Yoon, Juyoung - Ewha Womans University - Department of Chemistry and Nano Science

个人简介

Education 1990 - 1994 Ohio State University, Columbus, Ohio, Ph. D. in Organic Chemistry Supervisor: Dr. Anthony W. Czarnik 1983 - 1987 Seoul National University, Korea, B. S. in Industrial Chemistry Professional Experience 2014 - Present Distinguished Professor, Department of Chemistry Nano Science, Ewha Womans University 2009 - Present Professor, Department of Chemistry Nano Science, Ewha Womans University 2002 - 2009 Assistant/Associate Professor, Department of Chemistry Nano Science,Ewha Womans University 1998 - 2002 Assistant Professor of Department of Chemistry, Silla University 1996 - 1998 Post-Doctoral Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA (Professor Kim D. Janda) 1994 - 1996 Post-Doctoral Fellow, Department of Chemistry, UCLA (Professor Doanld J. Cram)

研究领域

Photodynamic Therapy(PDT) & Theranostics PDT(Photodynamic therapy) is based on the induction of tissue and cellular damage by the combined effects of three components including a photosensitizer (PS), light and oxygen. PDT is a promising cancer treatment modality in which the therapeutic action can be satisfied by generating singlet oxygen in tumors regions. One important contribution to the critically needed tumor selectivity of PDT is associated with the fact that PSs, which can be designed and constructed with targeting groups (active targeting strategy) or nano-delivery systems (passive targeting strategy), have tendencies to accumulate in tumor tissues to a greater extent than they do in normal tissues. On the other hand, irradiation light (in the red or near IR region) used for exciting the PS can be tightly focused on the tumor regions, essentially assuring the selective generation of singlet oxygen. Moreover, some other advantages of PDT, such as enhancement in the immune response and minimally invasive treatment methods, make PDT very attractive in clinical applications compared to conventional therapies. Activatable Photosensitizers Photosensitizers (PSs) are synthetic or natural chemicals that participate as light absorbing species in PDT processes. An ideal PS for PDT should possess the following characteristics: (1) readily obtained, (2) pure chemical form of known composition, (3) soluble and stable in physiological media or pharmaceutically acceptable formulations, (4) high extinction coefficient in the phototherapeutic window (650–850 nm) and low absorption in 400–600 nm, (5) inherently high quantum yield for ROS formation, especially 1O2, (6) minimal dark toxicity, (7) greater accumulation in diseased over healthy tissues, and (8) rapid clearance from body after treatment.

近期论文

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Clinical Development and Potential of Photothermal and Photodynamic Cancer Therapy Xingshu Li, Jonathan F. Lovell*, Juyoung Yoon*, and Xiaoyuan Chen* Nat. Rev. Clin. Oncol. 2020 , in revision. Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents Luling Wu, Chusen Huang,* Ben P. Emery, Adam C. Sedgwick, Steven D. Bull, Xiao-Peng He, He Tian,* Juyoung Yoon* Jonathan L. Sessler,* and Tony D. James* Chem. Soc. Rev 2020 , in revision. A Lysosome-Localized Thionaphthalimide as a Potential Heavy-Atom-Free Photosensitizer for Selective Photodynamic Therapy Van-Nghia Nguyen, Gain Baek, Sujie Qi, Seonye Heo, Yubin Yim, and Juyoung Yoon* Dyes and Pigments 2020 DOWNLOAD LINK Fine-tuning the electronic structure of heavy-atom-free BODIPY photosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy Sujie Qi, Nahyun Kwon, Yubin Yim, Van-Nghia Nguyen,* and Juyoung Yoon* Chem. Sci. 2020 DOWNLOAD LINK Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPYs for Photodynamic Therapy and Bioimaging Van-Nghia Nguyen, Yubin Yim, Sangin Kim, Bokyeong Ryu, K. M. K. Swamy, Gyoungmi Kim, Nahyun Kwon, C-Yoon Kim,* Sungnam Park* and Juyoung Yoon*Angew. Chem. Int. Ed. 2020 , accepted. DOWNLOAD LINK Nano Theranostics Platforms that Utilize Proteins Songyi Lee, Thanh Chung Pham, Chaeeon Bae, Yong Kyun Kim, Yeong Hwan Choi, Juyoung Yoon*Coord. Chem. Rev. 2020 , 412 , 213258 DOWNLOAD LINK Observing Fluctuations in the Activity of an Overexpressed Tumor Enzyme via Activatable AIEgens with High Fidelity for Surgical Excision Haidong Li, Qichao Yao, Feng Xu, Yueqing Li, Dayeh Kim, Jeewon Chung, Gain Baek, Xiaofeng Wu, Prima Fitria Hillman, Eun Young Lee, Haoying Ge, Jiangli Fan, Jingyun Wang, Sang-Jip Nam, Xiaojun Peng,* Juyoung Yoon* Angew. Chem. Int. Ed. 2020 , in press. Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy Xingshu Li, Eun-Yeong Park, Youngnam Kang, Nahyun Kwon, Mengyao Yang, Seunghyun Lee, Won Jong Kim,* Chulhong Kim,* and Juyoung Yoon*Angew. Chem. Int. Ed. 2020 , 132 , 2-7. DOWNLOAD LINK A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria Zhi-Hao Yu, Xingshu Li, Fugui Xu, Xi-Le Hu, Jiatao Yan, Nahyun Kwon, Guo-Rong Chen, Tingting Tang, Xiaojing Dong, Yiyong Mai,* Daijie Chen,* Juyoung Yoon,* Xiao-Peng He,* and He Tian Angew. Chem. Int. Ed. 2020 , 59 , 3568-3664. DOWNLOAD LINK Bio‐Conjugated Advanced Materials for Targeted Disease TheranosticsXi‐Le Hu, Nahyun Kwon, Kai‐Cheng Yan, Adam C. Sedgwick, Guo‐Rong Chen, Xiao‐Peng He*, Tony D. James*, Juyoung Yoon* Adv. Funct. Mater. 2020 , 30(13) , 1907906. DOWNLOAD LINK An APN-Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying Haidong Li, Qichao Yao, Wen Sun, Kun Shao, Yang Lu, Jeewon Chung, Dayeh Kim, Jiangli Fan, Saran Long, Jianjun Du, Yueqing Li, Jingyun Wang, Juyoung Yoon,*, and Xiaojun Peng* J. Am. Chem. Soc. 2020 , 142(13) , 6381-6389. DOWNLOAD LINK Optical and Fluorescent Dual Sensing of Aminoalcohols by in situ Generation of BODIPY-like Chromophore Mukesh Eknath Shirbhate, Seongyeon Kwon, Ayoung Song, Seungha Kim, Dayeh Kim, Haofei Huang, Youngmee Kim, Hanna Lee, Sung-Jin Kim, Mu-Hyun Baik,* Juyoung Yoon,* Kwan Mook Kim* J. Am. Chem. Soc. 2020 , 142(11) , 4975-4979. DOWNLOAD LINK Control strategy of displacement processes to sense biothiols via fluorescent changes Nahyun Kwon, Joohee Hong, Gyoungmi Kim, Eun Jin Jun, and Juyoung Yoon* Dyes and Pigments 2020 , 173 , 107871. DOWNLOAD LINK Assembly strategies of organic-based imaging agents for fluorescence and photoacoustic bioimaging applications Hong-Bo Cheng, Yuanyuan Li, Ben Zhong Tang,* and Juyoung Yoon* Chem. Soc. Rev. 2020 , 49(1) , 21-31. DOWNLOAD LINK Synthetic ratiometric fluorescent probes for detection of ions Sang-Hyun Park, Nahyun Kwon, Jee-Hyeon Lee, Juyoung Yoon* and Injae Shin* Chem. Soc. Rev. 2020 , 49(1) , 143-179. An azulene-derived fluorescent probe for bioimaging: Detection of reactive oxygen and nitrogen species by two-photon microscopy Lloyd Murfin, Maria Weber, Sang Jun Park, Won Tae Kim, Carlos Lopez-Alled, Claire McMullin, Fabienne Pradaux-Caggiano, Catherine Lyall, Gabriele Kociok-Kohn, Jannis Wenk, Steven Bull, Juyoung Yoon, Hwan Myung Kim,* Tony James* and Simon Lewis,* J. Am. Chem. Soc. 2020 , 141(49) , 19389-19396. DOWNLOAD LINK 2019 347 Naphthoimidazolium based ratiometric fluorescent probes for F- and CN- and anion-activated CO2 sensing Nahyun Kwon, Gain Baek, K. M. K. Swamy, Minji Lee, Qingling Xu, Youngmee Kim, Sung-Jin Kim, and Juyoung Yoon* Dyes and Pigments 2019 , 171 , 107679. DOWNLOAD LINK 346 A Selective Colorimetric and Fluorometric Chemosensor Based on Conjugated Polydiacetylenes for Cadmium Ion Detection Thanh Chung Pham, Yong Kyun Kim, Jung Bin Park, Sumin Jeon, Juhyeon Ahn, Yubin Yim, Juyoung Yoon* and Songyi Lee,* ChemPhotoChem 2019 , 3(11) , 1133-1137. DOWNLOAD LINK 345 A Paper-Based Chemosensor for Highly Specific, Ultrasensitive, and Instantaneous Visual Detection of Toxic Phosgen Lintao Zeng,*a,c Hongyan Zeng,c Shuangfei Wang,a Shan Wang,b Ji-Ting Hou*b and Juyoung Yoon* Chem. Commun. 2019 , 55(91) , 13753-13756.