David Lawrence works to understand the biochemical processes of the cell by studying them as they happen in the cell as opposed to studying them in vitro. He currently focuses on applying his discoveries to cancer detection and treatment and, to a more limited extent, inflammatory diseases.
Lawrence is a Fred Eshelman Distinguished Professor of Medicinal Chemistry and holds joint appointments in the Department of Chemistry and the Department of Pharmacology and is a member of the UNC Lineberger Comprehensive Cancer Center.
Before joining the University of North Carolina at Chapel Hill in 2007, Lawrence spent eleven years as a professor of biochemistry at the Albert Einstein College of Medicine at Yeshiva University in New York. Before that, he was at the State University of New York at Buffalo for ten years.
Light Activated Drugs
Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S. Lawrence, John B. Buse, and Zhen Gu, “Red Blood Cells for Glucose Responsive-Insulin Delivery”, Advanced Materials, 2017, 29, 1606617.
Colin P. O’Banion, Melanie A. Priestman, Robert M. Hughes, Laura E. Herring, Stephen J. Capuzzi, and David S. Lawrence, “Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase”, Cell Chemical Biology, 2017, 24, in press.
Melanie A. Priestman, Qunzhao Wang, Finith E. Jernigan, Ruma Chowdhury, Marion Schmidt, and David S. Lawrence "Multicolor Monitoring of the Proteasome’s Catalytic Signature," ACS Chemical Biology, 2015, 10, 433 – 40.
Zachary L. Rodgers, Robert M. Hughes, Laura M. Doherty, Jennifer R. Shell, Brian P. Molesky, Alexander M. Brugh, Malcolm D. E. Forbes, Andrew M. Moran, and David S. Lawrence "B12-Mediated, Long Wavelength Photo-polymerization of Hydrogels," J. Amer. Chem. Soc. 2015, 137, 3372 – 80.
Robert M. Hughes, David J. Freeman, Kelsey N. Lamb, Rebecca M. Pollet, Weston J. Smith, and David S. Lawrence, "Optogenetic Apoptosis: Light-Triggered Cell Death," Angewandte Chemie International Edition, 2015, 54, 12064 - 8.
Thomas A. Shell and David S. Lawrence, "Vitamin B12: A Tunable, Long Wavelength, Light-Responsive Platform for Launching Therapeutic Agents," Accounts of Chemical Research, 2015, 48, 2866 - 74.
Colin P. O’Banion, Luong T. Nguyen, Qunzhao Wang, Melanie A. Priestman, Stephen P. Holly, Leslie V. Parise, and David S. Lawrence, "The Plasma Membrane as a Reservoir, Protective Shield, and Light-Triggered Launch Pad for Peptide Therapeutics," Angewandte Chemie International Edition, 2016, 55, 950 - 54.
Abigail H. Turner, Michael S. Lebhar, David S. Lawrence, and Nancy L. Allbritton, "A Conformationally-Constrained Tyrosine Analog that is Dephosphorylation-Resistant Enables In Cellulo Measurement of Tyrosine Kinase Activity by Directed Metabolic Cytometry," ACS Chemical Biology, 2016, 11, 355-62.
Zachary L. Rodgers, Thomas A. Shell, Alexander M. Brugh, Hannah L. Nowotarski, Malcolm D.E. Forbes, and David S. Lawrence, "Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins," Inorganic Chemistry, 2016, 55, 1962-69.
Emilie R. Mainz, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton, “An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells”, Angewandte Chemie International Edition, 2016, 55, 13095 - 8.
Angela Proctor, Imola G. Zigoneanu, Qunzhao Wang, Christopher E. Sims, David S. Lawrence, and Nancy L. Allbritton, “Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells”, Analyst, 2016, 141, 6008 - 17.
Robert M. Hughes, Christina M. Marvin, Zachary L. Rodgers, Song Ding, Nathan P. Oien, Weston J. Smith, and David S. Lawrence, “Photo-Triggered Secretion of Membrane Compartmentalized Bioactive Agents”, Angewandte Chemie International Edition, 2016, 55, 16080 - 3. Received “Hot Paper” designation.