Title: Redox Neutral Radical-Relay Cobalt Catalysis toward C–H Fluorination and Amination

ABSTRACT: A redox neutral radical-relay cobalt-catalyzed intramolecular C-H fluorination of N-fluoroamides featuring the in situ formed cobalt fluorides as the latent radical fluorinating agents is reported. Moreover, the reactivity of such a cobalt catalysis could be diverted from C-H fluorination to amination by engineering substrates’ conformational flexibility. Preliminary mechanistic studies (uv-vis spectroscopy, cyclic voltammetry studies and DFT calculations etc.) support the reaction proceeding a redox neutral radical-relay mechanism. 

links: https://pubs.acs.org/doi/10.1021/acs.orglett.0c01072