Nanomaterials intervene in cell senescence to reinforce cancer therapy

Abstract: Cell senescence refers to irreversible cell cycle arrest prompted by a multitude of intrinsic and extrinsic factors, such as DNA damage, oxidative stress, and telomere shortening. Although senescent cells cease to divide, they remain metabolically active and can secrete various cytokines that exert diverse biological effects within the tumor microenvironment (TME). As a pivotal mechanism in cell fate determination, cell senescence is highly important in tumor therapy. Nanomaterials have garnered widespread application in the biomedical field, particularly in oncology, demonstrating substantial potential. The induction of cell senescence via nanomaterials not only inhibits tumor growth directly but also activates the immune system and mitigates treatment-related side effects. In this review, we systematically elucidate the biological attributes of senescent cells, including the definitions, characteristics, initiating signaling pathways, and interplay with TME, and highlight recent advancements in nanomaterial-induced cell senescence for anti-tumor therapy. This review provides a novel perspective for optimizing nanomaterial design and application, as well as developing more efficacious tumor treatment strategies.

链接：https://www.sciencedirect.com/science/article/pii/S001085452500582X