Zhou, Steve - Nanyang Technological University - Division of Chemistry and Biological Chemistry

个人简介

PhD (Organic Chemistry) Massachusetts Institute of Technology 2005 MSc (Organic Chemistry) National University of Singapore 2000 BSc (Chemistry) (Hons) 1st Class National University of Singapore 1998 BSc (Chemistry & Biochemistry) National University of Singapore 1997

研究领域

My research programs will be focused to devise efficient and practical ways to access important chiral building blocks from cheap, readily available feedstock chemicals. The importance of this quest is underscored by over $ 200 billion sales of chiral drugs, projected for 2008. Despite tremendous advances in asymmetric catalysis, preparation of several key building blocks still needs much improvement. My research programs will specifically target these classes of compounds, e.g., epoxides, alkyl amines, alkyl alcohols, carbocycles, and heterocycles. I am also interested in the synthesis of fluorinated arenes and heteroarenes, due to their frequent occurrence in both pharmaceuticals and agrochemicals. To achieve these goals, my group will be engaged in the design and synthesis of both transition metal and organic catalysts, method development and mechanistic investigations. My other interests include: general-purpose, organic platforms for both structural and functional modeling of metalloenzyme active sites; new designs of organic polymers and oligomers for solar energy harvesting and conversion.

近期论文

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Copper-Catalyzed Asymmetric 1,2-Addition of Organoborons to Aldimines via an Elementary Step of 1,4-Addition. Chunlin Wu, Adhitya Mangala Putra Moeljadi, Hajime Hirao,* Jianrong Steve Zhou* (HH contributed DFT calculation) J. Am. Chem. Soc. 2017, under review Nickel-Catalyzed N-Alkylation of both Acylhydrazines and Arylamines with Alcohols and Enantioselective Examples. Peng Yang, Caili Zhang, Yu Ma, Caiyun Zhang, Aijie Li, Bo Tang* and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, under review Asymmetric intermolecular Heck reaction of propargylic acetates and cycloalkenes to access fused cyclobutenes. Zhiwei Jiao, Qi Shi, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, under revision Nickel-catalyzed asymmetric reductive Heck cyclization of aryl halides to Access indolines. Xurong Qin, Marcus Wen Yao Lee, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, online. DOI: 10.1002/anie.201707134 14 Aug 2017 Nickel-catalyzed direct synthesis of aryl olefins from ketones and organoboron reagents under neutral conditions. Chuanhu Lei, Yong Jie Yip, Jianrong Steve Zhou* J. Am. Chem. Soc. 2017, 139, 6086. DOI: 10.1021/jacs.7b02742 12 Apr 2017 One of the most read JACS articles of the month. Cited by Chemeurope.com and x-mol.com Palladium-Catalyzed Arylation of Ketones and Acetonitrile with ortho-Alkylation of Aryl Rings: de novo Synthesis of Tetralines and Benzocycloheptenes. Chuanhu Lei, Jiajia Cao, Jianrong Steve Zhou* Org. Lett. 2016, 18, 6120. DOI: 10.1021/acs.orglett.6b03130 22 Nov 2016 Cited by Chemsrc.com and x-mol.com Palladium-Catalyzed Asymmetric -Arylation of Alkylnitriles. Zhiwei Jiao, Kwok Wei Chee, Jianrong Steve Zhou* J. Am. Chem. Soc. 2016,138, 16240. DOI: 10.1021/jacs.6b11610 7 Dec 2016 One of most read JACS articles of the month. Highlighted by Hisashi Yamamoto et al. in Synfacts 2017, 13(3), 274. Cited by organometallics.blogspot.com and x-mol.com Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones. Zhiwei Jiao, Jason Beiger, Yushu Jin, Shaozhong Ge, Jianrong Steve Zhou,* John F. Hartwig* (Each team contributed catalytic reaction methods of complementary substrate scope) J. Am. Chem. Soc. 2016, 138, 15980. DOI: 10.1021/jacs.6b09580 6 Nov 2016 One of most read JACS articles of the month. Highlighted by Lautens et al. in Synfacts 2017, 13(2), 155. DOI: 10.1055/s-0036-1589898 N,N-Dimethylformamide as Hydride Source in Nickel-Catalyzed Asymmetric Hydrogenation of -Unsaturated Esters. Siyu Guo, Jianrong Steve Zhou* Org. Lett. 2016, 18, 5344. DOI: 10.1021/acs.orglett.6b02662 6 Oct 2016 One of the most read Org Lett articles of the month. Highlighted by Lautens et al. in Synfacts 2016, 12, 1270 Highlighted by Organic Chemistry Portal in 2017 Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide. Peng Yang, Li Hui Lim, Pratanphorn Chuanprasit, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed calculation) Angew. Chem. Int. Ed. 2016, 55, 12083. DOI: 10.1002/anie.201606821 30 Aug 2016 Featured by x-mol.com in 2016 Palladium-Catalyzed Alkynylation and Concomitant ortho-Alkylation of Aryl Iodides. Chuanhu Lei, Xiaojia Jin, Jianrong (Steve) Zhou* ACS Catal. 2016, 6, 1635. DOI: 10.1021/acscatal.6b00169 3 Feb 2016 Asymmetric Conjugate Addition of Organoboron Reagents to Common Enones Using Copper Catalysts. Chunlin Wu, Guizhou Yue, Christian Duc-Trieu Nielson, Kai Xu, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed DFT calculation) J. Am. Chem. Soc. 2016,138, 742. DOI: 10.1021/jacs.5b11441 15 Jan 2016 One of the most read JACS articles of the month. Highlighted by Lautens et al. in Synfacts 2016, 12(4), 394. DOI: 10.1055/s-0035-1561815 Highlighted by Organic Chemistry Portal in 2016. Cited by x-mol.com