from http://qinlab.sls.cuhk.edu.hk/ENPD/index

Eukaryotic Nucleic acid binding Protein Database (ENPD) is an online library of nucleic acid binding proteins (NBPs) and their functional information. Nucleic acid binding proteins (NBPs), i.e., DNA binding proteins (DBPs), RNA-binding proteins (RBPs) as well as DNA and RNA binding proteins (DRBPs) are capable of regulating genes by interacting with DNA, RNA or both respectively. They are highly cooperated with each other and perform vital functions in every stage of gene regulation (1-3). To enhance and facilitate our understanding towards gene regulation mediated by nucleic acid binding proteins, the Nucleic acid binding proteins (NBPs) repertoires of various eukaryotic organisms- Eukaryotic Nucleic acid binding Protein Database have been constructed based on manual curation and a new developed pipeline by analyzing sequenced transcriptomes and genomes. From transcriptomes and genomes available for around 1770 and 790 eukaryotic species respectively, 662 NBP families with more than 2866174 of NBPs were predicted with inferred binding motifs for a total number of 2423 species, constituting the largest NBP database that includes DBPs, RBPs, and DRBPs.

Nucleic Binding Protein statistic summary from 6 model organisms

Ref.  ENPD - A Database of Eukaryotic Nucleic Acid Binding Proteins: Linking Gene Regulations to Proteins

Ricky Wai Tak Leung1, Xiaosen Jiang2,3,4, Ka Hou Chu1,2 and Jing Qin1,2,5,*

1School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China,

2Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, 

3School of FutureTechnology, The University of Chinese Academy of Sciences, Beijing 100049, China, 

4College of Life Science &Technology, Huazhong University of Science and Technology, Wuhan 430074, China and 

5School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China