研究方向聚焦单颗粒单细胞传感成像领域，构建了多种单颗粒传感检测平台，发展了纳米颗粒形成和结构调控机制的可视化研究策略；原创性提出配位诱导结构刚性化的磷光增强机制，克服了磷光分析技术难以在水溶液中进行的不足，实现了复杂生物体系中待测物精准可靠的磷光检测。研究成果发表在Angew. Chem., Adv. Mater., Anal. Chem.等SCI期刊，并出版英文专著1部，授权专利2项。

代表性论文（^#代表共同第一作者，* 代表通讯作者）

1. Ya Ting Gao, Yi Lin Zhu, Xiao Yuan Wang, Li Ya Liang, Meng Li Liu, Shuai Chang, Han Bin Xu, Da Wei Li,* and Bin Bin Chen,* Pure organic electrophosphorochromism system, Chin. Chem. Lett., 2025, 110855.

2. Li Ya Liang,#Bin Bin Chen,#, * Ya Ting Gao, Jian Lv, Meng Li Liu, and Da Wei Li,* Aqueous solution enhanced room temperature phosphorescence through coordination-induced structural rigidity, Adv. Mater., 2024, 36, 2308180.

3. Bin Bin Chen,* Yue Wang, Meng Li Liu, Shuai Chang, Jian Lv, Ya Ting Gao, and Da Wei Li,* Bandgap engineering of scandium microspheres for anti-counterfeiting and multicolor imaging, Adv. Optical Mater., 2023, 11, 2202850.

4. Bin Bin Chen,*, # Meng Li Liu,# Ya Ting Gao,# Shuai Chang, Ruo Can Qian, and Da Wei Li,* Design and applications of carbon dots-based ratiometric fluorescent probes: A review, Nano Res., 2023, 16, 1064-1083.

5. Li Ya Liang, Bin Bin Chen,* Yue Wang, Ya Ting Gao, Shuai Chang, Meng Li Liu, Da Wei Li,* Inorganic salt recrystallization strategy for achieving ultralong room temperature phosphorescence through structural confinement and aluminized reconstruction, J. Colloid Interface Sci., 2023, 649, 445-455.

6. Bin Bin Chen,# Meng Li Liu,# Hong Yan Zou, Yang Liu, Yuan Fang Li, Mark T Swihart,* and Cheng Zhi Huang,* In situ imaging of ion motion in a single nanoparticle: Structural transformations in selenium nanoparticles, Angew. Chem. Int. Ed., 2022, 61, e202210313.

7. Bin Bin Chen, Shuai Chang, Lei Jiang, Jian Lv, Ya Ting Gao, Yue Wang, Ruo Can Qian, Da Wei Li,* and Mahmoud Elsayed Hafez, Reversible polymerization of carbon dots based on dynamic covalent imine bond, J. Colloid Interface Sci., 2022, 621, 464-469.

8. Bin Bin Chen, Meng Li Liu,and Cheng Zhi Huang,* Recent advances of carbon dots in imaging-guided theranostics, TrAC Trends Anal. Chem., 2021, 134, 116116.

9. Bin Bin Chen, Meng Li Liu,and Cheng Zhi Huang,* Carbon dot-based composites for catalytical applications, Green Chem., 2020, 22, 4034-4054.

10. Bin Bin Chen, Meng Li Liu, Lei Zhan, Chun Mei Li,and Cheng Zhi Huang,* Terbium (III) modified fluorescent carbon dots for highly selective and sensitive ratiometry of stringent, Anal. Chem., 2018, 90, 4003-4009.