成熟的机制和应用研究，2022.04-2025.03，20万，在研，主持
5. 上海市2020年度“科技创新行动计划”，20DZ2255100，上海干细胞转化医学工程技术研究中心，2020.12.01-2022.11.30，3319.45万元，参与，结题
6. 纤维板层型肝癌基金项目（Fibrolamellar Carcinoma Foundation），纤维板层型肝癌类器官体的体外扩增（Fibrolamellar Carcinoma Organoids Expansion），2019.10- 2020. 03，43万，课题骨干，结题
四、论文发表
共同第一作者用#标注；共同通讯作者用*标注
a. 第一作者文章
1. Wencheng Zhang#*, Yangyang Cui#, Mengqi Lu#, Mingyang Xu#, Yuting Li#, Haimeng Song#, Yong Yang, Yi Luo, Xicheng Wang, Jinjia Song, Lijun Liao, Yunfang Wang, Lola Reid*, Zhiying He*. Hormonally and Chemically Defined Expansion Conditions for Organoids of Biliary Tree Stem Cells. Bioactive Materials. 2024: 672-695. https://doi.org/10.1016/j.bioactmat.2024.08.010 (Co-first and corresponding author) (Impact factor 18/Q1)
2. Shengwei Shen#, Wencheng Zhang#, Chang Xu#, Zhaoxuan Dong, Xicheng Wang, Changcheng Liu, Fengfeng Lu, Yihui Hu, Qinghe Tang*, Yu Cheng*, Zhiying He*. Magnetotactic hepatocytes promote liver repopulation after transplantation. Chemical Engineering Journal. 2024, 150278. https://doi.org/10.1016/j.cej.2024.150278 (Impact factor 13.3/Q1)
3.Wencheng Zhang1#, Yongmei Xu2#, Xicheng Wang3#, Tsunekazu Oikawa, Guowei Su, Eliane Wauthier, Guoxiu Wu, Praveen Sethupathy, Zhiying He3*, Jian Liu2*, and Lola M. Reid1*. Fibrolamellar carcinomas-growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides. First or corresponding senior authors on 1stem cell biology and matrix biology and chemistry. 2glycosaminoglycan chemistry; 3bioinformatics analyses. Matrix Biology. 2023,121:194–216. https://doi.org/10.1016/j.matbio.2023.06.008 (Impact factor 4.6/Q1)
4. Wencheng Zhang#, Xicheng Wang#, Giacomo Lanzoni, Eliane Wauthier, Sean Simpson, Jennifer Ashley Ezzell, Amanda Allen, Caroline Suitt, Jonah Krolik, Alexander Jhirad, Juan Dominguez-Bendala, Vincenzo Cardinale, Domenico Alvaro, Diletta Overi, Eugenio Gaudio, Praveen Sethupathy*, Guido Carpino*, Christopher Adin*, Jorge Piedrahita*, Kyle Mathews*, Zhiying He*, and Lola M. Reid*. A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans. 2023. npj Regenerative Medicine. 2023, 8(1):40. DOI : 10.1038/s41536-023-00303-5 (Impact factor 6.4/Q1)
5. Wencheng Zhang#, Yangyang Cui#, Yuan Du#, Yong Yang#, Ting Fang#, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid* and Zhiying He*. Liver cell therapies: cellular sources and grafting strategies. 2023. Frontiers of Medicine. 2023 Jul 4. doi: 10.1007/s11684-023-1002-1. Epub ahead of print. https://doi.org/10.1007/s11684-023-1002-1 (Impact factor 3.9/Q1)
6. Yong Yang#, Wencheng Zhang#, Xicheng Wang, Jingxian Yang, Yangyang Cui, Haimeng Song, Weiping Li, Wei Li, Le Wu, Yao Du, Zhiying He*, Jun Shi*, Jiangnan Zhang*. A passage-dependent network for estimating the in vitro senescence of mesenchymal stromal/stem cells using microarray, bulk and single cell RNA sequencing. 2023. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2023.998666 Accpeted on 1/26/2023 (Impact factor 4.6/Q1)
7. Wencheng Zhang, Eliane Wauthier, Giacomo Lanzoni, Homayoun Hani, Xianwen Yi, Diletta Overi, Lei Shi, Sean Simpson, Amanda Allen, Carolyn Suitt, Jennifer Ashley Ezzell, Domenico Alvaro, Vincenzo Cardinale, Eugenio Gaudio, Guido Carpino, Glenn Prestwich, Juan Dominguez-Bendala, David Gerber, Kyle Mathews, Jorge Piedrahita, Christopher Adin, Praveen Sethupathy, Zhiying He, and Lola M. Reid. Patch Grafting of Organoids of Stem/progenitors into Solid Organs Can Correct Genetic-Based Disease States. Biomaterials, 2022; 121647. http://doi.org/10.1016/j.biomaterials.2022.121647 . Available online 7 August 2022. (Impact factor 14/Q1)
8. Wenjian Chen#, Wencheng Zhang#, Miaomiao Chen, Chao Yang, Ting Fang, Haifeng Wang, Lola M. Reid, He Zhiying. Applications and Mechanisms of CDK4/6 Inhibitor PD-0332991. Cell Oncol (Dordr). 2022 Sep 10， https://doi.org/10.1007/s13402-022-00714-4. (Impact factor 6.6/Q2)
9. Yuan Du#, Wencheng Zhang#, Hua Qiu#, Canjun Xiao, Jun Shi*, Lola M Reid*, Zhiying He*. Mouse Models of Liver Parenchyma Injuries and Regeneration. Frontiers in Cell and Developmental Biology, 2022; 3: 903740. http://doi:10.3389/fcell.2022.903740 eCollection 2022. May 3. (Impact factor 5.5/Q1)
10. Wencheng Zhang, Giacomo Lanzoni, Homayoun Hani, Diletta Overi, Vincenzo Cardinale, Sean Simpson, Wendy Pitman, Amanda Allen, Xianwen Yi, Xicheng Wang, David Gerber, Glenn Prestwich, Oswaldo Lozoya, Eugenio Gaudio, Domenico Alvaro, Debra Tokaz, Juan Dominguez-Bendala, Christopher Adin, Jorge Piedrahita, Kyle Matthews, Praveen Sethupathy, Guido Carpino, Zhiying He, Eliane Wauthier and Lola M Reid. Patch Grafting, Strategies for Transplantation of Organoids into Solid Organs such as Liver. Biomaterials, 2021;121067. http://doi:10.1016/j.biomaterials.2021.121067 Epub 2021 Aug 25. (Impact factor 15.304)
11. Xicheng Wang#, Wencheng Zhang#, Yong Yang, Jiansong Wang, Hua Qiu, Lijun Liao, Tsunekazu Oikawa, Eliane Wauthier, Praveen Sethupathy*, Lola M Reid*, Zhongmin Liu *, Zhiying He*. A MicroRNA-Based Network Highlights the Crucial Role of PI3K/AKT Signaling for Human Hepatic Lineage Maturation. Frontiers in Cell and Developmental Biology, 2021; 9: 670059. Http://doi:10.3389/fcell.2021.670059. eCollection 2021. Jun 1. (Impact factor 6.081)
12. Fengfeng Lu#, Xin Pan#, Wencheng Zhang#, Xin Su, Yuying Gu, Hua Qiu, Shengwei Shen, Changcheng Liu, Wei Liu, Zhenzhen Zhan, Zhongmin Liu*, Zhiying He*. A Three-dimensional Imaging Method of Quantification and Localization for Dynamic Cell Tracking Post-transplantation. Frontiers in Cell and Developmental Biology, 2021 /fcell.2021.698795 http://doi:10.3389/fcell.2021.698795 . eCollection 2021 Sep 7. (Impact factor 6.081)
13. Yunfang Wang#*, Jinhua Qin#, Shuyong Wang #, Wencheng Zhang #, Jialei Duan, Jing Zhang, Xin Wang, Fang Yan, Mingyang Chang, Xiaofang Liu, Bo Feng, Jiang Liu, Xuetao Pei*. Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. Cell Stem Cell, 2016; 6;19(4):449-461. Http://doi:10.1016/j.stem.2016.06.006 . Epub 2016 Jul 21. (Impact factor 22.387)
14. Wencheng Zhang, Hailei Yao, Sihan Wang, Shuangshuang Shi, Yang Lv, Lijuan He, Xue Nan, Wen Yue, Yanhua Li*, Xuetao Pei*. Wnt3a is involved in the early stage of miPSC and mESC haemopoietic differentiation. Cell Biol International, 2012; 36(3): 267-71. Http://doi:10.1042/CBI20100766 . 2012 Mar 1. (Impact factor 1.747)
b. 通讯作者文章
2. Wangping Hao#, Yi Luo#, Jia Tian#, Yuefeng Lu#, Yangyang Cui, Ying Zhang, Xiao Jin, Hongjuan Ye, Mengqi Lu, Jinjia Song, Weiqing Zhou*, Wencheng Zhang*, Zhiying He*. Scale-up of Human Amniotic Epithelial Cells through Regulation of Epithelial-Mesenchymal Plasticity under Defined Conditions. Advanced Science, 2025 Jan 13. DOI: 10.1002/advs.202408581(Impact factor 15.1/Q1) https://doi.org/10.1002/advs.202408581
3. Jinjia Song1-3#, Mengqi Lu1,4#, Zhiying He*, and Wencheng Zhang*. Models of Fibrolamellar Carcinomas, Tools for Evaluation of a New Era of Treatments. Frontiers in Immunology, 2024. 15:1459942. https://doi.org/10.3389/fimmu.2024.1459942 (Impact factor 5.7/Q1) 2024 Nov 8
4. Jing Yang#, Yuefeng Lu#, Jinping Zhao#, Yi Luo#, Wangping Hao#, Wencheng Zhang*, Zhiying He*. Reinvesting the Cellular Properties of Human Amniotic Epithelial Cells and Their Therapeutic Innovations. Review, Frontiers in Immunology,.15:1466529. https://doi.org/10.3389/fimmu.2024.1466529 ((Impact factor 5.7/Q1) 2024 Oct 15
5. Yong Yang, Jun Shi, Zhiying He*, Wencheng Zhang*. Biliary Tree Stem Cells and Their Applications in Liver and Pancreas Regeneration. Journal of Tongji University (Medical Science), 2021; 2:152-157. http://doi:10.12289/j. issn.1008-0392.21017. 2021 Apr 2. (Review published in Chinese)
c. 共同作者文章
1. Jia Tian, Wangping Hao, Juan Li, Xiangming Na, Shuang Wang, Wei Wei, Yuefeng Lu, Yangyang Cui, Wencheng Zhang, Zhiying He, Guanghui Ma, Weiqing Zhou, Microcarrier stiffness controls human amniotic epithelial cells (hAECs) proliferation and epithelial-mesenchymal transition (EMT) via remodeling ECM and Wnt/β-catenin pathway, Chemical Engineering Journal, 2025, 160558, ISSN 1385-8947, https://doi.org/10.1016/j.cej.2025.160558 (Impact factor 13.3)
2. Miaomiao Chen, Wenjian Chen, Shiwen Sun, Yanli Lu, Guoxiu Wu, Hongyu Xu, Huiru Yang, Chong Li, Weizhi He, Mingyang Xu, Xiuhua Li, Dong Jiang, Yongchao Cai, Changcheng Liu, Wencheng Zhang, Zhiying He. CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells. Journal of Advanced Research, 2024. 2024 Aug 31; doi: 10.1016/j.jare.2024.08.034. (Impact factor 10.4)
3. Miaomiao Chen, Guoxiu Wu, Yanli Lu, Shiwen Sun, Zhao Yu, Xin Pan, Wenjian Chen, Hongyu Xu, Hua Qiu, Weizhi He, Xiuhua Li, Xicheng Wang, Yi Luo, Yuan Du, Jialing Wu, Ke Wei, Wencheng Zhang, Zhongmin Liu, Zhiying He. A p21-ATD Mouse Model for Monitoring and Eliminating Senescent Cells and Its Application in Liver Regeneration post Injury. Mol Ther. 2024 Apr 5: S1525-0016(24)00218-1. doi: 10.1016/j.ymthe.2024.04.002. Epub ahead of print. PMID: 38582962. (Impact factor 12.1)
4. Vincenzo Cardinale#, Guido Carpino#, Diletta Overi, Samira Safarikia, Wencheng Zhang, Matt Kanke, Antonio Franchitto, Daniele Costantini, Olga Riccioni, Lorenzo Nevi, Michele Chiappetta, Paolo Onori, Yu-Han Hung, Quirino Lai, Ilaria Zizzari, Marianna Nuti, Massimo Rossi, Praveen Sethupathy, Lola M. Reid, Domenico Alvaro, Eugenio Gaudio. Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential. Journal of Hepatology 2022 Sep 8; S0168-8278(22)03068-9. http://doi:org/10.1016/j.jhep.2022.08.037 . (Impact factor 25.7)
5. Fang Yan#, Yi Wang#, Wencheng Zhang, Mingyang Chang, Zhiying He, Jinbo Xu, Changzhen Shang, Tao Chen, Jiang Liu, Xin Wang, Xuetao Pei, Yunfang Wang. Human ES Cell-derived Hepatoblasts are an Optimal Lineage Stage for HCV Infection. Hepatology, 2017; 66(3):717-735. http://doi:10.1002/hep.29134 Epub 2017 Jul 27. (Impact factor 13.246)
6. Haiyun Pei #, Chao Zhai #, Huilin Li, Fang Yan, Jinhua Qin, Hongfeng Yuan, Rui Zhang, Sihan Wang, Wencheng Zhang, Mingyang Chang, Yunfang Wang*, Xuetao Pei*. Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes. Stem Cell Res Ther, 2017; 7;8(1):252. http://doi:10.1186/s13287-017-0703-2 . 2017 Nov 7. (Impact factor 4.963)
7. Jing Wang #, Shang Wang #, Wencheng Zhang, Tao Wang, Peiyao Li, Xiaoling Zhao, Chao Niu, Ying Liu, Xinxing Wang, Qiang Ma *. Proteomic profiling of heat acclimation in cerebrospinal fluid of rabbit. J Proteomics, 2016; 20; 144:113-122. http://doi:10.1016/j.jprot.2016.04.028 . Epub 2016 May 18. (Impact factor 3.941)
五、 专著编写
1. Lou, Y.-R., Zhang, W., Zhou, J., He, Z., eds. (2022). Stem cells in Tissues. Homeostasis and Disease. Lausanne: Frontiers Media SA. Http://doi:10.3389/978-2-88974-801-3 ; ISSN 1664-8714; ISBN 978-2-88974-801-3.
2. Wencheng Zhang, Guido Carpino, Kirk J. Wangensteen, Hexin Yan and Zhiying He. Editorial: Cell Therapy, Liver Diseases, and Regeneration. Frontiers in Cell and Developmental Biology 2022 Sep 5; 10:999305.
3. 张文成，何志颖，刘薇，陈昱安，译. 干细胞驱动的肝脏和胰腺器官发生中的成熟谱系. 《肝脏：生物学与病理生物学 第6版》（2024），中国科学技术出版社，ISBN: 9787523604588
4. Wencheng Zhang, Amanda Allen, Eliane Wauthier, Xianwen Yi, Homayoun Hani, Praveen Sethupathy, David Gerber, Vincenzo Cardinale, Guido Carpino, Juan Dominguez‐Bendala, Giacomo Lanzoni, Domenico Alvaro, Eugenio Gaudio, Lola Reid. Stem Cell‐Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis. In The Liver (eds I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson and A.W. Wolkoff).2020; 521-538. ISBN: 978-1-119-43682-9.
5. 张文成，李艳华*，裴雪涛*. iPS细胞中转录因子的作用. 再生医学 —理论与技术(2010). ISBN 978-7-03-027266-9.
6. Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume II. Zuo, Y., Zhou, M., Su, J., Zhang, X., eds. (2022). Today’s Nutrition and Tomorrow’s Public Health: Challenges and Opportunities. Lausanne: Frontiers Media SA. Http://doi:10.3389/978-2-88974-777-1 .
六、专利申请获批情况
1. 王韫芳，王术勇，张文成，覃金华。将消化道来源上皮细胞重编程为内胚层干/祖细胞的小分子化合物组合、重编程试剂盒（申请日：2017-08-29，申请号：CN107099499A，授权日：2021-02-02，专利号：ZL201710389705.0；失效日 2037-05-27）。
2. 王韫芳，王术勇，张文成，覃金华，王璇，常铭洋，闫舫，裴雪涛。将消化道来源上皮细胞重编程为内胚层干/祖细胞的方法及应用（申请日：2014-09-08，申请号：CN107142240A；授权日：2021-01-29，专利号：ZL201710389711.6；失效日 2037-05-27）。
3. 王韫芳，王术勇，张文成，覃金华，王璇，常铭洋，闫舫，裴雪涛。由消化道来源上皮细胞重编程获得的内胚层干/祖细胞的传代方法及应用（申请日：2021-07-23，申请号：CN113151157A；授权日：2022-06-28；失效日 2037-05-27）。
4. Lola M. Reid, Wencheng Zhang, Eliane Wauthier. Patch graft compositions for cell engraftment. （申请日：2018-06-12，申请号US16006464；授权日：2021-09-28，公开号: US11129923B2；失效日 2038-06-12）。
5. 何志颖，刘中民，王喜城，张文成。评估肝谱系细胞成熟度的标志物、双组学试剂盒及构建方法（申请日：2021-03-24，申请号：CN113106160A，授权日：2022-09-05）。
6. 国际PCT专利：Wencheng Zhang, Eliane Wauthier, Lola M. Reid. Patch graft compositions for cell engraftment（申请日：2018-06-11，申请号：PCT/US2018/036960；公开日：2018-12-20，公开号: PCT: WO2018231726A1；失效日 2038-06-11）。已获美国、中国、日本、澳大利亚、欧洲等国家和地区授权。
7. 国际PCT专利：Lola M. Reid, Wencheng Zhang, Eliane Wauthier. Patch grafting of stem/progenitors into solid organs. （申请日：2020-05-22，申请号：PCT/US2020/034250；公开日：2020-12-03，公开号：WO2020242952A1；失效日：2040-05-22）。
8. 国际PCT专利：Yunfang Wang, Shuyong Wang, Wencheng Zhang, Jinhua Qin,Xuan Wang, Mingyang Chang, Fang Yan, Xuetao Pei. Small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, reprogramming method and application（申请日：2017-05-27，申请号：PCT/CN2017/086336; 公开日：2017-12-07；公开号：WO2017206837A1，失效日：2023-05-27）。已获美国（US11149253B2）、日本、欧洲（EP2017805782）等国家或地区授权。
9. 张文成，何志颖，崔洋洋。胆管树干细胞的扩增或传代体系及其应用（申请日：2023-04-07，申请号：202310369365.0）
10. 何志颖，刘中民，王喜城，张文成，吴国秀，崔洋洋。一种生物样本信息的处理方法、系统以及存储介质（申请日：2023-04-18，申请号：202310414041.4
11. 何志颖，郝王平，张文成，张传宇，罗以，鲁岳峰，崔洋洋。羊膜上皮细胞的属性及体外扩增方法（申请日：2024-07-19，申请号：CN2024109701829）
12. 何志颖，叶红娟，胡锦庆，杨超，蔡永超，张文成。一种薄膜组织的纵向固定包埋盒（专利申请日：2023-03-22，专利号：ZL 2023 2 0578601.5；授 权 公 告 日：2023-07-11，授 权 公 告 号：CN 219328665 U）- 实用新型专利
13. 白硕，李蕊，菅红磊，何志颖，张文成，宋海萌。一种肝前体细胞体外扩增的方法（专利申请日：2024-10-08；申请号：CN202411396427.8）
14. 何志颖，白硕，张文成，宋海萌，李玉婷，李蕊，菅红磊。一种促进肝前体细胞向成熟肝细胞定向分化并增殖的方法（专利申请日：2024-09-14；申请号：CN202411293427.5）
七、获奖
1. 张文成，“春昇杯”医学创新人才大赛（2024•上海），人羊膜上皮干细胞治疗帕金森病的转化研究，一等奖，2024.11
2. 张文成，何志颖，崔洋洋，王喜城，宋海萌，鲁凤凤，李秀花，杨羊，刘长城，蔡永超。可实现干细胞向肝脏高效定植的补片移植技术，第三十五届上海市优秀发明铜奖，2024.01
3. 鲁凤凤，何志颖，张文成，路梦琦，宋锦佳。一种基于仿生微载体的3D培养体系在肝前体细胞中的应用，2024年度浦东职工科技创新入围奖，2024.12
4. 杨羊，何志颖，张文成，王喜城，徐茗扬，李玉婷。一种在体外长期培养和扩增成熟肝细胞的方法，2023年度浦东职工科技创新三等奖，2023.12
5. 张文成，李秀花，杨羊，何志颖，崔洋洋，宋海萌。可实现干细胞向肝脏高效定植的补片移植技术，2022年度浦东职工科技创新二等奖，2022.12
6. 王喜城，张文成，方婷，杨超，徐茗扬。评估肝谱系细胞成熟度的标志物、双组学试剂盒及构建方法。2023年高等院校发明选拔赛铜奖，2023.05
八、教学授课
1. 2020 《干细胞与肝脏再生》，同济大学附属东方医院学位博士专业课课程
2. 2021 《干细胞与肝脏再生》，同济大学附属东方医院学位博士专业课课程
3. 2021《干细胞基础研究和临床应用》，本科生专业课课程
4. 2021《生物科学前沿》，同济大学附属东方医院在职博士研究生课程
5. 2021《干细胞与肝脏再生》，同济大学附属东方医院学位博士专业课课程
6. 2022《细胞生物学实验技术：细胞工程技术》，锦州医学院本科专业课
7. 2022《细胞生物学实验技术：干细胞研究与应用》，锦州医学院本科专业课
8. 2022《生物科学前沿》，同济大学附属东方医院在职博士研究生课程
9. 2023《细胞生物学实验技术：细胞工程技术》，锦州医学院本科专业课
10. 2024《细胞生物学实验技术：细胞工程技术》，锦州医学院本科专业课
11. 2024《生物科学前沿》，同济大学附属东方医院在职博士研究生课程