1. 靶向G-四链体的金属配合物的设计，1名。

2. 核酸纳米水凝胶在生物医学中的应用，1名。

邵昉伟博士在美国加州理工学院化学与化工学院院长Jacquelien K. Barton教授的指导下完成了博士学位，在美国哈佛大学医学院和马塞诸萨州总医院进行了博士后的研究。2010年，加入了新加坡南洋理工大学化学与生物化学系，获得南洋助理教授计划的支持，建立独立课题研究组，开展科研与教学并重的学术研究工作。2019年，加入浙江大学伊利诺伊大学厄巴纳香槟校区联合学院。研究方向：核酸化学；生物无机化学；化学生物学；生物纳米材料. 代表性通讯作者论文发表于J. Am. Chem. Soc, Angewandte Chemie International Edition, Nucleic Acids Res等权威性国际期刊。更多信息请见邵老师个人主页 https://person.zju.edu.cn/fwshao。

岗位一：

1、有金属配合物的合成经验。能够基于四链体核酸结构，设计、制备有机配体，合成金属配合物，熟悉生物无机化学领域相关的各种表征和测试手段。

2、乐于思考，勇于尝试。基于四链体核酸和无机分子的相互作用，在分子探针、疾病诊疗、催化化学等方面的应用进行探索。

岗位二：

1、具有核酸合成，或有机高分子/无机金属纳米粒子合成及表征的经验。熟悉纳米粒子在细胞内的各种成像，生物代谢测试的手段。

2、有志于探索核酸纳米科技在各类生物医学前沿技术中的拓展应用，具体在组织工程学，靶向诊疗，基因编辑等方面。

岗位要求

1、 品学兼优、身体健康，年龄不超过35周岁；

2、近三年内获得国内C9高校或第四轮学科评估A+学科或海外顶尖大学博士学位者优先；

3、具有良好的学术表现及学术发展潜力，勤奋主动，责任心强，认真负责，具有良好的团队协作精神。

发送个人简历（包括个人基本信息、学习工作经历、参与科研项目、科研成果），代表性论文5篇以及其它能证明科研能力的材料。经导师和院系通过后报浙江大学审批。经学校批准录用人员，须登录中国博士后网注册，并按浙江大学博士后进站程序办理进站。

入选者在导师指导下在浙江大学国际联合校区开展研究工作，根据浙江大学博士后管理工作规定完成相应的考核，完成研究工作并达到相应学科的博士后出站要求后办理出站。博后为2~3年。学校与导师将给予每年最高共20万元的资助，并结合文章发表给与绩效奖励。入选者在资助期内享受浙江大学和国际校区的各类博士后相关福利。

浙江省海宁市海州东路718号，浙江大学伊利诺伊大学厄巴纳香槟校区联合学院（ZJU-UIUC）

有意者，请将简历发送至fangweishao@intl.zju.edu.cn.

Postdoctoral Research Position at Zhejing University-UIUC Institute

1. Research Direction

A）Metal complexes for targeting DNA/RNA G-qaudraplex

B）DNA hydrogels for the applications in biomedical technologies

2. Research Group and PI:

Dr Fangwei Shao graduated from Fudan University with BS and MS in Chemistry. She then moved to USA to pursue her Ph.D. at California Institute of Technology under the supervision of Professor Jacqueline K. Barton from 2002 to 2007. She further obtained postdoctoral research training at Harvard Medical School/Massachusetts General Hospital from 2007-2010 at Professor (M.D.) Ralph Weissleder’s group. She has begun her independent academic career at Division of Chemistry and Biological Chemistry at Nanyang Technological University (Singapore) as Nanyang Assistant Professor since 2010. In early 2019, She joined ZJU-UIUC as an associate professor. She is member of ACS, RSC, SNIC, and many professional societies. Her research group hold expertise in nucleic acid chemistry and DNA nanotechnology. The applications are across the interface of bioinorganic chemistry, bioconjugate chemistry, chemical biology, biomedical chemistry, material chemistry and catalysis. She has published on many prestigious journals, including JACS, PNAS, Angewandte Chemie, Nucleic Acid Res, etc and was invited to give talks and seminars on many international conference and universities overseas. She was invited as regular reviewers for many journals from ACS, RSC, Wiley, Nature and Elsevier. Please refer to the research group home page for details: http://person.zju.edu.cn/fwshao/.

3. Eligibility

A) Position I:

1.The candidate should have experience in the metal complex synthesis and characterization and is capable to design and to prepare metal complexes based upon the structure of G-quadruplex DNA.

2.The candidate have experience in the study of the nucleic acid or protein binding ligands and their interactions/reactions and have interests in exploring the applications of the metal complexes as molecular probes, theranostic agents and catalysts.

B) Postistion II:

1.The candidate should have experience in a) the synthesis and characterization of nanoparticles and/or oligonucleotides/PNA, and b) molecular biology techniques, including cell culture, bioimaging, RT-PCR, flow cytometry, etc.

2.The candidate have interests in exploring the fabrication of DNA hydrogels and the applications to variety of biomedical technology.

C) General requirement:

1. The applicants shall be under 35 years old or obtain PhD degree in the past three years, of good moral character, and in good health.

2. Ph.D. degree from domestic C9 universities, or from “A plus” disciplines of the fourth round of national discipline assessment by China Academic Degrees & Graduate Education Development Center, or from top overseas universities are highly appreciated.

3. Applicants shall have good academic performance and research capability, and be diligent, active, and responsible, and have a good spirit of teamwork.

4. Application Procedures

Send a resume (including basic personal information, study and work experiences, participation in research projects, publication list, etc), 5 representative papers and other materials by email. Shortlisted candidates will be interviewed by PI and/or institute and be reported to Zhejiang University for approval. Upon successful application, the selected candidates shall finish the registration procedures and will be subject to the management of Zhejiang University.

5. Assessment and Salary

The selected candidates will carry out research work under the guidance of supervisors of Dr Shao Fangwei at ZJU-UIUC campus in Haining, Zhejiang, China. The candidates shall fulfill the corresponding assessments according to the post-doctoral management regulations of Zhejiang University, complete the research work, and reach the post-doctoral requirements of the corresponding disciplines.

The successful candidates will be funded for two to three years. The full salary will be ￥200,000/year from Zhejiang University and/or PI’s research grants. Stimulus bonus will be awarded based upon performance and the publications. Successful candidates will also enjoy the benefits of the common postdoctoral program at Zhejiang University.

6. Contacts

Dr Shao Fangwei

Address: ZJU_UIUC Institute, Zhejiang University, 718 Haizhou East Road, Haining, Zhejiang, China 314400

E-mail addresses: fangweishao@intl.zju.edu.cn