近日，2023级硕士生何浩贤在SCI一区期刊Chemical Engineering Journal (IF=13.2)发表一种由镓姜黄素纳米粒子组成的电纺纳米纤维膜敷料，其纳米粒子被共价有机框架包裹，具有抗菌和抗氧化能力，可促进伤口愈合与恢复。“An electrospun nanofibrous membrane dressing composed of gallium curcumin nanoparticles encapsulated by covalent organic framework with antibacterial and antioxidant abilities for enhanced wound healing and recovery”。

原文链接：https://doi.org/10.1016/j.cej.2025.170467

Abstract

During wound healing, bacterial infection and elevated reactive oxygen species (ROS) levels often lead to de layed healing and potential pathological complications. Traditional wound dressings are difficult to have the ef fects of sustained anti-bacteria, scavenging ROS and promotion of angiogenesis simultaneously. This study inno vatively constructed a novel electrospun nanofibrous membrane (NFMs) composite as wound dressings to ad dress delayed healing caused by bacterial infections and ROS-rich microenvironments in chronic wounds. The novel NFMs wound dressing (Ga-CurNPs@COF-NFMs) was composed of gallium-curcumin nanoparticles (Ga CurNPs) encapsulated by covalent-organic framework (COF). The Ga-CurNPs show good antibacterial and an tioxidant capabilities and the high porosity of NFMs and COF ensures controlled release of Ga-CurNPs. The physicochemical properties, release characteristics, biocompatibility, antibacterial properties, anti-inflammatory and in vivo retention of Ga-CurNPs@COF-NFMs were evaluated. At the cellular level, the pro-angiogenic and an tioxidant effects of Ga-CurNPs@COF-NFMs and their mechanisms were explored. Finally, the effect of Ga CurNPs@COF-NFMs on wound healing in rats was investigated, and the in vivo antibacterial mechanism was ex plored. This study not only provides a novel strategy for chronic wound treatment but also contributes to the de velopment and promotion of chronic wound therapy.

Scheme 1. Synthesis and application diagram of Ga-CurNPs@COF-NFMs as multifunctional wound dressings. (A) Synthesis pathway of Ga-CurNPs at room temperature. (B) In situ preparation of Ga-CurNPs@COF at 60ºC. (C) Schematic diagram of in situ preparation of Ga-CurNPs@COF-NFMs and their promotion of wound healing and angiogenesis.