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当前位置: 首页   >  课题组新闻   >  祝贺胡颖,胡彬静,王吉鑫,静婧,林杰,刘星辰等同学的研究论文被Nat. Commun.接收发表
祝贺胡颖,胡彬静,王吉鑫,静婧,林杰,刘星辰等同学的研究论文被Nat. Commun.接收发表
发布时间:2023-03-15

Here we report a practical preparation of stereoselective tri- and tetrasubstituted alkenyl silanes and stannanes by performing cobalt-catalyzed CO silylation and stannylation of alkenyl acetates using silylzinc pivalate and stannylzinc chloride as the nucleophiles. This protocol features a complete control of chemoselectivity, stereoselectivity, as well as excellent functional group compatibility. The resulting alkenyl silanes and stannanes show high reactivities in arylation and alkenylation by Hiyama and Stille reactions. The synthetic utility is further illustrated by the facile late-stage modifications of natural products and drug-like molecules. Mechanistic studies suggest that the reaction might involve a chelation-assisted oxidative insertion of cobalt species to CO bond. We anticipate that our findings should prove instrumental for potential applications of this technology to organic syntheses and drug discoveries in medicinal chemistry.