《Frontiers in Cellular and Infection Microbiology》 本期特刊 Metabolic Rewiring and Viral Infection 专题简介
About this Research Topic
Viruses are intracellular pathogens that rely on hijacking host resources to complete their life cycle. Specifically, upon infection of hosts, efficient viral replication and virion biogenesis are processes that need an extremely high turnover of cellular molecules such as metabolites that are intermediates or products of biochemical reactions. Therefore, it is not surprising that many viruses have evolved numerous strategies to shape metabolic rewiring in host cells solely facilitate optimal virus production. Meanwhile, such metabolic alterations also involve in mounting the host immune responses that impact the outcome of infection. Improved understanding of cellular metabolic rewiring upon viral infection could provide the key insights into a novel aspect of virus-host interaction, with a view toward therapeutic intervention.
病毒是细胞内病原体，依靠劫持宿主资源来完成其生命周期。在感染宿主后，高效的病毒复制增殖依赖于细胞分子（例如作为生化反应的中间体或产物的代谢物）的极高周转率。 因此，许多病毒已进化出多种策略来重塑宿主细胞的代谢途径，以利于病毒自身的增殖。 同时，这种代谢改变还宿主免疫反应并影响感染结局。深入的理解病毒感染引起的细胞代谢重塑将提供对病毒-宿主相互作用方面的新见解，以期进行干预治疗。
This Research Topic （Metabolic Rewiring and Viral Infection） aims to highlight recent discoveries in understanding of how viruses and virus-encoded proteins modulate cellular metabolic pathways for their fitness and how the hosts utilize metabolic adaptions to overcome viral infection. Contributions should focus on the mechanistic studies identifying viral component(s) for metabolic rewiring as well as consequences of virus-induced metabolic reprogramming, and the manipulation of metabolic events in vivo to change the progression of virus infection. Studies on improved technologies for detailed metabolic measurements in vitro or in vivo during virus infection are also invited.
The scope of this Research Topic is to provide readers a comprehensive understanding of virus-host interaction in terms of metabolism, highlighting the novel antiviral approaches through targeted inhibition of specific cellular metabolic pathways. We welcome the submission of article types including Review, Original Research, and Perspective.
Keywords: viruses, viral replication, cellular metabolism, metabolic pathways, immune response, antiviral therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
专刊编辑 Topic Editors：
University of Texas Southwestern Medical Center
25 January 2022 Abstract
26 March 2022 Manuscript